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Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.
This book is aimed at two kinds of readers: firstly, people working in or near mathematics, who are curious about continued fractions; and secondly, senior or graduate students who would like an extensive introduction to the analytic theory of continued fractions. The book contains several recent results and new angles of approach and thus should be of interest to researchers throughout the field. The first five chapters contain an introduction to the basic theory, while the last seven chapters present a variety of applications. Finally, an appendix presents a large number of special continued fraction expansions. This very readable book also contains many valuable examples and problems.
An Introduction to Wavelets is the first volume in a new series,
WAVELET ANALYSIS AND ITS APPLICATIONS. This is an introductory
treatise on wavelet analysis, with an emphasis on spline wavelets
and time-frequency analysis. Among the basic topics covered in this
book are time-frequency localization, integral wavelet transforms,
dyadic wavelets, frames, spline-wavelets, orthonormal wavelet
bases, and wavelet packets. In addition, the author presents a
unified treatment of nonorthogonal, semiorthogonal, and orthogonal
wavelets. This monograph is self-contained, the only prerequisite
being a basic knowledge of function theory and real analysis. It is
suitable as a textbook for a beginning course on wavelet analysis
and is directed toward both mathematicians and engineers who wish
to learn about the subject. Specialists may use this volume as a
valuable supplementary reading to the vast literature that has
already emerged in this field.
The collected works of Turing, including a substantial amount of unpublished material, will comprise four volumes: Mechanical Intelligence, Pure Mathematics, Morphogenesis and Mathematical Logic. Alan Mathison Turing (1912-1954) was a brilliant man who made major contributions in several areas of science. Today his name is mentioned frequently in philosophical discussions about the nature of Artificial Intelligence. Actually, he was a pioneer researcher in computer architecture and software engineering; his work in pure mathematics and mathematical logic extended considerably further and his last work, on morphogenesis in plants, is also acknowledged as being of the greatest originality and of permanent importance. He was one of the leading figures in Twentieth-century science, a fact which would have been known to the general public sooner but for the British Official Secrets Act, which prevented discussion of his wartime work. What is maybe surprising about these papers is that although they were written decades ago, they address major issues which concern researchers today.
The collected works of Turing, including a substantial amount of unpublished material, will comprise four volumes: Mechanical Intelligence, Pure Mathematics, Morphogenesis and Mathematical Logic. Alan Mathison Turing (1912-1954) was a brilliant man who made major contributions in several areas of science. Today his name is mentioned frequently in philosophical discussions about the nature of Artificial Intelligence. Actually, he was a pioneer researcher in computer architecture and software engineering; his work in pure mathematics and mathematical logic extended considerably further and his last work, on morphogenesis in plants, is also acknowledged as being of the greatest originality and of permanent importance. He was one of the leading figures in Twentieth-century science, a fact which would have been known to the general public sooner but for the British Official Secrets Act, which prevented discussion of his wartime work. What is maybe surprising about these papers is that although they were written decades ago, they address major issues which concern researchers today.
A book intended for food science researchers, technologists, students, and polymer chemists.;A fundamental understanding of polymers has evolved in recent years concurrent with advances in analytical instrumentation. The theories and methodologies developed for the galacturonan biopolymers (collectively called pectins) have seldom been discoursed comprehensively in the context of the new knowledge. This text explains the scientific and technical basis of many of the practices followed in processing and preparing foods fabricated with or containing pectin. The material is presented in a very readable fashion for those with limited technical training. Topics discussed include structural analysis, commercial extractions methods, pectin formulations and tropical fruit analysis, molecular mechanisms of gelatin, enzymology, and polymer confrontation techniques.
The aim of this book is to show how supramolecular complexity of
cell organization can dramatically alter the functions of
individual macromolecules within a cell. The emergence of new
functions which appear as a consequence of supramolecular
complexity, is explained in terms of physical chemistry.
Innovations in Adolescent Substance Abuse Interventions focuses on developmentally appropriate approaches to the assessment, prevention, or treatment of substance use problems among adolescents. Organized into 16 chapters, this book begins with an assessment of adolescent substance use; theory, methods, and effectiveness of a drug abuse prevention approach; and problem behavior prevention programming for schools and community groups. Some chapters follow on the community-, family- and school-based interventions for adolescents with substance use problems. Other chapters explain psychopharmacological therapy; the assertive aftercare protocol for adolescent substance abusers; and twelve-step-based interventions for adolescents.
Interest in studying the phenomena of convective heat and mass
transfer between an ambient fluid and a body which is immersed in
it stems both from fundamental considerations, such as the
development of better insights into the nature of the underlying
physical processes which take place, and from practical
considerations, such as the fact that these idealised
configurations serve as a launching pad for
Threshold graphs have a beautiful structure and possess many important mathematical properties. They have applications in many areas including computer science and psychology. Over the last 20 years the interest in threshold graphs has increased significantly, and the subject continues to attract much attention. The book contains many open problems and research ideas which will appeal to graduate students and researchers interested in graph theory. But above all "Threshold Graphs and Related Topics" provides a valuable source of information for all those working in this field.
This book represents the research efforts of individuals whose scientific expertise lies in reflection on what Sartre described as reflective acts. Theory in the cognitive psychology of mental imagery, endeavors not only being able to describe the contents and nature of mental imagery, but also being able to understand the underlying functional cognition. Psychologists need not solely rely on the techniques of introspection, and the last two decades have seen highly creative developments in techniques for eliciting behavioural data to be complemented by introspective reports. This level of sophistication has provided singular insights into the relationship between imagery and other consequential and universal aspects of human cognition: perception, memory, verbal processes and problem solving. The recognition that imagery, despite its ubiquitous nature, differs between individuals both in prevalence and in kind, and the dramatic rise in cognitive science has provided the additional potential for integrating our understanding of cognitive function with our understanding of neuroanatomy and of computer science.All of these relationships, developments and issues are dealt with in detail in this book, by some of the most distinguished authors in imagery research, working at present in both Europe and the U.S.A.
The world within reach is characterised to a large extent by our
ability to sense objects through touch. Research into the sensation
of touch has a long history. However, it is only relatively
recently that significant advances have been made in understanding
how information about objects we touch is represented in both the
peripheral and central divisions of the nervous systems. This
volume draws together the increasing body of knowledge regarding
the mechanisms underlying tactile sensation and how they relate to
tactile perception.
What factors affect creativity and the generation of creative images? What factors affect the ability to reinterpret those images? Research described in this book indicates that expectations constrain both of these attributes of creativity. Characteristics of the imagined pattern, such as cohesiveness or its psychological goodness, also affect image generation and reinterpretation. Other evidence indicates that images can be combined mentally to yield new, manipulable composites. Cognitive models encompass the research and extend it to fields as diverse as architecture, music, and problem solving.
This volume presents a variety of articles that encompass the broad
scope of supramolecular chemistry. Reusch's chapter covers
biological channel compounds, while the work of Hall and Kirkovits
looks into their synthetic counterparts. Metal ion sensors,
calixarenes and "crystal engineering" are described by pioneers in
these fields. This work, whilst current and authoritative, shows us
that much remains to be undertaken and understood. It is hoped that
this volume will be of interest to those who wish to fill these
gaps; scientists already in the field and those who may see
extensions of their own work that will bring them into it.
This is an abridged edition of the author's previous two-volume work, Ring Theory, which concentrates on essential material for a general ring theory course while ommitting much of the material intended for ring theory specialists. It has been praised by reviewers: **"As a textbook for graduate students, Ring Theory joins the best....The experts will find several attractive and pleasant features in Ring Theory. The most noteworthy is the inclusion, usually in supplements and appendices, of many useful constructions which are hard to locate outside of the original sources....The audience of nonexperts, mathematicians whose speciality is not ring theory, will find Ring Theory ideally suited to their needs....They, as well as students, will be well served by the many examples of rings and the glossary of major results."**--NOTICES OF THE AM
The three chapters of this book are entitled Basic Concepts, Tensor Norms, and Special Topics. The first may serve as part of an introductory course in Functional Analysis since it shows the powerful use of the projective and injective tensor norms, as well as the basics of the theory of operator ideals. The second chapter is the main part of the book: it presents the theory of tensor norms as designed by Grothendieck in the Resume and deals with the relation between tensor norms and operator ideals. The last chapter deals with special questions. Each section is accompanied by a series of exercises.
Transformers and Motors is an in-depth technical reference which
was originally written for the National Joint Apprenticeship
Training Committee to train apprentice and journeymen electricians.
This book provides detailed information for equipment installation
and covers equipment maintenance and repair. The book also includes
troubleshooting and replacement guidelines, and it contains a
minimum of theory and math.
Now in its third edition, this classic text covers many aspects of
infrared and Raman spectroscopy that are critical to the chemist
doing structural or compositional analysis. This work includes
practical and theoretical approaches to spectral interpretation as
well as a discussion of experimental techniques. Emphasis is given
to group frequencies, which are studied in detailed discussions,
extensive tables, and over 600 carefully chosen and interpreted
spectral examples. Also featured is a unique treatment of group
frequencies that stresses their mechanical origin. This qualitative
approach to vibrational analysis helps to simplify spectral
interpretation.
This book constitutes a first- or second-year graduate course in operator theory. It is a field that has great importance for other areas of mathematics and physics, such as algebraic topology, differential geometry, and quantum mechanics. It assumes a basic knowledge in functional analysis but no prior acquaintance with operator theory is required.
This is the first comprehensive treatment of the theoretical aspects of the discrete cosine transform (DCT), which is being recommended by various standards organizations, such as the CCITT, ISO etc., as the primary compression tool in digital image coding. The main purpose of the book is to provide a complete source for the user of this signal processing tool, where both the basics and the applications are detailed. An extensive bibliography covers both the theory and applications of the DCT. The novice will find the book useful in its self-contained treatment of the theory of the DCT, the detailed description of various algorithms supported by computer programs and the range of possible applications, including codecs used for teleconferencing, videophone, progressive image transmission, and broadcast TV. The more advanced user will appreciate the extensive references. Tables describing ASIC VLSI chips for implementing DCT, and motion estimation and details on image compression boards are also provided.
This book is a comprehensive survey of matrix perturbation theory, a topic of interest to numerical analysts, statisticians, physical scientists, and engineers. In particular, the authors cover perturbation theory of linear systems and least square problems, the eignevalue problem, and the generalized eignevalue problem as wellas a complete treatment of vector and matrix norms, including the theory of unitary invariant norms.
With the substantial advances in the miniaturization of electronic
components, wildlife biologists now routinely monitor the movements
of free-ranging animals with radio-tracking devices. This book
explicates the many analytical techniques and computer programs
available to extract biological information from the radio tracking
data.
Difficulties in motor behavior are commonly associated with a
variety of disabilities. Early research efforts focused on
descriptions of specific groups of people or on evaluations of
intervention programs. Only recently have investigators begun to
explore questions from a variety of theoretical positions in an
attempt to build a more fundamental understanding of the disabled
person. The present volume represents views of major methodological
issues, current research fronts and selected applied concerns from
the perspective of the disabled performer. Authors write from a
number of theoretical viewpoints and sketch future research
directions in these chapters. |
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