The Bayesian network is one of the most important architectures for representing and reasoning with multivariate probability distributions. When used in conjunction with specialized informatics, possibilities of real-world applications are achieved. Probabilistic Methods for BioInformatics explains the application of probability and statistics, in particular Bayesian networks, to genetics. This book provides background material on probability, statistics, and genetics, and then moves on to discuss Bayesian networks and applications to bioinformatics.

Rather than getting bogged down in proofs and algorithms, probabilistic methods used for biological information and Bayesian networks are explained in an accessible way using applications and case studies. The many useful applications of Bayesian networks that have been developed in the past 10 years are discussed. Forming a review of all the significant work in the field that will arguably become the most prevalent method in biological data analysis.
Unique coverage of probabilistic reasoning methods applied to bioinformatics data--those methods that are likely to become the standard analysis tools for bioinformatics.Shares insights about when and why probabilistic methods can and cannot be used effectively; Complete review of Bayesian networks and probabilistic methods with a practical approach.

The Eclipse environment solves the problem of having to maintain your own Integrated Development Environment (IDE), which is time consuming and costly. Embedded tools can also be easily integrated into Eclipse. The C/C++CDT is ideal for the embedded community with more than 70% of embedded developers using this language to write embedded code. Eclipse simplifies embedded system development and then eases its integration into larger platforms and frameworks.
In this book, Doug Abbott examines Eclipse, an IDE, which can be vital in saving money and time in the design and development of an embedded system. Eclipse was created by IBM in 2001 and then became an open-source project in 2004. Since then it has become the de-facto IDE for embedded developers. Virtually all of the major Linux vendors have adopted this platform, including MontVista, LynuxWorks, and Wind River.
*Details the Eclipse Integrated Development Environment (IDE) essential to streamlining your embedded development process
*Overview of the latest C/C++ Developer's Toolkit (CDT)
*Includes case studies of Eclipse use including Monta Vista, LynuxWorks, and Wind River

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.
* The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years
* Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control.
* The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation.
* Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.
* Involves all of the leading researchers in the field.
* INcludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field.

Mobile communications users are demanding increased reliability, functionality, and accessibility; they want "always on" access to voice, e-mail, text, and multimedia services as they roam from home to auto to office to outdoor/indoor locations. In addition, there is an increasing deamnd to replace separate landline/mobile telephones with a single handset that can be used wherever its owner might be. Answering those customer needs, fixed/mobile convergence (FMC) marries the mobility provided by cellular networks with the extended connectivity provided by 802.11-based WiFi services and integrates them with landline networks using a single handset. This book provides the theoretical and practical background necessary to successfully plan, develop, and deploy effective FMC networks.
This book discusses the various 802.11 and VoIP protocols used in FMC networks, open and proprietary communications protocols, integration of FMC networks to wired telephone networks, mobilizing applications such as text messaging and video, security issues, mobile handset requirements for FMC networks, and the administration/management of FMC networks. Special attention is given to selecting appropriate components for FMC, and numerous case histories and examples from the author's experience are provided.
This book is an essential tutorial and reference for any RF/wireless, communications, and networking professional who will work with the next generation of wireless networks.
CONTENTS:
Chapter 1 Unbounded Mobile Communications
Chapter 2 Mobile Communications - State of the Technology
Chapter 3 Unbounded Mobile Communications - what is it?
Chapter 4 UMC - an overview of the technologyrequirements & considerations
Chapter 5 UMC - Current Market Solution Overview
Chapter 6 UMC - Layer 1 & 2 - Media requirements
Chapter 7 VoIP - Layer 3 & 4, the IP infrastructure
Chapter 8 Voice Optimized Networks - the network orphan
Chapter 9 Mobile Handset Solutions
Chapter 10 Hotspot & Hotzone Access
Chapter 11 Security considerations
Chapter 12 PBX features & integration
Chapter 13 UMC Management and Statute conformance considerations
Chapter 14 Mobilizing applications
Chapter 15 The Final Challenge - Sales/support channel considerations
Chapter 16 Unbounded mobile communications - beyond FMC
Glossary
KEY FEATURES
* Describes how to develop, deploy, and manage networks that seamlessly combine landline, cellular, and WiFi networks into one converged communications network.
* Thorough coverage of various 802.11 and voice over internet protocol (VoIP) standards and how they impact integration with cellular networks.
* Discusses security considerations and how to successfully manage converged networks.
* Includes numerous case histories and examples from the author's experience---this is not a purely theoretical treatment of the subject!

"Neurological Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer s disease, Parkinson s disease, Huntington disease, ALS, and the epilepsies. "Neurological Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the second volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, which is also available for purchase individually.
- Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process
- Critical evaluation of animal and translational models improving transition from drug discovery and clinical development
- Emphasis on what results mean to the overall drug discovery process
- Exploration of issues in clinical trial design and conductance in each therapeutic area"

"Psychiatric Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. "Psychiatric Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the first volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, andis also available for purchase individually.
Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery processCritical evaluation of animal and translational models improving transition from drug discovery and clinical developmentEmphasizes what results mean to the overall drug discovery processExplores issues in clinical trial design and conductance in each therapeutic areaPsychiatric Disorders is available for purchase individually."

"Advances in Imaging and Electron Physics" merges two long-running serials--"Advances in Electronics and Electron Physics" and "Advances in Optical and Electron Microscopy." This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
This monograph summarizes the authors' knowledge and experience acquired over many years in their work on computational charged particle optics. Its main message is that even in this era of powerful computers with a multitude of general-purpose and problem-oriented programs, asymptotic analysis based on perturbation theory remains one of the most effective tools to penetrate deeply into the essence of the problem in question.

The book deals with both the abstract and practical aspects of moving from a univerisity laboratory to a position in the biotech industry. Each chapter lists common and unique features to evaluate breaking down complex decisions into manageable elements. Several sections provide "how to" guides for the preparation of manuscripts, patents, grants, and internal company documents.
*Written by an experienced academician and successful biotechnology entrepreneur
*Reviews the basic tools taught in a traditional university
*Identifies new ways these these tools will be used in the corporate world
*Details the 'nuts and bolts' necessary to negotiate a successful position in the biotech industry

This volume investigates the implications of how our brain directs our movements on decision making. An extensive body of knowledge in chapters from international experts is presented as well as integrative group reports discussing new directions for future research.
The understanding of how people make decisions is of central interest to experts working in fields such as psychology, economics, movement science, cognitive neuroscience, neuroinformatics, robotics, and sport science. For the first time the current volume provides a multidisciplinary overview of how action and cognition are integrated in the planning of and decisions about action.
* Offers intense, focused, and genuine interdisciplinary perspective
* Conveys state-of-the-art and outlines future research directions on the hot topic of mind and motion (or embodied cognition)
* Includes contributions from psychologists, neuroscientists, movement scientists, economists, and others

This volume reviews the techniques Forster Resonance Energy Transfer (FRET) and Fluorescence Lifetime Imaging Microscopy (FLIM) providing researchers with step by step protocols and handy hints and tips. Both have become staple techniques in many biological and biophysical fields.

Modern embedded systems require high performance, low cost and low power consumption. Such systems typically consist of a heterogeneous collection of processors, specialized memory subsystems, and partially programmable or fixed-function components. This heterogeneity, coupled with issues such as hardware/software partitioning, mapping, scheduling, etc., leads to a large number of design possibilities, making performance debugging and validation of such systems a difficult problem.

Embedded systems are used to control safety critical applications such as flight control, automotive electronics and healthcare monitoring. Clearly, developing reliable software/systems for such applications is of utmost importance. This book describes a host of debugging and verification methods which can help to achieve this goal.
Covers the major abstraction levels of embedded systems design, starting from software analysis and micro-architectural modeling, to modeling of resource sharing and communication at the system levelIntegrates formal techniques of validation for hardware/software with debugging and validation of embedded system design flowsIncludes practical case studies to answer the questions: does a design meet its requirements, if not, then which parts of the system are responsible for the violation, and once they are identified, then how should the design be suitably modified?

ZigBee is a standard based on the IEEE 802.15.4 standard for wireless personal networks. This standard allows for the creation of very lost cost and low power networks - these applications run for years rather than months. These networks are created from sensors and actuators and can wireless control many electrical products such as remote controls, medical, industrial, and security sensors.
Hundreds of companies are creating applications including Mitsubishi, Motorola, Freescale, and Siemens. This book is written for engineers who plan to develop ZigBee applications and networks, to understand how they work, and to evaluate this technology to see if it is appropriate to a particular project. This book does not simply state facts but explains what ZigBee can do through detailed code examples.
CONTENTS:
CHAPTER 1 HELLO ZIGBEE
CHAPTER 2 DECIDING ON ZIGBEE
CHAPTER 3 THE ZIGBEE DEVELOPMENT ENVIRONMENT
CHAPTER 4 ZIGBEE APPLICATIONS
CHAPTER 5 ZIGBEE, ZDO AND ZDP
CHAPTER 6 THE ZIGBEE CLUSTER LIBRARY
CHAPTER 7 THE ZIGBEE NETWORKING LAYER
CHAPTER 8 COMMISSIONING ZIGBEE NETWORKS
CHAPTER 9 ZIGBEE GATEWAYS
APPENDIX A ZIGBEE 2007 AND ZIGBEE PRO
APPENDIX B ZIGBEE QUICK REFERENCE
APPENDIX C ZIGBEE CLUSTER LIBRARY QUICK REFERENCE
*Details how to plan and develop applications and networks
*Zigbee sensors have many applications including industrial automation, medical sensing, remote controls, and security
*Hot topic for today's electrical engineer because it is low cost and low power

This is the first book dedicated to the developing knowledge on how the world's largest ice sheet formed and changed over its 34 million years history. In explaining the story of Antartica, information on terrestrial and marine geology, sedimentology, glacier geophysics (including airborne reconnaissance), shipborne geophysics, and numerical ice sheet and climate modelling, will be interwoven within eleven chapters, each deling with an important historical theme. The approach will be to first 'set the scene', involving chapters dedicated to how ice sheets and their glacial history can be measured. This opening section will provide information necessary to comprehend the latter section of the book, in which five chapters will related the glacial and climate evolution of Antartica during the most important time-frames in which changes have occurred.
* An overview of antarctic climate change, analysing historical, present day and future developments
* Contributions from leading experts and scholars from around the world
* Informs and updates climate change scientists and experts in related areas of study

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers both researchers and clinicians expert, gold-standard analysis of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoprosis, and, hypoparathyroidism.
* Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems.
* Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work.
* Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field.

Volume 3 of Biomembranes covers receptors of cell adhesion and cellular recognition. Proteins in the plasma membrane of cells are heavily involved in processes of cell adhesion, but such proteins were not actually isolated and characterized until the mid-1970s. Since then, application of the methods of molecular biology has led to the recognition of four major classes of cell adhesion molecule (CAMs), the immunoglobulin super family, the cadherins, the integrins, and the selecting. A convenient system in which to study the importance of cell adhesion is in blood platelets where aggregation eventually leads to thrombus formation in a process involving a range of surface glycoproteins. Interaction with the extracellular matrix is exemplified by CD44, the receptor for hyaluronan, and a complex carbohydrate that is a major component of the extracellular matrix surrounding migrating and proliferating cells. Membrane-associated mucins have a variety of effects on cell adhesion. The super family of immunoglobulin related proteins also include the T cell receptors and the major histocompatibility complex (MHC), which, together with the receptors for immunoglobulins (the Fc receptors), are of fundamental importance in the processes of immunity. Volume 3 of Biomembranes explores the structures and functions of the molecules involved in these important functions of the cell.

Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective.

The contents are organized by biological system or molecule. Each chapter discusses insights that have been revealed about their mechanism, structure or function by single molecule techniques. Among the topics covered are enzymes, motor proteins, membrane channels, DNA, ribozymes, cytoskeletal proteins, and other key molecules of current interest. An introduction by the editor provides a concise review of key principles and an historical overview. The last section discusses applications in molecular diagnostics and drug discovery.

* Organized by biological system or molecule.

* Each chapter discusses insights into mechanism of action, structure, and function

* Covers enzymes, motor proteins, membrane channels, DNA, ribozymes, etc.

* Includes an introduction to key principles and an historical overview.

* Discusses applications in molecular diagnostics and drug discovery.

* Provides an expert's perspective on future developments.

The Fly River and its tributaries, the Ok Tedi and Strickland rivers, are located in the Western Province of Papua New Guinea. All three rivers have their source in the rugged central mountain range of the island and eventually flow, via the Fly River delta, into the Gulf of Papua to the north of Australia's Great Barrier Reef. With a catchment area still largely covered by tropical rainforest and relatively few human inhabitants, this remote part of Papua New Guinea presents a rare opportunity to document and understand the dynamics of a large tropical river system largely unaffected by human activity.
In 1984 the Ok Tedi Mining Company Limited began mining copper and gold mineralisation from Mt. Fubilan, which is located at the headwaters of the Ok Tedi. In 1990, mining begin at the Porgera gold mine located at the headwaters of the Strickland River. Since that time both companies have intensely monitored the environment of the Fly River system in order to better understand the possible impact of mining.
This book is intended to assemble and summarise this vast amount of information, much of it contained in internal company reports, to better understand the environmental complexity and dynamics of this large and relatively undisturbed tropical river system.
The approach to be taken in achieving this outcome is to solicit contributions summarising each of the scientific disciplines to be covered from recognised experts with experience in the region.
* documents physical and biologic change in a large tropical river system brought about largely by mining in an otherwise pristine environment.
* this book brings together a broad rand of disciplines to provide acomprehensive overview of change in a complex and dynamical tropical river system based largely on previously unpublished company reports.
* the book provides examples of state-of-the-art strategies and methodologies for monitoring environmental impact in a large river system.

Delays in construction projects are frequently expensive, since there is usually a construction loan involved which charges interest, management staff dedicated to the project whose costs are time dependent, and ongoing inflation in wage and material prices. Many techniques are used to analyze delays. Some of these methods have inherent weaknesses and should be avoided. This book points out the shortcomings of these faulty methods and explains how a delay analysis should be performed. It then describes specifically how the analysis is done with CPM schedules. A explanation of delays and delay damages, presented in a straightforward, accessible manner, should be useful to public and private owners, construction managers, general contractors, subcontractors, designers, suppliers, and attorneys whose work involves them in the construction industry. The discussion will include subtleties of the process, such as shifts in the critical path, and non-critical delays. The subject of damages is covered in detail, including the major categories of extended field overhead and unabsorbed home office overhead. Likewise, the damages suffered by the owner, either actual or liquidated, are also explained. Finally, a chapter is devoted to managing the risk of delays and time extensions from the viewpoints of the various parties to a construction project. A discussion of early completion schedules and constructive acceleration is also included.
In this new ediion, all chapters are updated to reflect the changes in the construction field since the first edition published over l6 years ago. The 2nd edition includs over 40% more information such as new methods for analyzing delays with examples of the proper approach. The author also includes a new chapter on risk managment which focuses on the delay-related risks of the various parties in a construction project.
Explains the different categories of delays
Addresses the concept of concurrency and also non-critical delays
Discusses the more common approaches used for measuring and analyzing delays and the strengths and weaknesses associated with them
Prevention of Time-Related Delay Problems

Dr. Harris has played a major role in the development of this organism as a model system. Her previous version of the "Chlamydomonas Sourcebook" which published in 1989, has been a classic in the field and is considered required reading for anyone working with this organism. This latest edition has been expanded to include three volumes providing molecular techniques, analysis of the recently sequenced genome, and reviews of the current status of the diverse fields in which Chlamydomonas is used as a model organism. Methods for Chlamydomonas research and best practices for applications in research, including methods for culture, preservation of cultures, preparation of media, lists of inhibitors and other additives to culture media, are included. Additions to this volume also include help with common laboratory problems such as contamination, student demonstrations, and properties of particular strains and mutants.
"This volume is part of a 3-Volume Set (ISBN: 978-0-12-370873-1) and is also sold individually."
* Expanded revision of gold standard reference
* Includes latest advances in research, including completion of the genome
* Provides broad perspective with studies in cell and molecular biology, genetics, plant physiology and related fields
* Available as part of a 3-Volume Set or sold individually

This textbook is a graduate-level introduction to the field of clinical psychology. While most textbooks focus on either assessment, treatment, or research, this book covers all three together specifically for the introductory level graduate course. Chapter coverage is diverse and contributors come from both PhD and PsyD programs and a variety of theoretical orientations. Chapter topics cover the major activities of the contemporary clinical psychologist with an introduction focusing on training models.
The book has a mentoring style designed to highlight the relevance of the topics discussed to clinicians in training. Assessment and treatment chapters focus on evidence-based practice, comparing and contrasting different options, the basis for clinical choice between them, and efficacy of same.
It will also introduce business and ethical aspects of the clinical career that current introductory books do not include, such ethics in assesstment, treatment and research; third party payors; technological developments; dissemination of research findings; cross-cultural issues; and the future of the profession.
* Includes assessment, treatment, and practice issues
* Compares and contrasts different therapeutic styles
* Exemplifies practical application through case studies
* Focuses on evidence-based practice
* Orients future clinicians to contemporary issues facing psychological practices

"Load and Global Response of Ships" gives an introductory background to naval architecture statistics and strength of materials. Each subject is treated in detail; starting from the first principle. The aim of this title was to derive and present the necessary theoretical framework for predicting the extreme loads and the corresponding hull girder stresses that a ship may be subjected to during its operational lifetime.
Although some account is given to reliability analysis, the present treatment has to be supplemented with methods for detailed stress evaluation and for structural strength assessment before a complete structural reliability analysis can be carried out.
The classification societies have issued rules and regulations for a proper structural analysis of a ship and selection of the scantlings. Previously, those rules rather explicitly gave formulae for the thickness of the hull plantings, the size of the stiffeners etc. Such empirical rules must necessarily be rather conservative in order to apply to a large variety of ships. With the advent of powerful computers, the rules have changed. Today, the naval architect can perform the structural analysis using mainly rational methods based on first principles. The classification society may then specify proper safety factors against local global failure modes, taking into account the consequences of failure and the analysis procedure used. A cruder method of analysis then necessitates a larger safety factor. Therefore the effort made by the experienced naval architect to perform a detailed structural analysis will be returned not just by a rational structural arrangement but also often in lower weight of the ship and thus a higher payload throughout the operational lifetime of the ship.
This analysis has attempted to make explicit one way in which designers limit the design space by creating rules to which they expect users to adhere. It is also an attempt to encourage designers to reconsider the 'rules of use' that they have used in their designs, so as to reconceptualise potential usage. This can help design behaviour where rule use is not blindly followed.
By making these rules visible, it is possible to expose the limitations of current technology, and development design solutions that do not restrict use to the 'normal' case of action. Rules are useful to designers because they are simplifications of activity. Rules encode the normal case, and these are simplistic representations of work that are, in many cases, accurate enough for the purpose of design. However, encoding behaviour in rules has dangers in that they do not encompass the whole range of behaviours that can be performed. Using examples, this title shows that being able to break rules means that people are able to engage in a richer more flexible set of actions (and therefore more appropriate to contingency) than when they are constrained to a limited range.

Volume 3 reviews virtually everything that is known about cell motility and behavior in Chlamydomonas. World experts in each area focus on mitosis and cytokinesis; flagellar assembly and motility; intraflagellar transport; dynein; the structure and function of centrioles/basal bodies and their associated structures; ciliary signaling; mating and gamete fusion; photobehaviors; and Chlamydomonas as a model for understanding human diseases of the cilium. The volume is richly illustrated and is supplemented by a website containing both classic and previously unpublished videos of cell motility in Chlamydomonas. A unique and especially valuable feature is the inclusion of tables listing the known proteins (with NCBI accession numbers) for each structure discussed, and the known mutations that affect each structure and process. Because Chlamydomonas has been the premier model for investigating the function and behavior of cilia and flagella, the chapters summarize the current state of knowledge in these areas as it applies to all ciliated organisms. Thus, this volume will be an essential source for all students and researchers interested in cell motility.
* Essential reference to a model species for the study of mechanisms of motility in free living cells
* Includes methods for Chlamydomonas motility research.
* Companion Website with videos illustrates the marvels of the Chlamydomonas flagella in action

The account in this inaugural volume of the series covers the period 1900 to 1960, but also outlines the principal developments in earlier centuries from which biochemistry emerged. Findings are considered in the light of present knowledge, rather than in a rigid historical framework.

Ground-penetrating radar (GPR) is a rapidly developing field that has seen tremendous progress over the past 15 years. The development of GPR spans aspects of geophysical science, technology, and a wide range of scientific and engineering applications. It is the breadth of applications that has made GPR such a valuable tool in the geophysical consulting and geotechnical engineering industries, has lead to its rapid development, and inspired new areas of research in academia. The topic of GPR has gone from not even being mentioned in geophysical texts ten years ago to being the focus of hundreds of research papers and special issues of journals dedicated to the topic. The explosion of primary literature devoted to GPR technology, theory and applications, has lead to a strong demand for an up-to-date synthesis and overview of this rapidly developing field. Because there are specifics in the utilization of GPR for different applications, a review of the current state of development of the applications along with the fundamental theory is required. This book will provide sufficient detail to allow both practitioners and newcomers to the area of GPR to use it as a handbook and primary research reference.
*Review of GPR theory and applications by leaders in the field
*Up-to-date information and references
*Effective handbook and primary research reference for both experienced practitioners and newcomers

"Reward Deficit Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. "Reward Deficit Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. "Reward Deficit Disorders" also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the third volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, which is also available for purchase individually.
Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery processCritical evaluation of animal and translational models improving transition from drug discovery and clinical developmentEmphasizes what results mean to the overall drug discovery processExplores issues in clinical trial design and conductance in each therapeutic areaNeurological Disorders is available for purchase individually.