This book provides a unified treatment of the characteristics of telescopes of all types, both those whose performance is set by geometrical aberrations and the effect of the atmosphere, and those diffraction-limited telescopes designed for observations from above the atmosphere. The emphasis throughout is on basic principles, such as Fermat's principle, and their application to optical systems specifically designed to image distant celestial sources.
The book also contains thorough discussions of the principles underlying all spectroscopic instrumentation, with special emphasis on grating instruments used with telescopes. An introduction to adaptive optics provides the needed background for further inquiry into this rapidly developing area.

* Geometrical aberration theory based on Fermat's principle
* Diffraction theory and transfer function approach to near-perfect telescopes
* Thorough discussion of 2-mirror telescopes, including misalignments
* Basic principles of spectrometry; grating and echelle instruments
* Schmidt and other catadioptric telescopes
* Principles of adaptive optics
* Over 220 figures and nearly 90 summary tables

This volume of "Advances in Cell Aging and Gerontology" critically reviews the rapidly advancing area of telomerase research with a focus at the molecular and cellular levels. The clearly established function of telomerase is to maintain chromosome ends during successive rounds of cell division by adding a six base DNA repeat on to the telomeric ends of chromosomes. As presented in the chapters of this volume, the mechanisms that regulate telomerase expression and activity are complex. Moreover, emerging data suggest additional roles for telomerase in the regulation of cell differentiation and survival.

It is expected that this quite comprehensive volume will provide a valuable resource for graduate students and postdocs in the telomerase field and for established investigators in other fields who are beginning to study telomerase in their particular research program. With an increasing number of proteins being brought into the fold of telomerase research (e.g., DNA damage and repair response proteins, heat-shock proteins, and proteins in various signal transduction cascades) many new scientists are beginning to study this enzyme from novel vantage points.

This book describes the risk management methodology as a specific process, a theory, or a procedure for determining your assets, vulnerabilities, and threats and how security professionals can protect them.
Risk Management for Security Professionals is a practical handbook for security managers who need to learn risk management skills. It goes beyond the physical security realm to encompass all risks to which a company may be exposed. Risk Management as presented in this book has several goals:
Provides standardized common approach to risk management through a framework that effectively links security strategies and related costs to realistic threat assessment and risk levels
Offers flexible yet structured framework that can be applied to the risk assessment and decision support process in support of your business or organization
Increases awareness in terms of potential loss impacts, threats and vulnerabilities to organizational assets
Ensures that various security recommendations are based on an integrated assessment of loss impacts, threats, vulnerabilities and resource constraints

Risk management is essentially a process methodology that will provide a cost-benefit payback factor to senior management.
Provides a stand-alone guide to the risk management process
Helps security professionals learn the risk countermeasures and their pros and cons
Addresses a systematic approach to logical decision-making about the allocation of scarce security resources

This volume emphasises studies related to
classical Stefan problems. The term "Stefan problem" is
generally used for heat transfer problems with
phase-changes such
as from the liquid to the solid. Stefan problems have some
characteristics that are typical of them, but certain problems
arising in fields such as mathematical physics and engineering
also exhibit characteristics similar to them. The term
classical" distinguishes the formulation of these problems from
their weak formulation, in which the solution need not possess
classical derivatives. Under suitable assumptions, a weak solution
could be as good as a classical solution. In hyperbolic Stefan
problems, the characteristic features of Stefan problems are
present but unlike in Stefan problems, discontinuous solutions are
allowed because of the hyperbolic nature of the heat equation. The
numerical solutions of inverse Stefan problems, and the analysis of
direct Stefan problems are so integrated that it is difficult to
discuss one without referring to the other. So no strict line of
demarcation can be identified between a classical Stefan problem
and other similar problems. On the other hand, including every
related problem in the domain of classical Stefan problem would
require several volumes for their description. A suitable
compromise has to be made.
The basic concepts, modelling, and analysis of the classical
Stefan problems have been extensively investigated and there seems
to be a need to report the results at one place. This book
attempts to answer that need. Within the framework of the
classical Stefan problem with the emphasis on the basic concepts,
modelling and analysis, it tries to include some weak
solutions and analytical and numerical solutions also. The main
considerations behind this are the continuity and the clarity of
exposition. For example, the description of some phase-field
models in Chapter 4 arose out of this need for a smooth transition
between topics. In the mathematical formulation of Stefan
problems, the curvature effects and the kinetic condition are
incorporated with the help of the modified Gibbs-Thomson relation.
On the basis of some thermodynamical and metallurgical
considerations, the modified Gibbs-Thomson relation can be
derived, as has been done in the text, but the rigorous
mathematical justification comes from the fact that this relation
can be obtained by taking appropriate limits of phase-field
models. Because of the unacceptability of some phase-field models
due their so-called thermodynamical inconsistency, some consistent
models have also been described. This completes the discussion of
phase-field models in the present context.
Making this volume self-contained would require reporting and
deriving several results from tensor analysis, differential
geometry, non-equilibrium thermodynamics, physics and functional
analysis. The text is enriched with appropriate
references so as not to enlarge the scope of the book. The proofs
of propositions and theorems are often lengthy and different from
one another. Presenting them in a condensed way may not be of much
help to the reader. Therefore only the main features of proofs
and a few results have been presented to suggest the essential
flavour of the theme of investigation. However at each place,
appropriate references have been cited so that inquisitive
readers can follow them on their own.
Each chapter begins with basic concepts, objectives and the
directions in which the subject matter has grown. This is followed
by reviews - in some cases quite detailed - of published works. In a
work of this type, the author has to make a suitable compromise
between length restrictions and understandability.

This book is an overview of ESIS Technical Committee 4's activities since the mid-1980s. A wide range of tests is described and the numerous authors is a reflection of the wide and enthusiastic support we have had.
With the establishment of the Technical Committee 4, two major areas were identified as appropriate for the activity. Firstly there was an urgent need for standard, fracture mechanics based, test methods to be designed for polymers and composites. A good deal of academic work had been done, but the usefulness to industry was limited by the lack of agreed standards. Secondly there was a perceived need to explore the use of such data in the design of plastic parts. Some modest efforts were made in early meetings to explore this, but little progress was made. In contrast things moved along briskly in the standards work and this has dominated the activity for the last fourteen years. The design issue remains a future goal.

During the past several years there has been a shortage of flight opportunities for biological and medical projects. And those that were available usually had severe restrictions on instrumentation, number of subjects, duration, time allotted for performing the experiments, a possibility for repetition of experiments. It is our hope and expectation that this will change once the international Space Station is in full operation. The advantages of a permanent space station, already demonstrated by the Russian Mir station, are continuous availability of expert crew and a wide range of equipment, possibility of long-term experiments where this is waranted, increased numbers of subjects through larger laboratory space, proper controls in the large 1-G centrifuge, easier repeatability of experiments when needed.
The limited number of flight opportunities during recent years probably explains why it has taken so long to acquire a sufficient number of high quality contributions for this seventh volume of Advances in Space Biology and Medicine. While initially the series wassailed at annually appearing volumes, we are now down to a biannual appearance. Hopefully, it will be possible to return to annual volumes in the future when results from space station experimentation at beginning to pour in.
The first three chapters of this volume deal with muscle. Fejtek and Wassersug provide a survey of all studies on muscle of rodents flown in space, and include an interesting demography of this aspect of space research. Riley reviews our current knowledge of the effects of long-term spaceflight and re-entry on skeletal muscle, and considers the questions still to be answered before we can be satisfied that long-term space missions, such as on the space station, can be safely undertaken. Stein reviews our understanding of the nutritional and hormonal aspects of muscle loss in spaceflight, and concludes that the protein loss in space could be deleterious to health during flight and after return. Strollo summarizes our understanding of the major endocrine systems on the ground, then considers what we know about their functioning in space, concluding that there is much to be learned about the changes taking place during spaceflight. The many problems of providing life support (oxygen regeneration and food supply) during extended stay on the Moon, on Mars, or in space by means of plant cultivation are discussed by Salisbury. The challenges of utilizing electrophoresis in microgravity for the separation of cells and proteins are illustrated and explained by Bauer and colleagues. Finally, the chapter on teaching of space life sciences by Schmitt shows that this field of science has come of age, but also that its multidisciplinary character poses interesting challenges to teaching it.

This widely-acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964. Almost all branches of chemistry and material science now interface with organometallic chemistry--the study of compounds containing carbon-metal bonds. Organometallic compounds range from species which are so reactive that they only have a transient existence at ambient temperatures to species which are thermally very stable. Organometallics are used extensively in the synthesis of useful compounds on both large and small scales. Industrial processes involving plastics, polymers, electronic materials, and pharmaceuticals all depend on advancements in organometallic chemistry.

Since publication of the first edition in 1988 many significant advances have occurred in IC chips that have driven the hybrid packaging processes toward even higher densities and greater performance. The almost exponential increase in density, complexity, and performance of integrated circuits over the past ten years (for example, ASIC (Application Specific Integrated Circuit), VHSIC (Very High Speed IC), VLSIC (Very Large Scale IC), and ULSIC (Ultra Large Scale IC) have driven developments in the interconnect substrates culminating in what is now known as multichip modules (MCM). However, the fundamentals of design, fabrication, and testing of MCMs are essentially the same as for hybrid microcircuit. In the authors' opinion MCMs are extensions of hybrid circuits that can accommodate the new generation of high-speed high-performance chips.

In this revised edition they have therefore expanded their treatment of hybrid circuits without finding it necessary to change the fundamentals. They have included a separate chapter on multichip modules and throughout the book have included new and emerging materials and processes that are beginning to be used. Examples include: metal-matrix composites and aluminum nitride as substrate materials, plastic encapsulated microcircuits and chip-on-board as low-cost alternatives to hermetic sealed packages, atmospheric friendly cleaning solvents and methods, and advanced high I/O density quad flat packages (QFP) and ball grid array (BGA) packages. Since the first edition, there have also been tremendous advances in software programs for thermal and electrical analysis and these are also treated in this new edition.

The abbreviated Table ofContents below includes the chapter titles and selected sub-headings.

This reference has been written for emergency response personnel, plant safety specialists, and emergency response coordinators. It has been prepared at a practical level to assist both in training safety personnel and to provide technical information that can assist in responding to a hazard material incident that could lead to a fire hazard situation. Considerable information and technical data are given on petroleum-based products since these are among the most widely consumed products; however, the reader will find ample information on other chemicals. Fire situations pose one of the most serious problems in an industrial setting, with the potential loss of lives and property, as well as damage to the environment. Proper response by trained personnel, as well as careful preplanning can minimize the risk and damage caused by fire.

Many controlled release veterinary drug delivery systems (CRVDDS) are presently in use, and recently there has been a host of new CRVDDS within veterinary medicine. The challenges of this area of drug delivery arise from the unique anatomy and physiology of the target animal, the cost constraints associated with the value of the animal being treated and the extended periods of time that delivery must be sustained for (often measured in months).

The purpose of this book is to introduce the reader to the unique opportunities and challenges of the field of CRVDDS and to explain and discuss the basic controlled release principles underlying the development of CRVDDS. Its aim is to provide an overview of many of the areas where CRVVDS have application, and to highlight the opportunities and prospects for controlled release technology in the veterinary field.

"Controlled Release Veterinary Drug Delivery" comprises chapters that provide workers in the field (and those interested in this area) with information on the design, development and assessment of a variety of CRVDDS. The book contains chapters that describe the relevant animal physiological and anatomical considerations alongside descriptions of current and emerging controlled release delivery systems for a variety of routes for drug delivery, and present overviews on the physical and chemical assessment of veterinary controlled release delivery systems.

The veterinary area is abound with opportunities for the development of controlled release drug delivery technologies. It is an area of medicine that is open to the acceptance of novel drug delivery devices, and which readily encompasses the use of novel routes of administration. It is an area of many unmet needs, most of which offer opportunities and unique challenges for the innovative formulation scientist to provide solutions. This book will provide an insight into the biological, clinical and pharmaceutical challenges that face the formulation scientist in this interesting and diverse area of research.

Designers of high-speed integrated circuits face a bewildering array of choices and too often spend frustrating days tweaking gates to meet speed targets. "Logical Effort: Designing Fast CMOS Circuits" makes high speed design easier and more methodical, providing a simple and broadly applicable method for estimating the delay resulting from factors such as topology, capacitance, and gate sizes.

The brainchild of circuit and computer graphics pioneers Ivan Sutherland and Bob Sproull, "logical effort" will change the way you approach design challenges. This book begins by equipping you with a sound understanding of the method's essential procedures and concepts-so you can start using it immediately. Later chapters explore the theory and finer points of the method and detail its specialized applications.
* Explains the method and how to apply it in two practically focused chapters.
* Improves circuit design intuition by teaching simple ways to discern the consequences of topology and gate size decisions.
* Offers easy ways to choose the fastest circuit from among an array of potential circuit designs.
* Reduces the time spent on tweaking and simulations-so you can rapidly settle on a good design.
* Offers in-depth coverage of specialized areas of application for logical effort: skewed or unbalanced gates, other circuit families (including pseudo-NMOS and domino), wide structures such as decoders, and irregularly forking circuits.
* Presents a complete derivation of the method-so you see how and why it works.

The AVR RISC Microcontroller Handbook is a comprehensive guide to designing with Atmel's new controller family, which is designed to offer high speed and low power consumption at a lower cost. The main text is divided into three sections: hardware, which covers all internal peripherals; software, which covers programming and the instruction set; and tools, which explains using Atmel's Assembler and Simulator (available on the Web) as well as IAR's C compiler.

Practical guide for advanced hobbyists or design professionals
Development tools and code available on the Web

Novel asymmetric synthetic methods are a vital strategem in the armoury of the organic chemist, particularly for those involved in the preparation or application of chiral organic molecules. this series is devoted to presenting the latest advances in the field of asymmetric synthesis, drawing contributions on emerging areas and articles providing authoritative perspectives on more developed synthetic stategies from leading researchers in the field. This volume consists of six contributions on a variety of topical areas, ranging from the preparation and application of chiral cylopentadienes, the synthesis of non-racemic amines, diketones and -keto esters and ferrocenes, to the use of biocatalysis and application of microbial methods for the synthesis of chiral molecules and fine chemicals.

Thinking and Problem-Solving presents a comprehensive and up-to-date review of literature on cognition, reasoning, intelligence, and other formative areas specific to this field. Written for advanced undergraduates, researchers, and academics, this volume is a necessary reference for beginning and established investigators in cognitive and educational psychology.
Thinking and Problem-Solving provides insight into questions such as: how do people solve complex problems in mathematics and everyday life? How do we generate new ideas? How do we piece together clues to solve a mystery, categorize novel events, and teach others to do the same?
Key Features
* Provides a comprehensive literature review
* Covers both historical and contemporary approaches
* Organized for ease of use and reference
* Chapters authored by leading scholars

This book focuses on emerging themes in the molecular mechanisms of calcium signal transduction through calmodulin-regulated pathways. It provides the reader with selected examples and experimental precedents that underlie current models of cell regulation through calmodulin-regulated pathways and their linkage with other regulatory pathways.
Highlights:
* Molecular mechanisms of calcium signal transduction through calmodulin-regulated enzymes
* Selected case studies and precedents related to molecular mechanisms
* Protein-protein recognition between calmodulin and the enzymes it regulates
* Cross-talk and interdigitation with other signal transduction pathways

Optically Stimulated Luminescence (OSL) has become the technique of choice for many areas of radiation dosimetry. The technique is finding widespread application in a variety of radiation dosimetry fields, including personal monitoring, environmental monitoring, retrospective dosimetry (including geological dating and accident dosimetry), space dosimetry, and many more. In this book we have attempted to synthesize the major advances in the field, covering both fundamental understanding and the many applications. The latter serve to demonstrate the success and popularity of OSL as a dosimetry method.

The book is designed for researchers and radiation dosimetry practitioners alike. It delves into the detailed theory of the process from the point of view of stimulated relaxation phenomena, describing the energy storage and release processes phenomenologically and developing detailed mathematical descriptions to enable a quantitative understanding of the observed phenomena. The various stimulation modes (continuous wave, pulsed, or linear modulation) are introduced and compared. The properties of the most important synthetic OSL materials beginning with the dominant carbon-doped Al2O3, and moving through discussions of other, less-well studied but nevertheless important, or potentially important, materials. The OSL properties of the two most important natural OSL dosimetry material types, namely quartz and feldspars are discussed in depth. The applications chapters deal with the use of OSL in personal, environmental, medical and UV dosimetry, geological dating and retrospective dosimetry (accident dosimetry and dating). Finally the developments in instrumentation that have occurred over the past decade or more are described.

The book will find use in those laboratories within academia, national institutes and the private sector where research and applications in radiation dosimetry using luminescence are being conducted. Potential readers include personnel involved in radiation protection practice and research, hospitals, nuclear power stations, radiation clean-up and remediation, food irradiation and materials processing, security monitoring, geological and archaeological dating, luminescence studies of minerals, etc.

This first volume of the Handbook of Asset and Liability Management presents the theories and methods supporting models that align a firm's operations and tactics with its uncertain environment. Detailing the symbiosis between optimization tools and financial decision-making, its original articles cover term and volatility structures, interest rates, risk-return analysis, dynamic asset allocation strategies in discrete and continuous time, the use of stochastic programming models, bond portfolio management, and the Kelly capital growth theory and practice. They effectively set the scene for Volume Two by showing how the management of risky assets and uncertain liabilities within an integrated, coherent framework remains the core problem for both financial institutions and other business enterprises as well.
*Each volume presents an accurate survey of a sub-field of finance
*Fills a substantial gap in this field
*Broad in scope

Volume 11 of this series presents five timely reviews on current research on alkaloids. Chapter 1 by Paul L. Schiff, Jr. is a monumental survey of research that has been carried out over the past decade on the "Thalictrum" alkaloids. Forty-six new alkaloids are described from fifteen species of the genus "Thalictrum," as well as 116 alkaloids of known structure from thirty-six species and subspecies of the genus. The chapter includes discussions of isolation and structure elucidation, analysis, biosynthesis, cell culture, and pharmacology. Also featured are inclusive compilations of botanical sources, alkaloids by alkaloid types, and calculated molecular weights of the "Thalictrum" alkaloids.

Chapter 2 by Giovanni Appendino provides a fascinating treatment of Taxine, a collective name referring to a mixture of diterpenoid alkaloids from the yew tree (genus: "Taxus"). Taxine is responsible for the toxic properties of the yew tree that has been documented in historical and fictional literature, from Julius Caesar to Shakespeare, and from Agatha Christie to T.S. Eliot. The chapter treats the history, isolation techniques, structure elucidation, chemistry, and pharmacology of Taxine.

Chapter 3 by Mary D. Menachery surveys the alkaloids of South American Menispermaceae (moonseed family). Many different structural types are included in this family. The alkaloid-bearing plants are woody-vines, shrubs, or small trees. Several of these species possess potent curare activity. The chemistry as well as pharmacology of these alkaloids is summarized.

Chapter 4 by Russell J. Molyneux, Robert J. Nash, and Naoki Asano treats the chemistry and biological activity of the calystegines and related "nor"tropane alkaloids. These polyhydroxylated bicyclic alkaloids represent another class of compounds that inhibit glycosidases, producing profound effects in biological systems by disrupting the essential cellular function of glycoprotein processing.

Chapter 5, a related chapter by Robert J. Nash, Naoki Asano, and Alison A. Watson, reviews polyhydroxylated alkaloids that inhibit glycosidases. Topics covered include distribution, ecological significance and toxicity, isolation, synthesis, and biosynthesis.

Agenda Relevance is the first volume in the authors' omnibus investigation of
the logic of practical reasoning, under the collective title, A Practical Logic
of Cognitive Systems. In this highly original approach, practical reasoning is
identified as reasoning performed with comparatively few cognitive assets,
including resources such as information, time and computational capacity. Unlike
what is proposed in optimization models of human cognition, a practical reasoner
lacks perfect information, boundless time and unconstrained access to
computational complexity. The practical reasoner is therefore obliged to be a
cognitive economizer and to achieve his cognitive ends with considerable
efficiency. Accordingly, the practical reasoner avails himself of various
scarce-resource compensation strategies. He also possesses neurocognitive
traits that abet him in his reasoning tasks. Prominent among these is the
practical agent's striking (though not perfect) adeptness at evading irrelevant
information and staying on task. On the approach taken here, irrelevancies are
impediments to the attainment of cognitive ends. Thus, in its most basic sense,
relevant information is cognitively helpful information. Information can then be
said to be relevant for a practical reasoner to the extent that it advances or
closes some cognitive agenda of his. The book explores this idea with a
conceptual detail and nuance not seen the standard semantic, probabilistic and
pragmatic approaches to relevance; but wherever possible, the authors seek to
integrate alternative conceptions rather than reject them outright. A further
attraction of the agenda-relevance approach is the extent to which its principal
conceptual findings lend themselves to technically sophisticated re-expression
in formal models that marshal the resources of time and action logics and
label led deductive systems.

Agenda Relevance is necessary reading for researchers in logic, belief
dynamics, computer science, AI, psychology and neuroscience, linguistics,
argumentation theory, and legal reasoning and forensic science, and will repay
study by graduate students and senior undergraduates in these same fields.

Key features:

relevance
action and agendas
practical reasoning
belief dynamics
non-classical logics
labelled deductive systems

"

Mental Health Outcome Evaluation bridges the gap between traditional research and evaluation methods by presenting an alternative to the highly technical and statistical methods developed in the laboratory for mental health care professionals. It focuses on outcome evaluation of mental health services for adults, concentrating on the general principles that can be used to assess the service effectiveness of community health centers, clinics, and private practices. The book presents a formidable argument for descriptive outcome studies through its evaluation of the results and consequences of care and treatment as well as clinician ratings. It is written in a non-technical style, making it accessible to anyone in the mental health industry.
Key Features
* Addresses industry efforts to monitor and assess information about results and consequences of mental health care and treatment
* Evaluates use of clinician ratings as outcome information
* Offers accessible general principles for managers and mental health services researchers
* Presents the best argument for descriptive outcome studies

"Stability of NonLinear Shells" is a compilation of the author's work on analyzing the behaviour of spherical caps and related shell structures under various (axisymmetric) load systems. Differing from other texts on shells of revolution, it is one of the first attempts to deal with effects of multi-parameter load systems. This extension leads to the discovery of some new, hitherto unknown phenomena exhibited by these structures. In addition, the book presents a novel way to characterize properties of solutions of the governing equations for spherical caps - a classification anchored in a theory called reciprocal systems. The author has introduced a deformation map, a projection of multi-dimensional solutions to two-dimensional graphs, to enable analysts to gain insight into the physical meaning of the results obtained.
Numerous examples illustrate the concepts introduced. This book also comes to grips with many misconceptions existing in engineering literature about the question of the stability of solutions.

The Second Edition of The Cache Memory Book introduces systems designers to the concepts behind cache design. The book teaches the basic cache concepts and more exotic techniques. It leads readers through someof the most intricate protocols used in complex multiprocessor caches. Written in an accessible, informal style, this text demystifies cache memory design by translating cache concepts and jargon into practical methodologies and real-life examples. It also provides adequate detail to serve as a reference book for ongoing work in cache memory design.
The Second Edition includes an updated and expanded glossary of cache memory terms and buzzwords. The book provides new real world applications of cache memory design and a new chapter on cache"tricks."
Key Features
* Illustrates detailed example designs of caches
* Provides numerous examples in the form of block diagrams, timing waveforms, state tables, and code traces
* Defines and discusses more than 240 cache specific buzzwords, comparing in detail the relative merits of different design methodologies
* Includes an extensive glossary, complete with clear definitions, synonyms, and references to the appropriate text discussions

This is the fourth volume in the series, aimed at those wishing to stay abreast of developments in the mechanisms and synthetic applications of 1,3-dipolar cycloaddition reactions.

This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

This series is devoted to the factors influencing accounting practice. It analyzes topics such as regulatory philosophy, self-regulation in accounting and regulatory policy. Each volume is structured into three parts - main articles, perspectives and book reviews. This volume includes a theoretical investigation of client internal control structures and management fraud. It also covers topics such as the volatility of pension costs, public accountant's professional conduct, an examination of borrower and lender perceptions, bank loan loss provisions after resignation, retirement or death, and the economic consequences of accounting standards and Islamic banks.