In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy.

* Provides updates on the latest developments in NMR spectroscopy * Includes comprehensive review articles * Highlights the increasing importance of NMR spectroscopy as a technique for structural determination

Volume 4 of Biomembranes covers endocytosis, exocytosis and related processes. A major role of the plasma membrane is as a permeability barrier, keeping the inside of the cell inside and the outside, outside. Mechanisms must then exist to allow movement of material between the cell and its environment. One mechanism for export from the cell is by exocytosis, a process in which the membranes of secretory vesicles fuse with the plasma membrane releasing the contents of the vesicle into the extracellular medium. The process has been studied in particular depth for the release of neurotransmitters at the synapse. Import into the cell is possible by the process of receptor-mediated endocytosis in which selected plasma membrane proteins are internalizes; when these proteins are receptors for macromolecules, the result is uptake of the macromolecule. Transferring, the low-density lipoprotein, and asialoglycoproteins are all taken up into cells in this way. Phagocytosis, the ingestion of cells and cell fragments by neutrophils and macrophages, also involves receptors - on the phagocytic membrane - of which the best studied are those for the Fc domain of IgG, for the third component of complement, and for the mannose/fructose carbohydrates. Protection of a host against infection can also be achieved by damaging the integrity of the plasma membrane of the invading organism. This is the strategy evolved by the cytotoxic T lymphocytes, which produce a pore-forming toxin, perforin. Volume 4 of Biomembranes explores the structures and mechanisms involved in these biologically and medically important processes.

The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.

This broad-ranging book equips programmers and designers with a thorough grounding in the techniques used to create truly network-enabled computer graphics and games. Written for graphics/game/VE developers and students, it assumes no prior knowledge of networking. The text offers a broad view of what types of different architectural patterns can be found in current systems, and readers will learn the tradeoffs in achieving system requirements on the Internet.

The book explains the foundations of networked graphics, then explores real systems in depth, and finally considers standards and extensions. Numerous case studies and examples with working code are featured throughout the text, covering groundbreaking academic research and military simulation systems, as well as industry-leading game designs.
Everything designers need to know when developing networked graphics and games is covered in one volume - no need to consult multiple sources.The many examples throughout the text feature real simulation code in C++ and Java that developers can use in their own design experiments.Case studies describing real-world systems show how requirements and constraints can be managed.

Taking into account toxicity levels at normal consumption levels, intake per kg bodyweight and other acknowledged considerations, each chapter in this book will be based on one or more proven examples. It is intended to provide specific examples and potential improvements to the safety of the world's food supply, while also increasing the amount of food available to those in undernourished countries. This book is designed to to provide science-based tools for improving legislation and regulation.
Benefits:
* Reduce amount of food destroyed due to difference in regulations between nations
* Positively impact the time-to-market of new food products by recognizing benefit of "one rule that applies to all"
* Use the comparison of regulations and resulting consequences to make appropriate, fully-informed decisions
* Employ proven science to obtain global consensus for regulations
* Understand how to harmonize test protocols and analytical methods for accurate measurement and evaluation
* Take advantage of using a risk/benefit based approach rather than risk/avoidance to maximize regulatory decisions

This book addresses a fundamental question about the nature of behavior: how does the brain process reward and makes decisions when facing multiple options? The book presents the most recent and compelling lesion, neuroimaging, electrophysiological and computational studies, in combination with hormonal and genetic studies, which have led to a clearer understanding of neural mechanisms behind reward and decision making. The neural bases of reward and decision making processes are of great interest to scientists because of the fundamental role of reward in a number of behavioral processes (such as motivation, learning and cognition) and because of their theoretical and clinical implications for understanding dysfunctions of the dopaminergic system in several neurological and psychiatric disorders (schizophrenia, Parkinson's disease, drug addiction, pathological gambling, ...).

* Comprehensive coverage of approaches to studying reward and decision making, including primate neurophysiology and brain imaging studies in healthy humans and in various disorders, genetic and hormonal influences on the reward system and computational models.

* Covers clinical implications of process dysfunction (e.g., schizophrenia, Parkinson's disease, eating disorders, drug addiction, pathological gambling)

* Uses multiple levels of analysis, from molecular mechanisms to neural systems dynamics and computational models.

" "This is a very interesting and authoritative handbook by some of the most outstanding investigators in the field of reward and decision making "," Professor Edmund T. Rolls, Oxford Center for Computational Neuroscience, UK

Electronics are used in a wide range of applications including computing, communication, biomedical, automotive, military and aerospace. They must operate in varying temperature and humidity environments including indoor controlled conditions and outdoor climate changes. Moisture, ionic contamination, heat, radiation and mechanical stresses are all highly detrimental to electronic devices and can lead to device failures. Therefore, it is essential that the electronic devices be packaged for protection from their intended environments, as well as to provide handling, assembly, electrical and thermal considerations.
Currently, more than 99% of microelectronic devices are plastic encapsulated. Improvements in encapsulant materials, and cost incentives have stretched the application boundaries for plastic electronic packages. Many electronic applications that traditionally used hermetic packages such as military are now using commercial-off-the-shelf (COTS) plastic packages. Plastic encapsulation has the advantages of low cost, smaller form factors, and improved manufacturability.
With recent trends in environmental awareness, new environmentally friendly or ' green' encapsulant materials (i.e. without brominated additives) have emerged. Plastic packages are also being considered for use in extreme high and low temperature electronics. 3-D packaging and wafer-level-packaging (WLP) require unique encapsulation techniques. Encapsulant materials are also being developed for micro-electro-mechanical systems (MEMS), bio-MEMS, bio-electronics, and organic light-emitting diodes (O-LEDs).
This book offers a comprehensive discussion of encapsulants in electronic applications. The main emphasis is on the encapsulation of microelectronic devices; however, the encapsulation of connectors and transformers is also addressed. This book discusses 2-D and 3-D packaging and encapsulation, encapsulation materials including environmentally friendly 'green' encapsulants, and the properties and characterization of encapsulants. Furthermore, this book provides an extensive discussion on defects and failures related to encapsulation, how to analyze such defects and failures, and how to apply quality assurance and qualification process for encapsulated packages. This book also provides information on the trends and challenges of encapsulation and microelectronic packages including application of nanotechnology.
Guidance on the selection and use of encapsulants in the electronics industry, with a particular focus on microelectronics
Coverage of environmentally friendly 'green encapsulants'
Practical coverage of faults and defects: how to analyze them and how to avoid them"

This book sets out to explain the development of modern electronic systems and devices from the viewpoint of the semiconductor materials (germanium, silicon, gallium arsenide and many others) which made them possible. It covers the scientific understanding of these materials and its intimate relationship with their technology and many applications. It began with Michael Faraday, took off in a big way with the invention of the transistor at Bell Labs in 1947 and is still burgeoning today. It is a story to match any artistic or engineering achievement of man and this is the first time it has been presented in a style suited to the non-specialist. It is written in a lively, non-mathematical style which brings out the excitement of discovery and the fascinating interplay between the demands of system pull and technological push. It also looks at the nature of some of the personal interactions which helped to shape the modern technological world.
An introductory chapter illustrates just how dependent we are on modern electronic systems and explains the significance of semiconductors in their development. It also provides, in as painless a way as possible, a necessary understanding of semiconductor properties in relation to these applications. The second chapter takes up the historical account and ends with some important results emerging from the Second World War including its effect on the organisation of scientific research. Chapter three describes the world-shaking discovery of the transistor and some of the early struggles to make it commercially viable, including the marketing of the first transistor radio. In chapter four we meet the integrated circuit which gave shape to much of our modern life in the form of the personal computer (and which gave rise to a famously long-running patent war ). Later chapters cover the application of compound semiconductors to light-emitting devices, such as LEDs and lasers, and light detecting devices such as photocells. We learn how these developments led to the invention of the CD player and DVD recorder, how other materials were applied to the development of sophisticated night vision equipment, fibre optical communications systems, solar photovoltaic panels and flat panel displays. Similarly, microwave techniques essential to our modern day love of mobile phoning are seen to depend on clever materials scientists who, not for the first time, "invented" new semiconductors with just the right properties.
Altogether, it is an amazing story and one which deserves to be more widely known. Read this book and you will be rewarded with a much deeper understanding and appreciation of the technological revolution which shapes so many aspects of our lives.
- A historical account of the development of semiconductor physics, devices and applications from the nineteenth century to the present day
- Coverage of the importance of material quality and its relation to the physics of the devices
- Presented in a strictly non-mathematical and anecedotal way, to appeal to a wide audience
- Provides the broad sweep of science history"

This volume investigates the implications of how our brain directs our movements on decision making. An extensive body of knowledge in chapters from international experts is presented as well as integrative group reports discussing new directions for future research.
The understanding of how people make decisions is of central interest to experts working in fields such as psychology, economics, movement science, cognitive neuroscience, neuroinformatics, robotics, and sport science. For the first time the current volume provides a multidisciplinary overview of how action and cognition are integrated in the planning of and decisions about action.
* Offers intense, focused, and genuine interdisciplinary perspective
* Conveys state-of-the-art and outlines future research directions on the hot topic of mind and motion (or embodied cognition)
* Includes contributions from psychologists, neuroscientists, movement scientists, economists, and others

This handbook provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans.
* Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine
* Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics
* Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches

This collection of original articles 8 years in the making shines a bright light on recent advances in financial econometrics. From a survey of mathematical and statistical tools for understanding nonlinear Markov processes to an exploration of the time-series evolution of the risk-return tradeoff for stock market investment, noted scholars Yacine Ait-Sahalia and Lars Peter Hansen benchmark the current state of knowledge while contributors build a framework for its growth. Whether in the presence of statistical uncertainty or the proven advantages and limitations of value at risk models, readers will discover that they can set few constraints on the value of this long-awaited volume.
Presents a broad survey of current research-from local characterizations of the Markov process dynamics to financial market trading activityContributors include Nobel Laureate Robert Engle and leading econometriciansOffers a clarity of method and explanation unavailable in other financial econometrics collections"

This work is an interdisciplinary, cross-cultural, widely-calibrated checklist for EU sustainable landscape management, which is intended to serve both as an analytical tool of reference as well as a design tool for local, regional and European policy making on sustainable developments.

The tool has been developed out of a multidisciplinary study in EU countries which was designed to find out what would be the overall requirements for a sustainable management of the landscape of rural areas. Could these stipulations be brought together in a comprehensive system with sufficient consistency to comply with the notion that the landscape is an entity, which should be managed accordingly? Cooperation of the scientific experts with those involved in the practical side, and alternating plenary reporting with subgroup visits to farms in the rural landscapes of the participants' countries, allowed for the development of some truly interdisciplinary teamwork. Organic agriculture has been included to find out how organic agriculture contributes to the rural landscape.

Intercellular communication is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their environment is the basis of growth and development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, diabetes, and neurological and psychiatric disorders. There is substantial drug development concentrating on this and intercellular communication is the basis of much of neuropharmacology. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be yielded. Neurotransmitters/receptors, synaptic structure and organization, gap junctions, neurotrophic factors and neuropeptides are all explored in this volume, as are the ways in which signaling controls neuroendocrinology, neuroimmunology and neuropharmacology. "Intercellular Communication in the Nervous System"provides a valuable desk reference for all scientists who consider signaling.

* Chapters offer impressive scope with topics addressing neurotransmitters/receptors, synaptic structure and organization, neuropeptides, gap junctions, neuropharmacology and more * Richly illustrated in full color with over 200 figures * Contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge"

Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbookreference exists on the market that provides researchers with more in-depth, high-levelinformation on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole.

This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject.
The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook informationThe 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the "Encyclopedia of Neuroscience" by one of the great developmental neuroscientists, Greg LemkeThe best researchers in the field provide their conclusions in the context of the latest experimental results"

The addictions treatment field is currently undergoing a period of increased scrutiny, upheaval and change. The growing emphasis on treatment accountability and cost effectiveness is leading to major changes in standards of care. Inconsistent practices based solely on clinical intuition rather than hard scientific evidence of treatment efficacy are rapidly becoming unacceptable.
Translating science-based treatments into clinical settings is an important priority in the addictions field and has been the subject of an influential Institute of Medicine report. Substance abuse treatment programs are now mandated to provide evidence-based treatments, with funding and insurance reimbursement contingent on their doing so.
Evidence-Based Addiction Treatment provides a state-of-the-art compilation of assessment and treatment practices with proven effectiveness. A substantial body of evidence is presented to provide students, academics and clinicians with specific science-based treatments that work. Written at a level appropriate for a variety of audiences, research studies are discussed but highly sophisticated knowledge in research methodology is not required.
- Treatments that work
- Explicit case examples
- Contributions by well-known researchers on addiction treatment
- Simple ways to evaluate treatment effectiveness
- Accompanying web-site with exam questions

Many high net worth individuals are interested in diversifying their portfolios and investing in collectibles. A collectible is any physical asset that appreciates in value over time because it is rare or desired by many. Stamps, coins, fine art, antiques, books, and wine are examples of collectibles. Where does the financial advisor or investment manager for these high net worth individuals go to learn about these investments? There is no comprehensive resource from the financial standpoint--until now. Dr Stephen Satchell of Trinity College, Cambridge, has developed a book in which experts in various types of collectibles analyze the financial aspects of investing in these collectibles. Chapters address issues such as: liquidity challenges, tax ramifications, appreciation timelines, the challenge of forecasting and measuring appreciation, and the psychological component of collecting and the role of emotion in collectible investing.

Key Features
Feature: Contributors are experts in collectible investing from around the world
Benefit: Gives financial advisors and wealth managers handy access to expert opinions to better advise clients interested in collectible investments
Feature: Experts discuss the pros and cons of collectibles from an investment perspective in their area of expertise
Benefit: One stop shopping, all expertise brought together in one volume, creating a handy reference guide
Feature: Experts discuss art, stamps, coins, antiques, wine, from around the world in one global perspective
Benefit: Wealth managers can gain information about a wide range of collectibles and learn about investing in these types with a global perspective

Elsevier now offers a series of derivative works based on the acclaimed "Meyler s Side Effect of Drugs, 15th Edition." These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician.
Opioids and analgesics are members of a diverse group of drugs used to relieve pain. They are frequently used in combination with prescription and nonprescription pain relievers, and misuse is prevalent. Pain medicine specialists and physicians or surgeons will find this volume useful in prescribing the appropriate drugs for pain therapy and for preventing misuse of the medication.
* The only drug guide that includes clinical case studies and expert analysis
* "UNIQUE " Features not only analgesics and anti-inflammatory drugs, but also all other drugs that act in an analgesic or anti-inflammatory manner
* Most complete cross referencing of drug-drug interactions available
* Latest content from the most highly regarded compilation of drug side effects: "Side Effects of Drugs Annual" serial"

Multi-scale analysis and simulation of chemical processing and reactions have received unprecedented attention in recent years; however, measurement technology focused on multi-scale structures, particularly on meso-scale phenomena, has not been sufficiently addressed. This volume of "Advances in Chemical Engineering" focuses on the ""Characterization of Flow, Particles and Interfaces" "to alert the chemical engineering community to this challenging issue presenting six meso-scale measurement technologies.

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that explains the phenomenon of stress, the neural, endocrine and molecular mechanisms involved, the clinical effects, and the impact on individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing s Syndrome: Addison s Disease) and the adverse impact of stress on human physicaland mental health . Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer s disease and Parkinson s disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is alsoplaced on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries.
Chapters offer impressive scope with topics addressing animal studies, disaster, diurnal rhythms, drug effects and treatments, cognition and emotion, physical illness, psychopathology, immunology and inflammation, lab studies and tests, and psychological / biochemical / genetic aspects

Richly illustrated with over 200 figures, 75 in color

Priced affordably, this compendium of articles appeals to the end user interested in stress research who would not otherwise purchase the larger Encyclopedia of Stress

Articles carefully selected by one of the world s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge "

Research is increasingly showing the effects of family, school, and culture on the social, emotional and personality development of children. Much of this research concentrates on grade school and above, but the most profound effects may occur much earlier, in the 0-3 age range.This volume consists of focused articles from the authoritative Encyclopedia of Infant and Early Childhood Development that specifically address this topic andcollates research in this area in a way that isn't readily available in the existent literature, covering such areas as adoption, attachment, birth order, effects of day care, discipline and compliance, divorce, emotion regulation, family influences, preschool, routines, separation anxiety, shyness, socialization, effects of television, etc.This one volume referenceprovides an essential, affordable reference for researchers, graduate students and clinicians interested in social psychology and personality, as well as those involved with cultural psychology and developmental psychology.
Presents literature on influences of families, school, and culture in one sourcesaving userstime searching for relevant related topics in multiple places and literatures in order to fully understand any one areaFocused content on age 0-3- save time searching for and wading through lit on full age range for developmentally relevant info Concise, understandable, and authoritative for immediate applicability in research "

Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft.
The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour.
This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise.
The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.

* The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system
* Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others
* The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community.
* Of great value not only for researchers and experts, but also for students and clinicians as a background reference.

Advances in Imaging and Electron Physics merges two long-running serials--Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy. This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.

Updated with contributions from leading international scholars and industry experts
Discusses hot topic areas and presents current and future research trends
Provides an invaluable reference and guide for physicists, engineers and mathematicians

This volume presents recent empirical advances using neuroscience techniques to investigate how culture influences neural processes underlying a wide range of human abilities, from perception and scene processing to memory and social cognition. It also highlights the theoretical and methodological issues with conducting cultural neuroscience research. Section I provides diverse theoretical perspectives on how culture and biology interact are represented. Sections II VI is to demonstrate how cultural values, beliefs, practices and experience affect neural systems underlying a wide range of human behavior from perception and cognition to emotion, social cognition and decision-making. The final section presents arguments for integrating the study of culture and the human brain by providing an explicit articulation of how the study of culture can inform the study of the brain and vice versa.

This is a well-established international series that examines major areas of basic and clinical research within neuroscience (as well as emerging and promising subfields): neuroanatomy, neurophysiology, neuroimaging, neurobiology, neuropharmacology, neuroendocrinology, neuropathology, neuropsychiatry, neurobehavior. This volume provides a thorough treatment of gene models of schizophrenia, presenting articles from leading contributors in this important area.

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.
* The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years
* Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control.
* The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation.
* Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.
* Involves all of the leading researchers in the field.
* INcludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field.