Volume 6 of Biomembranes covers transmembrane receptors and channels. A particularly important role for the membrane is that of passing messages between a cell and its environment. Part I of this volume covers receptors for hormones and growth factors. Here, as in so many other areas of cell biology, the application of the methods of molecular biology have led to the recognition of a number of families of receptors. Typically, such receptors contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular catalytic domain whose activation, as a result of ligand binding, leads to generation of second messengers within the cell and stimulation of a range of cytosolic enzymes. An alternative signaling strategy, exploited in particular in the nervous system, is to use ion channels to allow controlled movement of monovalent (Na+, K+) or divalent (Ca2+) cations in or out of the cell, resulting in changes in membrane potential or alterations in the intracellular concentration of Ca2+. Part II of this volume is concerned with these ion channels and with other, often simpler, ion channel systems whose study can throw light on channel mechanism.

"Readingsfrom the Treatise onGeochemistry" offers an interdisciplinary reference for scientists, researchers and upper undergraduate and graduate levelgeochemistry students that ismore affordable than the full Treatise. For professionals, this volume will provide anoverview of the field as a whole. For students, it will provide morein-depth introductory content thanis found inbroad-based geochemistry textbooks. Articleswere selected from chapters across all volumes of the full Treatise, and include: The Origin and Earliest History of the Earth, Compositional Evolution of the Mantle, Evolution of Sedimentary Rocks, Soil Formation, Geochemistry of Groundwater, Geologic History of Seawater, Hydrothermal Processes, and Biogeochemistry of Primary Production in the Sea.
Comprehensive, interdisciplinary and authoritative content selected by leading subject expertsRobust illustrations, figures and tablesAffordably priced sampling ofcontent from the full "Treatise on Geochemistry""

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.

Practical Security Training is designed to help security departments develop effective security forces from the personnel screening and selection process to ensuring that proper, cost-efficient training is conducted. Using the building block and progressive method approach allows security staff to become increasingly more effective and more confident. Flexible and practicle, these tools allow security practitioners to adapt them as needed in different environments.
Considering hypothetical situations and case studies, performing drills and continually evaluating performance, the security staff can be better prepared to deal with both routine and emergency situations.
Advocates performance related training similar to that in a military environment
Describes performance-oriented drills
Considers and analyzes hypothetical situations

Volume 5 of Biomembranes covers an important group of membrane proteins, the ATPases. The P-type ATPases couple the hydrolysis of ATP to the movement of ions across a membrane and are characterized by the formation of a phosphoyrlated intermediate. Included are the plasma membrane and muscle sarcoplasmic reticulum Ca2+ -ATPases, the (Na+ -K+) -ATPase, the gastric (H+ -K+) -ATPase, the plasma membrane H+ -ATPase of fungi and plants, the Mg2+ - transport ATPase, the Salmonella typhimurium, and the K+ -ATPase of Escherichia coli, KdpB. The other important classes of ATPase in eukaryotic systems are the vacuolar H+ -ATPases and the F0F1 ATP synthase, and, in bacteria, the anion-translocating ATPases, responsible for resistance to arsenicals and antimonials, and the (Na+ -Mg2+) -ATPase of Acholeplasma. Finally, eukaryotic systems contain a variety of ectonucleotidases important, for example, in hydrolysis of extracellular ATP released as a cotransmitter from cholinergic and adrenergic nerve terminals. Volume 5 of Biomembranes explores structure-function relationships for these mebrane-bound ATPases.

This is a unique book on thyroid neoplasms in that it covers many current topics in the area including tumor development, tumor markers and preclinical treatment for advanced cancer as well as practical approaches (radioiodine, ultrasound, thyroglobulin monitoring and PET scanning). This book will give the general reader and specialist a good foundation for what is currently going on in the area of thyroid neoplasms.
*A translational approach to thyriod neoplasms
*Contributions from national experts in research and clinical medicine
*Current and practical approaches to patients with thyroid neoplasms

Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

This volume is a collection of articles covering "Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. "Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.

This fully revised 2e provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader s understanding.
More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
"

This unique and much needed textbook will meet the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.
The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.
*Uses individual drugs to explain molecular actions
*Full color art program explains molecular and chemical concepts graphically
*Logical structure reflecting the current state of pharmacology and translational research, starting with receptors and finishing with target molecules
*Covers such intricacies as drug resistance and cell death
*Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

In this book we study function spaces of low Borel complexity.
Techniques from general topology, infinite-dimensional topology, functional analysis and descriptive set theory
are primarily used for the study of these spaces. The mix of
methods from several disciplines makes the subject
particularly interesting. Among other things, a complete and self-contained proof of the Dobrowolski-Marciszewski-Mogilski Theorem that all function spaces of low Borel complexity are topologically homeomorphic, is presented.
In order to understand what is going on, a solid background in
infinite-dimensional topology is needed. And for that a fair amount of knowledge of dimension theory as well as ANR theory is needed. The necessary material was partially covered in our previous book Infinite-dimensional topology, prerequisites and introduction'. A selection of what was done there can be found here as well, but completely revised and at many places expanded with recent results. A scenic' route has been chosen towards the
Dobrowolski-Marciszewski-Mogilski Theorem, linking the
results needed for its proof to interesting recent research developments in dimension theory and infinite-dimensional topology.
The first five chapters of this book are intended as a text for
graduate courses in topology. For a course in dimension theory, Chapters 2 and 3 and part of Chapter 1 should be covered. For a course in infinite-dimensional topology, Chapters 1, 4 and 5. In Chapter 6, which deals with function spaces, recent research results are discussed. It could also be used for a graduate course in topology but its flavor is more that of a research monograph than of a textbook; it is therefore
more suitable as a text for a research seminar. The book
consequently has the character of both textbook and a research monograph. In Chapters 1 through 5, unless stated
otherwise, all spaces under discussion are separable and
metrizable. In Chapter 6 results for more general classes of spaces are presented.
In Appendix A for easy reference and some basic facts that are important in the book have been collected. The book is not intended as a basis for a course in topology; its purpose is to collect knowledge about general topology.
The exercises in the book serve three purposes: 1) to test the reader's understanding of the material 2) to supply proofs of statements that are used in the text, but are not proven there
3) to provide additional information not covered by the text.
Solutions to selected exercises have been included in Appendix B.
These exercises are important or difficult.

During the past two decades, there has been a dramatic increase in interest in the study of ageing-related changes in cognitive abilities. In this volume researchers from a variety of theoretical perspectives discuss adult age differences in a wide range of cognitive skills. Of special interest is the extent to which ageing effects on performance are related to variations in the representation, organization and utilization of knowledge, broadly defined. Recent research and theory in the field of ageing has emphasized the need to examine such processes more closely in order to provide a more complete understanding of ageing effects on cognitive behaviour.

Much has been written about dolphins and whales, and excellent books exist especially on the charismatic bottlenose dolphins; and killer, humpback, and sperm whales. But detailed studies have been carried out on a handful of other species, and this book summarizes our state of knowledge of a little dolphin the southern hemisphere dusky, and compares its behavioral strategies in different environs. The editors, Bernd and Mel Wursig, began studying duskies in Patagonia Argentina in 1972. Although they have been to many parts of the Earth since then -- including work on Amazon and Yangtze river dolphins, Hawai i for the delicate lovely spinner dolphin, the Arctic for bowhead and gray whale work, and bottlenose dolphins in several milieus -- they have always returned to their first love of unraveling the social patterns and life strategies of duskies that exist in small groups in semi-enclosed bays and as herds of well over one thousand in the open ocean. This book documents the latest research, from their feeding patterns to their acrobatic skills. It is full of scientific facts, with a sense of poetry and wonder of the unknown.
- Only book fully devoted to the southern hemisphere "dusky" dolphin
- Heavily illustrated with charts, figures, tables, and all color photos
- Written by a cadre of experts intimately familiar with dolphin field work
- Written in an accurate yet accessible style for the scientist and natural historian alike"

Volume 4 of Biomembranes covers endocytosis, exocytosis and related processes. A major role of the plasma membrane is as a permeability barrier, keeping the inside of the cell inside and the outside, outside. Mechanisms must then exist to allow movement of material between the cell and its environment. One mechanism for export from the cell is by exocytosis, a process in which the membranes of secretory vesicles fuse with the plasma membrane releasing the contents of the vesicle into the extracellular medium. The process has been studied in particular depth for the release of neurotransmitters at the synapse. Import into the cell is possible by the process of receptor-mediated endocytosis in which selected plasma membrane proteins are internalizes; when these proteins are receptors for macromolecules, the result is uptake of the macromolecule. Transferring, the low-density lipoprotein, and asialoglycoproteins are all taken up into cells in this way. Phagocytosis, the ingestion of cells and cell fragments by neutrophils and macrophages, also involves receptors - on the phagocytic membrane - of which the best studied are those for the Fc domain of IgG, for the third component of complement, and for the mannose/fructose carbohydrates. Protection of a host against infection can also be achieved by damaging the integrity of the plasma membrane of the invading organism. This is the strategy evolved by the cytotoxic T lymphocytes, which produce a pore-forming toxin, perforin. Volume 4 of Biomembranes explores the structures and mechanisms involved in these biologically and medically important processes.

"Advances in Imaging and Electron Physics " merges two long-running serials--"Advances in Electronics and Electron Physics" and "Advances in Optical and Electron Microscopy."
This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
* Contributions from leading international scholars and industry experts
* Discusses hot topic areas and presents current and future research trends
* Invaluable reference and guide for physicists, engineers and mathematicians

The contents of this monograph are two-scope. First, it intends to provide a synthetic but complete account of the thermodynamic and kinetic foundations on which the reaction path modeling of geological CO2 sequestration is based. In particular, a great effort is devoted to review the thermodynamic properties of CO2 and of the CO2-H2O system and the interactions in the aqueous solution, the thermodynamic stability of solid product phases (by means of several stability plots and activity plots), the volumes of carbonation reactions, and especially the kinetics of dissolution/precipitation reactions of silicates, oxides, hydroxides, and carbonates.
Second, it intends to show the reader how reaction path modeling of geological CO2 sequestration is carried out. To this purpose the well-known high-quality EQ3/6 software package is used. Setting up of computer simulations and obtained results are described in detail and used EQ3/6 input files are given to guide the reader step-by-step from the beginning to the end of these exercises.
Finally, some examples of reaction-path- and reaction-transport-modeling taken from the available literature are presented. The results of these simulations are of fundamental importance to evaluate the amounts of potentially sequestered CO2, and their evolution with time, as well as the time changes of all the other relevant geochemical parameters (e.g., amounts of solid reactants and products, composition of the aqueous phase, pH, redox potential, effects on aquifer porosity). In other words, in this way we are able to predict what occurs when CO2 is injected into a deep aquifer.
* Provides applications for investigating and predicting geological carbon dioxide sequestration
* Reviews the geochemical literature in the field
* Discusses the importance of geochemists in the multidisciplinary study of geological carbon dioxide sequestration

This book begins by laying out a history of espionage that clearly shows that when a new technology or technique becomes available to the information gatherers in public and private sectors, they can quickly be adopted for Netspionage use. It then moves on to describe how the Internet and associated technologies have already revolutionized the collection and analysis of competitive information. The convergence of dependency on networked and exploitation tools (often propagated by "hackers," "cyberpunks," and even intelligence agencies) has already resulted in several incidents that foreshadow the perilous future. Close study of these incidents demonstrates how difficult yet how important it is to confront the challenges of "netspionage" and its less intrusive cousins. The authors present a set of the known incidents and then outline protective measures that will reduce the potential and consequences of netspionage.
Unlike most security books, this one is written for managers and executives in non-protection roles of the organization, since they are the ones who must take a leadership role in safeguarding the information assets of the networked enterprise.

*Practical guide written from front-line experience
*Explains the evolution of information collection and why it has never been easier
*Highlights the tools of the trade and how they can be put to best use

This handbook provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans.
* Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine
* Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics
* Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches

The addictions treatment field is currently undergoing a period of increased scrutiny, upheaval and change. The growing emphasis on treatment accountability and cost effectiveness is leading to major changes in standards of care. Inconsistent practices based solely on clinical intuition rather than hard scientific evidence of treatment efficacy are rapidly becoming unacceptable.
Translating science-based treatments into clinical settings is an important priority in the addictions field and has been the subject of an influential Institute of Medicine report. Substance abuse treatment programs are now mandated to provide evidence-based treatments, with funding and insurance reimbursement contingent on their doing so.
Evidence-Based Addiction Treatment provides a state-of-the-art compilation of assessment and treatment practices with proven effectiveness. A substantial body of evidence is presented to provide students, academics and clinicians with specific science-based treatments that work. Written at a level appropriate for a variety of audiences, research studies are discussed but highly sophisticated knowledge in research methodology is not required.
- Treatments that work
- Explicit case examples
- Contributions by well-known researchers on addiction treatment
- Simple ways to evaluate treatment effectiveness
- Accompanying web-site with exam questions

Many high net worth individuals are interested in diversifying their portfolios and investing in collectibles. A collectible is any physical asset that appreciates in value over time because it is rare or desired by many. Stamps, coins, fine art, antiques, books, and wine are examples of collectibles. Where does the financial advisor or investment manager for these high net worth individuals go to learn about these investments? There is no comprehensive resource from the financial standpoint--until now. Dr Stephen Satchell of Trinity College, Cambridge, has developed a book in which experts in various types of collectibles analyze the financial aspects of investing in these collectibles. Chapters address issues such as: liquidity challenges, tax ramifications, appreciation timelines, the challenge of forecasting and measuring appreciation, and the psychological component of collecting and the role of emotion in collectible investing.

Key Features
Feature: Contributors are experts in collectible investing from around the world
Benefit: Gives financial advisors and wealth managers handy access to expert opinions to better advise clients interested in collectible investments
Feature: Experts discuss the pros and cons of collectibles from an investment perspective in their area of expertise
Benefit: One stop shopping, all expertise brought together in one volume, creating a handy reference guide
Feature: Experts discuss art, stamps, coins, antiques, wine, from around the world in one global perspective
Benefit: Wealth managers can gain information about a wide range of collectibles and learn about investing in these types with a global perspective

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that explains the phenomenon of stress, the neural, endocrine and molecular mechanisms involved, the clinical effects, and the impact on individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing s Syndrome: Addison s Disease) and the adverse impact of stress on human physicaland mental health . Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer s disease and Parkinson s disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is alsoplaced on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries.
Chapters offer impressive scope with topics addressing animal studies, disaster, diurnal rhythms, drug effects and treatments, cognition and emotion, physical illness, psychopathology, immunology and inflammation, lab studies and tests, and psychological / biochemical / genetic aspects

Richly illustrated with over 200 figures, 75 in color

Priced affordably, this compendium of articles appeals to the end user interested in stress research who would not otherwise purchase the larger Encyclopedia of Stress

Articles carefully selected by one of the world s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge "

Dynamic fracture in solids has attracted much attention for over a century from engineers as well as physicists due both to its technological interest and to inherent scientific curiosity. Rapidly applied loads are encountered in a number of technical applications. In some cases such loads might be applied deliberately, as for example in problems of blasting, mining, and comminution or fragmentation; in other cases, such dynamic loads might arise from accidental conditions. Regardless of the origin of the rapid loading, it is necessary to understand the mechanisms and mechanics of fracture under dynamic loading conditions in order to design suitable procedures for assessing the susceptibility to fracture. Quite apart from its repercussions in the area of structural integrity, fundamental scientific curiosity has continued to play a large role in engendering interest in dynamic fracture problems
* In-depth coverage of the mechanics, experimental methods, practical applications
* Summary of material response of different materials
* Discussion of unresolved issues in dynamic fracture

In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy.

* Provides updates on the latest developments in NMR spectroscopy * Includes comprehensive review articles * Highlights the increasing importance of NMR spectroscopy as a technique for structural determination

Using the author's considerable experience of applying Mathcad to engineering problems, Essential Mathcad introduces the most powerful functions and features of the software and teaches how to apply these to create comprehensive calculations for any quantitative subject. The simple, step-by-step approach makes this book an ideal Mathcad text for professional engineers as well as engineering, science, and math students. Examples from a variety of fields demonstrate the power and utility of Mathcad's tools, while also demonstrating how other software, such as Excel spreadsheets, can be incorporated effectively.
*Many more applied examples and exercises from a wide variety of engineering, science, and math fields
* New: more thorough discussions of differential equations, 3D plotting, and curve fitting.
* A step-by-step approach enables easy learning for professionals and students alike

This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.
Offers an essentialintroduction to molecular genetics and the "molecular" aspects of human diseaseTeaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human diseaseIn-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology. "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicineStudent web site hosts "self-assessment" questions; Professor web site hosts all figures from bookEach chapter ends with Key Summary Points and Suggested Readings

"

You don t need coddling; you don t need to be told what you already know. What you need is a book that uses your experience as a Java or C++ programmer to give you a leg up into the challenges and rewards of C#. And this Practical Guide is precisely what you re after.
Written by a team that boasts extensive experience teaching C# to professionals, this book provides a practical, efficient explanation of the language itself, covering basic to advanced features and calling out all that s new in 2.0. Its instruction is always firmly situated within the context of the .NET framework and bolstered by code examples, key lessons in object-oriented programming, and installments of a realistic application programming tutorial. Concise and incisive, this is the best way to master the world s fastest-growing and most marketable programming language.
Features
* Provides a carefully focused explanation of every aspect of the C# language, including entire chapters on the unified type system, advanced types, collections, generics, reflection and attributes.
* Highlights all features new to the latest version of C# and organizes its presentation of C# according to the key principles of object-oriented programming and the .NET framework.
* Using end-of-chapter exercises, incrementally develops a cohesive application programming tutorial.
* Includes an easy-to-use appendix on the grammatical rules of C# and provides downloadable example code via the companion website.
* Provides a carefully focused explanation of every aspect of the C# language, including entire chapters on the unified type system, advanced types, collections, generics, reflection and attributes.
* Highlights all features new to the latest version of C# and organizes its presentation of C# according to the key principles of object-oriented programming and the .NET framework.
* Using end-of-chapter exercises, incrementally develops a cohesive application programming tutorial.
* Includes an easy-to-use appendix on the grammatical rules of C# and provides downloadable example code via the companion website."