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Books > Academic & Education > Professional & Technical
Volume 3 of Biomembranes covers receptors of cell adhesion and
cellular recognition. Proteins in the plasma membrane of cells are
heavily involved in processes of cell adhesion, but such proteins
were not actually isolated and characterized until the mid-1970s.
Since then, application of the methods of molecular biology has led
to the recognition of four major classes of cell adhesion molecule
(CAMs), the immunoglobulin super family, the cadherins, the
integrins, and the selecting. A convenient system in which to study
the importance of cell adhesion is in blood platelets where
aggregation eventually leads to thrombus formation in a process
involving a range of surface glycoproteins. Interaction with the
extracellular matrix is exemplified by CD44, the receptor for
hyaluronan, and a complex carbohydrate that is a major component of
the extracellular matrix surrounding migrating and proliferating
cells. Membrane-associated mucins have a variety of effects on cell
adhesion. The super family of immunoglobulin related proteins also
include the T cell receptors and the major histocompatibility
complex (MHC), which, together with the receptors for
immunoglobulins (the Fc receptors), are of fundamental importance
in the processes of immunity. Volume 3 of Biomembranes explores the
structures and functions of the molecules involved in these
important functions of the cell.
Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective. The contents are organized by biological system or molecule.
Each chapter discusses insights that have been revealed about their
mechanism, structure or function by single molecule techniques.
Among the topics covered are enzymes, motor proteins, membrane
channels, DNA, ribozymes, cytoskeletal proteins, and other key
molecules of current interest. An introduction by the editor
provides a concise review of key principles and an historical
overview. The last section discusses applications in molecular
diagnostics and drug discovery. * Organized by biological system or molecule. * Each chapter discusses insights into mechanism of action, structure, and function * Covers enzymes, motor proteins, membrane channels, DNA, ribozymes, etc. * Includes an introduction to key principles and an historical overview. * Discusses applications in molecular diagnostics and drug discovery. * Provides an expert's perspective on future developments.
The Fly River and its tributaries, the Ok Tedi and Strickland
rivers, are located in the Western Province of Papua New Guinea.
All three rivers have their source in the rugged central mountain
range of the island and eventually flow, via the Fly River delta,
into the Gulf of Papua to the north of Australia's Great Barrier
Reef. With a catchment area still largely covered by tropical
rainforest and relatively few human inhabitants, this remote part
of Papua New Guinea presents a rare opportunity to document and
understand the dynamics of a large tropical river system largely
unaffected by human activity.
Delays in construction projects are frequently expensive, since
there is usually a construction loan involved which charges
interest, management staff dedicated to the project whose costs are
time dependent, and ongoing inflation in wage and material prices.
Many techniques are used to analyze delays. Some of these methods
have inherent weaknesses and should be avoided. This book points
out the shortcomings of these faulty methods and explains how a
delay analysis should be performed. It then describes specifically
how the analysis is done with CPM schedules. A explanation of
delays and delay damages, presented in a straightforward,
accessible manner, should be useful to public and private owners,
construction managers, general contractors, subcontractors,
designers, suppliers, and attorneys whose work involves them in the
construction industry. The discussion will include subtleties of
the process, such as shifts in the critical path, and non-critical
delays. The subject of damages is covered in detail, including the
major categories of extended field overhead and unabsorbed home
office overhead. Likewise, the damages suffered by the owner,
either actual or liquidated, are also explained. Finally, a chapter
is devoted to managing the risk of delays and time extensions from
the viewpoints of the various parties to a construction project. A
discussion of early completion schedules and constructive
acceleration is also included.
Advances in Physical Organic Chemistry provides the chemical
community with authoritative and critical assessments of the many
aspects of physical organic chemistry. The field is a rapidly
developing one, with results and methodologies finding application
from biology to solid state physics.
Dr. Harris has played a major role in the development of this
organism as a model system. Her previous version of the
"Chlamydomonas Sourcebook" which published in 1989, has been a
classic in the field and is considered required reading for anyone
working with this organism. This latest edition has been expanded
to include three volumes providing molecular techniques, analysis
of the recently sequenced genome, and reviews of the current status
of the diverse fields in which Chlamydomonas is used as a model
organism. Methods for Chlamydomonas research and best practices for
applications in research, including methods for culture,
preservation of cultures, preparation of media, lists of inhibitors
and other additives to culture media, are included. Additions to
this volume also include help with common laboratory problems such
as contamination, student demonstrations, and properties of
particular strains and mutants.
Sharon Johnson is the author of the best selling Therapist's Guide
to Clinical Intervention now in its second edition. In this new
book on PTSD, she lends her practical outline format to
understanding PTSD assessment, treatment planning, and
intervention. The book begins with a summary information on PTSD
definition, and prevalence, assessment, and the evidence basis
behind different treatment options. The book offers adjunctive
skill building resources to supplement traditional therapy choices
as well as forms for use in clinical practice.
This book is the definitive guide to the techniques and applications of position location, covering both terrestrial and satellite systems. It gives all the techniques, theoretical models, and algorithms that engineers need to improve their current location schemes and to develop future location algorithms and systems. Comprehensive coverage is given to system design trade-offs, complexity issues, and the design of efficient positioning algorithms to enable the creation of high-performance location positioning systems. Traditional methods are also reexamined in the context of the challenges posed by reconfigurable and multihop networks. Applications discussed include wireless networks (WiFi, ZigBee, UMTS, and DVB networks), cognitive radio, sensor networks and multihop networks. Features Contains a complete guide to models, techniques, and applications of position location Includes applications to wireless networks, demonstrating the relevance of location positioning to these "hot" areas in research and development Covers system design trade-offs and the design of efficient positioning algorithms, enabling the creation of future location positioning systems Provides a theoretical underpinning for understanding current position location algorithms, giving researchers a foundation to develop future algorithms David Munoz is Director and Cesar Vargas is a member of the
Center for Electronics and Telecommunications, Tecnologico de
Monterrey, Mexico. Frantz Bouchereau is a senior communications
software developer at The MathWorks Inc. in Natick, MA. Rogerio
Enriquez-Caldera is at Instituto Nacional de Atrofisica, Optica y
Electronica (INAOE), Puebla, Mexico.
"Deploying QoS for IP Next Generation Networks: The Definitive
Guide" provides network architects and planners with insight into
the various aspects that drive QoS deployment for the various
network types. It serves as a single source of reference for
businesses that plan to deploy a QoS framework for voice, video,
mobility and data applications creating a converged infrastructure.
It further provides detailed design and implementation details for
various service deployments across the various Cisco platforms such
as the CRS-1, 12000, 7600 & 7200 series routers that are widely
deployed in most Carrier Networks.
This textbook is a graduate-level introduction to the field of
clinical psychology. While most textbooks focus on either
assessment, treatment, or research, this book covers all three
together specifically for the introductory level graduate course.
Chapter coverage is diverse and contributors come from both PhD and
PsyD programs and a variety of theoretical orientations. Chapter
topics cover the major activities of the contemporary clinical
psychologist with an introduction focusing on training models.
Hyaluronan biology is being recognized as an important regulator of
cancer progression. Paradoxically, both hyaluronan (HA) and
hyaluronidases, the enzymes that eliminate HA, have also been
correlated with cancer progression. Hyaluronan, a long-chain
polymer of the extracellular matrix, opens up tissue spaces through
which cancer cells move and metastasize. It also confers motility
upon cells through interactions of cell-surface HA with the
cytoskeleton. Embryonic cells in the process of movement and
proliferation use the same strategy. It is an example of how cancer
cells have commandeered normal cellular processes for their own
survival and spread. There are also parallels between cancer and
wound healing, cancer occasionally being defined as a wound that
does not heal.
"Load and Global Response of Ships" gives an introductory
background to naval architecture statistics and strength of
materials. Each subject is treated in detail; starting from the
first principle. The aim of this title was to derive and present
the necessary theoretical framework for predicting the extreme
loads and the corresponding hull girder stresses that a ship may be
subjected to during its operational lifetime.
Volume 3 reviews virtually everything that is known about cell
motility and behavior in Chlamydomonas. World experts in each area
focus on mitosis and cytokinesis; flagellar assembly and motility;
intraflagellar transport; dynein; the structure and function of
centrioles/basal bodies and their associated structures; ciliary
signaling; mating and gamete fusion; photobehaviors; and
Chlamydomonas as a model for understanding human diseases of the
cilium. The volume is richly illustrated and is supplemented by a
website containing both classic and previously unpublished videos
of cell motility in Chlamydomonas. A unique and especially valuable
feature is the inclusion of tables listing the known proteins (with
NCBI accession numbers) for each structure discussed, and the known
mutations that affect each structure and process. Because
Chlamydomonas has been the premier model for investigating the
function and behavior of cilia and flagella, the chapters summarize
the current state of knowledge in these areas as it applies to all
ciliated organisms. Thus, this volume will be an essential source
for all students and researchers interested in cell motility.
The third edition of this long-serving successful reference work is
a 'must-have' reference for anyone needing or desiring an
understanding of the structure, chemistry, properties, production
and uses of starches and their derivatives. * Includes specific information on corn, wheat, potato, rice, and new chapters on rye, oat and barley (including waxy barley) starches * Covers the isolation processes, properties, functionalities, and uses of the most commonly used starches. * Explores the genetics, biochemistry, and physical structure of starches * Presents current and emerging application trends for starch
The account in this inaugural volume of the series covers the period 1900 to 1960, but also outlines the principal developments in earlier centuries from which biochemistry emerged. Findings are considered in the light of present knowledge, rather than in a rigid historical framework.
"Reward Deficit Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. "Reward Deficit Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. "Reward Deficit Disorders" also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, "Animal and
Translational Models for CNS Drug Discovery" 978-0-12-373861-5,
which is also available for purchase individually.
In this book the author presents the state-of-the-art
electromagnetic (EM)
As a reference that contains original and innovative research on
the sociology of emotion, this book will not only appeal to
sociologists but also to scholars of psychology, psychiatry,
anthropology, history, social work, and business/management. With
contributions from experts in the field, this text examines the
role and influence of emotion in everyday social circumstances. It
poses clear questions and presents the contemporary theoretical
developments and empirical research linking social structure and
emotion.
Seismic waves generated by earthquakes have been interpreted to
provide us information about the Earth s structure across a variety
of scales. For short periods of less than 1 second, the envelope of
seismograms changes significantly with increased travel distance
and coda waves are excited by scattering due to randomly
distributed heterogeneities in the Earth. Deterministic structures
such as horizontally uniform velocity layer models in traditional
seismology cannot explain these phenomena. This book focuses on the
Earth heterogeneity and scattering effects on seismic waves. Topics
covered are recent developments in wave theory and observation
including: coda wave analysis for mapping medium heterogeneity and
monitoring temporal variation of physical properties, radiation of
short-period seismic waves from an earthquake fault, weak
localization of seismic waves, attenuation of seismic waves in
randomly porous media, synthesis of seismic wave envelopes in short
periods, and laboratory investigations of ultrasonic wave
propagation in rock samples.
"Advances in Imaging and Electron Physics" merges two long-running serials--"Advances in Electronics and Electron Physics" and "Advances in Optical and Electron Microscopy." This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
A unique and thorough investigation of the shift towards
Europe-wide energy regulation, markets and business strategies, and
the extent to which energy systems have become more liberalised
over this period.
Railways are an environmentally friendly means of transport well
suited to modern society. However, noise and vibration are key
obstacles to further development of the railway networks for
high-speed intercity traffic, for freight and for suburban metros
and light-rail. All too often noise problems are dealt with
inefficiently due to lack of understanding of the problem.
Catalysis is the acceleration of a chemical reaction by a catalyst,
a substance that notably affects the rate of a chemical reaction
without itself being consumed or altered. Since 1948, "Advances in
Catalysis" has filled the gap between the papers that report on and
the textbooks that teach in the diverse areas of catalysis
research. The editors of and contributors to "Advances in
Catalysis" are dedicated to recording progress in this area.
The whole world wants to invest in India. But how to do this
successfully? Written by two Indian financial experts with a
seasoned expert of the Chicago Mercantile Exchange, this book tells
you the why and how of investing in India. It explains how India's
financial markets work, discusses the amazing growth of the Indian
economy, identifies growth drivers, uncovers areas of uncertainty
and risk. It describes how each market works: private equity and
IPOs, bonds, stocks, derivatives, commodities, real estate,
currency. The authors include a discussion of capital controls in
each section to address the needs of foreign investors. Learn about
the the markets, the instruments, the participants, and the
institutions governing trading, clearing, and settlement of
transactions, as well as the legal and regulatory framework
governing financial securities transactions.
Peer-to-Peer (P2P) networks enable users to directly share digital
content (such as audio, video, and text files) as well as real-time
data (such as telephony traffic) with other users without depending
on a central server. Although originally popularized by unlicensed
online music services such as Napster, P2P networking has recently
emerged as a viable multimillion dollar business model for the
distribution of academic and clinical information,
telecommunications, and social networking. Written at an accessible
level for any reader familiar with fundamental Internet protocols,
Peer-to-Peer Networking and Applications explains the conceptual
operations and architecture underlying basic P2P systems using
well-known commercial systems as models. The book also delineates
the latest research directions, thereby providing not only a
sophisticated understanding of current systems, but also the means
to improve upon these systems with innovations that will better
performance, security, and flexibility. Peer-to-Peer Networking and
Applications is thus both a valuable starting point and an
important reference to those practioners employed by any of the 200
companies with approximately $400 million invested in this new and
lucrative technology. |
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