The Second Sino-US Symposium Workshop on Recent Advancement of Computational Mechanics in Structural Engineering was held between May 25-28, 1998, in Dalian, China. The objectives were: to share the insights and experiences gained from recent developments in theory and practice; to assess the current state of knowledge in various topic areas of mechanics and computational methods and to identify joint research opportunities; to stimulate future cooperative research and to develop joint efforts in subjects of common needs and interests; to build and to strengthen the long-term bilateral scientific relationship between academic and professional practicing communities.
Topics discussed covered the entire field of computational structural mechanics. These topics have advanced broad applications in the engineering practice of modern structural analysis, design and construction of buildings and other structures, and in natural hazard mitigation.

This book is a comprehensive contributed volume that aims to describe and explain the design, fabrication, operating characteristics, and specific applications of the most popular and useful types of specialty optical fibers. These "specialty fibers" include any kind of optical fiber that has been architecturally manipulated to diverge from a conventional structure. For instance, metal-coated fibers can be utilized for bandwidth improvement, and hollow core fibers offer more controllable dispersion for sensitive medical procedures.
Applications for these specialty fibers abound in the biomedical, sensors, and industrial fields, as well as in more traditional communications capacities. This book will act as a specialty fiber "guided tour," hosted by the top names in the discipline. The globally renowned editors, Drs. Mendez and Morse, have extensive experience in research, academia, and industry.
*Completely covers biomedical and industrial sensor technology with emphasis on real world applications
*Comparative studies of pros and cons of all fiber types with relation to test and measurement, mechanical properties and strength, and reliability
*Easy to access essential facts and details at the begining of each chapter

Generally, welding produces welding deformation and residual stress in the products, which influences the quality and performance of the products. Although many engineers and researchers have made great effort how to control these incidents, they have still remained unresolved. "Welding Deformation and Residual Stress Prevention" provides a unique computational approach to the prediction of the effects of deformation and residual stress on materials. The goal is to provide engineers and designers with the ability to create their own computational system for predicting and possibly avoiding the problem altogether.
The basic theories including "theory of elastic-plastic analysis" and "inherent strain theory," and analysis procedures are described using a simple three-bar model.

Online simulation software to perform basic analysis on welding mechanics

Examples of strategic methods and procedures are illustrated to have solved various welding-related problems encountered in the process of construction.

Appendices present data bases for welding residual stresses, temperature dependent material properties, etc. "

This volume will be a collection of chapters from authors with wide experience in their research field. The purpose is to produce a coherent book that reflects the common theme of theory in medical thinking and multidisciplinary research practice. In this context "theory" relates to frameworks of concepts, facts, models etc that help to inform practitioners (clinicians, scientists and engineers) both within their own fields and as they seek to share dialogue with colleagues from other fields.
The book will therefore be integrative across a broad spectrum of fields within medicine. To achieve this the chapters will be associated with others in a number of meaningful ways. Each chapter will share a number of points of contact that will include at least two of the following:

*similar biomedical area (e.g., immunity, neuroscience, endocrinology, pathology, oncology, haematology, ...)
*similar multidisciplinary theoretical contexts (e.g., modelling, analysis, description, visualization, complex systems, ...)
*similar multidisciplinary medical issues and questions (e.g., clinical practice, decision making, informatics, ...)
-Uniquely explores role of interdisciplinary exchange in the development and expansion of medical theory
-Timely and insightful essays on the growth and development of medical theories from some of the world's top clinicians and medical researchers, including Werner Arber, Frank Vertosick, and David Weatherall
-Assembles diverse perspectives on medicine and physiology from biology, statistics, ethics, computer science, philosophy, history
-Uniquely illuminates the social and historical processes through which theoretical research translates intoclinical practice
-Reveals the growing role of technology, especially computational modelling, in changing the nature of Western medicine

This volume is intended to complete the Cell Chemistry and physiology module. It is about how the traditional boundaries of cell chemistry and physiology are being erased by molecular biology. We do not think it necessary to elaborate on this theme, particularly since the body of core knowledge found in this volume brings us a stage closer to answering the question, "what makes cell biology into a new discipline?"
The first part of the volume deals with the chemistry of actin and myosin and is followed by chapters on cell motility, ATP synthesis in muscle, and contraction in smooth and skeletal muscle. Here the reader is immediately made aware of the contributions molecular biology is making to our understanding of the molecular mechanisms underlying muscle contraction. It is perhaps enough to point out that Huxley's concept of the cross-bridge cycle and generation of force can now be explained in molecular terms. Topics such as muscle fatigue and muscle disorders, as well as malignant hyperthermia are bound to arouse active learning in the student and set the stage for problem-based learning.
Most medical students look askance at thermobiology. We think this is a mistake; hence, we have included a section dealing with this subject. This brings us to the chapter on the heat shock response, which at the very outset makes clear that many stressors besides heat are known to result in heat shock gene expression. Many of the heat shock proteins occur in unstressed cells and some of them behave as chaperones. These proteins also reach high levels in a wide range of diseases including neurodegenerative disorders. Whether certain diseases are the result of mutations in the heat shock genes is not yet known. As will be appreciated, much of the work done in this field involved the use of cultured cells. Animal cells in culture are the subject of the last chapter.

This is the first volume in a series on membrane protein transfer. Membrane protein transport underlies the topological disposition of many proteins within cells and it is this disposition that allows for the co-ordination of the central cellular processes, such as metabolism.

Power electronics is an area of extremely important and rapidly changing technology. Technological advancements in the area contribute to performance improvement and cost reduction, with applications proliferating in industrial, commercial, residential, military and aerospace environments. This book is meant to help engineers operating in all these areas to stay up-to-date on the most recent advances in the field, as well as to be a vehicle for clarifying increasingly complex theories and mathematics. This book will be a cost-effective and convenient way for engineers to get up-to-speed on the latest trends in power electronics.

The reader will obtain the same level of informative instruction as they would if attending an IEEE course or a training session, but without ever leaving the office or living room! The author is in an excellent position to offer this instruction as he teaches many such courses.
* Self-learning advanced tutorial, falling between a traditional textbook and a professional reference.
* Almost every page features either a detailed figure or a bulleted chart, accompanied by clear descriptive explanatory text.
* The companion CD will include figures as PowerPoint presentations, so the reader can follow along on his or her home computer.

This series of volumes covers all the major aspects of numerical analysis, serving as the basic reference work on the subject. Each volume concentrates on one to three particular topics. Each article, written by an expert, is an in-depth survey, reflecting up-to-date trends in the field, and is essentially self-contained. The handbook will cover the basic methods of numerical analysis, under the following general headings: solution of equations in Rn; finite difference methods; finite element methods; techniques of scientific computing; optimization theory; and systems science. It will also cover the numerical solution of actual problems of contemporary interest in applied mathematics, under the following headings: numerical methods for fluids; numerical methods for solids; and specific applications - including meteorology, seismology, petroleum mechanics and celestial mechanics.

Enantioselective synthetic methods are not only in the forefront of chemical and pharmaceutical research but activity in this area is constantly increasing. It is stimulated by the urgency to obtain drugs or compounds of medicinal interest as single anantiomers, and the keeness to synthesize natural products in nonracemic form. This volume presents seven chapters from pioneers and authorities in this rapidly expanding field.

Structured to be a companion to the recently published Handbook of Transfusion Medicine, the Handbook of Pediatric Transfusion Medicine is dedicated to pediatric hematology-oncology and transfusion medicine, a field which remains ambiguous and which has generated few comprehensive texts. This book stands alone as one of the few texts that addresses transfusion issues specific to pediatric medicine. Written in an eminently readable style, this authoritative handbook is a requirement for any pediatric physician or caregiver.
* Neonatal and fetal immune response and in utero development issues
* Blood compatability and pre-transfusion testing issues specific to pediatric and neonatal transfusion
* Therapeutic apheresis including red blood cell exchange and prophylactic chronic erythrocytapheresis for sickle cell patients
* Also includes a section that concentrates on the consent, quality and legal issues of blood transfusion and donation

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia.
Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

This English translation of the author's original work has been thoroughly revised, expanded and updated.

The book covers logical systems known as "type-free" or "self-referential." These traditionally arise from any discussion on logical and semantical paradoxes. This particular volume, however, is not concerned with paradoxes but with the investigation of type-free sytems to show that: (i) there are rich theories of self-application, involving both operations and truth which can serve as foundations for property theory and formal semantics; (ii) these theories provide a new outlook on classical topics, such as inductive definitions and predicative mathematics; (iii) they are particularly promising with regard to applications.

Research arising from paradoxes has moved progressively closer to the mainstream of mathematical logic and has become much more prominent in the last twenty years. A number of significant developments, techniques and results have been discovered.

Academics, students and researchers will find that the book contains a thorough overview of all relevant research in this field.

For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship.

Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions.

The book is conveniently divided into two parts: Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders.

If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.

As one of the most massive and successful business sectors, the pharmaceutical industry is a potent force for good in the community, yet its behaviour is frequently questioned: could it serve society at large better than it has done in the recent past? Its own internal ethics, both in business and science, may need a careful reappraisal, as may the extent to which the law - administrative, civil and criminal - succeeds in guiding (and where neccessary contraining) it.
The rules of behavior that may be considered to apply to today's pharmaceutical industry have emerged over a very long period and the process goes on. Even the immensely detailed standards for quality, safety and efficacy laid down in drug law and regulation during the second half of the twentieth century have their limitations as tools for ensuring that the public interest is well served. In particular, national and regional regulatory agencies are heavily dependent on industrial data for their decision-making, their standards and competence vary, and even the existing network of agencies does not cover the entire world. What is more there are many areas of law and regulation affecting the industry, concerning for example the pricing of medicines, the conduct of clinical studies, the health protection of workers and concern for the environment. In some fields it is indeed hardly possible to maintain standards through regulation.
Professor N.M. Graham Dukes, a physician and lawyer with long term experience in industrial research management, academic study and international drug policy, provides here a powerfully documented analysis into the way this industry thinks, acts, and is viewed, and examines the current trends pointing to change.
*Provides a balanced picture of the current role of the pharmaceutical industry in society
*Includes indices of conventions, laws, and regulations; as well as judicial and disciplinary cases
*This is the only book addressing the legal implications of big pharma activities and ethical standards

This volume illustrates the extent to which the traditional distinction between biochemical and physiological processes is being obliterated by molecular biology. It can hardly be doubted that the revolution in cell and molecular biology is leading to core knowledge that provides an outline of the integrative and reductionist approach. We view this as the beginning of a new era, that of the integration of learning.
As in the preceding volumes, the choice of topics has been deliberate not only because of the need to keep the volume within reasonable bounds but also because of the need to avoid information over-load. Several relevant topics are dealt with in other modules; for example, the role of G proteins in transmembrane signalling is covered in the Membranes and Cell Signalling module (i.e., Volume 7). Omissions are of course inevitable but they are minor. A case in point is the subject of phosphatases, the treatment of which does not take into account calcineurin. One of the key functions of this Ca2+ -activated protein phosphatase that is also regulated by calmodulin is to desphosphorylate voltage-dependent Ca2+ channels. The mere recognition of such omissions before or after consulting textbooks and journals should be a spur to a more complete discussion by the student of the subject in a small group teaching setting.

Global Bank Regulation: Principles and Policies covers the global regulation of financial institutions. It integrates theories, history, and policy debates, thereby providing a strategic approach to understanding global policy principles and banking. The book features definitions of the policy principles of capital regularization, the main justifications for prudent regulation of banks, the characteristics of tools used regulate firms that operate across all time zones, and a discussion regarding the 2007-2009 financial crises and the generation of international standards of financial institution regulation. The first four chapters of the book offer justification for the strict regulation of banks and discuss the importance of financial safety. The next chapters describe in greater detail the main policy networks and standard setting bodies responsible for policy development. They also provide information about bank licensing requirements, leading jurisdictions, and bank ownership and affiliations. The last three chapters of the book present a thorough examination of bank capital regulation, which is one of the most important areas in international banking. The text aims to provide information to all economics students, as well as non-experts and experts interested in the history, policy development, and theory of international banking regulation.

" Genetic Aberrancies and Neurodegenerative Disorders" presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested.

The text is for a two semester course in advanced calculus. It develops the basic ideas of calculus rigorously but with an eye to showing how mathematics connects with other areas of science and engineering. In particular, effective numerical computation is developed as an important aspect of mathematical analysis.
* Maintains a rigorous presentation of the main ideas of advanced calculus, interspersed with applications that show how to analyze real problems
* Includes a wide range of examples and exercises drawn from mechanics, biology, chemical engineering and economics
* Describes links to numerical analysis and provides opportunities for computation; some MATLAB
codes are available on the author's webpage
* Enhanced by an informal and lively writing style

The book on Heavy-Fermion Systems is a part of the Book series "Handbook of Metal Physics," each volume of which is written to facilitate the research of Ph.D. students, faculty and other researchers in a specific area. The Heavy-Fermions (sometimes known as Heavy-Electrons) is a loosely defined collection of intermetallic compounds containing rare-earth (mostly Ce) or actinide (mostly U) elements. These unusual names were given due to the large effective mass (100-1,000 times greater than the mass of a free electron) below a critical temperature. They have a variety of ground states including superconducting, antiferromagnetic, paramagnetic or semiconducting. Some display unusual magnetic properties such as magnetic quantum critical point and metamagnetism. This book is essentially a summary as well as a critical review of the theoretical and experimental work done on Heavy Fermions.
- Extensive research references.
- Comprehensive review of a very rapidly growing number of theories.
- Summary of all important experiments.
- Comparison with other highly correlated systems such as High-Tc Superconductors.
- Possible Technological applications.

Lipobiology is a rapidly evolving interdisciplinary field which incorporates critical aspects of lipid and lipoprotein chemistry into the disciplines of cell biology and physiology. This series focuses on salient aspects of the role of lipids in metabolic regulation and cellular activation.

This is the first of a 4-volume module that is an introduction to the study of cell chemistry and physiology. It is not intended to be encyclopedic in nature but rather a general survey of the subject with an emphasis on those topics that are central to an understanding of cell biology and those that are certain to become of increasing importance in the teaching of modern medicine.
We have followed what appeared to as to be the logical divisions of the subject beginning with proteins. Allewell and her colleagues stress the point that proteins fold spontaneously to form complex three-dimensional structures and that some of them unfold with the help of proteins called chaperones. Michaelis-Menten kinetics are shown by Nelsestuen to describe the behaviour of enzymes in the test tube. The formalism is particularly useful in the search for agents of therapeutic value, as exemplified by methotrexate. Uptake by mammalian cells of substrates and their metabolic conversions are discussed by van der Vusse and Reneman. However, both Welch and Savageau expound the view that the cell is not simply a bagful of enzymes. The biologist is urged by Savageau to abandon Michaelis-Menten formalism and apply the Power Law. The biologist is also told that the approach to arriving at a theory of metabolic control would have to be one of successive approximations requiring the use of the computer. Information gained from comparative biochemistry is shown by Storey and Brooks to have shed new light on mechanisms of metabolic rate depression and freeze tolerance, and to be applicable to organ transplantation technology. We are reminded that enzyme adaptation is partly the result of the presence of a hydrating shell of vicinal water that stabilises conformation of the enzyme. Vicinal water, according to Drost-Hausen and Singleton, lies adjacent to most solids and protein interfaces. The kinks or breaks observed in the slope of the Arrhenius plot are attributed to structural changes in vicinal water. Regulation of cell volume is shown by Hempling to involve regulation of cell water. It could be that the osmo-receptor or volume detection system is a protein that links the cytoskeleton to specific K and C1 channels. Additionally, it is interesting that aquaporins, which are water channel-forming membrane proteins, are now known to exist in both renal and extra-renal tissues. One of the renal porins is affected by vasopressin.
We then pass on to protein synthesis (Rattan) and other important topics including protein glycosylation (Hounsell), methylation (Clarke), ADP-ribosylation (Pearson) and prenylation (Gelb). Among the four types of lipids attached to membrane proteins are the prenyl groups. Ford and Gross in their chapter on lipobiology drive home the point that there is an accumulation of acyl carnitine and lysophospholipids during myocardial infarction.

Acronycine, a potent antitumor agent, was discovered in the bark of the small Australian Rutaceous tree, Acronychia baueri Schott. This new work presents a comprehensive survey of the isolation, structure determination, methods of synthesis, and the biological properties of acronycine, as well as an account of natural and synthetic analogues of acronycine, and their biological properties.
Solanum alkaloids were reviewed in 1990 and this book surveys the new developments (isolation procedures, structural elucidation methods) and critically updates earlier reviews.
In addition it presents the interesting chemistry and synthesis of cyclopeptide alkaloids. These cyclopeptide alkaloids have been isolated from ascidians, sea hares, and cyanobacteria.
Also included are reviews of the use of the functionalized lactam, pyroglutamic acid, as a chiral template for the synthesis of alkaloids.
The second review examines the on-line coupling of capillary electrophoresis (CE) and mass spectrometry (MS) for the analysis of alkaloid mixtures.
Finally a review of oxygenated analogs of the alkaloid Marcfortine for their potent antiparasitic activity is included at the end of this work.
Each chapter in this volume has been reviewed by at least one expert in the field. Indexes for both subjects and organisms are provided.

Obesity is a continuing issue around the world and in many contexts. The growing number of obese people is an increasing concern for those in the medical profession, and obesity can pose specific challenges in relation to fertility and pregnancy. Patients who are obese require specific considerations and knowledge. Bringing together experts from a variety of specialties to examine the issues and challenges of obesity, this book discusses how obesity affects fertility, reproduction, and pregnancy. Beginning with an exploration of the epidemiology of obesity, further chapters focus on specific issues related to obesity and both male and female reproduction, the complications of obesity during pregnancy and labour, and the long term effects of obesity. This is the most comprehensive resource to examine the topic of obesity and reproductive issues, making it invaluable for medical students, professionals, and researchers in public policy and medicine.
Comprehensive examination of fertility issues arising from male and female obesityClinical knowledge and expertise given to the subjectsIn-depth examination through 47 chapters of a growing, but often overlooked, issue in fertility and pregnancy

In the 11 articles in this first of two parts, top scholars summarize and analyze recent scholarship incorporate finance. Covering subjects from corporate taxes to behavioral corporate finance and econometric issues, their articlesreveal how specializations resonate with each other and indicate likely directions for future research. By includingboth established and emerging topics, Volume 2 will have the same long shelf life and high citations that characterize Volume 1 (2003).
Presents coherent summaries of major finance fields, marking important advances and revisionsDescribes the best corporate finance research created about the 2008 financial crisesExposes readers to a wide range of subjects described and analyzed by the best scholars"