Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.

The conference took place in Lviv, Ukraine and was dedicated to a famous Polish mathematician Stefan Banach { the most outstanding representative of the Lviv mathematical school. Banach spaces, introduced by Stefan Banach at the beginning of twentieth century, are familiar now to every mathematician. The book contains a short historical article and scientific contributions of the conference participants, mostly in the areas of functional analysis, general topology, operator theory and related topics.

This book is aimed at two kinds of readers: firstly, people working in or near mathematics, who are curious about continued fractions; and secondly, senior or graduate students who would like an extensive introduction to the analytic theory of continued fractions. The book contains several recent results and new angles of approach and thus should be of interest to researchers throughout the field. The first five chapters contain an introduction to the basic theory, while the last seven chapters present a variety of applications. Finally, an appendix presents a large number of special continued fraction expansions. This very readable book also contains many valuable examples and problems.

Innovations in Adolescent Substance Abuse Interventions focuses on developmentally appropriate approaches to the assessment, prevention, or treatment of substance use problems among adolescents. Organized into 16 chapters, this book begins with an assessment of adolescent substance use; theory, methods, and effectiveness of a drug abuse prevention approach; and problem behavior prevention programming for schools and community groups. Some chapters follow on the community-, family- and school-based interventions for adolescents with substance use problems. Other chapters explain psychopharmacological therapy; the assertive aftercare protocol for adolescent substance abusers; and twelve-step-based interventions for adolescents.

In the tradition of its predecessor, the main purpose of this volume is the dissemination of statistical methodologies in the area of biological and medical sciences. The chapters are written by specialists with considerable experience in the application of statistical techniques for investigating biological issues. The volume is divided into four parts and the chapters illustrate some recent work on many issues. Most of the papers discuss the statistical principles in conjunction with specific applications. As a result biological as well as statistical readers will benefit from this exposition, and obtain the current state of knowledge in these areas. Many authors emphasize the open problems that might lead to further work on these subjects.

An Introduction to Wavelets is the first volume in a new series, WAVELET ANALYSIS AND ITS APPLICATIONS. This is an introductory treatise on wavelet analysis, with an emphasis on spline wavelets and time-frequency analysis. Among the basic topics covered in this book are time-frequency localization, integral wavelet transforms, dyadic wavelets, frames, spline-wavelets, orthonormal wavelet bases, and wavelet packets. In addition, the author presents a unified treatment of nonorthogonal, semiorthogonal, and orthogonal wavelets. This monograph is self-contained, the only prerequisite being a basic knowledge of function theory and real analysis. It is suitable as a textbook for a beginning course on wavelet analysis and is directed toward both mathematicians and engineers who wish to learn about the subject. Specialists may use this volume as a valuable supplementary reading to the vast literature that has already emerged in this field.
Key Features
* This is an introductory treatise on wavelet analysis, with an emphasis on spline-wavelets and time-frequency analysis
* This monograph is self-contained, the only prerequisite being a basic knowledge of function theory and real analysis
* Suitable as a textbook for a beginning course on wavelet analysis

The collected works of Turing, including a substantial amount of unpublished material, will comprise four volumes: Mechanical Intelligence, Pure Mathematics, Morphogenesis and Mathematical Logic. Alan Mathison Turing (1912-1954) was a brilliant man who made major contributions in several areas of science. Today his name is mentioned frequently in philosophical discussions about the nature of Artificial Intelligence. Actually, he was a pioneer researcher in computer architecture and software engineering; his work in pure mathematics and mathematical logic extended considerably further and his last work, on morphogenesis in plants, is also acknowledged as being of the greatest originality and of permanent importance. He was one of the leading figures in Twentieth-century science, a fact which would have been known to the general public sooner but for the British Official Secrets Act, which prevented discussion of his wartime work. What is maybe surprising about these papers is that although they were written decades ago, they address major issues which concern researchers today.

The collected works of Turing, including a substantial amount of unpublished material, will comprise four volumes: Mechanical Intelligence, Pure Mathematics, Morphogenesis and Mathematical Logic. Alan Mathison Turing (1912-1954) was a brilliant man who made major contributions in several areas of science. Today his name is mentioned frequently in philosophical discussions about the nature of Artificial Intelligence. Actually, he was a pioneer researcher in computer architecture and software engineering; his work in pure mathematics and mathematical logic extended considerably further and his last work, on morphogenesis in plants, is also acknowledged as being of the greatest originality and of permanent importance. He was one of the leading figures in Twentieth-century science, a fact which would have been known to the general public sooner but for the British Official Secrets Act, which prevented discussion of his wartime work. What is maybe surprising about these papers is that although they were written decades ago, they address major issues which concern researchers today.

A book intended for food science researchers, technologists, students, and polymer chemists.;A fundamental understanding of polymers has evolved in recent years concurrent with advances in analytical instrumentation. The theories and methodologies developed for the galacturonan biopolymers (collectively called pectins) have seldom been discoursed comprehensively in the context of the new knowledge. This text explains the scientific and technical basis of many of the practices followed in processing and preparing foods fabricated with or containing pectin. The material is presented in a very readable fashion for those with limited technical training. Topics discussed include structural analysis, commercial extractions methods, pectin formulations and tropical fruit analysis, molecular mechanisms of gelatin, enzymology, and polymer confrontation techniques.

What factors affect creativity and the generation of creative images? What factors affect the ability to reinterpret those images? Research described in this book indicates that expectations constrain both of these attributes of creativity. Characteristics of the imagined pattern, such as cohesiveness or its psychological goodness, also affect image generation and reinterpretation. Other evidence indicates that images can be combined mentally to yield new, manipulable composites. Cognitive models encompass the research and extend it to fields as diverse as architecture, music, and problem solving.

The aim of this book is to show how supramolecular complexity of cell organization can dramatically alter the functions of individual macromolecules within a cell. The emergence of new functions which appear as a consequence of supramolecular complexity, is explained in terms of physical chemistry.
The book is interdisciplinary, at the border between cell biochemistry, physics and physical chemistry. This interdisciplinarity does not result in the use of physical techniques but from the use of physical concepts to study biological problems.
In the domain of complexity studies, most works are purely theoretical or based on computer simulation. The present book is partly theoretical, partly experimental and theory is always based on experimental results. Moreover, the book encompasses in a unified manner the dynamic aspects of many different biological fields ranging from dynamics to pattern emergence in a young embryo.
The volume puts emphasis on dynamic physical studies of biological events. It also develops, in a unified perspective, this new interdisciplinary approach of various important problems of cell biology and chemistry, ranging from enzyme dynamics to pattern formation during embryo development, thus paving the way to what may become a central issue of future biology.

Transformers and Motors is an in-depth technical reference which was originally written for the National Joint Apprenticeship Training Committee to train apprentice and journeymen electricians. This book provides detailed information for equipment installation and covers equipment maintenance and repair. The book also includes troubleshooting and replacement guidelines, and it contains a minimum of theory and math.
In this easy-to-understand, practical sourcebook, you'll discover:
* Explanations of the fundamental concepts of transformers and motors
* Transformer connections and distribution systems
* Installation information for transformers and motors
* Preventive maintenance, troubleshooting, and repair tips and techniques
* Helpful illustrations, glossary, and appendices
* End-of-chapter quizzes to test your progress and understanding
In-depth source for installation, maintenance, troubleshooting, repairing, & replacing transformers & motors.
Reviewed by the National Joint Apprenticeship and Training Committee for the Electrical Industry
Designed to train apprentice and journeyman electricians.

This is an abridged edition of the author's previous two-volume work, Ring Theory, which concentrates on essential material for a general ring theory course while ommitting much of the material intended for ring theory specialists. It has been praised by reviewers: **"As a textbook for graduate students, Ring Theory joins the best....The experts will find several attractive and pleasant features in Ring Theory. The most noteworthy is the inclusion, usually in supplements and appendices, of many useful constructions which are hard to locate outside of the original sources....The audience of nonexperts, mathematicians whose speciality is not ring theory, will find Ring Theory ideally suited to their needs....They, as well as students, will be well served by the many examples of rings and the glossary of major results."**--NOTICES OF THE AM

This book represents the research efforts of individuals whose scientific expertise lies in reflection on what Sartre described as reflective acts. Theory in the cognitive psychology of mental imagery, endeavors not only being able to describe the contents and nature of mental imagery, but also being able to understand the underlying functional cognition. Psychologists need not solely rely on the techniques of introspection, and the last two decades have seen highly creative developments in techniques for eliciting behavioural data to be complemented by introspective reports. This level of sophistication has provided singular insights into the relationship between imagery and other consequential and universal aspects of human cognition: perception, memory, verbal processes and problem solving. The recognition that imagery, despite its ubiquitous nature, differs between individuals both in prevalence and in kind, and the dramatic rise in cognitive science has provided the additional potential for integrating our understanding of cognitive function with our understanding of neuroanatomy and of computer science.All of these relationships, developments and issues are dealt with in detail in this book, by some of the most distinguished authors in imagery research, working at present in both Europe and the U.S.A.

Threshold graphs have a beautiful structure and possess many important mathematical properties. They have applications in many areas including computer science and psychology. Over the last 20 years the interest in threshold graphs has increased significantly, and the subject continues to attract much attention.

The book contains many open problems and research ideas which will appeal to graduate students and researchers interested in graph theory. But above all "Threshold Graphs and Related Topics" provides a valuable source of information for all those working in this field.

The world within reach is characterised to a large extent by our ability to sense objects through touch. Research into the sensation of touch has a long history. However, it is only relatively recently that significant advances have been made in understanding how information about objects we touch is represented in both the peripheral and central divisions of the nervous systems. This volume draws together the increasing body of knowledge regarding the mechanisms underlying tactile sensation and how they relate to tactile perception.
Individual chapters address; the response of mechanoreceptors to stimuli (including movement and shape), the role of the somatosensory cortex in processing tactile information, the psychophysics and neurophysiology of the detection and categorisation of somesthetic stimuli, perceptual constancy, recent findings in regard to short term and long term plasticity in the somatosensory cortex and the psychophysical correlates of this plasticity, and parallel versus serial information processing in the cortex.
The authors look at past and current research, and comment on the direction of future investigation, relating findings from psychophysical studies of tactile behavior to our growing understanding of the underlying neural mechanisms.

General concepts and methods that occur throughout mathematics and now also in theoretical computer science are the subject of this book. It is a thorough introduction to Categories, emphasizing the geometric nature of the subject and explaining its connections to mathematical logic. The book should appeal to the inquisitive reader who has seen some basic topology and algebra and would like to learn and explore further.
The first part contains a detailed treatment of the fundamentals of Geometric Logic, which combines four central ideas: natural transformations, sheaves, adjoint functors, and topoi.
A special feature of the work is a general calculus of relations presented in the second part. This calculus offers another, often more amenable framework for concepts and methods discussed in part one. Some aspects of this approach find their origin in the relational calculi of Peirce and Schroeder from the last century, and in the 1940's in the work of Tarski and others on relational algebras. The representation theorems discussed are an original feature of this approach.
"

This volume presents a variety of articles that encompass the broad scope of supramolecular chemistry. Reusch's chapter covers biological channel compounds, while the work of Hall and Kirkovits looks into their synthetic counterparts. Metal ion sensors, calixarenes and "crystal engineering" are described by pioneers in these fields. This work, whilst current and authoritative, shows us that much remains to be undertaken and understood. It is hoped that this volume will be of interest to those who wish to fill these gaps; scientists already in the field and those who may see extensions of their own work that will bring them into it.

Interest in studying the phenomena of convective heat and mass transfer between an ambient fluid and a body which is immersed in it stems both from fundamental considerations, such as the development of better insights into the nature of the underlying physical processes which take place, and from practical considerations, such as the fact that these idealised configurations serve as a launching pad for
modelling the analogous transfer processes in more realistic physical systems. Such idealised geometries also provide a test ground for checking the validity of theoretical
analyses. Consequently, an immense research effort has been expended in exploring and understanding the convective heat and mass transfer processes between a fluid and submerged objects of various shapes. Among several geometries which have received considerable attention are plates, circular and elliptical cylinders, and spheres, although much information is also available for some other bodies, such as
corrugated surfaces or bodies of relatively complicated shapes.
The book is a unified progress report which captures the spirit of the work in progress in boundary-layer heat transfer research and also identifies potential difficulties and areas for further study. In addition, this work provides new material on convective heat and mass transfer, as well as a fresh look at basic methods in heat transfer. Extensive references are included in order to stimulate further studies of the problems considered. A state-of-the-art picture of boundary-layer heat transfer today is presented by listing and commenting also upon the most recent successful efforts and identifying the needs for further research.

This is the first comprehensive treatment of the theoretical aspects of the discrete cosine transform (DCT), which is being recommended by various standards organizations, such as the CCITT, ISO etc., as the primary compression tool in digital image coding. The main purpose of the book is to provide a complete source for the user of this signal processing tool, where both the basics and the applications are detailed. An extensive bibliography covers both the theory and applications of the DCT. The novice will find the book useful in its self-contained treatment of the theory of the DCT, the detailed description of various algorithms supported by computer programs and the range of possible applications, including codecs used for teleconferencing, videophone, progressive image transmission, and broadcast TV. The more advanced user will appreciate the extensive references. Tables describing ASIC VLSI chips for implementing DCT, and motion estimation and details on image compression boards are also provided.

This book constitutes a first- or second-year graduate course in operator theory. It is a field that has great importance for other areas of mathematics and physics, such as algebraic topology, differential geometry, and quantum mechanics. It assumes a basic knowledge in functional analysis but no prior acquaintance with operator theory is required.

Difficulties in motor behavior are commonly associated with a variety of disabilities. Early research efforts focused on descriptions of specific groups of people or on evaluations of intervention programs. Only recently have investigators begun to explore questions from a variety of theoretical positions in an attempt to build a more fundamental understanding of the disabled person. The present volume represents views of major methodological issues, current research fronts and selected applied concerns from the perspective of the disabled performer. Authors write from a number of theoretical viewpoints and sketch future research directions in these chapters.

Now in its third edition, this classic text covers many aspects of infrared and Raman spectroscopy that are critical to the chemist doing structural or compositional analysis. This work includes practical and theoretical approaches to spectral interpretation as well as a discussion of experimental techniques. Emphasis is given to group frequencies, which are studied in detailed discussions, extensive tables, and over 600 carefully chosen and interpreted spectral examples. Also featured is a unique treatment of group frequencies that stresses their mechanical origin. This qualitative approach to vibrational analysis helps to simplify spectral interpretation.
Additional topics include basic instrumental components and sampling techniques, quantitative analysis, Raman polarization data, infrared gas contours, and polarized IR studies, among others.
Key Features
* Focuses on group frequency correlations and how to use them in spectral interpretation
* Revised and updated by a pioneer in the field, Norman Colthup, who for thirty years has served as an expert lecturer for the Fisk Infrared Institute
* Explores new group frequency studies in aromatics, alkanes and olefins, among others
* Includes completely updated section on instrumentation

This book is a comprehensive survey of matrix perturbation theory, a topic of interest to numerical analysts, statisticians, physical scientists, and engineers. In particular, the authors cover perturbation theory of linear systems and least square problems, the eignevalue problem, and the generalized eignevalue problem as wellas a complete treatment of vector and matrix norms, including the theory of unitary invariant norms.

This book provides a series of concise lectures on the fundamental theories of statistical mechanics, carefully chosen examples and a number of problems with complete solutions.
Modern physics has opened the way for a thorough examination of infra-structure of nature and understanding of the properties of matter from an atomistic point of view. Statistical mechanics is an essential bridge between the laws of nature on a microscopic scale and the macroscopic behaviour of matter. A good training in statistical mechanics thus provides a basis for modern physics and is indispensable to any student in physics, chemistry, biophysics and engineering sciences who wishes to work in these rapidly developing scientific and technological fields.
The collection of examples and problems is comprehensive. The problems are grouped in order of increasing difficulty.