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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins

Heparin-Binding Proteins (Hardcover): H. Edward Conrad Heparin-Binding Proteins (Hardcover)
H. Edward Conrad
R2,900 Discovery Miles 29 000 Ships in 12 - 19 working days

This book describes the complex structures of heparins and heparan sulfates (heparinoids) and how they are generated by their biosynthetic pathways. The book also details the methodologies for studying these structures and their cellular metabolism. Heparin-Binding Proteins introduces the general nature of interactions between heparinoids and proteins, and presents the role for these structures in their interactions with the proteins of the hemostatic mechanisms, fibroblasts growth factors, superoxide dismutase, and lipoproteins.
Key Features
* Covers cellular metabolism of heparinoid proteoglycans
* Written by a distinguished expert in the field of carbohydrate biochemistry
* Describes the roles of heparan sulfate proteoglycans in
* * Blood coagulation and fibrinolysis
* Lipoprotein metabolism
* Superoxide dismutase activity
* Fibroblast growth factor responses of cells

Protein'Ligand Interactions - Methods and Applications (Hardcover, 2005 ed.): G. Ulrich Nienhaus Protein'Ligand Interactions - Methods and Applications (Hardcover, 2005 ed.)
G. Ulrich Nienhaus
R5,712 Discovery Miles 57 120 Ships in 10 - 15 working days

A readily reproducible collection of established and emerging techniques for studying the interaction between proteins and ligands, including biochemical/bulk techniques, structure analysis, spectroscopy, single-molecule studies, and theoretical/computational tools. Among the highlights are surface plasmon resonance (SPR) and reflectometric biosensor approaches, high-throughput screening with confocal optics microscopy, single molecule fluorescence and fluorescence correlation spectroscopy (FCS), atomic force microscopy (AFM), crystallography of reaction intermediates, and time-resolved x-ray crystallography. The protocols follow the successful Methods in Molecular Biologya"[ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Novel Synthetic Chemistry of Ureas and Amides (Hardcover, 2013 ed.): Marc Hutchby Novel Synthetic Chemistry of Ureas and Amides (Hardcover, 2013 ed.)
Marc Hutchby
R2,872 Discovery Miles 28 720 Ships in 10 - 15 working days

In this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.

Proteomics in Functional Genomics - Protein Structure Analysis (Hardcover, 2nd edition): P. Jolles, Hans Joernvall Proteomics in Functional Genomics - Protein Structure Analysis (Hardcover, 2nd edition)
P. Jolles, Hans Joernvall
R5,630 Discovery Miles 56 300 Ships in 10 - 15 working days

A wealth of information has accumulated over the last few years on the human genome. The new insights have completely changed the focus of protein analysis. It is no longer time-consuming analysis of unknown products, but rather selective identifications of individual forms, modifications and processings, and overall analysis of global protein outputs from cells and tissues in health and disease. This book gears to the rising need of sensitive, accurate, and fast separation and identification techniques in proteomics. It discusses current methodologies of modern protein analysis, from isolation and sample preparation, over analysis and identification, to final characterization. Several evaluations concentrate on the now productive approaches of two-dimensional gel electrophoresis and mass spectrometry, but alternative methods and further perspectives are also outlined. The book includes an overlook over current databases to connect protein analysis data with all available information, ...

Urea Transporters (Hardcover, 2014 ed.): Baoxue Yang, Jeff M. Sands Urea Transporters (Hardcover, 2014 ed.)
Baoxue Yang, Jeff M. Sands
R4,998 Discovery Miles 49 980 Ships in 12 - 19 working days

The mechanisms and physiological functions of urea transporters across biological membranes are subjects of long-standing interests. Although urea represents roughly 40% of all urinary solutes in normal human urine, the handling of urea in the tissues has been largely neglected in the past and few clinical or experimental studies now report data on urea. Most recent physiological text books include chapters on water and electrolyte physiology but no chapter on urea. Our aim in writing this book is to stimulate further research in new directions by providing novel and provocative insights into the further mechanisms and physiological significance of urea metabolism and transport in mammals. This book offers a state-of-the-art report on recent discoveries concerning urea transport and where the field is going. It mainly focuses on advances made over the past 20 years on the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. It will help graduate students and researchers to get an overall picture of mammalian urea transporters and may also yield benefits for pharmaceutical companies with regard to drug discovery based on the urea transporter. Baoxue Yang is a professor and vice chairman of the Department of Pharmacology, Peking University. He is also an adjunct professor of Jilin University and a visiting professor of Northeast Normal University. Prof. Yang has been researching urea transporters for nearly 20 years and has published more than 70 original research articles in this field.

Protein Interactions - Biophysical Approaches for the Study of Complex Reversible Systems (Hardcover, 2007 ed.): Peter Schuck Protein Interactions - Biophysical Approaches for the Study of Complex Reversible Systems (Hardcover, 2007 ed.)
Peter Schuck
R5,726 Discovery Miles 57 260 Ships in 10 - 15 working days

This volume successfully and clearly examines how biophysical approaches can be used to study complex systems of reversibly interacting proteins. It deals with the methodology behind the research and shows how to synergistically incorporate several methodologies for use. Each chapter treats and introduces the reader to different biological systems, includes a brief summary of the physical principles, and mentions practical requirements.

Data Mining in Crystallography (Hardcover, 2010 ed.): D.W.M. Hofmann, Liudmila N. Kuleshova Data Mining in Crystallography (Hardcover, 2010 ed.)
D.W.M. Hofmann, Liudmila N. Kuleshova
R5,584 Discovery Miles 55 840 Ships in 10 - 15 working days

Humans have been "manually" extracting patterns from data for centuries, but the increasing volume of data in modern times has called for more automatic approaches. Early methods of identifying patterns in data include Bayes' theorem (1700s) and Regression analysis (1800s). The proliferation, ubiquity and incre- ing power of computer technology has increased data collection and storage. As data sets have grown in size and complexity, direct hands-on data analysis has - creasingly been augmented with indirect, automatic data processing. Data mining has been developed as the tool for extracting hidden patterns from data, by using computing power and applying new techniques and methodologies for knowledge discovery. This has been aided by other discoveries in computer science, such as Neural networks, Clustering, Genetic algorithms (1950s), Decision trees (1960s) and Support vector machines (1980s). Data mining commonlyinvolves four classes of tasks: * Classi cation: Arranges the data into prede ned groups. For example, an e-mail program might attempt to classify an e-mail as legitimate or spam. Common algorithmsinclude Nearest neighbor,Naive Bayes classi er and Neural network. * Clustering: Is like classi cation but the groups are not prede ned, so the algorithm will try to group similar items together. * Regression: Attempts to nd a function which models the data with the least error. A common method is to use Genetic Programming. * Association rule learning: Searches for relationships between variables. For example, a supermarket might gather data of what each customer buys.

Bread-making quality of wheat - A century of breeding in Europe (Hardcover, Partly reprinted from PLANT FOODS FOR HUMAN... Bread-making quality of wheat - A century of breeding in Europe (Hardcover, Partly reprinted from PLANT FOODS FOR HUMAN NUTRITION, 55:1, 2000)
Bob Belderok, Hans Mesdag, Dingena A. Donner
R6,570 Discovery Miles 65 700 Ships in 10 - 15 working days

Wheat is the world's most important agricultural commodity. In Europe, where wheat is the main staple, bread wheat (Triticum aestivum) covers the majority of land on which wheat is cropped. Wheat breeders and technologists have contributed greatly to the continued success of bread wheat and its products. The bread-making quality' of a wheat variety can be described in relation to the processing its kernels must undergo to make a good bread. Bread wheat kernels must be suitable for proper milling into a flour that can produce a dough capable of becoming fine bread. The type of bread varies depending on local bread-making practices. Part I of this book contains a study of the anatomy and chemical composition of wheat kernels, and of the fundamental difference between soft' and hard' kernelled varieties. It relates these characteristics to the processes of milling, dough-making and manufacturing of bread, and to biscuit and pasta making. The genetic basis for these characteristics is illustrated, and assay methods for characterizing wheat varieties - ranging from Saunders' chewing test to the most recent developments in glutenin and gliadin research - are evaluated. Part II briefly describes - country by country - how bread-making quality has been integrated into wheat-breeding programmes throughout Europe, and how breeders have attempted to resolve the conflict between yield and quality. It describes how quality wheats travelled' around the world - from their endogenic source in Eastern Europe to North America, and back again to Europe. This explains how specific genetic material can appear in the pedigrees of varieties grown in a wide range of agro-ecological zones. In addition to givingan interesting historical survey, the book points the way forward for breeders' efforts in the future. Bread-Making Quality updates and interprets knowledge in a way that makes it particularly accessible for food technologists, breeders, students, and teachers.

Protein Structure, Stability, and Folding (Hardcover, 2nd Revised edition): Kenneth P. Murphy Protein Structure, Stability, and Folding (Hardcover, 2nd Revised edition)
Kenneth P. Murphy
R2,893 Discovery Miles 28 930 Ships in 10 - 15 working days

In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.

Neuropeptide Y and Drug Development (Hardcover): Lars Grundemar, Stephen R. Bloom Neuropeptide Y and Drug Development (Hardcover)
Lars Grundemar, Stephen R. Bloom
R3,126 Discovery Miles 31 260 Ships in 12 - 19 working days

Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions.
This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance.
This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets.
Key Features
* The hypothalamic role of NPY and its relationship with eating disorders and diabetes
* The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders
* Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology
* Development of peptide and non-peptide receptor antagonists

The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation (Hardcover, 1st ed. 2021): Carlo Rossetti,... The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation (Hardcover, 1st ed. 2021)
Carlo Rossetti, Francesco Peri
R2,873 Discovery Miles 28 730 Ships in 10 - 15 working days

TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs). This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade. The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer's diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.

G Protein Methods and Protocols - Role of G Proteins in Psychiatric and Neurological Disorders (Hardcover, 1997 ed.): Ram K.... G Protein Methods and Protocols - Role of G Proteins in Psychiatric and Neurological Disorders (Hardcover, 1997 ed.)
Ram K. Mishra, Glen B. Baker, Alan A. Boulton
R4,423 Discovery Miles 44 230 Ships in 10 - 15 working days

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G,, G,, G,, and G12.

Protein Engineering and Design (Hardcover): Paul R. Carey Protein Engineering and Design (Hardcover)
Paul R. Carey
R2,750 Discovery Miles 27 500 Ships in 12 - 19 working days

The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design.
Key Features
* Introduces and defines the techniques involved in protein engineering and design
* Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides

Techniques in Protein Chemistry, Volume 7 (Paperback): Daniel R. Marshak Techniques in Protein Chemistry, Volume 7 (Paperback)
Daniel R. Marshak
R1,914 Discovery Miles 19 140 Ships in 12 - 19 working days

Techniques in Protein Chemistry VII, a valuable bench-top reference tool for protein chemists, features the most up-to-date advances in protein methodologies.
Key Features
* Protein sequencing and amino acid analysis
* Mass spectral analysis of peptides and proteins
* Posttranslational processing
* High-sensitivity protein and peptide separations
* Protein folding and NMR
* Functional domain analysis
* Protein design and engineering

Amyloid Proteins - Methods and Protocols (Hardcover, 2nd ed. 2012): Einar M Sigurdsson, Miguel Calero, Maria Gasset Amyloid Proteins - Methods and Protocols (Hardcover, 2nd ed. 2012)
Einar M Sigurdsson, Miguel Calero, Maria Gasset
R4,504 Discovery Miles 45 040 Ships in 10 - 15 working days

Amyloid diseases are characterized by the deposition of insoluble fibrous amyloid proteins. The word "amyloid" indicates a starch-like compound, and though a misnomer, continues to be the accepted term for this group of protein conformational disorders. The second edition of Amyloid Proteins expands upon the previous edition with current, detailed protocols for the preparation of amyloid and its precursors, specific analytical methods for studying these proteins, cell culture models and assays for production of amyloid proteins, and protocols for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Amyloid Proteins, Second Edition seeks to aid scientists in the amyloid field to establish new techniques in their laboratories. Authoritative and practical, Amyloid Proteins, Second Edition seeks to aid scientists in the amyloid field to establish new techniques in their laboratories.

Heterologous Expression of Membrane Proteins - Methods and Protocols (Hardcover, 2nd ed. 2016): Isabelle Mus-Veteau Heterologous Expression of Membrane Proteins - Methods and Protocols (Hardcover, 2nd ed. 2016)
Isabelle Mus-Veteau
R4,627 R3,770 Discovery Miles 37 700 Save R857 (19%) Ships in 12 - 19 working days

This detailed volume encompasses chapters from leading experts in the area of membrane proteins who describe step-by-step protocols developed these last few years to improve the functional production and stabilization of recombinant integral membrane proteins (IMPs). Membrane proteins play a key role in numerous pathologies such as cancer, cystic fibrosis, epilepsy, hyperinsulinism, and Alzheimer's disease, yet studies on these and other disorders are hampered by a lack of information about the proteins involved. This book sets out to aid researchers in rectifying this situation. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Heterologous Expression of Membrane Proteins: Methods and Protocols, Second Edition serves as an ideal guide for scientists attempting to delve deeper into the myriad unique IMP structures.

Peptides - Synthesis, Structures, and Applications (Hardcover): Bernd Gutte Peptides - Synthesis, Structures, and Applications (Hardcover)
Bernd Gutte
R1,299 Discovery Miles 12 990 Ships in 12 - 19 working days

In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries.
In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides.
Coverage includes:
* The history of peptide chemistry
* Amide formation, deprotection, and disulfide formation in peptide synthesis
* Solid-phase peptide synthesis
* a-helix formation by peptides in water
* Stability and dynamics of peptide conformation
* An overview of structure-function studies of peptide hormones
* Neuropeptides: peptide and nonpeptide analogs
* Reversible inhibitors of serine proteinases
* Design of polypeptides
* Current capabilities and future possibilities of soluble chemical combinatorial libraries
* Epitope mapping with peptides
* Synthesis and applications of branched peptides in immunological methods and vaccines

Bacterial Protein Secretion Systems - Methods and Protocols (Hardcover, 1st ed. 2017): Laure Journet, Eric Cascales Bacterial Protein Secretion Systems - Methods and Protocols (Hardcover, 1st ed. 2017)
Laure Journet, Eric Cascales
R6,468 Discovery Miles 64 680 Ships in 10 - 15 working days

This volume details protocols that cover the broad arsenal of techniques used to study a secretion system from A to Z. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as reporters to follow effector transport. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Protein Secretion Systems: Methods and Protocol aims to provide techniques that are not restricted to the study of secretion systems but are also of specific interest for any researcher interested on multi-protein complexes of the bacterial cell envelope.

Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) - Methods and Protocols (Hardcover, 2014 ed.): Bettina Warscheid Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) - Methods and Protocols (Hardcover, 2014 ed.)
Bettina Warscheid
R3,912 Discovery Miles 39 120 Ships in 12 - 19 working days

"Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC): Methods and ""Protocols "provides a synopsis of a large array of different SILAC methods by presenting a set of protocols that have been established by renowned scientists and their working groups. These include methods and protocols for the labeling of various model organisms as well as advanced strategies relying on SILAC, e.g. for the analysis of protein interactions, the mapping of posttranslational modifications or the characterization of subcellular proteomes. Written in the highly successful "Methods in Molecular Biology "series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, "Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC): ""Methods and Protocols "will serve students and experienced scientists alike as a valuable reference of how to make use of the SILAC technology for their own research.

Peptides - Biology and Chemistry (Hardcover, 2002 ed.): Xiao-Yu Hu, Rui Wang, James P. Tam Peptides - Biology and Chemistry (Hardcover, 2002 ed.)
Xiao-Yu Hu, Rui Wang, James P. Tam
R4,526 Discovery Miles 45 260 Ships in 10 - 15 working days

The Fifth Chinese Peptide Symposium, hosted by Lanzhou University, was held at Lanzhou, China July 14-17, 1998, with 156 participants, including 30 scientists from abroad, representing nine countries. The four-day conference was both intense and spiritually rewarding. Our goal for CPS-98 was to provide a forum for the exchange of knowledge, cooperation and friendship between the international and Chinese scientific communities, and we believe this goal was met. The symposium consisted of 8 sessions with 42 oral and 90 poster presentations, including synthetic methods, molecular diversity and peptide libraries, structure and conformation of peptides and proteins, bioactive peptides, peptide immunology, De Novo design and synthesis of proteins and peptides, ligand-receptor interactions, the chemistry-biology-interface and challenging problems in peptides. The enthusiastic cooperation and excellent contributions were gratifying and the active response of the invited speakers contributed to the success of the symposium. The presentations were of excellent caliber and represented the most current and significant aspects of peptide science. Dr. Kit Lam of the University of Arizona and Dr. Yun-Hua Ye of Peking University were the recipients of "The Cathay Award" sponsored by the H. H. Liu Education Foundation, offered for their seminal contribution in peptide science and the Chinese Peptide Symposium. Four outstanding young scientists were selected by the organizing committee to receive awards sponsored by Haikou Nanhai Pharmaceutical Industry Co. Ltd. (Zhong He Group).

Non-coding RNAs and Cancer (Hardcover, 2014 ed.): Muller Fabbri Non-coding RNAs and Cancer (Hardcover, 2014 ed.)
Muller Fabbri
R4,378 Discovery Miles 43 780 Ships in 10 - 15 working days

The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.

Mass Spectrometry of Glycoproteins - Methods and Protocols (Hardcover, 2013 ed.): Jennifer J. Kohler, Steven M. Patrie Mass Spectrometry of Glycoproteins - Methods and Protocols (Hardcover, 2013 ed.)
Jennifer J. Kohler, Steven M. Patrie
R4,428 Discovery Miles 44 280 Ships in 10 - 15 working days

Glycosylation is the most abundant post-translational modification of proteins. Estimates vary widely, but a common assessment is that upwards of 50% of eukaryotic proteins are modified by some type of glycan. In Mass Spectrometry of Glycoproteins: Methods and Protocols, expert researchers in the field detail many of the methods that are now commonly used for glycoproteomics. These methods and techniques include robust sample preparation techniques; advanced chromatographic strategies for improving dynamic range; state-of-the-art mass spectrometry instrumentation and associated ionization and fragmentation methods; and informatics tools used for identifying glycoproteins and characterizing the associated glycans. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mass Spectrometry of Glycoproteins: Methods and Protocol is an essential resource for those who work at the interface of glycobiology and mass spectrometry.

Peptides for Youth - The Proceedings of the 20th American Peptide Symposium (Hardcover, 2009 ed.): Susan Valle, Emanuel Escher,... Peptides for Youth - The Proceedings of the 20th American Peptide Symposium (Hardcover, 2009 ed.)
Susan Valle, Emanuel Escher, William D. Lubell
R8,719 Discovery Miles 87 190 Ships in 10 - 15 working days

The American Peptide Society (APS) provides a forum for advancing and promoting knowledge of the chemistry and biology of peptides. The approximately one thousand members of the Society come from North America and from more than thirty other countries throughout the world. Establishment of the APS was a result of the rapid worldwide growth that has occurred in peptide-related research, and of the increasing interaction of peptide scientists with virtually all fields of science. Peptides for Youth: The Proceedings of the the 20th American Peptide Symposium will highlight many of the recent developments in peptide science, with a particular emphasis on how these advances are being applied to basic problems in biology and medicine. The 20th American Peptide Symposium will take place June 26 - 30, 2007 in Montreal, Canada.

Food Proteins and Lipids (Hardcover, 1997 ed.): Srinivasan Damodaran Food Proteins and Lipids (Hardcover, 1997 ed.)
Srinivasan Damodaran
R4,542 Discovery Miles 45 420 Ships in 10 - 15 working days

John E. Kinsella, Dean ofthe College of Agricultural and Environmental Sciences at the University of California-Davis, passed away on May 2, 1993, at the age of 55. In August 1995, fonner students and post-doctoral fellows of Dr. Kinsella met at the American Chemical Society National Meeting in Chicago to convene a Symposium on Food Proteins and Lipids to honor Dr. Kinsella's enonnous contribution to the field of food science and nutrition. This book is a collection of papers presented at that symposium. A native of Ireland, Dr. Kinsella received his bachelor's degree in agricultural sciences in 1961 from the University of Dublin. He received his master's degree in biology in 1965 and a doctorate in food chemistry in 1967 from Pennsylvania State University. He joined the Food Science faculty at Cornell University in 1967. While at Cornell, he served as Chair of the Department of Food Science from 1977-1985 and Director of the Institute of Food Science from 1980-1987. He was designated Liberty Hyde Bailey Professor of Food Biochemistry in 1981, a Fulbright Fellow in 1983, and was selected as the General Foods Distinguished Professor of Food Science in 1984. He was named a Leading Professor in the State University of New York, the highest professorial honor in the SUNY system. In 1990 he joined the University of California at Davis as Dean of the College of Agricultural and Environmental Sciences. Dr.

Vascular Ion Channels in Physiology and Disease (Hardcover, 1st ed. 2016): Irena Levitan, PhD, Alex M. Dopico, MD, PhD Vascular Ion Channels in Physiology and Disease (Hardcover, 1st ed. 2016)
Irena Levitan, PhD, Alex M. Dopico, MD, PhD
R5,846 Discovery Miles 58 460 Ships in 12 - 19 working days

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

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