Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system.

This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures.
Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.

This is the second volume of Morgan Kaufmann's "GPU Computing Gems," offering an all-new set of insights, ideas, and practical "hands-on" skills from researchers and developers worldwide. Each chapter gives you a window into the work being performed across a variety of application domains, and the opportunity to witness the impact of parallel GPU computing on the efficiency of scientific research.

"GPU Computing Gems: Jade Edition" showcases the latest research solutions with GPGPU and CUDA, including: Improving memory access patterns for cellular automata using CUDALarge-scale gas turbine simulations on GPU clustersIdentifying and mitigating credit risk using large-scale economic capital simulationsGPU-powered MATLAB acceleration with JacketBiologically-inspired machine visionAn efficient CUDA algorithm for the maximum network flow problem"30 more chapters" of innovative GPU computing ideas, written to be accessible to researchers from any industry

"GPU Computing Gems: Jade Edition" contains 100% new material covering a variety of application domains: algorithms and data structures, engineering, interactive physics for games, computational finance, and programming tools.
This second volume of "GPU Computing Gems "offers 100% new material of interest across industry, including finance, medicine, imaging, engineering, gaming, environmental science, green computing, and more Covers new tools and frameworks for productive GPU computing application development and offers immediate benefit to researchers developing improved programming environments for GPUsEven more hands-on, proven techniques demonstrating how general purpose GPU computing is changing scientific research Distills the best practices of the community of CUDA programmers; each chapter provides insights and ideas as well as 'hands on' skills applicable to a variety of fields

This textbook offers a technical, architectural, and management approach to solving the problems of protecting national infrastructure and includes practical and empirically-based guidance for students wishing to become security engineers, network operators, software designers, technology managers, application developers, Chief Security Officers, etc.. This approach includes controversial themes such as the deliberate use of deception to trap intruders. In short, it serves as an attractive framework for a new national strategy for cyber security. Each principle is presented as a separate security strategy, along with pages of compelling examples that demonstrate use of the principle. A specific set of criteria requirements allows students to understand how any organization, such as a government agency, integrates the principles into their local environment. The STUDENT EDITION features several case studies illustrating actual implementation scenarios of the principals and requirements discussed in the text. It also includes helpful pedagogical elements such as chapter outlines, chapter summaries, learning checklists, and a 2-color interior. And it boasts a new and complete instructor ancillary package including test bank, IM, Ppt slides, case study questions, and more.

Provides case studies focusing on cyber security challenges and solutions to display how theory, research, and methods, apply to real-life challenges

Utilizes, end-of-chapter case problems that take chapter content and relate it to real security situations and issues

Includes instructor slides for each chapter as well as an instructor s manual with sample syllabi and test bank"

Pulp and paper production has increased globally and will continue to increase in the near future. Approximately 155 million tons of wood pulp is produced worldwide and about 260 million is projected for 2010. To cope with the increasing demand, an increase in production and improved environmental performance is needed as the industry is under constant pressure to reduce environmental emissions to air and water. This book gives updated information on environmentally benign approaches for pulp bleaching, which can help solve the problems associated with conventional bleaching technologies.
Main focus is on the environmentally-friendly technologies that can help solve some of the problems associated with conventional bleaching technologiesInformation given is up-to-date, authoritative, and cites the experiences of many mills and pertinent research, which is of interest to those working in the industry or intending to do soCovers in great depth all the aspects of various bleaching processes including environmental issues

Neuroendocrinology, the discipline concerned with how the nervous system controls hormonal secretion and how hormones control the brain, is pivotal to physiology and medicine. Neuroendocrinology has disclosed and underpins fundamental physiological, molecular biological and genetic principles such as the regulation of gene transcription and translation, the mechanisms of chemical neurotransmission and intracellular and systemic feedback control systems. Reproduction, growth, stress, aggression, metabolism, birth, feeding and drinking and blood pressure are some of the bodily functions that are triggered and/or controlled by neuroendocrine systems. In turn, neuroendocrine dysfunction due to genetic or other deficits can lead, for example, to infertility, impotence, precocious or delayed puberty, defective or excessive growth, obesity and anorexia, Cushing s Syndrome, hypertension or thyroid disorders. These as well as neuroendocrine tumors are some of the themes covered in the 36 chapters of the Handbook. Drafted by internationally acknowledged experts in the field, the Handbook chapters feature detailed up-to-date bibliographies as well as "how do we know?" call out sections that highlight the experimental or technical foundations for major concepts, principles, or methodological advances in each area. Aimed at senior undergraduate and graduate students, post-doctoral fellows and faculty in neuroscience, medicine, endocrinology, psychiatry, psychology and cognate disciplines, the "Handbook of Neuroendocrinology" satisfies an unmet need that will prove useful at the laboratory bench as well as in the office.
The most comprehensive up-to-date source covering basic principles, neural regulation, hormone/brain function and behavior, and neuroendocrine pathology "How do we know?" callout sections highlight core conceptsHeavily illustrated with over 350 figures, 4-color throughout"

Modern embedded systems are used for connected, media-rich, and highly integrated handheld devices such as mobile phones, digital cameras, and MP3 players. All of these embedded systems require networking, graphic user interfaces, and integration with PCs, as opposed to traditional embedded processors that can perform only limited functions for industrial applications. While most books focus on these controllers, "Modern Embedded Computing" provides a thorough understanding of the platform architecture of modern embedded computing systems that drive mobile devices.

The book offers a comprehensive view of developing a framework for embedded systems-on-chips. Examples feature the Intel Atom processor, which is used in high-end mobile devices such as e-readers, Internet-enabled TVs, tablets, and net books. Beginning with a discussion of embedded platform architecture and Intel Atom-specific architecture, modular chapters cover system boot-up, operating systems, power optimization, graphics and multi-media, connectivity, and platform tuning. Companion lab materials compliment the chapters, offering hands-on embedded design experience.
Learn embedded systems design with the Intel Atom Processor, based on the dominant PC chip architecture. Examples use Atom and offer comparisons to other platformsDesign embedded processors for systems that support gaming, in-vehicle infotainment, medical records retrieval, point-of-sale purchasing, networking, digital storage, and many more retail, consumer and industrial applicationsExplore companion lab materials online that offer hands-on embedded design experience

Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that bring together industrial, analytical and technological aspects of biochemistry, organic chemistry and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.
Features contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field

Whether or not, you are on the job site or back in the office, this book will help you to avoid mistakes, code violations, and wasted time and money. The book s four part treatment begins with constituent materials followed by self contained parts on Concrete Properties, Processes, and Concrete Repair and Rehabilitation.

Designed to be an "all in one" reference, the author includes a wealth information for the most popular types of testing. This includes: Analysis of Fresh Concrete; Testing Machines; Accelerated Testing Methods; Analysis of Hardened Concrete and Mortar; Core Sampling and Testing; Assessment of Concrete Construction; Repair; Quality Concepts; Quality Control; Statistics; Standards, Specifications, and Codes of Practice. With this book in hand, construction engineers and even technicians find valuable information regarding Exposed Concrete Finishes, Repairing Concrete, Formwork, Precast Concrete, Concrete Roads, and Industrial Floors.

Project managers and owners will find this reference a valuable guide to concrete both in terms of its applications in construction projects and the science and chemistry of concrete for its own sake.
Fundamentals of Concrete Chemistry

Handy at your figure tip calculations

Tips for working with all types of concretes

Covers Roads, floors, and finishes

Principles of Precast, Reinforced and Prestressed Concrete "

The internal combustion is widely used as a power source in engineering. As the demands placed upon engines have increased, tribology has come to play an increasingly important role in their development.
This book is a creative combination of intelligent design technology and the tribological design of engines: engine tribology, information science, artificial intelligence, non numerical algorithms, modern design technology and dynamics to propose new methodology and technology for tribological engine design. It not only presents an effective approach to l engine design but also explores a new pattern for research and l design methodology.
. An essential reference for the design of more effective and efficient engines
. Proposes new techniques for tribological engine design
. Combines advanced design technologies with traditional tribological design methods

The Side Effects of Drugs Annual was first published in 1977. It has been published continuously since then, as a yearly update to the encyclopaedic volume Meyler's Side Effects of Drugs. Each new Annual provides clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists have contributed to the Annuals by selecting from each year's publications all that is truly new and informative, by critically interpreting it, and by pointing out whatever is misleading. The use of the book is enhanced by separate indexes, allowing the reader to enter the text via the drug name, adverse effect, or drug interaction. Special features of the Annuals are the Side Effects of Drugs Essay, usually written by a guest author, and the special reviews: short articles, within the different chapters, that give extra attention to topics of current interest. The Essay in Annual 27 is entitled 'The General Practice Research Database' (by Dr. H. Jick) and there is a Historical Essay entitled 'Louis Lewin - Meyler's Predecessor' (by Dr. J.K. Aronson). The special reviews in this volume include, among others: The effects of NSAIDs on blood pressure Risks of inhaled corticosteroids in children Leukotriene receptor antagonists and Churg-Strauss syndrome Amiodarone and thyroid disease Surveillance of adverse events following immunization Smallpox vaccination Safety aspects of folic acid Inhibitors of topoisomerase I and topoisomerase II Liver damage from kava kava

"Private Security and the Law, 4th Edition," is a unique resource that provides analysis of practices in the security industry as they relate to law, regulation, licensure, and constitutional questions of case and statutory authority.This bookdescribes the legal requirements facedin the area of private security.It emphasizes the liability problems common to security operations, including negligence and tortious liability, civil actions frequently litigated, and strategies to avoid legal actions that affect business efficiency.The textalso examines the constitutional and due-process dimensions of private security both domestically and internationally, including recent cases and trends that will set pace for future private security laws and regulations. As private security becomes more closely involved in national and international security, cases like Blackwater are examined. Charles Nemeth takesyou step by step through the analysis of case law as it applies to situations commonly faced in the private security practice, providing a solid introduction to the legal and ethical standards that shape the industry.

*Authoritative, scholarly treatise sheds light on this increasingly important area of the law *Historical background helps readers understand the present by seeing the full context of recent developments *National scope provides crucial parameters to security practitioners throughout the US *NEW TO THIS EDITION A chapter on the legal implications of private contractors operating in war zones like Afghanistan, updated coverage of statutory authority, updated coverage of state and federal processes of oversight and licensure, special analysis of public-private cooperative relationships in law enforcement"

"Advances in Imaging and Electron Physics "merges two long-running serials--"Advances in Electronics and Electron Physics" and "Advances in Optical and Electron Microscopy."
This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
* Contributions from leading international scholars and industry experts
* Discusses hot topic areas and presents current and future research trends
* Invaluable reference and guide for physicists, engineers and mathematicians

Strategy and Statistics in Clinical Trials deals with the research processes and the role of statistics in these processes. The book offers real-life case studies and provides a practical, how to guide to biomedical R&D. It describes the statistical building blocks and concepts of clinical trials and promotes effective cooperation between statisticians and important other parties. The discussion is organized around 15 chapters. After providing an overview of clinical development and statistics, the book explores questions when planning clinical trials, along with the attributes of medical products. It then explains how to set research objectives and goes on to consider statistical thinking, estimation, testing procedures, and statistical significance, explanation and prediction. The rest of the book focuses on exploratory and confirmatory clinical trials; hypothesis testing and multiplicity; elements of clinical trial design; choosing trial endpoints; and determination of sample size. This book is for all individuals engaged in clinical research who are interested in a better understanding of statistics, including professional clinical researchers, professors, physicians, and researchers in laboratory. It will also be of interest to corporate and government laboratories, clinical research nurses, members of the allied health professions, and post-doctoral and graduate students.

Private cloud computing enables you to consolidate diverse enterprise systems into one that is cloud-based and can be accessed by end-users seamlessly, regardless of their location or changes in overall demand. Expert authors Steve Smoot and Nam K. Tan distill their years of networking experience to describe how to build enterprise networks to create a private cloud. With their techniques you'll create cost-saving designs and increase the flexibility of your enterprise, while maintaining the security and control of an internal network. "Private Cloud Computing "offers a complete cloud architecture for enterprise networking by synthesizing WAN optimization, next-generation data centers, and virtualization in a network-friendly way, tying them together into a complete solution that can be progressively migrated to as time and resources permit.
Describes next-generation data center architectures such as the virtual access-layer, the unified data center fabric and the "rack-and-roll" deployment modelProvides an overview of cloud security and cloud management from the server virtualization perspectivePresents real-world case studies, configuration and examples that allow you to easily apply practical know-how to your existing enterprise environmentOffers effective private cloud computing solutions to simplify the costly and problematic challenge of enterprise networking and branch server consolidation

What is the value of an education? Volume 4 of the Handbooks in the Economics of Education combines recent data with new methodologies to examine this and related questions from diverse perspectives. School choice and school competition, educator incentives, the college premium, and other considerations help make sense of the investments and returns associated with education. Volume editors Eric A. Hanushek (Stanford), Stephen Machin (University College London) and Ludger Woessmann (Ifo Institute for Economic Research, Munich) draw clear lines between newly emerging research on the economics of education and prior work. In conjunction with Volume 3, they measure our current understanding of educational acquisition and its economic and social effects.
Winner of a 2011 PROSE Award Honorable Mention in Economics from the Association of American PublishersDemonstrates how new methodologies are yielding fresh perspectives in education economicsPresents topics and authors whose data and conclusions attest to the globalization of research Complements the policy and social outcomes themes of volume 3

Rock iguanas of the West Indies are considered to be the most endangered group of lizards in the world. They are a flagship species in the Caribbean and on most islands are the largest native land animals. Unfortunately, human encroachment and introduced animals have brought this species to the brink of extinction. "Cyclura: Natural History, Husbandry, and Conservation of the West Indian Iguanas" is the first book to combine the natural history and captive husbandry of these remarkable reptiles, while at the same time outlining the problems researchers and conservationists are battling to save these beautiful, iconic animals of the Caribbean islands.

Authors Jeffrey Lemm and Allison Alberts have been studying West Indian iguanas for nearly 20 years in the wild and in captivity; their experiences with wild iguanas and their exquisite photos of these charismatic lizards in the wild make this book a must-have for reptile researchers, academics and enthusiasts, as well as anyone interested in nature and conservation.
Includes chapters with contributions by leading experts on rock iguana taxonomy, nutrition, and diseases Features color photos of all taxa, including habitat and captive shotsProvides easily understandable and usable information gleaned from experience and hands-on reptile research

Choice, Behavioural Economics and Addiction is about the theory, data, and applied implications of choice-based models of substance use and addiction. The distinction between substance use and addiction is important, because many individuals use substances but are not also addicted to them. The behavioural economic perspective has made contributions to the analysis of both of these phenomena and, while the major focus of the book is on theories of addiction, it is necessary also to consider the behavioural economic account of substance use in order to place the theories in their proper context and provide full coverage of the contribution of behavioural economics to this field of study.
The book discusses the four major theories of addiction that have been developed in the area of economic science/behavioural economics. They are:
- hyperbolic discounting
- melioration
- relative addiction
- rational addiction
The main objective of the book is to popularise these ideas among addiction researchers, academics and practitioners. The specific aims are to articulate the shared and distinctive elements of these four theories, to present and discuss the latest empirical work on substance abuse and addiction that is being conducted in this area, and to articulate a range of applied implications of this body of work for clinical, public health and public policy initiatives.
The book is based on an invitation-only conference entitled, Choice, Behavioural Economics and Addiction: Theory, Evidence and Applications held at the University of Alabama at Birmingham, March 30 - April 1, 2001. The conference was attended by prominent scientists and scholars, representing a rangeof disciplines concerned with theories of addiction and their consequences for policy and practice. The papers in the book are based on the papers given at the above conference, together with commentaries by distinguished experts and, in many cases, replies to these comments by the presenters.

Starting Electronics is unrivalled as a highly practical introduction for technicians, non-electronic engineers, software engineers, students, and hobbyists. Keith Brindley introduces readers to the functions of the main component types, their uses, and the basic principles of building and designing electronic circuits. Breadboard layouts make this very much a ready-to-run book for the experimenter, and the use of readily available, inexpensive components makes this practical exploration of electronics easily accessible to all levels of engineer and hobbyist.

Other books tell readers what to do, but sometimes fail to explain why - Brindley gives readers hands-on confidence in addition to real scientific knowledge, and insight into the principles as well as the practice. All written explanations and steps are supplemented with numerous photos, charts, tables and graphs. Concepts and practical aspects are explained thoroughly with mathematical formulae and technical schematic drawings.

Each chapter introduces a concept or tool, explains the basic theory, and provides clear instructions for a simple experiment to apply the concept or tool, with quiz sections and answers, at the end of each chapter. New chapters on multimeters and soldering will be added, covering the fundamentals and experiments, with a basic parts list and an expanded and updated buyer s guide.
Guides the reader through the basics of electronics, from fundamentals of theory to practical work and experimentsStructured for learning and self-study: each chapter introduces a concept or tool, explains the basic theory, and provides clear instructions for a simple experiment to apply the concept or tool, with quiz sections and answers, at the end of each chapterNew chapters on multimeters and soldering, covering the fundamentals and experiments, with a basic parts list. Expanded and updated buyer s guide to accompany parts lists"

What new theories, evidence, andpolicies have shaped health economicsin the 21st century?

Editors Mark Pauly, Thomas McGuire, and Pedro Pita Barros assemblethe expertise of leading authoritiesin this survey ofsubstantive issues. In 16chapters theycover recent developments in health economics, from medical spending growth to the demand for health care, the markets for pharmaceutical products, the medical workforce, and equity in health and health care.Its global perspective, including an emphasis on low and middle-income countries, will result in the same high citations that made Volume 1 (2000) a foundational text.
Presents coherent summaries of major subjects and methodologies, marking important advances and revisions. Serves as a frequently used non-journal reference. Introduces non-economists to the best research in health economics. "

This monograph is the last volume in the series 'Acoustic and Elastic
Wave Fields in Geophysics'. The previous two volumes published by Elsevier (2000, 2002) dealt mostly with wave propagation in liquid media.

The third volume is dedicated to propagation of plane, spherical and cylindrical elastic waves in different media including isotropic and transversely isotropic solids, liquid-solid models, and media with cylindrical inclusions (boreholes).
* Prevalence of physical reasoning on formal mathematical derivations
* Readers do not need to have a strong background in mathematics and mathematical physics
* Detailed analysis of wave phenomena in various types of elastic and liquid-elastic media

This volume of "Progess in Brain Research" follows on from the 32nd International Symposium of the Groupe de recherche sur le systeme nerveux central (GRSNC), May 2010, and aims to provide an overview of the various neural mechanisms that contribute to learning new motor and sensory skills, and to adapting to changed circumstances, including the use of devices and implants to substitute for lost sensory or motor abilities (brain machine interfaces). The focus is on recent developments covering five major themes: Mechanisms to improve motor performanceNeuro-rehabilitation of motor functionMechanisms to enhance sensory perceptionCross modal interationc for enhancing sensorimotor performanceAssistive technologies to enhance sensorimotor performance

This volume focuses on the translation of scientific knowledge into applications and strategies that can help restore lost function following injury or disease including assistive neuroprosthetic technologies to enhance sensorimotor performance and neurorehabilitation.
Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist"

Solid state physics is the branch of physics primarily devoted to the study of matter in its solid phase, especially at the atomic level. This prestigious serial presents timely and state-of-the-art reviews pertaining to all aspects of solid state physics.

Advances in Catalysis fills the gap between the journal papers and the textbooks across the diverse areas of catalysis research. For more than 60 years Advances in Catalysis has been dedicated to recording progress in the field of catalysis and providing the scientific community with comprehensive and authoritative reviews. This series in invaluable to chemical engineers, physical chemists, biochemists, researchers and industrial chemists working in the fields of catalysis and materials chemistry.

*In-depth, critical, state-of-the-art reviews * Comprehensive, coversof all aspects of catalysis research "

In this book, the general theory of submanifolds in a multidimensional projective space is constructed. The topics dealt with include osculating spaces and fundamental forms of different orders, asymptotic and conjugate lines, submanifolds on the Grassmannians, different aspects of the normalization problems for submanifolds (with special emphasis given to a connection in the normal bundle) and the problem of algebraizability for different kinds of submanifolds, the geometry of hypersurfaces and hyperbands, etc. A series of special types of submanifolds with special projective structures are studied: submanifolds carrying a net of conjugate lines (in particular, conjugate systems), tangentially degenerate submanifolds, submanifolds with asymptotic and conjugate distributions etc. The method of moving frames and the apparatus of exterior differential forms are systematically used in the book and the results presented can be applied to the problems dealing with the linear subspaces or their generalizations.

Graduate students majoring in differential geometry will find this monograph of great interest, as will researchers in differential and algebraic geometry, complex analysis and theory of several complex variables.