"Annual Reports in Medicinal Chemistry "provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
Timely and critical reviews of important topics in medicinal chemistry

This new edition of Linux for Embedded and Real-Time Applications provides a practical introduction to the basics and the latest developments in this rapidly evolving technology. Ideal for those new to using Linux in an embedded environment, it takes a hands-on approach and covers key concepts plus specific applications.

Key features include:

Substantially updated to focus on a specific ARM-based single board computer (SBC) as a target for embedded application programming

Includes an introduction to Android programming

With this book you will learn:

The basics of Open Source, Linux and the embedded space

How to set up a simple system and tool chain

How to use simulation for initial application testing

Network, graphics and Android programming

How to use some of the many Linux components and tools

How to configure and build the Linux kernel, BusyBox and U-Boot bootloader
Provides a hands-on introduction for engineers and software developers who need to get up to speed quickly on embedded Linux, its operation and its capabilities - including AndroidUpdated and changed accompanying tools, with a focus on the author s specially-developed Embedded Linux Learning Kit"

Inorganic Chemistry, Second Edition, provides essential information for students of inorganic chemistry or for chemists pursuing self-study. The presentation of topics is made with an effort to be clear and concise so that the book is portable and user friendly. The text emphasizes fundamental principles-including molecular structure, acid-base chemistry, coordination chemistry, ligand field theory, and solid state chemistry. It is organized into five major themes (structure, condensed phases, solution chemistry, main group and coordination compounds) with several chapters in each. There is a logical progression from atomic structure to molecular structure to properties of substances based on molecular structures, to behavior of solids, etc. The textbook contains a balance of topics in theoretical and descriptive chemistry. For example, the hard-soft interaction principle is used to explain hydrogen bond strengths, strengths of acids and bases, stability of coordination compounds, etc. Discussion of elements begins with survey chapters focused on the main groups, while later chapters cover the elements in greater detail. Each chapter opens with narrative introductions and includes figures, tables, and end-of-chapter problem sets. This new edition features new and improved illustrations, including symmetry and 3D molecular orbital representations; expanded coverage of spectroscopy, instrumental techniques, organometallic and bio-inorganic chemistry; and more in-text worked-out examples to encourage active learning and to prepare students for their exams. This text is ideal for advanced undergraduate and graduate-level students enrolled in the Inorganic Chemistry course. This core course serves Chemistry and other science majors. The book may also be suitable for biochemistry, medicinal chemistry, and other professionals who wish to learn more about this subject area.

Epilepsy, Part I, "Basic Principles and Diagnosis," Volume 107, in the"Handbook of Clinical Neurology"series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. "Epilepsy, Part II," "Treatment, " Volume 108, continues coverage of epilepsy with a focus on treatment. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.
*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care."

Epilepsy, Part II, "Treatment, " Volume 108, provides a full description of epilepsy pathology and etiology, antiepileptic drug treatment, the approach to surgical evaluation and alternative procedures to be considered, in both children and adults, as well as brain stimulation and diet treatment. Economic and psychosocial issues such as stigma are fully covered. The special problems of epilepsy treatment in the developing world are described. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. "Epilepsy, Part I," "Basic Principles and Diagnosis," Volume 107, establishes the scientific and practical diagnosis of epilepsy. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.
*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

The series "Advances in Dendritic Macromolecules" aims to cover the synthesis and supramolecular chemistry of dendritic or cascade super-molecules as well as their less perfect hyperbranched cousins.
In Volume 3, Chapter 1 describes the synthesis and characterization of dendrimers and hyperbranched polyesters, both based on 2,2-bis(hydroxymethyl)propionic acid, as the AB2-monomer. Chapter 2, discusses the advantages and drawbacks of dendritic molecular architectures necessary to create polymeric organic magnetic materials. In Chapter 3, Balzani and colleagues delineate their contributions to the field of polynuclear transition metal complexes in the design and construction of dendritic nanostructures; these luminesence and redox-active complexes suggest their role as photochemical molecular devices operating by photoinduced energy and electron transfer processes. Chapter 4, reviews the overall progress on redox-active dendrimers, especially as redox catalysts, organic conductors, modified electrodes, and models for electron transfer proteins. Chapter 5, summarizes the pioneering research in organometallic dendritic macromolecules and then delineates the redox properties of a series of silicon-based ferrocenyl-containing dendrimers.

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.

Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain.

Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes.

Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.

Gindis introduces AutoCAD with step by step instructions, stripping away complexities tobegin working in AutoCAD immediately. All concepts are explained first in theory, and then shown in practice, helping the reader understand "what "it is they are doing and why, before they do it.

Divided into three parts, the book covers beginning through advanced AutoCAD, including 3D features.

Also included is an extensive Appendix

for each part, detailing additional useful CAD-related information not often found

in other text books

The book contains supporting graphics (screen shots) and a summary with a self-test section at the end of each chapter. Also included are drawing examples and exercises, and tworunning projects that the student works on as he/she progresses through the chapters .

1) Strips away complexities, both real and perceived and reduces AutoCAD to easy-to-understand basic concepts.

2) Teaches only what is essential to operating AutoCAD first, thereby immediately building student confidence.

3) All basic commands are documented step-by-step, meaning that what the student needs to type in and how AutoCAD responds is all spelled out in discrete and clear steps with screen shots added as needed.

4) Using the author s extensive multi-industry knowledge of what is important and widely used in practice versus what is not, the material is presented by immediately immersing the student in practical, critically essential knowledge, with no padding of text or filler material.

5) All concepts are explained first in theory, and only then is AutoCAD introduced and the actual button pushing discussed. This is one of the key concepts in having students understand exactly what it is they are doing and why, before they do it."

"Coal and Peat Fires: A Global Perspective "is a compelling collection of research conducted by scientists and engineers around the world. It presents the scientific and industrial communities as well as the interested lay reader with studies about prehistoric as well as historic coal and peat fires and magnificent illustrations of such fires and related research from countries around the world-a totally new contribution to science. The second of four volumes in the collection, "Photographs and Multimedia Tours "features stunning photographs from around the world, including Australia, Canada, Northern China, India, Borneo, Italy, Poland, Portugal, Russia, the United States, and more. This essential reference also includes a companion website with a collection of slide presentations and videosabout coal and peat fires.
Authored by world-renowned experts in coal and peat firesGlobal in scope-countries from all of the world are representedBeautiful full-color illustrations and online materials including research data banks, an interactive online world map of coal and peat fires, multi-media presentations, and videos bring the contents to life"

Discussed in this book is the association between speech and movements, especially those of the preferred hand. Both are skilled motor activities that appear to depend upon a similar neural organization that is available in the left hemisphere of the brain. The nature of this association of the cerebral control of speech and skilled manual performance is discussed in four sections: 1. Motor control and speech examines speech as a motor activity; 2. Language and gesture examines the correspondence between spoken language and manual gesture; 3. Motor performance and aphasia examines the motor impairments associated with aphasias; 4. Interactions of speech and manual performance examines the interactions that occur between concurrent verbal and manual activities.

The imaging of small cellular components requires powerful instruments, and an entire family of equipment and techniques based on the confocal principle has been developed over the past 30 years. Such methods are commonly used by neuroscience researchers, but the majority of these users do not have a microscopy or a cell biology backgrounds and do can encounter difficulties in obtaining and interpreting results. This volume brings experts in high-resolution optical microscopy applications in neuroscience and cell biology together to document the state of the art. Outlining what is currently possible, the volume also discusses promising developments for the future and aids readers in selecting the most scientifically meaningful approach to solve their questions. Each chapter discusses instrumentation and technology in relationship to application in research. All of the common and cutting edge trends are covered - fluorescence / laser electron / nonlinear microscopy, infrared fluorescence, multiphoton imaging, tomography, FRAP, live imaging, STED, PALM/STORM, etc.
* Single and multiphoton confocal microscopy, and 4-pi confocal microscopy
* Obtaining nanoresolution via photoactivation localization microscopy (PALM)
* Several procedures that correlate observations in optical fluorescence microscopy and electron microscopy
* Study of morphology and function via high-resolution fluorescence procedures
* Additional high-resolution microscopic techniques

Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.
Features contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field

Up and Running with Autocad (R) 2013 started out as a set of classroom notes that outlined, in an easy to understand manner, exactly how AutoCAD is used and applied, in contrast to theoretical musings or clinical descriptions of the commands as found in other books. This book attempts to use experience and top-level knowledge to sort out what is important and what is secondary, and to explain the essentials in plain language. This volume comprises 20 chapters, beginning with the AutoCAD fundamentals. The following chapters then focus on layers, colors, linetypes, and properties; text, Mtext, editing, and style; and hatch patterns; dimensions; blocks, Wblocks, dynamic blocks, groups, and purge. Other chapters cover polar, rectangular, and path arrays; basic printing and output; advanced linework; options, shortcuts, CUI, design center, and express tools; advanced design and file management tools; advanced output and pen settings; and isometric drawing. Each chapter in the book ends with a summary and some review questions to aid the reader in retaining essential concepts. This book will be of interest to engineers, architects, and industrial designers.

Each chapter in this book is written by, and devoted to the original work of a leading researcher in his or her own field. The book presents an integrative approach to the psychological study of time in an attempt to bring to light similarities between bodies of research which have been developed independently within different theoretical frameworks - from Piaget's structuralist-organismic model, to information processing approaches. The chapters are organized in a life-span perspective, with different chapters focusing on different age-levels. It includes analyses of time perception in infancy, temporal systems in the developing language, time conception, time measurement and time reading in middle childhood and adolescence, as well as various models of time perception in the adult, both normal and abnormal. A rich concept such as time sheds light on a wide variety of major topics in psychology; the book will be of value to cognitive, developmental and educational psychologists, as well as to psycholinguists.

"TherapeuticDrug Monitoring: Newer Drugs andBiomarkers"features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presentsnew and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety.

Includes both the technical and clinical issues associated with therapeutic drug monitoring.

Discusses theutility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc.

Provides up-to-date information onissues inpharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants.

Covers important content on thelimitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques. "

China's economic growth has been more robust in some regions than others. In a country as large as China, examinations of regional differences can provide a viable way tolearn about the economy as a whole. Rongxing Guoprovides a systematic introduction to the economies of China by describing their external and internal drivers and by placing them within geopolitical and even socio-cultural boundaries. Hispairingsofcase studies andempirical techniques reveala rich, deep appreciationof the growth process and ofinteractions between key factors.This book delves more deeply into issues surrounding the economy than other books, offering a unique and important perspective that many will find useful. Covering history and administrative structures, unique economic features, some domestic economic issues, and international economic engagement, itdescribesanoften inaccessibleperspectivewith nuances all students of China will find valuable
Introduces China s regional economies, often overlooked in US and European texts within larger contexts of social and geopolitical concernsExplains the reform process since 1978 in a comprehensive, non-technical, and accessible mannerIncludes online ancillaries of documents, links, and more, expanding the text and keeping it up-to-dateFeatures case studies in each chapter"

Volume 14 of this series presents three interesting reviews of research on alkaloids. Chapter 1, by Paul L. Schiff, Jr., is a monumental effort, presenting a selective, comprehensive tabular review of research on the bisbenzylisoquinoline alkaloids, with an analysis of the respective alkaloid types. The chapter should serve as a very useful tool for the bench research scientist who is involved in the isolation and elucidation of structures of bisbenzylisoquinoline alkaloids. Moreover, the data in these tables provides the botanical distribution and occurrence (family, genus, species) of the various classes of these alkaloids. The alkaloids are also categorized by their molecular weights and structural types.
Chapter 2, by Toh-Seok Kam, is a review of alkaloids derived from Malaysian flora. Malaysia's position near the Equator confers on it a tropical climate characterized by high temperatures, humidity, and rainfall, conditions favorable for plant life that has resulted in a rich flora of about 15,000 species of higher plants. This review concentrates on work published during the past twenty years and where appropriate compares the occurrence of alkaloids with studies of similar plants from countries neighboring to Malaysia, especially Thailand and Indonesia.
Chapter 3, by Jie Jack Li, presents a collection of very interesting total syntheses of naturally occurring indole alkaloids where palladium chemistry plays a central role in the syntheses. Five different types of palladium-mediated reactions are treated: (1) oxidative cyclization reactions promoted by palladium (II) species; (2) transmetallation reactions with organoboranes, organostannanes, and organozinc reagents; (3)inter- and intramolecular Heck reactions; (4) reactions with &pgr; -allylpalladium as the intermediate; and (5) reactions using C-N bond formation as the key step for the synthesis.

Part of a series which aims to present work across a broad spectrum of regulation issues, with papers covering a wide range of topics. The volumes review essays of recent books, offering insights into regulation and its processes. A glossary related to securities, law and accounting is included.

"Advanced Remote Sensing" is an application-based reference that provides a single source of mathematical concepts necessary for remote sensing data gathering and assimilation. It presents state-of-the-art techniques for estimating land surface variables from a variety of data types, including optical sensors such as RADAR and LIDAR. Scientists in a number of different fields including geography, geology, atmospheric science, environmental science, planetary science and ecology will have access to critically-important data extraction techniques and their virtually unlimited applications. While rigorous enough for the most experienced of scientists, the techniques are well designed and integrated, making the book s content intuitive, clearly presented, and practical in its implementation.

* Comprehensive overview of various practical methods and algorithms * Detailed description of the principles and procedures of the state-of-the-art algorithms * Real-world case studies open several chapters * More than 500 full-color figures and tables * Edited by top remote sensing experts with contributions from authors across the geosciences"

This special volume of "Advances in Imaging and Electron Physics "details the current theory, experiments, and applications of neutron and x-ray optics and microscopy for an international readership across varying backgrounds and disciplines. Edited by Dr. Ted Cremer, these volumes attempt to provide rapid assimilation of the presented topics that include neutron and x-ray scatter, refraction, diffraction, and reflection and their potential application.
Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

While it would appear that contractors are not affected by the liabilities of the work of others, it is important that they understand the documentation that establishes culpability and the terms of restitution. A "boots on the ground" approach to the pre and post construction inspections as well as all activities in between, Construction Worksite Compliance Guide: Mold provides expert time saving tips to ensure that the job is done right the first time and according to state and Federal regulation. In this book, Woodson shares over 30 years of real-world experience for planning and monitoring the daily work activities on mold contaminated worksites. Packed with checklist, tables and "quick lookup" materials, this manual provides a step by step approach for monitoring workers who are performing the activities specified in a mold abatement work plans.
Expert advice for avoiding liabilities of the work of othersPacked with checklists, tables, and "quick lookup" materials Tips for conducting pre and post worksite inspectionsStep by step approach to planning and monitoring the daily worksite activities

This comprehensive yet brief overview of the adolescent human brain discusses how the brain develops during this critical period of life and how that development impacts decision-making and risk-taking behavior in the adolescent.

This originated as a white paper requested by the Canadian government for a specific group looking to understand adolescent brain development in the context of adolescent behavior. The paper was not made available to the Canadian government outside of the specific task force that requested it nor to the general public. The authors have since decided that having put so much effort into concisely summarizing research on adolescent brain development, it would be a useful addition to researchers in psychology generally. The original paper has since been updated and revised considerably.

"Advances in Imaging and Electron Physics "merges two long-running serials--"Advances in Electronics and Electron Physics" and "Advances in Optical and Electron Microscopy."

This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Combining solid theoretical discussions with practical design examples, this book is an essential reference on developing RF and microwave switchmode power amplifiers. With this book you will be able to: Design high-efficiency RF and microwave power amplifiers on different types of bipolar and field-effect transistors using well-known and novel theoretical approaches, nonlinear simulation tools, and practical design techniques Design any type of high-efficiency switchmode power amplifiers operating in Class D or E at lower frequencies and in Class E or F and their subclasses at microwave frequencies, with specified output power Understand the theory and practical implementation of load-network design techniques based on lumped and transmission-line elements Combine multi-stage Doherty architecture and switchmode power amplifiers to significantly increase efficiency of the entire radio transmitter Learn the different types of predistortion linearization techniques required to improve the quality of signal transmission in a nonlinear amplifying system New to this edition: Comprehensive overview of different Doherty architectures which are, and will be used in modern communication systems to save power consumption and reduce costs A new chapter on analog and digital predistortion techniques Coverage of broadband Class-F power amplifiers, high-power inverse Class-F power amplifiers for WCDMA systems, broadband Class-E techniques

This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment.
*Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment
*Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders
*A must have reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain"