Autodesk(r) Inventor(r) Simulation is an essential element in the Autodesk Digital Prototyping workflow that enables engineers, designers and manufacturers to transition from traditional design and physical prototyping methods to the innovative use of 3D modeling for evaluating form, fit and function. This allows virtual exploration and testing of objects, components and products before they are made, saving critical development time and cost. Autodesk Inventor Simulation provides the dynamic tools required to revolutionize the product design process, but these tools are complex to learn and use to their full potential.

Up and Running with Autodesk(r) Inventor(r) Simulation 2011 is dedicated to the requirements of Inventor users who need to quickly learn or refresh their skills and apply the dynamic simulation, stress analysis, frame analysis, and optimization capabilities of Inventor Simulation 2011. Providing clear guidance and all-important real-world tutorials, the step-by-step, heavily-illustrated approach of this book will help designers, engineers, and manufacturers of all skill levels become Simulation experts.
Get up to speed fast with real-life, step-by-step design problems-3 new to this edition Discover how to convert CAD models to working digital prototypes, enabling you to enhance designs and simulate real-world performance without creating physical prototypesLearn all about the frame analysis environment-new to Autodesk Inventor Simulation 2011-and other key features of this powerful software, including modal analysis, assembly stress analysis, parametric optimization analysis, effective joint creation, and moreManipulate and experiment with design solutions from the book using datasets provided on the book's companion website (http: //www.elsevierdirect.com/v2/companion.jsp?ISBN=9780123821027) and move seamlessly onto tackling your own design challenges with confidenceNew edition features enhanced coverage of key areas, including stress singularities, h-p convergence, curved elements, mechanism redundancies, FEA and simulation theory, with hand calculations, and more

Since its inception in 1945, this serial has provided criticalarticles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates.
Features contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field
"

Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience.

Volumes 181 and 182 of Progress in Brain Researchprovide a rapid view of the major points presently discussed at biological and clinical levels.

The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques.

The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers (prostate, breast, etc, ). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes).

The best researchers in the field provide their conclusions in the context of the latest experimental results

Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered

Of great value for researchers and experts, but also for students as a background reference"

Volume 5 of Biomembranes covers an important group of membrane proteins, the ATPases. The P-type ATPases couple the hydrolysis of ATP to the movement of ions across a membrane and are characterized by the formation of a phosphoyrlated intermediate. Included are the plasma membrane and muscle sarcoplasmic reticulum Ca2+ -ATPases, the (Na+ -K+) -ATPase, the gastric (H+ -K+) -ATPase, the plasma membrane H+ -ATPase of fungi and plants, the Mg2+ - transport ATPase, the Salmonella typhimurium, and the K+ -ATPase of Escherichia coli, KdpB. The other important classes of ATPase in eukaryotic systems are the vacuolar H+ -ATPases and the F0F1 ATP synthase, and, in bacteria, the anion-translocating ATPases, responsible for resistance to arsenicals and antimonials, and the (Na+ -Mg2+) -ATPase of Acholeplasma. Finally, eukaryotic systems contain a variety of ectonucleotidases important, for example, in hydrolysis of extracellular ATP released as a cotransmitter from cholinergic and adrenergic nerve terminals. Volume 5 of Biomembranes explores structure-function relationships for these mebrane-bound ATPases.

Dynamic fracture in solids has attracted much attention for over a century from engineers as well as physicists due both to its technological interest and to inherent scientific curiosity. Rapidly applied loads are encountered in a number of technical applications. In some cases such loads might be applied deliberately, as for example in problems of blasting, mining, and comminution or fragmentation; in other cases, such dynamic loads might arise from accidental conditions. Regardless of the origin of the rapid loading, it is necessary to understand the mechanisms and mechanics of fracture under dynamic loading conditions in order to design suitable procedures for assessing the susceptibility to fracture. Quite apart from its repercussions in the area of structural integrity, fundamental scientific curiosity has continued to play a large role in engendering interest in dynamic fracture problems
* In-depth coverage of the mechanics, experimental methods, practical applications
* Summary of material response of different materials
* Discussion of unresolved issues in dynamic fracture

This is a unique book on thyroid neoplasms in that it covers many current topics in the area including tumor development, tumor markers and preclinical treatment for advanced cancer as well as practical approaches (radioiodine, ultrasound, thyroglobulin monitoring and PET scanning). This book will give the general reader and specialist a good foundation for what is currently going on in the area of thyroid neoplasms.
*A translational approach to thyriod neoplasms
*Contributions from national experts in research and clinical medicine
*Current and practical approaches to patients with thyroid neoplasms

"Annual Reports in Medicinal Chemistry "provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
* Covers findings related to cardiovascular, inflammation, and pulmonary diseases
* Examines issues in oncology, from mTor inhibitors to drug targets
* Incorporates up-to-date information on drug design and discovery, including delivery to market

Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.

Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

This volume is a collection of articles covering "Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. "Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.

How does technology advance? How can we best assimilate innovation? These questions and others are considered by experts on the theories and applications of technological innovations. Considering subjects as diverse as the diffusion of new technologies and their industrial applications, governmental policies, and manifestations of innovation in our institutions, history, and environment, our contributors map milestones in research and speculate about the roads ahead. Wasteful, inefficient, and frequently wrongheaded, the process of technological changes is here revealed as a describable, scientific force.

- Two volumes, available separately and as a set

Expert articles consider the best ways to establish optimal incentives in technological progress.

Science and innovation, both their theories and applications, are examined at the intersections of the marketplace, policy, and social welfare.

Economists are only part of an audience that includes attorneys, educators, and anyone involved in new technologies."

The contents of this monograph are two-scope. First, it intends to provide a synthetic but complete account of the thermodynamic and kinetic foundations on which the reaction path modeling of geological CO2 sequestration is based. In particular, a great effort is devoted to review the thermodynamic properties of CO2 and of the CO2-H2O system and the interactions in the aqueous solution, the thermodynamic stability of solid product phases (by means of several stability plots and activity plots), the volumes of carbonation reactions, and especially the kinetics of dissolution/precipitation reactions of silicates, oxides, hydroxides, and carbonates.
Second, it intends to show the reader how reaction path modeling of geological CO2 sequestration is carried out. To this purpose the well-known high-quality EQ3/6 software package is used. Setting up of computer simulations and obtained results are described in detail and used EQ3/6 input files are given to guide the reader step-by-step from the beginning to the end of these exercises.
Finally, some examples of reaction-path- and reaction-transport-modeling taken from the available literature are presented. The results of these simulations are of fundamental importance to evaluate the amounts of potentially sequestered CO2, and their evolution with time, as well as the time changes of all the other relevant geochemical parameters (e.g., amounts of solid reactants and products, composition of the aqueous phase, pH, redox potential, effects on aquifer porosity). In other words, in this way we are able to predict what occurs when CO2 is injected into a deep aquifer.
* Provides applications for investigating and predicting geological carbon dioxide sequestration
* Reviews the geochemical literature in the field
* Discusses the importance of geochemists in the multidisciplinary study of geological carbon dioxide sequestration

PIC Microcontrollers are a favorite in industry and with hobbyists. These microcontrollers are versatile, simple, and low cost making them perfect for many different applications. The 8-bit PIC is widely used in consumer electronic goods, office automation, and personal projects. Author, Dogan Ibrahim, author of several PIC books has now written a book using the PIC18 family of microcontrollers to create projects with SD cards.
This book is ideal for those practicing engineers, advanced students, and PIC enthusiasts that want to incorporate SD Cards into their devices. SD cards are cheap, fast, and small, used in many MP3 players, digital and video cameras, and perfect for microcontroller applications.
Complete with Microchip's C18 student compiler and using the C language this book brings the reader up to speed on the PIC 18 and SD cards, knowledge which can then be harnessed for hands-on work with the eighteen projects included within. Two great technologies are brought together in this one practical, real-world, hands-on cookbook perfect for a wide range of PIC fans.

*Eighteen fully worked SD projects in the C programming language
*Details memory cards usage with the PIC18 family
*Companion Web site with project code listings to run onMicrochip's C18 student compiler"

Rajiv Kohli and Kash Mittal have brought together the work of experts from different industry sectors and backgrounds to provide a state-of-the-art survey and best practice guidance for scientists and engineers engaged in surface cleaning or handling the consequences of surface contamination.

Topics covered include: A systems analysis approach to contamination control Physical factors that influence the behavior of particle deposition in enclosures An overview of current yield models and description of advanced modelsTypes of strippable coatings, their properties and applications of these coatings for removal of surface contaminants In-depth coverage of ultrasonic cleaning Contamination and cleaning issues at the nanoscaleExperimental results illustrating the impact of model parameters on the removal of particle contamination

The expert contributions in this book provide a valuable source of information on the current status and recent developments in surface contamination and cleaning. The book will be of value to industry, government and academic personnel involved in research and development, manufacturing, process and quality control, and procurement specifications across sectors including microelectronics, aerospace, optics, xerography and joining (adhesive bonding).

ABOUT THE EDITORS

Rajiv Kohli is a leading expert with The Aerospace Corporation in contaminant particle behavior, surface cleaning, and contamination control. At the NASA Johnson Space Center in Houston, Texas, he provides technical support for contamination control related to ground-based and manned spaceflight hardware for the Space Shuttle, the International Space Station, and the new Constellation Program that is designed to meet the United States Vision for Space Exploration.

Kashmiri Lal "Kash" Mittal was associated with IBM from 1972 to 1994. Currently, he is teaching and consulting in the areas of surface contamination and cleaning, and in adhesion science and technology. He is the Editor-in-Chief of the Journal of Adhesion Science and Technology and is the editor of 98 published books, many of them dealing with surface contamination and cleaning.

"Also available"

Developments in Surface Contamination and Cleaning, Volume 1: Fundamentals and Applied Aspects (edited by Rajiv Kohli & K.L. Mittal). ISBN: 9780815515555.

. Provides guidance on best-practice cleaning techniques and the avoidance of surface contamination

. Covers contamination and cleaning issues at the nanoscale

. Includes an in-depth look at ultrasonic cleaning"

This fully revised 2e provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader s understanding.
More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
"

This unique and much needed textbook will meet the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.
The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.
*Uses individual drugs to explain molecular actions
*Full color art program explains molecular and chemical concepts graphically
*Logical structure reflecting the current state of pharmacology and translational research, starting with receptors and finishing with target molecules
*Covers such intricacies as drug resistance and cell death
*Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

In this book we study function spaces of low Borel complexity.
Techniques from general topology, infinite-dimensional topology, functional analysis and descriptive set theory
are primarily used for the study of these spaces. The mix of
methods from several disciplines makes the subject
particularly interesting. Among other things, a complete and self-contained proof of the Dobrowolski-Marciszewski-Mogilski Theorem that all function spaces of low Borel complexity are topologically homeomorphic, is presented.
In order to understand what is going on, a solid background in
infinite-dimensional topology is needed. And for that a fair amount of knowledge of dimension theory as well as ANR theory is needed. The necessary material was partially covered in our previous book Infinite-dimensional topology, prerequisites and introduction'. A selection of what was done there can be found here as well, but completely revised and at many places expanded with recent results. A scenic' route has been chosen towards the
Dobrowolski-Marciszewski-Mogilski Theorem, linking the
results needed for its proof to interesting recent research developments in dimension theory and infinite-dimensional topology.
The first five chapters of this book are intended as a text for
graduate courses in topology. For a course in dimension theory, Chapters 2 and 3 and part of Chapter 1 should be covered. For a course in infinite-dimensional topology, Chapters 1, 4 and 5. In Chapter 6, which deals with function spaces, recent research results are discussed. It could also be used for a graduate course in topology but its flavor is more that of a research monograph than of a textbook; it is therefore
more suitable as a text for a research seminar. The book
consequently has the character of both textbook and a research monograph. In Chapters 1 through 5, unless stated
otherwise, all spaces under discussion are separable and
metrizable. In Chapter 6 results for more general classes of spaces are presented.
In Appendix A for easy reference and some basic facts that are important in the book have been collected. The book is not intended as a basis for a course in topology; its purpose is to collect knowledge about general topology.
The exercises in the book serve three purposes: 1) to test the reader's understanding of the material 2) to supply proofs of statements that are used in the text, but are not proven there
3) to provide additional information not covered by the text.
Solutions to selected exercises have been included in Appendix B.
These exercises are important or difficult.

Concise but comprehensive, "Structural Elements for Architects and Builders" is primarilyfocused onthe design and analysis of structural elements: columns, beams, tension members and their connections. The material is organized into a single, self-sufficient volume, including all necessary data for the preliminary design and analysis of these structural elements in wood, steel, and reinforced concrete.

Every chapter contains insights developed by the author and generally not found elsewhere. Additionally, the Appendices included at the end of the text contain numerous tables and graphs, based on material contained in industry publications, but reorganized and formatted especially for this text to improve clarity and simplicity, without sacrificing comprehensiveness.
Based on the standards and codes from For timber: The American Institute of Timber Construction's (AITC), The American Institute of Steel Construction's (AISC) The American Concrete Institute's (ACI) Building Code Requirements for Structural Concrete and Commentary (ACI 318 and ACI 318R)and the American Society of Civil Engineers
Contains graphs, charts, and tables to solve basic structural design problems
Step-by-step illustrative examples
Cover common connectors such as nails, bolts, and welds
"

By their very nature, construction projects can create seemingly endless opportunities for conflict. Written by a best selling author with over 40 years of experiences in the construction and general contracting business, Construction Process Planning and Management provides you with the necessary tools to save time and money on your construction project. In this book, Sid Levy provides valuable advice for avoiding or working through the common problems that are a result of the long-term nature of construction projects, failure to select a ?project delivery system? appropriate to the project, incomplete drawing and specifications, unrealistic scheduling, poor communication and coordination among participants, and inadequate contract administration. From project genesis, through design development to contractor and contract selection, on to construction oversight, punch list and successful project close-out, this book will point out those pitfalls to avoid and offer practical advice at every step along the way.
Administer the general construction process including solicitation of contractor's qualifications (pre-qualify bidders), comparative analysis of bid packages, recommendation for contract award, contract document negotiation and documentation of job change orders.
Provide Project Planning and on-site management and coordination of all construction projects.
Ensure compliance of building construction rules and regulations and collaborate with chief engineers to monitor quality of construction.
Conduct technical/plan review of construction documents and submit written responses identifying required corrections or changes.
Design, implement and oversee Company standards for construction policies, practices and processes.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields.

This volume explores interdisciplinary research on Attention and interaction of Attention with other cognitive processes including perception, learning, and memory. The papers cover major research on attention in Cognitive Neuroscience and Cognitive Psychology. The volume presents recent advances on attention including binding, dynamics of attention, attention and perceptual organization, attention and consciousness, emotion and attention, development of attention, crossmodal attention, computational modeling of attention, control of actions, attention and memory, and meditation.

This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.
Offers an essentialintroduction to molecular genetics and the "molecular" aspects of human diseaseTeaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human diseaseIn-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology. "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicineStudent web site hosts "self-assessment" questions; Professor web site hosts all figures from bookEach chapter ends with Key Summary Points and Suggested Readings

"

During the past two decades, there has been a dramatic increase in interest in the study of ageing-related changes in cognitive abilities. In this volume researchers from a variety of theoretical perspectives discuss adult age differences in a wide range of cognitive skills. Of special interest is the extent to which ageing effects on performance are related to variations in the representation, organization and utilization of knowledge, broadly defined. Recent research and theory in the field of ageing has emphasized the need to examine such processes more closely in order to provide a more complete understanding of ageing effects on cognitive behaviour.

Much has been written about dolphins and whales, and excellent books exist especially on the charismatic bottlenose dolphins; and killer, humpback, and sperm whales. But detailed studies have been carried out on a handful of other species, and this book summarizes our state of knowledge of a little dolphin the southern hemisphere dusky, and compares its behavioral strategies in different environs. The editors, Bernd and Mel Wursig, began studying duskies in Patagonia Argentina in 1972. Although they have been to many parts of the Earth since then -- including work on Amazon and Yangtze river dolphins, Hawai i for the delicate lovely spinner dolphin, the Arctic for bowhead and gray whale work, and bottlenose dolphins in several milieus -- they have always returned to their first love of unraveling the social patterns and life strategies of duskies that exist in small groups in semi-enclosed bays and as herds of well over one thousand in the open ocean. This book documents the latest research, from their feeding patterns to their acrobatic skills. It is full of scientific facts, with a sense of poetry and wonder of the unknown.
- Only book fully devoted to the southern hemisphere "dusky" dolphin
- Heavily illustrated with charts, figures, tables, and all color photos
- Written by a cadre of experts intimately familiar with dolphin field work
- Written in an accurate yet accessible style for the scientist and natural historian alike"

This volume provides a broad overview of important new advances in the field of Neuropharmacology. In 20 chapters, a selection of international contributors discuss topics including endocannabinoid function, pain, stress, astrocytes etc, and new possibilities for treatments of neurological diseases with neuropharmacological approaches.
- Cutting-edge articles in neuropharmacology
- Discusses new possibilities for treatments of neurological disorders
- Very international authorship providing a global view of the state of research

Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men.

This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger - 8.5 x 11. This editionof Osteoporosis in Menbrings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.
Brings together more eminent investigators and clinicians to interpret developments in this growing field.

Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.

There is no book on the market that covers osteoporosis in men as comprehensively as this book. "

Industrialists developing new food and pharmaceutical products face the challenge of innovation in an increasingly competitive market that must consider incredient cost, product added-value, expectations of a healthy life-style, improved sensory impact, controlled delivery of active compounds and last, but not lease, product stability. While much work has been done to explore, understand, and address these issues, a gap has emerged between recent advances in fundamental knowledge and its direct application to product situations with a growing need for scientific input.
Modern Biopolymer Science matches science to application by first acknowledging the differing viewpoints between those working with low-solids and those working with high-solids, and then sharing the expertise of those two camps under a unified framework of materials science.

* Real-world utilisation of fundamental science to achieve breakthroughs in product development
* Includes a wide range of related aspects of low and high-solids systems for foods and pharmaceuticals
* Covers more than bio-olymer science in foods by including biopolymer interactions with bioactive compounds, issues of importance in drug delivery and medicinal chemistry