Immunohistochemistry is the use of specific antibodies to stain particular molecular species in situ. This technique has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer.
This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today.
This book is the second volume of three planned, individually-sold volumes on this topic. Like Volume 1, this book fully explains the principles and applications of modern techniques used in the field of molecular genetics. It will be of particular interest to pathologists and molecular pathologists conducting both academic and/or clinical research.
* The only book available that translates molecular genetics into cancer diagnosis
* The results of each Immunohistochemical and in situ hybridization method are presented in the form of color illustrations
* Methods discussed were either developed or refined by expert contributors in their own laboratories

This book is the latest volume in a highly successful series within Comprehensive Biochemistry and provides a historical and autobiographical perspective of the development of the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. The book is essential reading for everybody, from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.

Reinforced concrete is one of the most widely used modern materials of construction. It is comparatively cheap, readily available, and suitable for a variety of building and construction applications.
This reference provides a detailed resource covering all aspects of this important material. Both servicability and durability aspects are well covered, with all the information needed maximise the life of buildings constructed from it.
Containing an up-to-date and comprehensive collection of technical information and data from world renound authors, it will be a valuable source of reference for academics, researchers, students and professionals alike.
*Provides information vital to prolong the life of buildings constructed from this versatile material
* Brings together a disparate body of knowledge from many parts of the world into a concise and authoritative text
*Containing an up-to-date and comprehensive collection of technical information

Location-based services (LBS) are a new concept integrating a user s geographic location with the general notion of services, such as dialing an emergency number from a cell phone or using a navigation system in a car. Incorporating both mobile communication and spatial data, these applications represent a novel challenge both conceptually and technically.
The purpose of this book is to describe, in an accessible fashion, the various concepts underlying mobile location-based services. These range from general application-related ideas to technical aspects. Each chapter starts with a high level of abstraction and drills down to the technical details. Contributors examine each application from all necessary perspectives, namely, requirements, services, data, and scalability. An illustrative example begins early in the book and runs throughout, serving as a reference.
. This book defines the LBS field and identifies its capabilities, challenges, and technologies.
. The contributors are recognized experts from academia and industry.
. Coverage includes navigation systems, middleware, interoperability, standards, and mobile communications.
. A sample application, the "find-friend" application, is used throughout the book to integrate the concepts discussed in each chapter."

Time-to-contact is the visual information that observers use in fundamental tasks such as landing an airplane or hitting a ball. Time-to-contact has been a hot topic in perception and action for many years and although many articles have been published on this topic, a comprehensive overview or assessment of the theory does not yet exist. This book fills an important gap and will have appeal to the perception and action community. The book is divided into four sections. Section one covers the foundation of time-to-contact, Section two covers different behavioral approaches to time-to-contact estimation, Section three focuses on time-to-contact as perception and strategy, and Section four covers time-to-contact and action regulation.

The flavor of a food is often the most desirable quality characteristic for the consumer, yet the understanding of flavour is a fascinatingly complicated subject, which calls for interdisciplinary research efforts. This latest volume presents the proceedings of the 11th Weurman Flavour Research Symposium and describes the most recent and original research advances related to the flavour of foods and beverages with contributions of experts from 25 countries world-wide.
* Efficiently summarises the current front line research within food flavor
* Highlights the modern approaches to flavor production using biotechnology, enzymes and gene-technology
* The dynamic effects of manipulation of food in the mouth during consumption influencing the release of flavour compounds is discussed in detail

Fully updated, revised, and expanded, this second edition of Modern Cable Television Technology addresses the significant changes undergone by cable since 1999--including, most notably, its continued transformation from a system for delivery of television to a scalable-bandwidth platform for a broad range of communication services. It provides in-depth coverage of high speed data transmission, home networking, IP-based voice, optical dense wavelength division multiplexing, new video compression techniques, integrated voice/video/data transport, and much more.
Intended as a day-to-day reference for cable engineers, this book illuminates all the technologies involved in building and maintaining a cable system. But it's also a great study guide for candidates for SCTE certification, and its careful explanations will benefit any technician whose work involves connecting to a cable system or building products that consume cable services.
*Written by four of the most highly-esteemed cable engineers in the industry with a wealth of experience in cable, consumer electronics, and telecommunications.
*All new material on digital technologies, new practices for delivering high speed data, home networking, IP-based voice technology, optical dense wavelength division multiplexing (DWDM), new video compression techniques, and integrated voice/video/data transport.
*Covers the latest on emerging digital standards for voice, data, video, and multimedia.
*Presents distribution systems, from drops through fiber optics, an covers everything from basic principles to network architectures.

More than two billion people worldwide have currently no access to grid electricity or other efficient energy supply. This is one third of humanity and the majority live in rural areas. The productivity and health of these people are diminished by reliance on traditional fuels and technologies, with women and children suffering most. Energy is the key element to empower people and ensure water, food and fodder supply as well as rural development. Therefore access to energy should be treated as the fundamental right to everybody. Renewable energy has the potential to bring power, not only in the literal sense, to communities by transforming their prospects.
This book offers options that meet the needs of people and communities for energy and engage them in identifying and planning their own provision. It describes updated renewable energy technologies and offers strategies and guidelines for the planning and implementation of sustainable energy supply for individuals and communities.

Since the publication of its first edition in 1999, 'The Hydraulics of Open Channel Flow' has been praised by professionals, academics, students and researchers alike as the most practical modern textbook on open channel flow available. This new edition includes substantial new material on hydraulic modelling, in particular addressing unsteady open channel flows. There are also many new exercises and projects, including a major new revision assignment.
This innovative textbook contains numerous examples and practical applications, and is fully illustrated with both colour and black and white photographs. Dr Chanson introduces the basic principles of open channel flow and takes readers through the key topics of sediment transport, hydraulic modelling and the design of hydraulic structures.
-Comprehensive coverage of the basic principles of key application areas of the hydraulics of open channel flow
-New exercises and examples added to aid understanding
-Ideal for use by students and lecturers in civil and environmental engineering

Therapist's Guide to Clinical Intervention, Second Edition is a must-have reference for clinicians completing insurance forms, participating in managed care, or practicing in treatment settings requiring formalized goals and treatment objectives. This practical, hands-on handbook outlines treatment goals and objectives for each type of psychopathology as defined by the diagnostic and statistical manual by the American Psychiatric Association, identifies skill-building resources, and provides samples of all major professional forms.
With over 30% new information, this new edition covers a variety of new special assessments including domestic violence, phobias, eating disorders, adult ADHD, and outpatient progress. New skill-building resources focus on surviving holiday blues, improving communication, overcoming shyness, teaching couples to fight "fair," surviving divorce, successful stepfamilies, managing anger, coping with post traumatic stress, and more. Additional professional forms have been added including treatment plans, a brief mental health evaluation, parent's questionnaire, and a contract for providing service for people with no insurance.
In a practical hands-on approach, this handbook:
* Outlines treatment goals and objectives for DSM-IV diagnoses
* Provides outlines for assessing special circumstances
* Offers skill building resources to supplement treatment
* Provides samples for a wide range of business and clinical forms
* Outlines treatment goals and objectives for DSM-IV diagnoses
* Outlines for assessing special circumstances
* Offers skill building resources to supplement treatment
* Provides samples for a wide range of business and clinical forms

This volume is the third in the series of sourcebooks on Failure Analysis and Structural Integrity published by Elsevier. It comprises 35 case studies describing detailed analyses of real engineering failures and structural integrity problems chosen from volumes 7, 8 and 9 of the Elsevier journal Engineering Failure Analysis.

It is an essential reference, helping people avoid or analyse engineering failures, design and manufacture for greater safety and economy, and assess operating, maintenance and fitness-for-purpose procedures.

The primary purpose of this book is to provide an integrated overview of incompressible flow turbomachines and their design, in this case pumps and turbines. Theory and empirical knowledge of turbomachines are brought together in detail to form a framework for a basic understanding of this complex subject. A step-by-step approach is used by means of solved problems at the end of each chapter to accomplish this.
.Presents a clear overview of incompressible flow turbomachines
.Treats both types of turbomachines in one text
.Includes a large number of illustative solved problems

This is a comprehensive medical and scientific dictionary for the 21st century. New vocabulary is constantly being introduced into fast moving medico-scientific disciplines such as genomics, clinical trials, medico-legal, health economics and pharmacovigilance. This new terminology is included in this dictionary, clearly defined and accurately translated into Spanish.

The dictionary contains more than 28,000 main entries and many subentries: (a) medical terms used outside the medical community, including colloquial usage; (b) technical medical terms in current use in clinical practice and research; (c) new technical terms in the fields of medicine, medical research and basic scientific research applied to medicine, defined in recent years.

The breadth of subjects covered and the accessibility of the definitions make it user-friendly for the educated general public, while the level of detail and state-of-the-art coverage of recent terminology make it a unique tool for professionals.

This book gives a theoretical base and a perspective for the analysis, design, and operation of information systems, particularly their information storage and retrieval (ISAR) component, whether mechanized or manual. Information systems deal with many types of entities: events, persons, documents, business transactions, museum objects, research projects, and technical parts, to name a few. Among the purposes the serve are to inform the public, to support managers, researchers, and engineers, and to provide a knowledge base for an artificial intelligence program. The principles discussed in this book apply to all these contexts. The book achieves this generality by drawing on ideas from two conceptually overlapping areas-data base management and the organization and use of knowledge in libraries-and by integrating these ideas into a coherent framework. The principles discussed apply to the design of new systems and, more importantly, to the analysis of existing systems in order to exploit their capabilities better, to circumvent their shortcomings, and to introduce modifications where feasible.

The book is meant to serve two purposes. The first and more obvious one is to present state of the art results in algebraic research into residuated structures related to substructural logics. The second, less obvious but equally important, is to provide a reasonably gentle introduction to algebraic logic. At the beginning, the second objective is predominant. Thus, in the first few chapters the reader will find a primer of universal algebra for logicians, a crash course in nonclassical logics for algebraists, an introduction to residuated structures, an outline of Gentzen-style calculi as well as some titbits of proof theory - the celebrated Hauptsatz, or cut elimination theorem, among them. These lead naturally to a discussion of interconnections between logic and algebra, where we try to demonstrate how they form two sides of the same coin. We envisage that the initial chapters could be used as a textbook for a graduate course, perhaps entitled Algebra and Substructural Logics.
As the book progresses the first objective gains predominance over the second. Although the precise point of equilibrium would be difficult to specify, it is safe to say that we enter the technical part with the discussion of various completions of residuated structures. These include Dedekind-McNeille completions and canonical extensions. Completions are used later in investigating several finiteness properties such as the finite model property, generation of varieties by their finite members, and finite embeddability. The algebraic analysis of cut elimination that follows, also takes recourse to completions. Decidability of logics, equational and quasi-equational theories comes next, where we show how proof theoretical methods like cut elimination are preferable for small logics/theories, but semantic tools like Rabin's theorem work better for big ones. Then we turn to Glivenko's theorem, which says that a formula is an intuitionistic tautology if and only if its double negation is a classical one. We generalise it to the substructural setting, identifying for each substructural logic its Glivenko equivalence class with smallest and largest element. This is also where we begin investigating lattices of logics and varieties, rather than particular examples. We continue in this vein by presenting a number of results concerning minimal varieties/maximal logics. A typical theorem there says that for some given well-known variety its subvariety lattice has precisely such-and-such number of minimal members (where values for such-and-such include, but are not limited to, continuum, countably many and two). In the last two chapters we focus on the lattice of varieties corresponding to logics without contraction. In one we prove a negative result: that there are no nontrivial splittings in that variety. In the other, we prove a positive one: that semisimple varieties coincide with discriminator ones.
Within the second, more technical part of the book another transition process may be traced. Namely, we begin with logically inclined technicalities and end with algebraically inclined ones. Here, perhaps, algebraic rendering of Glivenko theorems marks the equilibrium point, at least in the sense that finiteness properties, decidability and Glivenko theorems are of clear interest to logicians, whereas semisimplicity and discriminator varieties are universal algebra par exellence. It is for the reader to judge whether we succeeded in weaving these threads into a seamless fabric.
- Considers both the algebraic and logical perspective within a common framework.
- Written by experts in the area.
- Easily accessible to graduate students and researchers from other fields.
- Results summarized in tables and diagrams to provide an overview of the area.
- Useful as a textbook for a course in algebraic logic, with exercises and suggested research directions.
- Provides a concise introduction to the subject and leads directly to research topics.
- The ideas from algebra and logic are developed hand-in-hand and the connections are shown in every level.

This timely book provides an overview of natural products/botanicals used for the management of insect-pest and diseases. It will help readers to update and widen their knowledge about natural products and their bio-activities against plant pathogens. The volume explores activity, chemistry, toxicity and geographic distribution of plants. Discussions concerning the methodology used for the detection of active principles, their mode of action and commercial prospects are of utmost importance and worthy of note.
* Focuses on recent achievements in natural bio-actives
* Global coverage of natural products / plants
* Targets the most important issues of natural botanicals/ biocides
* Includes innovative ideas with lucid explanations
* Contains specialized chapters, such as, natural control of multi-drug resistant organisms, anti-salmonella agents, natural house-dust-mite control agents, and naturally occurring anti-insect proteins, etc.
* Covers research on bioactives: From Lab to Field and Field to Market
* Includes eco-friendly and economically viable herbal technology

"Multicast Sockets: Practical Guide for Programmers" is a hands-on, application-centric approach to multicasting (as opposed to a network-centric one) that is filled with examples, ideas, and experimentation. Each example builds on the last to introduce multicast concepts, frameworks, and APIs in an engaging manner that does not burden the reader with lots of theory and jargon. The book is an introduction to multicasting but assumes that the reader has a background in network programming and is proficient in C or Java. After reading the book, you will have a firm grasp on how to write a multicast program.
Features:
* Author team of instructor and application programmer is reflected in this rich instructional and practical approach to the subject material
* Only book available that provides a clear, concise, application-centric approach to programming multicast applications and covers several languages C, Java, and C# on the .NET platform
* Covers important topics like service models, testing reachability, and addressing and scoping.
* Includes numerous examples and exercises for programmers and students to test what they have learned"

Mathematics for Electrical Engineering and Computing embraces many applications of modern mathematics, such as Boolean Algebra and Sets and Functions, and also teaches both discrete and continuous systems - particularly vital for Digital Signal Processing (DSP). In addition, as most modern engineers are required to study software, material suitable for Software Engineering - set theory, predicate and prepositional calculus, language and graph theory - is fully integrated into the book.
Excessive technical detail and language are avoided, recognising that the real requirement for practising engineers is the need to understand the "applications" of mathematics in everyday engineering contexts. Emphasis is given to an appreciation of the fundamental concepts behind the mathematics, for problem solving and undertaking critical analysis of results, whether using a calculator or a computer.
The text is backed up by numerous exercises and worked examples throughout, firmly rooted in engineering practice, ensuring that all mathematical theory introduced is directly relevant to real-world engineering. The book includes introductions to advanced topics such as Fourier analysis, vector calculus and random processes, also making this a suitable introductory text for second year undergraduates of electrical, electronic and computer engineering, undertaking engineering mathematics courses.
The book is supported with a number of free online resources. On the companion website readers will find:
* over 60 pages of "Background Mathematics" reinforcing introductory material for revision purposes in advance of your first year course
* plotXpose software (for equation solving, and drawing graphs of simple functions, their derivatives, integrals and Fourier transforms)
* problems and projects (linking directly to the software)
In addition, for lecturers only, http: //textbooks.elsevier.com features a complete worked solutions manual for the exercises in the book.
Dr Attenborough is a former Senior Lecturer in the School of Electrical, Electronic and Information Engineering at South Bank University. She is currently Technical Director of The Webbery - Internet development company, Co. Donegal, Ireland.
* Fundamental principles of mathematics introduced and applied in engineering practice, reinforced through over 300 examples directly relevant to real-world engineering
* Over 60 pages of basic revision material available to download in advance of embarking on a first year course
* Free website support, featuring complete solutions manual, background mathematics, plotXpose software, and further problems and projects enabling students to build on the concepts introduced, and put the theory into practice

This volume highlights aspects and approaches to questions on the development and findings of biotic indicator (systems), considering the complex problems of conversion into practice. Biotic indication in relation to sustainable land use and biodiversity is discussed from many angles.

Covered in this volume are the following topics:

• 
  
• Political requirements and statements on biotic agri-environmental indicators;
• 
  
• Requirements regarding agri-environmental indicators from a scientific as well as an applied point of view;
• 
  
• Scientific reviews and critical discussions of "state of the art" knowledge regarding several kinds of agri-environmental indicators for biodiversity and/or sustainable agriculture;
• 
  
• Original experiments on certain aspects regarding indication of biodiversity in agroecosystems;
• 
  
• Practical experience with the application and suitability of agri-environmental indicators (as far as they are already established);
• 
  
• Conceptions and models to show the economic effects and possibilities of practical application of such indicators.
  
• 
  

Sobolev Spaces presents an introduction to the theory of Sobolev Spaces and other related spaces of function, also to the imbedding characteristics of these spaces. This theory is widely used in pure and Applied Mathematics and in the Physical Sciences.
This second edition of Adam's 'classic' reference text contains many additions and much modernizing and refining of material. The basic premise of the book remains unchanged: Sobolev Spaces is intended to provide a solid foundation in these spaces for graduate students and researchers alike.
* Self-contained and accessible for readers in other disciplines.
* Written at elementary level making it accessible to graduate students.

Digital arithmetic plays an important role in the design of general-purpose digital processors and of embedded systems for signal processing, graphics, and communications. In spite of a mature body of knowledge in digital arithmetic, each new generation of processors or digital systems creates new arithmetic design problems. Designers, researchers, and graduate students will find solid solutions to these problems in this comprehensive, state-of-the-art exposition of digital arithmetic.
Ercegovac and Lang, two of the field's leading experts, deliver a unified treatment of digital arithmetic, tying underlying theory to design practice in a technology-independent manner. They consistently use an algorithmic approach in defining arithmetic operations, illustrate concepts with examples of designs at the logic level, and discuss cost/performance characteristics throughout. Students and practicing designers alike will find Digital Arithmetic a definitive reference and a consistent teaching tool for developing a deep understanding of the "arithmetic style" of algorithms and designs.
-Guides readers to develop sound solutions, avoid known mistakes, and repeat successful design decisions.
-Presents comprehensive coverage3/4from fundamental theories to current research trends.
-Written in a clear and engaging style by two masters of the field.
-Concludes each chapter with in-depth discussions of the key literature.
-Includes a full set of over 250 exercises, an on-line appendix with solutions to one-third of the exercises and 600 lecture slides

This book is designed for the reader who wants to get a general view of the terminology of General Topology with minimal time and effort. The reader, whom we assume to have only a rudimentary knowledge of set theory, algebra and analysis, will be able to find what they want if they will properly use the index. However, this book contains very few proofs and the reader who wants to study more systematically will find sufficiently many references in the book.

Key features:

- More terms from General Topology than any other book ever published
- Short and informative articles
- Authors include the majority of top researchers in the field
- Extensive indexing of terms

The multicore revolution has reached the deployment stage in embedded systems ranging from small ultramobile devices to large telecommunication servers. The transition from single to multicore processors, motivated by the need to increase performance while conserving power, has placed great responsibility on the shoulders of software engineers. In this new embedded multicore era, the toughest task is the development of code to support more sophisticated systems. This book provides embedded engineers with solid grounding in the skills required to develop software targeting multicore processors. Within the text, the author undertakes an in-depth exploration of performance analysis, and a close-up look at the tools of the trade. Both general multicore design principles and processor-specific optimization techniques are revealed. Detailed coverage of critical issues for multicore employment within embedded systems is provided, including the Threading Development Cycle, with discussions of analysis, design, development, debugging, and performance tuning of threaded applications. Software development techniques engendering optimal mobility and energy efficiency are highlighted through multiple case studies, which provide practical how-to advice on implementing the latest multicore processors. Finally, future trends are discussed, including terascale, speculative multithreading, transactional memory, interconnects, and the software-specific implications of these looming architectural developments.
Table of Contents
Chapter 1 - Introduction
Chapter 2 Basic System and Processor Architecture
Chapter 3 Multi-core Processors & Embedded
Chapter 4 Moving To Multi-core Intel Architecture
Chapter 5 Scalar Optimization & Usability
Chapter 6 Parallel Optimization Using Threads
Chapter 7 - Case Study: Data Decomposition
Chapter 8 - Case Study: Functional Decomposition
Chapter 9 Virtualization & Partitioning
Chapter 10 Getting Ready For Low Power Intel Architecture
Chapter 11 - Summary, Trends, and Conclusions
Appendix I
Glossary
References
*This is the only book to explain software optimization for embedded multi-core systems
*Helpful tips, tricks and design secrets from an Intel programming expert, with detailed examples using the popular X86 architecture
*Covers hot topics, including ultramobile devices, low-power designs, Pthreads vs. OpenMP, and heterogeneous cores"

Signal Transduction now in paperback, is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work.
* Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine
* Conceptual colour artwork assists with the comprehension of key topics
* Extensive referencing provides an invaluable link to the core and historical literature
* Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

In this brand new volume, Ian Poole begins with a fine introduction to radio, suitable for almost all readers. ...the book is an excellent way for neophytes to step into radio and learn something about it. It begins with the basics and gradually brings in more advanced concepts. We recommend it as an additon to the technical libraries of intermediate-level technical readers. It is an interesting read even for the advanced engineer. - QEX July/August 2004
Ian Poole has written a fascinating guide to the technology and applications of modern radio and communications equipment. His approach provides a useful foundation for college students and technicians seeking an update on the latest technology, but each topic is introduced from the basics, ensuring that the book is equally rewarding for managers in the communications industry, sales staff, and anyone seeking to update their knowledge of this exciting and rapidly expanding area of technology.
The key areas covered by this book are:
Radio principles
Broadcasting, including Digital Radio
Private mobile radio, (PMR) including trunking and TETRA
Cellular telecommunications, including GSM and 3G
Data communications, including Bluetooth and 802.11
As well as a survey of established and cutting-edge technologies the underpinning science and electronics is introduced.
*Includes a survey of established and cutting-edge communication technologies
*Introduces the underpinning science and electronics of the subject
*Provides an emphasis on circuits and how they work