Episodic memory is the name of the kind of memory that records personal experiences instead of the mere remembering of impersonal facts and rules. This type of memory is extremely sensitive to ageing and disease so an understanding of the mechanisms of episodic memory might lead to the development of therapies suited to improve memory in some patient populations. Episodic memory is unique in that it includes an aspect of self-awareness and helps us to remember who we are in terms of what we did and what we have been passed through and what we should do in the future.
This book brings together a renowned team of contributors from the fields of cognitive psychology, neuropsychology and behavioural and molecular neuroscience. It provides a detailed and comprehensive overview of recent developments in understanding human episodic memory and animal episodic-like memory in terms of concepts, methods, mechanisms, neurobiology and pathology. The work presented within this book will have a profound effect on the direction that future research in this topic will take.
- The first and most current comprehensive handbook on what we know about episodic memory, the memory of events, time, place, and emotion, and a key feature of awareness and consciousness
- Articles summarize our understanding of the mechanisms of episodic memory as well as surveying the neurobiology of epsidodic memory in patients, animal studies and functional imaging work
- Includes 34 heavily illustrated chapters in two sections by the leading scientists in the field

Volume 3 of Biomembranes covers receptors of cell adhesion and cellular recognition. Proteins in the plasma membrane of cells are heavily involved in processes of cell adhesion, but such proteins were not actually isolated and characterized until the mid-1970s. Since then, application of the methods of molecular biology has led to the recognition of four major classes of cell adhesion molecule (CAMs), the immunoglobulin super family, the cadherins, the integrins, and the selecting. A convenient system in which to study the importance of cell adhesion is in blood platelets where aggregation eventually leads to thrombus formation in a process involving a range of surface glycoproteins. Interaction with the extracellular matrix is exemplified by CD44, the receptor for hyaluronan, and a complex carbohydrate that is a major component of the extracellular matrix surrounding migrating and proliferating cells. Membrane-associated mucins have a variety of effects on cell adhesion. The super family of immunoglobulin related proteins also include the T cell receptors and the major histocompatibility complex (MHC), which, together with the receptors for immunoglobulins (the Fc receptors), are of fundamental importance in the processes of immunity. Volume 3 of Biomembranes explores the structures and functions of the molecules involved in these important functions of the cell.

Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective.

The contents are organized by biological system or molecule. Each chapter discusses insights that have been revealed about their mechanism, structure or function by single molecule techniques. Among the topics covered are enzymes, motor proteins, membrane channels, DNA, ribozymes, cytoskeletal proteins, and other key molecules of current interest. An introduction by the editor provides a concise review of key principles and an historical overview. The last section discusses applications in molecular diagnostics and drug discovery.

* Organized by biological system or molecule.

* Each chapter discusses insights into mechanism of action, structure, and function

* Covers enzymes, motor proteins, membrane channels, DNA, ribozymes, etc.

* Includes an introduction to key principles and an historical overview.

* Discusses applications in molecular diagnostics and drug discovery.

* Provides an expert's perspective on future developments.

"Annual Reports in Medicinal Chemistry" provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
* covers findings related to cardiovascular, inflammation, and pulmonary diseases
* examines issues in oncology, from mTor inhibitors to drug targets
* incorporates up-to-date information on drug design and discovery, including delivery to market

Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous sub-disciplines and subspecialties. This volume pulls all of the critical information into one volume eliminating the need to search through numerous books and journals which can be exhaustive and demanding. It provides cardiovascular physiologists with an integrated, in-depth evaluation of the latest research developments and will aide in developing new pathways of research and scholarship.
Key Features
* Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship.
* Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume.

Most employeers are astounded at how easily and quickly their proprietary information can get out of their control. In a large number of cases, theft of trade secrets often involves employees leaving a company to start their own business or work for a direct competitor.
Nearly all books that address the topic of trade secrets have the spy vs. spy perspective. The author approaches the topic from a practical business perspective and not simply creating paranoia for paranoia s sake. The material for this book comes from the author s extensive work experience as a computer forensics consultant and manager on numerous theft of trade secrets cases.
No-nonsense solutions to the most common intellectual property problems facing security managers, computer security professionals, corporate legal counsel, and human resource managersSample agreements and forms that address specific business needsCoverage of threats ranging from physical security lapses to hackers to social engineering"

The Fly River and its tributaries, the Ok Tedi and Strickland rivers, are located in the Western Province of Papua New Guinea. All three rivers have their source in the rugged central mountain range of the island and eventually flow, via the Fly River delta, into the Gulf of Papua to the north of Australia's Great Barrier Reef. With a catchment area still largely covered by tropical rainforest and relatively few human inhabitants, this remote part of Papua New Guinea presents a rare opportunity to document and understand the dynamics of a large tropical river system largely unaffected by human activity.
In 1984 the Ok Tedi Mining Company Limited began mining copper and gold mineralisation from Mt. Fubilan, which is located at the headwaters of the Ok Tedi. In 1990, mining begin at the Porgera gold mine located at the headwaters of the Strickland River. Since that time both companies have intensely monitored the environment of the Fly River system in order to better understand the possible impact of mining.
This book is intended to assemble and summarise this vast amount of information, much of it contained in internal company reports, to better understand the environmental complexity and dynamics of this large and relatively undisturbed tropical river system.
The approach to be taken in achieving this outcome is to solicit contributions summarising each of the scientific disciplines to be covered from recognised experts with experience in the region.
* documents physical and biologic change in a large tropical river system brought about largely by mining in an otherwise pristine environment.
* this book brings together a broad rand of disciplines to provide acomprehensive overview of change in a complex and dynamical tropical river system based largely on previously unpublished company reports.
* the book provides examples of state-of-the-art strategies and methodologies for monitoring environmental impact in a large river system.

Dr. Harris has played a major role in the development of this organism as a model system. Her previous version of the "Chlamydomonas Sourcebook" which published in 1989, has been a classic in the field and is considered required reading for anyone working with this organism. This latest edition has been expanded to include three volumes providing molecular techniques, analysis of the recently sequenced genome, and reviews of the current status of the diverse fields in which Chlamydomonas is used as a model organism. Methods for Chlamydomonas research and best practices for applications in research, including methods for culture, preservation of cultures, preparation of media, lists of inhibitors and other additives to culture media, are included. Additions to this volume also include help with common laboratory problems such as contamination, student demonstrations, and properties of particular strains and mutants.
"This volume is part of a 3-Volume Set (ISBN: 978-0-12-370873-1) and is also sold individually."
* Expanded revision of gold standard reference
* Includes latest advances in research, including completion of the genome
* Provides broad perspective with studies in cell and molecular biology, genetics, plant physiology and related fields
* Available as part of a 3-Volume Set or sold individually

Network processors are the basic building blocks of today's high-speed, high-demand, quality-oriented communication networks. Designing and implementing network processors requires a new programming paradigm and an in-depth understanding of network processing requirements. This book leads the reader through the requirements and the underlying theory of networks, network processing, and network processors. It covers implementation of network processors and intergrates EZchip Microcode Development Environment so that you can gain hands-on experience in writing high-speed networking applications. By the end of the book, the reader will be able to write and test applications on a simulated network processor.
Comprehensive, theoretical, and pracitical coverage of networks and high-speed networking applicationsDescirbes contemporary core, metro, and access networks and their processing algorithmsCovers network processor architectures and programming models, enabling readers to assess the optimal network processor typer and configuration for their applicationFree download from http: //www.cse.bgu.ac.il/npbook includes microcode development tools that provide hands-on experience with programming a network processor

Digital signal processing is commonplace in most electronics including MP3 players, HDTVs, and phones, just to name a few of the applications. The engineers creating these devices are in need of essential information at a moment's notice. The Instant Access Series provides all the critical content that a signal or communications engineer needs in his or her daily work.
This book provides an introduction to DSPs as well as succinct overviews of linear systems, digital filters, and digital compression. This book is filled with images, figures, tables, and easy to find tips and tricks for the engineer that needs material fast to complete projects to deadline.

*Tips and tricks feature that will help engineers get info fast and move on to the next issue
*Easily searchable content complete with tabs, chapter table of contents, bulleted lists, and boxed features
*Just the essentials, no need to page through material not needed for the current project

This book provides a comprehensive examination of Internet QoS theory, standards, vendor implementation and network deployment from the practitioner's point of view, including extensive discussion of related economic and regulatory issues. Written in a technology-light way so that a variety of professionals and researchers in the information and networking industries can easily grasp the material. Includes case studies based on real-world experiences from industry.
The author starts by discussing the economic, regulatory and technical challenges of the existing QoS model. Key coverage includes defining a clear business model for selling and buying QoS in relation to current and future direction of government regulation and QoS interoperability (or lack thereof) between carriers and networking devices. The author then demonstrates how to improve the current QoS model to create a clear selling point, less regulation uncertainty, and higher chance of deployment success. This includes discussion of QoS re-packaging to end-users; economic and regulatory benefits of the re-packaging; and the overall benefits of an improved technical approach. Finally, the author discusses the future evolution of QoS from an Internet philosophy perspective and lets the reader draw the conclusions.
This book is the first QoS book to provide in depth coverage on the commercial and regulatory aspects of QoS, in addition to the technical aspect. From that, readers can grasp the commercial and regulatory issues of QoS and their implications on the overall QoS business model. This book is also the first QoS book to provide case studies of real world QoS deployments, contributed by the people who did the actual deployments. From that, readers can grasp the practical issues of QoS in real world. This book is also the first QoS book to cover both wireline QoS and wireless QoS. Readers can grasp the QoS issues in the wireless world. The book was reviewed and endorsed by a long list of prominent industrial and academic figures.
* The only book to discuss QoS technology in relation to economic and regulatory issues
* Includes case studies based on real-world examples from industry practitioners.
* Provides unique insight into how to improve the current QoS model to create a clear selling point, less regulatory uncertainty, and higher chance of deployment success.

The aim of this Handbook is to acquaint the reader with the current status of the theory of evolutionary partial differential equations, and with some of its applications. Evolutionary partial differential equations made their first appearance in the 18th century, in the endeavor to understand the motion of fluids and other continuous media. The active research effort over the span of two centuries, combined with the wide variety of physical phenomena that had to be explained, has resulted in an enormous body of literature. Any attempt to produce a comprehensive survey would be futile. The aim here is to collect review articles, written by leading experts, which will highlight the present and expected future directions of development of the field. The emphasis will be on nonlinear equations, which pose the most challenging problems today.
. Volume I of this Handbook does focus on the abstract theory of evolutionary equations.
. Volume 2 considers more concrete problems relating to specific applications.
. Together they provide a panorama of this amazingly complex and rapidly developing branch of mathematics.

With the increasing awareness of food safety and quality, consumers continuously demand the reassurance of origin and content of their foods. Furthermore, manufacturers must be able to confirm the authenticity of components of their products in order to comply with government legislation. Protection of the rights of consumers, genuine food processors, and prevention of fraudulent or deceptive practices and the adulteration of food is an important and challenge facing the food industry.
Rapid scientific and technological advances in the determination of food authenticity have taken place in recent years and Modern Techniques for Food Authentication focuses on many of those novel techniques. Including coverage of various spectroscopic technologies, methods based on isotopic analysis and chromatography, DNA, enzymatic analysis, electrophosresis and thermal methods, this book provides a valuable, international resource on the latest developments in food authentication.
*A comprehensive overview of authentication techniques and technology
*Written by an international group of academic and professional peers
*Provides an excellent complement to more general books on food safety

This textbook is a graduate-level introduction to the field of clinical psychology. While most textbooks focus on either assessment, treatment, or research, this book covers all three together specifically for the introductory level graduate course. Chapter coverage is diverse and contributors come from both PhD and PsyD programs and a variety of theoretical orientations. Chapter topics cover the major activities of the contemporary clinical psychologist with an introduction focusing on training models.
The book has a mentoring style designed to highlight the relevance of the topics discussed to clinicians in training. Assessment and treatment chapters focus on evidence-based practice, comparing and contrasting different options, the basis for clinical choice between them, and efficacy of same.
It will also introduce business and ethical aspects of the clinical career that current introductory books do not include, such ethics in assesstment, treatment and research; third party payors; technological developments; dissemination of research findings; cross-cultural issues; and the future of the profession.
* Includes assessment, treatment, and practice issues
* Compares and contrasts different therapeutic styles
* Exemplifies practical application through case studies
* Focuses on evidence-based practice
* Orients future clinicians to contemporary issues facing psychological practices

This book focuses on the life and work of Nathan Zuntz (1847-1920), a German physiologist, who made significant contributions to high altitude physiology and aviation medicine.
He achieved fame for his invention of the Zuntz-Geppert respiratory apparatus in 1886 and the first treadmill (Laufband) in 1889. He also invented an X-ray apparatus to observe cardiac changes during exercise and constructed a climate chamber to study exercise under varying and sometimes extreme climates.
* Focuses on Zuntz's contribution to high altitude physiology and aviation medicine

"Load and Global Response of Ships" gives an introductory background to naval architecture statistics and strength of materials. Each subject is treated in detail; starting from the first principle. The aim of this title was to derive and present the necessary theoretical framework for predicting the extreme loads and the corresponding hull girder stresses that a ship may be subjected to during its operational lifetime.
Although some account is given to reliability analysis, the present treatment has to be supplemented with methods for detailed stress evaluation and for structural strength assessment before a complete structural reliability analysis can be carried out.
The classification societies have issued rules and regulations for a proper structural analysis of a ship and selection of the scantlings. Previously, those rules rather explicitly gave formulae for the thickness of the hull plantings, the size of the stiffeners etc. Such empirical rules must necessarily be rather conservative in order to apply to a large variety of ships. With the advent of powerful computers, the rules have changed. Today, the naval architect can perform the structural analysis using mainly rational methods based on first principles. The classification society may then specify proper safety factors against local global failure modes, taking into account the consequences of failure and the analysis procedure used. A cruder method of analysis then necessitates a larger safety factor. Therefore the effort made by the experienced naval architect to perform a detailed structural analysis will be returned not just by a rational structural arrangement but also often in lower weight of the ship and thus a higher payload throughout the operational lifetime of the ship.
This analysis has attempted to make explicit one way in which designers limit the design space by creating rules to which they expect users to adhere. It is also an attempt to encourage designers to reconsider the 'rules of use' that they have used in their designs, so as to reconceptualise potential usage. This can help design behaviour where rule use is not blindly followed.
By making these rules visible, it is possible to expose the limitations of current technology, and development design solutions that do not restrict use to the 'normal' case of action. Rules are useful to designers because they are simplifications of activity. Rules encode the normal case, and these are simplistic representations of work that are, in many cases, accurate enough for the purpose of design. However, encoding behaviour in rules has dangers in that they do not encompass the whole range of behaviours that can be performed. Using examples, this title shows that being able to break rules means that people are able to engage in a richer more flexible set of actions (and therefore more appropriate to contingency) than when they are constrained to a limited range.

Digital video is everywhere! The engineers creating HDTV, mp3 players, and smart phones and their components are in need of essential information at a moment's notice. The Instant Access Series provides all the critical content that a digital video engineer needs in his or her daily work.
This book provides an introduction to video as well as succinct overviews of analog and digital interfaces along with signal processing. This book is filled with images, figures, tables, and easy to find tips and tricks for the engineer that needs material fast to complete projects to deadline.
*Tips and tricks feature that will help engineers get up and running fast and move on to the next issue
*Easily searchable content complete with tabs, chapter table of contents, bulleted lists, and boxed features
*Just the essentials, no need to page through material not needed for the current project

Behavioral finance is the study of how psychology affects financial decision making and financial markets. It is increasingly becoming the common way of understanding investor behavior and stock market activity. In this 2nd Edition Hersh Shefrin examines the reigning assumptions of asset pricing theory and reconstructs them to incorporate findings from behavioral finance. In other words, he takes the traditional tools in asset pricing and behavioralizes them. He constructs a solid, intact structure that challenges classic assumptions and at the same time provides a strong theory and efficient empirical tools. Building on the models developed by both traditional asset pricing theorists and behavioral asset pricing theorists, Shefrin's book takes the discussion to the next step. He provides a general behaviorally based intertemporal treatment of asset pricing theory that extends to the discussion of derivatives, fixed income securities, mean-variance efficient portfolios, and the market portfolio, based on all the latest research and theory.
* The second edition continues the tradition of the first edition by being the one and only book to focus completely on how behavioral finance principles affect asset pricing, now with its theory deepened and enriched by a plethora of research since the first edition
* A companion website contains a series of examples worked out as Excel spreadsheets so that readers can input their own data to test the results

This book brings all of the elements of data mining together in a single volume, saving the reader the time and expense of making multiple purchases. It consolidates both introductory and advanced topics, thereby covering the gamut of data mining and machine learning tactics ? from data integration and pre-processing, to fundamental algorithms, to optimization techniques and web mining methodology.
The proposed book expertly combines the finest data mining material from the Morgan Kaufmann portfolio. Individual chapters are derived from a select group of MK books authored by the best and brightest in the field. These chapters are combined into one comprehensive volume in a way that allows it to be used as a reference work for those interested in new and developing aspects of data mining.
This book represents a quick and efficient way to unite valuable content from leading data mining experts, thereby creating a definitive, one-stop-shopping opportunity for customers to receive the information they would otherwise need to round up from separate sources.
* Chapters contributed by various recognized experts in the field let the reader remain up to date and fully informed from multiple viewpoints.
* Presents multiple methods of analysis and algorithmic problem-solving techniques, enhancing the reader's technical expertise and ability to implement practical solutions.
* Coverage of both theory and practice brings all of the elements of data mining together in a single volume, saving the reader the time and expense of making multiple purchases.

Volume 3 reviews virtually everything that is known about cell motility and behavior in Chlamydomonas. World experts in each area focus on mitosis and cytokinesis; flagellar assembly and motility; intraflagellar transport; dynein; the structure and function of centrioles/basal bodies and their associated structures; ciliary signaling; mating and gamete fusion; photobehaviors; and Chlamydomonas as a model for understanding human diseases of the cilium. The volume is richly illustrated and is supplemented by a website containing both classic and previously unpublished videos of cell motility in Chlamydomonas. A unique and especially valuable feature is the inclusion of tables listing the known proteins (with NCBI accession numbers) for each structure discussed, and the known mutations that affect each structure and process. Because Chlamydomonas has been the premier model for investigating the function and behavior of cilia and flagella, the chapters summarize the current state of knowledge in these areas as it applies to all ciliated organisms. Thus, this volume will be an essential source for all students and researchers interested in cell motility.
* Essential reference to a model species for the study of mechanisms of motility in free living cells
* Includes methods for Chlamydomonas motility research.
* Companion Website with videos illustrates the marvels of the Chlamydomonas flagella in action

The account in this inaugural volume of the series covers the period 1900 to 1960, but also outlines the principal developments in earlier centuries from which biochemistry emerged. Findings are considered in the light of present knowledge, rather than in a rigid historical framework.

This book focuses on broadband distribution and systems architecture and concentrates on practical concepts that will allow the reader to do their own design, improvement, and troubleshooting work. The objective is to enhance the skill sets of a large population that designs and builds broadband cable plants, as well as those maintaining and troubleshooting it. A large cross-section of technical personnel who need to learn these skills design, maintain, and service HFC systems from signal creation through transmission to reception and processing at the customer end point. In addition, data/voice and video specialists need to master and reference the basics of HFC design and distribution before contending with the intricacies of their own unique services. This book serves as an essential reference to all cable engineers-those who specifically design and maintain the HFC distribution plant as well as those primarily concerned with data/voice technology as well as video technology. Included is an online component consisting of spreadsheets that were used in developing the material presented in the book.
* Concentrates on practical concepts that will allow the user to do his own design, improvement, and trouble-shooting work.
* Prepares cable engineers and technicians to work with assurance as they face the latest developments and future directions.
* Concise and tightly focused, allowing readers to easily find answers to questions about an idea or concept they are developing in this area.

Ground-penetrating radar (GPR) is a rapidly developing field that has seen tremendous progress over the past 15 years. The development of GPR spans aspects of geophysical science, technology, and a wide range of scientific and engineering applications. It is the breadth of applications that has made GPR such a valuable tool in the geophysical consulting and geotechnical engineering industries, has lead to its rapid development, and inspired new areas of research in academia. The topic of GPR has gone from not even being mentioned in geophysical texts ten years ago to being the focus of hundreds of research papers and special issues of journals dedicated to the topic. The explosion of primary literature devoted to GPR technology, theory and applications, has lead to a strong demand for an up-to-date synthesis and overview of this rapidly developing field. Because there are specifics in the utilization of GPR for different applications, a review of the current state of development of the applications along with the fundamental theory is required. This book will provide sufficient detail to allow both practitioners and newcomers to the area of GPR to use it as a handbook and primary research reference.
*Review of GPR theory and applications by leaders in the field
*Up-to-date information and references
*Effective handbook and primary research reference for both experienced practitioners and newcomers

"Reward Deficit Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. "Reward Deficit Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. "Reward Deficit Disorders" also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the third volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, which is also available for purchase individually.
Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery processCritical evaluation of animal and translational models improving transition from drug discovery and clinical developmentEmphasizes what results mean to the overall drug discovery processExplores issues in clinical trial design and conductance in each therapeutic areaNeurological Disorders is available for purchase individually.

This volume provides a vital and comprehensive resource on stroke, including research, diagnosis, prevention, and treatment modalities. Practitioners in these fields will find invaluable information in this handbook, from basic mechanisms of the disease, to enhanced diagnostic and therapeutic capabilities for patient care.

With the field of cerebrovascular disorders, including stroke, making rapid advancements, clinicians will find illuminating and insightful chapters on the pathophysiological basis of this disorder.

Advances in our understanding of the biochemical background of strokes, coupled with an examination of breakthroughs in epidemiology, genetics, neuroimaging, interventional radiology, surgery, and even clinical psychology are also explored, giving researchers and clinicians a profoundly altered way to approach stroke research, diagnosis, and patient treatment and care.
* A comprehensive resource on stroke, prevention techniques, diagnosis, and treatment modalities
* Illuminating and insightful information on the pathophysiological basis of stroke
* A thorough examination of the rapid advancements made in the field of cerebrovascular disorders and their applications to stroke