Peer-to-Peer (P2P) networks enable users to directly share digital content (such as audio, video, and text files) as well as real-time data (such as telephony traffic) with other users without depending on a central server. Although originally popularized by unlicensed online music services such as Napster, P2P networking has recently emerged as a viable multimillion dollar business model for the distribution of academic and clinical information, telecommunications, and social networking. Written at an accessible level for any reader familiar with fundamental Internet protocols, Peer-to-Peer Networking and Applications explains the conceptual operations and architecture underlying basic P2P systems using well-known commercial systems as models. The book also delineates the latest research directions, thereby providing not only a sophisticated understanding of current systems, but also the means to improve upon these systems with innovations that will better performance, security, and flexibility. Peer-to-Peer Networking and Applications is thus both a valuable starting point and an important reference to those practioners employed by any of the 200 companies with approximately $400 million invested in this new and lucrative technology.
* Uses well-known commercial P2P systems as models, thus demonstrating real-world applicability.
* Discusses how current research trends in wireless networking, high-def content, DRM, etc. will intersect with P2P, allowing readers to account for future developments in their designs.
* Provides online access to the Overlay Weaver P2P emulator, an open source tool that supports a number of peer-to-peer applications with which readers can practice.

The intent in initiating this volume was to bring together a series of essays which would define our present understanding of the endosome and lysosome and their interrelationship. The editors deliberately encouraged the contributors to be speculative; to strive to put order to the "real" world of incomplete and sometimes conflicting data. Seeing science from the laboratory bench can often be like viewing an impressionistic painting from up close; a series of paint dabs with no apparent order. The contributors to this volume were asked to step back and leave the reader with a sense of the whole as well as the detail. To the extent that this has happened, the credit should go to the individual authors.
Our understanding of endosomes and lysosomes has undergone a molecular revolution over the last decade. Hence, we now know much about the molecular features required for internalization of an endocytic receptor, or the function of mannose 6-phosphate receptors in the transport of lysosomal enzymes. We can trace and follow the flow of molecules. In this volume current molecular knowledge concerning the function and relationship of endosomes and lysosomes is presented. Because of this vast increase in knowledge of molecules, we have realized that endosomes in particular are very ephemeral organelles. In fact, endosomes may well not be discrete entities but rather continuously changing and evolving in their molecular composition. The dynamic nature of the relationship between endosomes and lysosomes is the unifying focus of the genetic, biochemical, microscopic, and molecular biological approaches described in the chapters which follow.

Written by a preeminent teacher and scientist in the field, this book provides specialists, students, and general readers with an understanding of the basic chemistry of interactions of inorganic substances with biological systems at the molecular level. The author presents bioinorganic concepts in context and brings a distinct chemistry perspective to the subject.
Provides the streamlined coverage appropriate for one-semester courses or independent study, with all of the necessary but none of the excessive information
Prepares readers to move to the next level of study (whether they continue on in the field or transition to medicine/industry)
Presents concepts through extensive four-color visuals, appealing to a range of learning styles
Promotes critical thinking through open-ended questions throughout the narrative and at the end of each chapter"

Understand the RF and Digital Signal Processing Principles Driving Software-defined Radios
Software-defined radio (SDR) technology is a configurable, low cost, and power efficient solution for multimode and multistandard wireless designs. This book describes software-defined radio concepts and design principles from the perspective of RF and digital signal processing as performed within this system. After an introductory overview of essential SDR concepts, this book examines signal modulation techniques, RF and digital system analysis and requirements, Nyquist and oversampled data conversion techniques, and multirate digital signal processing..

KEY TOPICS
Modulation techniques
Master analog and digital modulation schemes
RF system-design parameters
Examine noise and link budget analysis and Non-linear signal analysis and design methodology
Essentials of baseband and bandpass sampling and gain control
IF sampling architecture compared to traditional quadrature sampling, Nyquist zones, automatic gain control, and filtering
Nyquist sampling converter architectures
Analysis and design of various Nyquist data converters
Oversampled data converter architectures
Analysis and design of continuous-time and discrete-time Delta-Sigma converters
Multirate signal processing
Gain knowledge of interpolation, decimation, and fractional data rate conversion
*Offers readers a powerful set of analytical and design tools
*Details real world designs
*Comprehensive coverage makes this a must have in the RF/Wireless industry"

Now in its fourth edition, this respected text delivers a comprehensive introduction to the principles and practice of refrigeration. Clear and straightforward, it is designed for students (NVQ/vocational level) and professional HVAC engineers, including those on short or CPD courses. Inexperienced readers are provided with a comprehensive introduction to the fundamentals of the technology. With its concise style yet broad sweep the book covers most of the applications professionals will encounter, enabling them to understand, specify, commission, use and maintain these systems. Many readers will appreciate the clarity with which the book covers the subject without swamping them with detailed technical or product specific information.
New material in this edition includes the latest developments in refrigerants and lubricants, together with updated information on compressors, heat exchangers, liquid chillers, electronic expansion valves, controls and cold storage. Topics also covered include efficiency, environmental impact, split systems, retail refrigeration (supermarket systems and cold rooms), industrial systems, fans, air infiltration and noise.
Author Information
Guy Hundy studied Mechanical Engineering at Leeds University, UK. He started his career in the refrigeration industry with J & E Hall Ltd, Dartford. In 1985 he joined Copeland Europe and in 1998 he was appointed Director, Application Engineering, Copeland Europe. He has authored and co-authored papers and articles on compressors, applications and refrigerant changeover topics. Guy Hundy is a Chartered Engineer and works as a Technical Consultant. He is past - President of the Institute of Refrigeration.
* Covers principles, methods and application of refrigeration, air conditioning and heat pumps in a concise volume, without the encumbrance of handbook information found in other volumes
* Ideal for students, and professionals in other disciplines, not too theoretical but with sufficient depth to give an understanding of the issues, this book takes the reader from the fundamentals, through to system design, applications, contract specifications and maintenance
* Full revision by Guy Hundy with new diagrams and illustrations

The term Quality of Service, abbreviated QoS, refers to network resource control mechanisms. Quality of Service is the ability to provide different priority to different applications, users, or data flows, or to guarantee a certain level of performance to a data flow. This book brings all of the elements of network quality of service (QoS) together in a single volume, saving the reader the time and expense of making multiple purchases. It introduces network QoS, explains the basics, describes the protocols, and discusses advanced topics, by the best and brightest experts in the field. It is a quick and efficient way to bring valuable content together from leading experts in the field while creating a one-stop-shopping opportunity for customers to receive the information they would otherwise need to round up from separate sources.
* Chapters contributed by recognized experts cover theory and practice of network quality of service (QoS), allowing the reader to develop a new level of knowledge and technical expertise.
* Presents methods of analysis and problem-solving techniques, enhancing the reader's grasp of the material and ability to implement practical solutions.
* Use of examples illustrate core QoS concepts for enhanced comprehension

Genetic Diseases of the Kidney identifies and analyzes genetic abnormalities causing renal diseases in human subjects. Although in a sense the genome contains all the instructions required for the formation of a phenotype, the information is encoded in an extremely complicated fashion. In primary genetic diseases, the genetic instruction specifies a phenotype clearly linked with a discreet lesion confined to the kidney. However, the genetic disturbance may be imbedded in a complicated physiologic ensemble, so that the nexus between the genetic disturbance and the phenotype may be obscured; in consequence, the causal sequence is extremely difficult to unravel. In many instances the renal disease is one component of a complicated systemic hereditary disease, either monogenic or polygenic. Indeed, renal disease may arise as the sum of minor inputs from many different, seemingly unrelated genes, so that the genetic contributions may be difficult to identify. Confounding the problem further are environmental influences, originating either in the chromosomal environment from modifier genes, or in the extra-chromosomal environmental from intrauterine or postnatal influences. These considerations have determined both the organization of the text as well as the detailed description of the genetic disorders and the physiologic derangements that emerge.
* Lays the essential foundation of mammalian genetics principles for medical professionals with little to no background in genetics
* Analyzes specific renal diseases - both monogenic disorders confined to the kidney as well as systemic diseases with renal involvement - and explains their genetic causes.
*World-renowned editors andauthors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension)

This book focuses on the life and work of Nathan Zuntz (1847-1920), a German physiologist, who made significant contributions to high altitude physiology and aviation medicine.
He achieved fame for his invention of the Zuntz-Geppert respiratory apparatus in 1886 and the first treadmill (Laufband) in 1889. He also invented an X-ray apparatus to observe cardiac changes during exercise and constructed a climate chamber to study exercise under varying and sometimes extreme climates.
* Focuses on Zuntz's contribution to high altitude physiology and aviation medicine

"Annual Reports in Medicinal Chemistry" provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
* covers findings related to cardiovascular, inflammation, and pulmonary diseases
* examines issues in oncology, from mTor inhibitors to drug targets
* incorporates up-to-date information on drug design and discovery, including delivery to market

A large number of volumes have been produced summarizing the work on generation and control of rhythmic movements, in particular locomotion. Unfortunately most of them focus on locomotor studies done on animals. This edited volume redresses that imbalance by focusing completely on human locomotor behaviour. The very nature of the problem has both necessitated and attracted researchers from a wide variety of disciplines ranging from psychology, neurophysiology, kinesiology, engineering, medicine to computer science. The different and unique perspectives they bring to this problem provide a comprehensive picture of the current state of knowledge on the generation and regulation of human locomotor behaviour.

A common unifying theme of this volume is studying the adaptability of human gait to obtain insights into the control of locomotion. The intentional focus on "adaptability" is meant to draw attention to the importance of understanding the generation and regulation of "skilled locomotor behaviour" rather than just the generation of basic locomotor patterns which has been the major focus of animal studies. The synthesis chapter at the end of the volume examines how the questions posed, the technology, and the experimental and theoretical paradigms have evolved over the years, and what the future has in store for this important research domain.

Network management refers to the activities, methods, procedures, and tools that pertain to the operation, administration, maintenance, and provisioning of networked systems, which includes controlling, planning, allocating, deploying, coordinating, and monitoring the resources of a network. This book brings all of the elements of network management together in a single volume, saving the reader the time and expense of making multiple purchases. It introduces network management, explains the basics, describes the protocols, and discusses advanced topics, by the best and brightest experts in the field. It is a quick and efficient way to bring valuable content together from leading experts in the field while creating a one-stop-shopping opportunity for customers to receive the information they would otherwise need to round up from separate sources.
* Chapters contributed by recognized experts in the field cover theory and practice of network management, allowing the reader to develop a new level of knowledge and technical expertise.
* This book's up-to-date coverage of network quality of service issues facilitates learning and lets the reader remain current and fully informed from multiple viewpoints.
* Presents methods of analysis and problem-solving techniques, enhancing the reader's grasp of the material and ability to implement practical solutions.
* Use of examples illustrate core network management concepts for enhanced comprehension.

This book brings all of the elements of data mining together in a single volume, saving the reader the time and expense of making multiple purchases. It consolidates both introductory and advanced topics, thereby covering the gamut of data mining and machine learning tactics ? from data integration and pre-processing, to fundamental algorithms, to optimization techniques and web mining methodology.
The proposed book expertly combines the finest data mining material from the Morgan Kaufmann portfolio. Individual chapters are derived from a select group of MK books authored by the best and brightest in the field. These chapters are combined into one comprehensive volume in a way that allows it to be used as a reference work for those interested in new and developing aspects of data mining.
This book represents a quick and efficient way to unite valuable content from leading data mining experts, thereby creating a definitive, one-stop-shopping opportunity for customers to receive the information they would otherwise need to round up from separate sources.
* Chapters contributed by various recognized experts in the field let the reader remain up to date and fully informed from multiple viewpoints.
* Presents multiple methods of analysis and algorithmic problem-solving techniques, enhancing the reader's technical expertise and ability to implement practical solutions.
* Coverage of both theory and practice brings all of the elements of data mining together in a single volume, saving the reader the time and expense of making multiple purchases.

Most employeers are astounded at how easily and quickly their proprietary information can get out of their control. In a large number of cases, theft of trade secrets often involves employees leaving a company to start their own business or work for a direct competitor.
Nearly all books that address the topic of trade secrets have the spy vs. spy perspective. The author approaches the topic from a practical business perspective and not simply creating paranoia for paranoia s sake. The material for this book comes from the author s extensive work experience as a computer forensics consultant and manager on numerous theft of trade secrets cases.
No-nonsense solutions to the most common intellectual property problems facing security managers, computer security professionals, corporate legal counsel, and human resource managersSample agreements and forms that address specific business needsCoverage of threats ranging from physical security lapses to hackers to social engineering"

The extensive additions, and the inclusion of a new chapter, has made this classic work by Jeffrey, now joined by co-author Dr. H.H. Dai, an even more essential reference for researchers and students in applied mathematics, engineering, and physics. It provides quick access to important formulas, relationships between functions, and mathematical techniques that range from matrix theory and integrals of commonly occurring functions to vector calculus, ordinary and partial differential equations, special functions, Fourier series, orthogonal polynomials, and Laplace and Fourier transforms. During the preparation of this edition full advantage was taken of the recently updated seventh edition of Gradshteyn and Ryzhik's Table of Integrals, Series, and Products and other important reference works. Suggestions from users of the third edition of the Handbook have resulted in the expansion of many sections, and because of the relevance to boundary value problems for the Laplace equation in the plane, a new chapter on conformal mapping, has been added, complete with an atlas of useful mappings. A unique feature of the fourth edition is the provision of a CD-ROM that provides ready access to the most frequently used parts of the book, together with helpful notes for users of the Handbook.
- Comprehensive coverage in reference form of the branches of mathematics used in science and engineering
- Organized to make results involving integrals and functions easy to locate
- Results illustrated by worked examples
- Unique CD-ROMthat provides access to the most frequently used parts of the book
- CD-ROM contains helpful notes for users

This volume provides a vital and comprehensive resource on stroke, including research, diagnosis, prevention, and treatment modalities. Practitioners in these fields will find invaluable information in this handbook, from basic mechanisms of the disease, to enhanced diagnostic and therapeutic capabilities for patient care.

With the field of cerebrovascular disorders, including stroke, making rapid advancements, clinicians will find illuminating and insightful chapters on the pathophysiological basis of this disorder.

Advances in our understanding of the biochemical background of strokes, coupled with an examination of breakthroughs in epidemiology, genetics, neuroimaging, interventional radiology, surgery, and even clinical psychology are also explored, giving researchers and clinicians a profoundly altered way to approach stroke research, diagnosis, and patient treatment and care.
* A comprehensive resource on stroke, prevention techniques, diagnosis, and treatment modalities
* Illuminating and insightful information on the pathophysiological basis of stroke
* A thorough examination of the rapid advancements made in the field of cerebrovascular disorders and their applications to stroke

This book brings all of the elements of database design together in a single volume, saving the reader the time and expense of making multiple purchases. It consolidates both introductory and advanced topics, thereby covering the gamut of database design methodology ? from ER and UML techniques, to conceptual data modeling and table transformation, to storing XML and querying moving objects databases.
The proposed book expertly combines the finest database design material from the Morgan Kaufmann portfolio. Individual chapters are derived from a select group of MK books authored by the best and brightest in the field. These chapters are combined into one comprehensive volume in a way that allows it to be used as a reference work for those interested in new and developing aspects of database design.
This book represents a quick and efficient way to unite valuable content from leading database design experts, thereby creating a definitive, one-stop-shopping opportunity for customers to receive the information they would otherwise need to round up from separate sources.
* Chapters contributed by various recognized experts in the field let the reader remain up to date and fully informed from multiple viewpoints.
* Details multiple relational models and modeling languages, enhancing the reader's technical expertise and familiarity with design-related requirements specification.
* Coverage of both theory and practice brings all of the elements of database design together in a single volume, saving the reader the time and expense of making multiple purchases.

Digital signal processing is commonplace in most electronics including MP3 players, HDTVs, and phones, just to name a few of the applications. The engineers creating these devices are in need of essential information at a moment's notice. The Instant Access Series provides all the critical content that a signal or communications engineer needs in his or her daily work.
This book provides an introduction to DSPs as well as succinct overviews of linear systems, digital filters, and digital compression. This book is filled with images, figures, tables, and easy to find tips and tricks for the engineer that needs material fast to complete projects to deadline.

*Tips and tricks feature that will help engineers get info fast and move on to the next issue
*Easily searchable content complete with tabs, chapter table of contents, bulleted lists, and boxed features
*Just the essentials, no need to page through material not needed for the current project

This book focuses on broadband distribution and systems architecture and concentrates on practical concepts that will allow the reader to do their own design, improvement, and troubleshooting work. The objective is to enhance the skill sets of a large population that designs and builds broadband cable plants, as well as those maintaining and troubleshooting it. A large cross-section of technical personnel who need to learn these skills design, maintain, and service HFC systems from signal creation through transmission to reception and processing at the customer end point. In addition, data/voice and video specialists need to master and reference the basics of HFC design and distribution before contending with the intricacies of their own unique services. This book serves as an essential reference to all cable engineers-those who specifically design and maintain the HFC distribution plant as well as those primarily concerned with data/voice technology as well as video technology. Included is an online component consisting of spreadsheets that were used in developing the material presented in the book.
* Concentrates on practical concepts that will allow the user to do his own design, improvement, and trouble-shooting work.
* Prepares cable engineers and technicians to work with assurance as they face the latest developments and future directions.
* Concise and tightly focused, allowing readers to easily find answers to questions about an idea or concept they are developing in this area.

Structural Analysis Rules of Thumb provides a comprehensive review of the classical methods of structural analysis and also the recent advances in computer applications. The prefect guide for the Professional Engineer's exam, Williams covers principles of structural analysis to advanced concepts. Methods of analysis are presented in a concise and direct manner and the different methods of approach to a problem are illustrated by specific examples. In addition, the book include the clear and concise approach to the subject and the focus on the most direct solution to a problem. Numerous worked examples are provided to consolidate the readers? understanding of the topics.
Structural Analysis Rules of Thumb is perfect for anyone who wishes to have handy reference filled with equations, calculations and modeling instructions as well as candidates studying for professional engineering registration examinations. It will also serve as a refresher course and reference manual for practicing engineers. Registered professional engineers and registered structural
Numerous worked examples are provided to consolidate the readers? understanding of the topics
Comprehensive coverage of the whole field of structural analysis
Supplementary problems are given at the end of each chapter with answers provided at the end of the book
Realistic situations encountered in practice and test the reader's ability to apply the concepts presented in the chapter
Classical methods of structural analysis and also the recent advances in computer applications

This volume provides a comprehensive exploration of stroke, from basic mechanisms of disease to enhanced diagnostic and therapeutic capabilities. The ongoing efforts within the neurological community are also highlighted, bringing a better understanding of the pathophysiological basis of this disorder.

Clinicians will find invaluable information that can be used to enhance the lives of an aging global population. Covered topics include the functional anatomy of the brain itself, as well as advancements in the understanding of the biochemical background of strokes.

Related fields and their dramatic impact on stroke research are also included, with findings in the fields of epidemiology, genetics, neuroimaging, and interventional radiology thoroughly explored. In addition, great attention is paid to therapeutic avenues, including investigation, prevention, and patient management.
* A comprehensive resource for information on diagnostic advancements, prevention, and treatment of strokes
* A clinical perspective on the ways related fields such as epidemiology, genetics, and neuroimaging, amongst others, are impacting new research in this disorder
* A foundation that will enable researchers to pursue new clinical investigations

This volume continues the tradition of the Advances series. It contains contributions from experts in the field of atomic, molecular, and optical (AMO) physics. The articles contain some review material, but are intended to provide a comprehensive picture of recent important developments in AMO physics. Both theoretical and experimental articles are included in the volume.
- International experts
- Comprehensive articles
- New developments

The Newnes Know It All Series takes the best of what our authors have written to create hard-working desk references that will be an engineer's first port of call for key information, design techniques and rules of thumb. Guaranteed not to gather dust on a shelf
Communications engineers need to master a wide area of topics to excel. The "Wireless Security Know It All" covers every angle including Emerging Wireless Technologies and Security Issues, Wireless LAN and MAN Security, as well as Wireless Personal Area Networks.
A 360-degree view from our best-selling authors
Topics include Today s Wireless Technology, Security Definitions and Concepts, and Wireless Handheld devices
The ultimate hard-working desk reference; all the essential information, techniques and tricks of the trade in one volume"

The quantity of information available about membrane proteins is now too large for any one person to be familiar with anything but a very small part of the primary literature. A series of volumes concentrating on molecular aspects of biological membranes therefore seems timely. The hope is that, when complete, these volumes will provide a convenient introduction to the study of a wide range of membrane functions.
Application of the techniques of molecular biology has provided the sequences of a very large number of membrane proteins, and has led to the discovery of superfamilies of membrane proteins of related structure. The classic example of the superfamily is the seven helix receptor superfamily, all related in structure to bacteriorhodpsin, and named after the seven trans-membrane a-helices identified in bacteriorhodpsin. This volume explores the structures and functions of this super family.

This volume contains contributions illuminating much of the current research occurring in the area of visual perception. It encompasses all aspects of vision and its relationship to vehicle design, including both the internal and external design of the vehicle as well as the perceptual and cognitive limitations of the vehicle controller.

Issues specifically related to the vision of the driver are initially addressed and the problems of vehicle glazing and light transmission are considered. The major topics of visual perception and vehicle control are covered in three related chapters encompassing: collision avoidance, vehicle signalling systems and the acquisition of visual information. Moving on to the external environment and its relationship to vision, traffic signs are discussed. Approaches to the measurement and modelling of driver behaviour are dealt with and the area of telerobotic control of vehicles is considered. In-vehicle displays are covered in two related chapters addressing issues of visual workload and effects of display type.

It is hoped that the book, contributed to by experts from a diverse range of disciplines, including optometrists, psychologists, physiologists, human factors specialists and engineers, will stimulate the progression of research in this area, as effectively as the preceding volumes did.

This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes.
A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place.
Therefore the book will provide a taste for the subject of glycobiology.
Covering the basics of carbohydrates and then the chemistry and reactions of carbohydrates this book will enable a chemist to gain essential knowledge that will enable them to move smoothly into the worlds of biochemistry, molecular biology and cell biology.

* includes perspective from new co-author Spencer Williams, who enhances coverage of the connection between carbohydrates and life
* describes the basic chemistry and biology of carbohydrates
* reviews the concepts, synthesis, reactions, and biology of carbohydrates