Since PET was first introduced clinically, brain tumors have been an important area for its use.? Diagnosing the cause of patients experiencing seizures has been an additional area for which PET has demonstrated its value.? PET imaging is also being investigated for the understanding of depression and other psychiatric disorders.? Also the challenges for developing radiotracers is reviewed in a separate article.

This issue reviews the wide range of uses of CT angiography.? After overview of technology and injection and image acquisition techniques, the issue proceeds to review the use of CT angiography for imaging the carotid artery and cerebrovascular circulation, the thoracic aorta, and the abdominal aorta and pelvic arteries.? Renal, hepatic and pancreatic, and mesenteric circulation are also covered as well as circulation in the upper and lower extremities. The uses of angiography in trauma patients and in pediatric patients are also reviewed.

This two part issue of PET Clinics provides a comprehensive review to the important topic of Breast Cancer. Although the focus of this issue is the use of PET and PET/CT in the diagnosis, staging, treatment planning, and follow up for patients with breast cancer, there are also articles providing correlates from other imaging modalities.

PET imaging has shown its value in diagnosing diseases affecting older people.? Most significantly this has been with regard to the diagnosis of Alzheimer's disease and other forms of dementia.? Parkinson's disease is another condition in which PET has proved valuable.? This issue also included articles on the uses of PET for diagnosing cerebrovascular disease and for assessing neuroplasticity.

This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.

Osteoporosis is a disease that primarily affects the elderly and usually with crippling effects.? Although osteoporosis is preventable and its effects somewhat reversible, early diagnosis is essential in order to make effective treatment decisions.? Covered in this issue are imaging with plain film, ultrasound, and CT.? Separate reviews of vertebral fractures and morphometry as well as well as percutaneous vertebroplasty are included.? Articles on densitometry in children and quality assurance round out the issue.

This issue of Perioperative Nursing Clinics, Guest Edited by Kathleen Gross, MSN, RN, BVC, CRN, on the topic of Radiology will include the following article topics: Contrast Media Nephropathy; Vein Ablation/Sclerotherapy; Radiation Exposure; Embolic and Sclerotherapy Agents; CO2 Contrast;? Sepsis in the Perioperative/Radiology Area; Local Anesthetics Used in Perioperative Areas; Hybrid IR; Uterine Artery Embolization; Periprocedural Hemostasis Management; Intraoperative MRI; Vertebral Augmentation: Vertebroplasty and Kyphoplasty; and IVC Filters.

Ultrasound is an ideal modality for imaging younger patients. Because of the effects of radiation on growing bodies, ultrasound is a safe and versatile option for radiologists to choose. This issue provides a timely overview of the important areas for which ultrasound can be used.

Damage to the kidneys continues to be a serious problem related to the use of gadolinium as a contrast agent. This issue not only describes the dangers and controversies related to contrast-induced nephropathies but also provides advice for identifying patients at risk and recommending other imaging options.

This book contains the full papers presented at the MICCAI 2013 workshop Computational Methods and Clinical Applications for Spine Imaging. The workshop brought together researchers representing several fields, such as Biomechanics, Engineering, Medicine, Mathematics, Physics and Statistic. The works included in this book present and discuss new trends in those fields, using several methods and techniques in order to address more efficiently different and timely applications involving signal and image acquisition, image processing and analysis, image segmentation, image registration and fusion, computer simulation, image based modelling, simulation and surgical planning, image guided robot assisted surgical and image based diagnosis.

This book provides comprehensive reviews on our most recent understanding of the molecular and cellular mechanisms underlying atherosclerosis and calcific aortic valve disease (CAVD) as visualized in animal models and patients using optical molecular imaging, PET-CT, ultrasound and MRI. In addition to presenting up-to-date information on the multimodality imaging of specific pro-inflammatory or pro-calcification pathways in atherosclerosis and CAVD, the book addresses the intriguing issue of whether cardiovascular calcification is an inflammatory disease, as has been recently supported by several preclinical and clinical imaging studies. In order to familiarize researchers and clinicians from other specialties with the basic mechanisms involved, chapters on the fundamental pathobiology of atherosclerosis and CAVD are also included. The imaging chapters, written by some of the foremost investigators in the field, are so organized as to reveal the nature of the involved mechanisms as disease progresses.

Now that the applications of positron emission tomography (PET) are becoming more clearly understood, PET is now being used in pediatric population. Important considerations in its use on children are patient preparation and radiation exposure. This issue reviews the use of PET to image children with Hodgkin and non-Hodgkin lymphoma, brain tumors, and inflammatory bowel disease, among other conditions. Also included is the use of PET to assess response to therapy.

This issue takes a multimodality approach to imaging of osteoarthritis. Clinical issues including an overview of the disease and imaging as an aid to evaluate patient functionality are also reviewed. Not only are current standards for imaging covered but also newer techniques under development.

This Neuroimaging publication presents topics on Current brain tumor classification and new concepts; Translation from animal to human in brain tumor research; Brain irradiation - effects on normal brain parenchyma and radiation necrosis; MR perfusion and permeability in high-grade brain tumors; Diffusion concept for survival estimation; Presurgical planning with MR Tractography and functional MR Imaging; Intra-operative brain mapping for tumor resection; Monitoring Responses of Brain Tumors to Treatment with Sodium MRI; Molecular imaging in brain tumors; and Advances and trends in chemotherapy and radiation therapy treatment of brain tumor.

Articles include: MR Imaging of the Pediatric Bone Marrow; The growing skeleton: MR appearances of developing cartilage; Infectious and Inflammatory Disorders; MRI of Pediatric Trauma; MRI of Pediatric Arthritis; MR Imaging of Primary Bone Tumors and Tumor-like Conditions in Children; MR Imaging of soft tissue masses in children; The hip: MR imaging of uniquely pediatric disorders; The knee: MR imaging of uniquely pediatric disorders; The foot and ankle: MR imaging of uniquely pediatric disorders; MRI in Congenital and Acquired Disorders of the Pediatric Upper Extremity.

This two part issue of PET Clinics provides a comprehensive review to the important topic of Breast Cancer. Although the focus of this issue is the use of PET and PET/CT in the diagnosis, staging, treatment planning, and follow up for patients with breast cancer, there are also articles providing correlates from other imaging modalities.

This issue reviews the latest advances in the use of multidetector CT for imaging of the chest. Included in this issue are articles on Thoracic CT (How far we have come), MDCT (Principles and Practice), and Contrast Enhancement. Topics such as Dual Energy Chest CT and Volumetric HRCT are also covered. The issue is completed with reviews of CT Pulmonary Angiography of Acute PE, Congenital Vascular Disease, CT Pulmonary Angiography: Beyond Acute PE, and Pre- and Postoperative Planning.

This issue provides a comprehensive overview of imaging of the prostate using PET and PET/CT. In addition to providing correlates from other modalities, this issue also covers treatment planning for radiation therapy and follow-up.

New radiotracers will make possible the imaging of other parts of the body using PET. This issue reviews the latest advances and provides a look to the future of PET imaging.

Nuclear cardiology is no longer a medical discipline residing solely in nuclear medicine. This is the first book to recognize this fact by integrating in-depth information from both the clinical cardiology and nuclear cardiology literature, and acknowledging cardiovascular medicine as the fundamental knowledge base needed for the practice of nuclear cardiology. The book is designed to increase the practitioner's knowledge of cardiovascular medicine, thereby enhancing the quality of interpretations through improved accuracy and clinical relevance.The text is divided into four sections covering all major topics in cardiology and nuclear cardiology:

• Basic Sciences and Cardiovascular Diseases

• Conventional Diagnostic Modalities
• Nuclear Cardiology
• Management of Cardiovascular Diseases

With the advent of combined modality imaging, it has become essential for the radiologists how structure and function relate to each other. Previously radiologists had to rely upon CT or MRI in order to tell the location of a problem but could not assess functionally what was going on within the patient. PET image has allowed radiologists to make a functional assessment to aid in the diagnosis and treatment planning for patients. This issue reviews the use of PET/CT and PET/MRI to evaluate patients with neurologic disorders, malignant and nonmalignant thoracic disorders, the cardiovascular system, breast diseases, musculoskeletal system, abdominal and pelvic disorders, and endocrine disorders.

Low- and middle-income countries have seen a dramatic rise in the incidence of breast and gynecological cancers in the past decade. Organized cancer screening programs are not widely available in developing countries, leading to disproportionately higher mortality rates compared to those in the developed world. This book addresses cost-effective strategies for implementing programs aimed at screening for the early detection of breast, cervical, endometrial, and ovarian cancers. A well woman clinic concept providing such services as part of women's health examinations is proposed, aiming to ensure patient compliance by limiting clinic visits required for initial testing and diagnosis of screen positive cases.

Angiography is a minimally invasive medical test that helps physicians diagnose and treat medical conditions. More and more physicians have been using Magnetic Resonance Angiography due to the fact that it is a noninvasive imaging technique that does not involve exposure to radiation. This current and up-to-date new issue of MRI Clinics explores MRA with many articles written by clinicians at the top of their field. Topics include: Dynamic 4D MRA of the Abdomen, Pediatric MR Angiography, and Non Contrast MRA.

Nuclear Cardiology is a dynamic, rapidly growing field. Because this field has grown so quickly, a shortage of trained physicians is projected. This first ever issue of Cardiology Clinics devoted to nuclear cardiology was planned to meet the demand for information in this field. Articles in the issue focus on the most recent developments.