New materials addressed for the first time include the chapters on minerals by Barber et al and the chapter on dislocations in colloidal crystals by Schall and Spaepen. Moriarty et al extend the first principles calculations of kink configurations in bcc metals to high pressures, including the use of flexible boundary conditions to model dilatational effects. Rabier et al clarify the issue of glide-shuffle slip systems in diamond cubic and related III-V compounds. Metadislocations, discussed by Feuerbacher and Heggen, represent a new type of defect in multicomponent metal compounds and alloys.
Kink mechanisms for dislocation motion at high pressure in bcc metals

Dislocation core structures identified in silicon at high stress

Metadislocations, a new type of defect, identified and described

Extension of dislocation concepts to complex minerals

First observations of dislocations in colloidal crystals

Anyone reading the business section of a newspaper lately knows that the financial exchanges--stock, bonds, FX, commodities, and so forth--are undergoing tremendous transformations. Fund managers, market makers, traders, exchange professionals, marekt data providers and analyzers, investors--anyone involved with the financial exchanges needs to understand the major forces pushing this transformation in order to position themselves and their institutions to the best advantage.
In this book, veteran exchange expert Michael Gorham joins his twenty-five years of experience with CME and CBOT to the technical expertise of Nidhi Singh of Goldman Sachs to write a book that tells the story of this dramatic transformation. They chronicle the shift:
--from floors to screens
--from private clubs to public companies, and
--from local and national to global competition.
They analyze each of these shifts, identify the drivers behind them and look forward to the implications arising out of them for exchange business in the future. They also explore several key trends:
--an increase in product innovation
--the integration of markets from all over the world onto a single screen,
--the rise of the modular exchange
--the outsourcing of various exchange functions, and
--the difficulty of transcending geography for regulatory purposes.
So join Gorham and Singh in learning the story of this fundamental transformation. As old ways of working are being destroyed, entirely new types of jobs are being created, and new ways of working with exchanges. This book will help you chart the way forward to financial success.
*Gorham is an exchange expert and Singh is an electronic trading expert, they combine their expertise to reveal the inner workings of the exchanges and where they will go in the future
*Only book to point to new skills needed and new ways of making money for users of exchange services

The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.

Rajiv Kohli and Kash Mittal have brought together the work of experts from different industry sectors and backgrounds to provide a state-of-the-art survey and best practice guidance for scientists and engineers engaged in surface cleaning or handling the consequences of surface contamination.

Topics covered include: A systems analysis approach to contamination control Physical factors that influence the behavior of particle deposition in enclosures An overview of current yield models and description of advanced modelsTypes of strippable coatings, their properties and applications of these coatings for removal of surface contaminants In-depth coverage of ultrasonic cleaning Contamination and cleaning issues at the nanoscaleExperimental results illustrating the impact of model parameters on the removal of particle contamination

The expert contributions in this book provide a valuable source of information on the current status and recent developments in surface contamination and cleaning. The book will be of value to industry, government and academic personnel involved in research and development, manufacturing, process and quality control, and procurement specifications across sectors including microelectronics, aerospace, optics, xerography and joining (adhesive bonding).

ABOUT THE EDITORS

Rajiv Kohli is a leading expert with The Aerospace Corporation in contaminant particle behavior, surface cleaning, and contamination control. At the NASA Johnson Space Center in Houston, Texas, he provides technical support for contamination control related to ground-based and manned spaceflight hardware for the Space Shuttle, the International Space Station, and the new Constellation Program that is designed to meet the United States Vision for Space Exploration.

Kashmiri Lal "Kash" Mittal was associated with IBM from 1972 to 1994. Currently, he is teaching and consulting in the areas of surface contamination and cleaning, and in adhesion science and technology. He is the Editor-in-Chief of the Journal of Adhesion Science and Technology and is the editor of 98 published books, many of them dealing with surface contamination and cleaning.

"Also available"

Developments in Surface Contamination and Cleaning, Volume 1: Fundamentals and Applied Aspects (edited by Rajiv Kohli & K.L. Mittal). ISBN: 9780815515555.

. Provides guidance on best-practice cleaning techniques and the avoidance of surface contamination

. Covers contamination and cleaning issues at the nanoscale

. Includes an in-depth look at ultrasonic cleaning"

The 3e of this well-respected textbook continues the tradition of providing clear and concise explanations for fixed income securities, pricing, and markets. The book matches well with fixed income securities courses. The book's organization emphasizes institutions in the first part, analytics in the second, selected segments of fixed income markets in the third, and fixed income derivatives in the fourth. This enables instructors to customize the material to suit their course structure and the mathematical ability of their students.
* New material on Credit Default Swaps, Collateralized Debt Obligations, and an intergrated discussion of the Credit Crisis have been added.
*Online Resources for instructors on password protected website provides worked out examples for each chapter.
* A detailed description of all key financial terms is provided in a glossary at the back of the book.

This collection of original articles 8 years in the making shines a bright light on recent advances in financial econometrics. From a survey of mathematical and statistical tools for understanding nonlinear Markov processes to an exploration of the time-series evolution of the risk-return tradeoff for stock market investment, noted scholars Yacine Ait-Sahalia and Lars Peter Hansen benchmark the current state of knowledge while contributors build a framework for its growth. Whether in the presence of statistical uncertainty or the proven advantages and limitations of value at risk models, readers will discover that they can set few constraints on the value of this long-awaited volume.
Presents a broad survey of current research-from local characterizations of the Markov process dynamics to financial market trading activityContributors include Nobel Laureate Robert Engle and leading econometriciansOffers a clarity of method and explanation unavailable in other financial econometrics collections"

Exchange Server is necessary to support Outlook and SharePoint in the enterprise messaging at virtually all Fortune 1000 firms. Microsoft(r) Exchange Server 2003 SP1 and SP2 Deployment and Migration describes everything that you need to know about designing, planning, and implementing an Exchange 2003 environment. This book covers, in detail, the tools and techniques that messaging system planners and administrators will require in order to establish a functioning interoperability environment between Exchange 2003 and previous versions of Exchange including Exchange 5.5 and Exchange 2000. The book describes various deployment topologies and environments to cater for a multitude of different organizational requirements. The book has been updated to reflect the new changes that Microsoft introduced with Exchange 2003 and SP1 and SP2 updates in relation to major architectural changes to migrations techniques and other services such as RPC over HTTP and journaling functionality.
* Details for consultants and system administrators to migrate from older versions of Exchange 5.5 and Exchange 2000 to the latest revisions of Exchange 2003
* Critical information on integration with Office 2003 and Windows 2003
* Based on actual implementations of the released version of Exchange
2003 in larger enterprise environments
* NEW! Cover critical updates to Exchange 2003 with updates from SP1 and SP2, such as new implementations of RPC over HTTP and cross site migrations
* NEW! Coverage of the Exchange journaling feature updates in Exchange
2003 SP1 and SP2

This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book.
This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security.
Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the market.
Includes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers time.

The Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the book.

Covers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with.

This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbookreference exists on the market that provides researchers with more in-depth, high-levelinformation on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole.

This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject.
The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook informationThe 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the "Encyclopedia of Neuroscience" by one of the great developmental neuroscientists, Greg LemkeThe best researchers in the field provide their conclusions in the context of the latest experimental results"

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that focuses on the physical and psychological consequences of stress for individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing s Syndrome: Addison s Disease) and the adverse impact of stress on human physical and mental health. Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer s disease and Parkinson s disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is also placed on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries.
Chapters offer impressive scope with topics addressing animal studies, disaster, diurnal rhythms, drug effects and treatments, cognition and emotion, physical illness, psychopathology, immunology and inflammation, lab studies and tests, and psychological / biochemical / genetic aspects Richly illustrated in full color with over 200 figures Articles carefully selected by one of the world s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge"

Intercellular communication is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their environment is the basis of growth and development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, diabetes, and neurological and psychiatric disorders. There is substantial drug development concentrating on this and intercellular communication is the basis of much of neuropharmacology. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be yielded. Neurotransmitters/receptors, synaptic structure and organization, gap junctions, neurotrophic factors and neuropeptides are all explored in this volume, as are the ways in which signaling controls neuroendocrinology, neuroimmunology and neuropharmacology. "Intercellular Communication in the Nervous System"provides a valuable desk reference for all scientists who consider signaling.

* Chapters offer impressive scope with topics addressing neurotransmitters/receptors, synaptic structure and organization, neuropeptides, gap junctions, neuropharmacology and more * Richly illustrated in full color with over 200 figures * Contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge"

By their very nature, construction projects can create seemingly endless opportunities for conflict. Written by a best selling author with over 40 years of experiences in the construction and general contracting business, Construction Process Planning and Management provides you with the necessary tools to save time and money on your construction project. In this book, Sid Levy provides valuable advice for avoiding or working through the common problems that are a result of the long-term nature of construction projects, failure to select a ?project delivery system? appropriate to the project, incomplete drawing and specifications, unrealistic scheduling, poor communication and coordination among participants, and inadequate contract administration. From project genesis, through design development to contractor and contract selection, on to construction oversight, punch list and successful project close-out, this book will point out those pitfalls to avoid and offer practical advice at every step along the way.
Administer the general construction process including solicitation of contractor's qualifications (pre-qualify bidders), comparative analysis of bid packages, recommendation for contract award, contract document negotiation and documentation of job change orders.
Provide Project Planning and on-site management and coordination of all construction projects.
Ensure compliance of building construction rules and regulations and collaborate with chief engineers to monitor quality of construction.
Conduct technical/plan review of construction documents and submit written responses identifying required corrections or changes.
Design, implement and oversee Company standards for construction policies, practices and processes.

Materials Science for Engineering Students offers students of introductory materials science and engineering, and their instructors, a fresh perspective on the rapidly evolving world of advanced engineering materials. This new, concise text takes a more contemporary approach to materials science than the more traditional books in this subject, with a special emphasis on using an inductive method to first introduce materials and their particular properties and then to explain the underlying physical and chemical phenomena responsible for those properties. The text pays particular attention to the newer classes of materials, such as ceramics, polymers and composites, and treats them as part of two essential classes, structural materials and functional materials, rather than the traditional method of emphasizing structural materials alone.
*Presents balanced coverage of both "structural" and "functional" materials.
*Types of materials are introduced first, followed by explanation of physical and chemical phenomena that drive their specific properties.
*Strong focus on engineering applications of materials
*The first materials science text to include a whole chapter devoted to batteries.
*Provides clear, mathematically simple explanations of basic chemistry and physics underlying materials properties.

The Bayesian network is one of the most important architectures for representing and reasoning with multivariate probability distributions. When used in conjunction with specialized informatics, possibilities of real-world applications are achieved. Probabilistic Methods for BioInformatics explains the application of probability and statistics, in particular Bayesian networks, to genetics. This book provides background material on probability, statistics, and genetics, and then moves on to discuss Bayesian networks and applications to bioinformatics.

Rather than getting bogged down in proofs and algorithms, probabilistic methods used for biological information and Bayesian networks are explained in an accessible way using applications and case studies. The many useful applications of Bayesian networks that have been developed in the past 10 years are discussed. Forming a review of all the significant work in the field that will arguably become the most prevalent method in biological data analysis.
Unique coverage of probabilistic reasoning methods applied to bioinformatics data--those methods that are likely to become the standard analysis tools for bioinformatics.Shares insights about when and why probabilistic methods can and cannot be used effectively; Complete review of Bayesian networks and probabilistic methods with a practical approach.

Industrialists developing new food and pharmaceutical products face the challenge of innovation in an increasingly competitive market that must consider incredient cost, product added-value, expectations of a healthy life-style, improved sensory impact, controlled delivery of active compounds and last, but not lease, product stability. While much work has been done to explore, understand, and address these issues, a gap has emerged between recent advances in fundamental knowledge and its direct application to product situations with a growing need for scientific input.
Modern Biopolymer Science matches science to application by first acknowledging the differing viewpoints between those working with low-solids and those working with high-solids, and then sharing the expertise of those two camps under a unified framework of materials science.

* Real-world utilisation of fundamental science to achieve breakthroughs in product development
* Includes a wide range of related aspects of low and high-solids systems for foods and pharmaceuticals
* Covers more than bio-olymer science in foods by including biopolymer interactions with bioactive compounds, issues of importance in drug delivery and medicinal chemistry

This volume provides a broad overview of important new advances in the field of Neuropharmacology. In 20 chapters, a selection of international contributors discuss topics including endocannabinoid function, pain, stress, astrocytes etc, and new possibilities for treatments of neurological diseases with neuropharmacological approaches.
- Cutting-edge articles in neuropharmacology
- Discusses new possibilities for treatments of neurological disorders
- Very international authorship providing a global view of the state of research

Multi-scale analysis and simulation of chemical processing and reactions have received unprecedented attention in recent years; however, measurement technology focused on multi-scale structures, particularly on meso-scale phenomena, has not been sufficiently addressed. This volume of "Advances in Chemical Engineering" focuses on the ""Characterization of Flow, Particles and Interfaces" "to alert the chemical engineering community to this challenging issue presenting six meso-scale measurement technologies.

The Eclipse environment solves the problem of having to maintain your own Integrated Development Environment (IDE), which is time consuming and costly. Embedded tools can also be easily integrated into Eclipse. The C/C++CDT is ideal for the embedded community with more than 70% of embedded developers using this language to write embedded code. Eclipse simplifies embedded system development and then eases its integration into larger platforms and frameworks.
In this book, Doug Abbott examines Eclipse, an IDE, which can be vital in saving money and time in the design and development of an embedded system. Eclipse was created by IBM in 2001 and then became an open-source project in 2004. Since then it has become the de-facto IDE for embedded developers. Virtually all of the major Linux vendors have adopted this platform, including MontVista, LynuxWorks, and Wind River.
*Details the Eclipse Integrated Development Environment (IDE) essential to streamlining your embedded development process
*Overview of the latest C/C++ Developer's Toolkit (CDT)
*Includes case studies of Eclipse use including Monta Vista, LynuxWorks, and Wind River

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.
* The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years
* Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control.
* The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation.
* Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.
* Involves all of the leading researchers in the field.
* INcludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields.

This volume explores interdisciplinary research on Attention and interaction of Attention with other cognitive processes including perception, learning, and memory. The papers cover major research on attention in Cognitive Neuroscience and Cognitive Psychology. The volume presents recent advances on attention including binding, dynamics of attention, attention and perceptual organization, attention and consciousness, emotion and attention, development of attention, crossmodal attention, computational modeling of attention, control of actions, attention and memory, and meditation.

Mobile communications users are demanding increased reliability, functionality, and accessibility; they want "always on" access to voice, e-mail, text, and multimedia services as they roam from home to auto to office to outdoor/indoor locations. In addition, there is an increasing deamnd to replace separate landline/mobile telephones with a single handset that can be used wherever its owner might be. Answering those customer needs, fixed/mobile convergence (FMC) marries the mobility provided by cellular networks with the extended connectivity provided by 802.11-based WiFi services and integrates them with landline networks using a single handset. This book provides the theoretical and practical background necessary to successfully plan, develop, and deploy effective FMC networks.
This book discusses the various 802.11 and VoIP protocols used in FMC networks, open and proprietary communications protocols, integration of FMC networks to wired telephone networks, mobilizing applications such as text messaging and video, security issues, mobile handset requirements for FMC networks, and the administration/management of FMC networks. Special attention is given to selecting appropriate components for FMC, and numerous case histories and examples from the author's experience are provided.
This book is an essential tutorial and reference for any RF/wireless, communications, and networking professional who will work with the next generation of wireless networks.
CONTENTS:
Chapter 1 Unbounded Mobile Communications
Chapter 2 Mobile Communications - State of the Technology
Chapter 3 Unbounded Mobile Communications - what is it?
Chapter 4 UMC - an overview of the technologyrequirements & considerations
Chapter 5 UMC - Current Market Solution Overview
Chapter 6 UMC - Layer 1 & 2 - Media requirements
Chapter 7 VoIP - Layer 3 & 4, the IP infrastructure
Chapter 8 Voice Optimized Networks - the network orphan
Chapter 9 Mobile Handset Solutions
Chapter 10 Hotspot & Hotzone Access
Chapter 11 Security considerations
Chapter 12 PBX features & integration
Chapter 13 UMC Management and Statute conformance considerations
Chapter 14 Mobilizing applications
Chapter 15 The Final Challenge - Sales/support channel considerations
Chapter 16 Unbounded mobile communications - beyond FMC
Glossary
KEY FEATURES
* Describes how to develop, deploy, and manage networks that seamlessly combine landline, cellular, and WiFi networks into one converged communications network.
* Thorough coverage of various 802.11 and voice over internet protocol (VoIP) standards and how they impact integration with cellular networks.
* Discusses security considerations and how to successfully manage converged networks.
* Includes numerous case histories and examples from the author's experience---this is not a purely theoretical treatment of the subject!

"Neurological Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer s disease, Parkinson s disease, Huntington disease, ALS, and the epilepsies. "Neurological Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the second volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, which is also available for purchase individually.
- Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process
- Critical evaluation of animal and translational models improving transition from drug discovery and clinical development
- Emphasis on what results mean to the overall drug discovery process
- Exploration of issues in clinical trial design and conductance in each therapeutic area"

"Psychiatric Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. "Psychiatric Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the first volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, andis also available for purchase individually.
Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery processCritical evaluation of animal and translational models improving transition from drug discovery and clinical developmentEmphasizes what results mean to the overall drug discovery processExplores issues in clinical trial design and conductance in each therapeutic areaPsychiatric Disorders is available for purchase individually."

"Advances in Imaging and Electron Physics" merges two long-running serials--"Advances in Electronics and Electron Physics" and "Advances in Optical and Electron Microscopy." This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
This monograph summarizes the authors' knowledge and experience acquired over many years in their work on computational charged particle optics. Its main message is that even in this era of powerful computers with a multitude of general-purpose and problem-oriented programs, asymptotic analysis based on perturbation theory remains one of the most effective tools to penetrate deeply into the essence of the problem in question.