This book provides an in-depth description and discussion of different multi-modal diagnostic techniques for cancer detection and treatment using exact optical methods, their comparison, and combination. Coverage includes detailed descriptions of modern state of design for novel methods of optical non-invasive cancer diagnostics; multi-modal methods for earlier cancer diagnostic enhancing the probability of effective cancer treatment; modern clinical trials with novel methods of clinical cancer diagnostics; medical and technical aspects of clinical cancer diagnostics, and long-term monitoring. Biomedical engineers, cancer researchers, and scientists will find the book to be an invaluable resource. Introduces optical imaging strategies; Focuses on multimodal optical diagnostics as a fundamental approach; Discusses novel methods of optical non-invasive cancer diagnostics.

This book covers virtually all aspects of image formation in medical imaging, including systems based on ionizing radiation (x-rays, gamma rays) and non-ionizing techniques (ultrasound, optical, thermal, magnetic resonance, and magnetic particle imaging) alike. In addition, it discusses the development and application of computer-aided detection and diagnosis (CAD) systems in medical imaging. Given its coverage, the book provides both a forum and valuable resource for researchers involved in image formation, experimental methods, image performance, segmentation, pattern recognition, feature extraction, classifier design, machine learning / deep learning, radiomics, CAD workstation design, human-computer interaction, databases, and performance evaluation.

This third edition overviews the essential contemporary topics of neuroengineering, from basic principles to the state-of-the-art, and is written by leading scholars in the field. The book covers neural bioelectrical measurements and sensors, EEG signal processing, brain-computer interfaces, implantable and transcranial neuromodulation, peripheral neural interfacing, neuroimaging, neural modelling, neural circuits and system identification, retinal bioengineering and prosthetics, and neural tissue engineering. Each chapter is followed by homework questions intended for classroom use. This is an ideal textbook for students at the graduate and advanced undergraduate level as well as academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals seeking to learn the latest developments in this emerging field.Advance Praise for Neural Engineering, 3rd Edition: "A comprehensive and timely contribution to the ever growing field of neural engineering. Bin He's edited volume provides chapters that cover both the fundamentals and state-of-the-art developments by the world's leading neural engineers." Dr. Paul Sajda, Department of Biomedical Engineering, Electrical Engineering and Radiology, Columbia University "Neural Engineering, edited by Prof. He, is an outstanding book for students entering into this fast evolving field as well as experienced researchers. Its didactic and comprehensive style, with each chapter authored by leading scientific authorities, provides the ultimate reference for the field." Dr. Dario Farina, Department of Bioengineering, Imperial College London, London, UK "Neural Engineering has come of age. Major advances have made possible prosthesis for the blind, mind control for quadraplegics and direct intervention to control seizures in epilepsy patients. Neural Engineering brings together reviews by leading researchers in this flourishing field. Dr. Terrence Sejnowski, Salk Institute for Biolgical Studies and UC San Diego

Use this atlas to accurately interpret images of musculoskeletal disorders! Taylor, Hughes, and Resnick's Skeletal Imaging: Atlas of the Spine and Extremities, 2nd Edition covers each anatomic region separately, so common disorders are shown within the context of each region. This allows you to examine and compare images for a variety of different disorders. A separate chapter is devoted to each body region, with coverage of normal developmental anatomy, developmental anomalies and normal variations, and how to avoid a misdiagnosis by differentiating between disorders that appear to be similar. All of the most frequently encountered musculoskeletal conditions are included, from physical injuries to tumors to infectious diseases. Over 2,100 images include radiographs, radionuclide studies, CT scans, and MR images, illustrating pathologies and comparing them with other disorders in the same region. Organization by anatomic region addresses common afflictions for each region in separate chapters, so you can see how a particular region looks when affected by one condition as compared to its appearance with other conditions. Coverage of each body region includes normal developmental anatomy, fractures, deformities, dislocations, infections, hematologic disorders, and more. Normal Developmental Anatomy sections open each chapter, describing important developmental landmarks in various regions of the body from birth to skeletal maturity. Practical tables provide a quick reference to essential information, including normal developmental anatomic milestones, developmental anomalies, common presentations and symptoms of diseases, and much more. 400 new and replacement images are added to the book, showing a wider variety of pathologies. More MR imaging is added to each chapter. Up-to-date research includes the latest on scientific advances in imaging. References are completely updated with new information and evidence.

Advances in Clinical Radiology was established to review the year's most important questions in clinical radiology. A distinguished editorial board, headed by Dr. Frank Miller, identifies key areas of major progress and controversy, and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in radiology bring concepts to a clinical level and explore their everday impact on patient care.

This issue of Radiologic Clinics of North America focuses on Renal Imaging and is edited by Drs. Steven C. Eberhardt and Steven S. Raman. Articles will include: Contrast Reaction Readiness for Your Department or Facility; Update on Hereditary RCC and Imaging Implications; Renal Surgical Imaging; Mimics and Pitfalls in Renal Imaging, Approach to Cystic Renal Masses, Diagnosis of Cystic Disease and Role of Radiology; Use of Contrast US for Renal Mass Evaluation; Radiomics and Texture Analysis of Kidney; Protocol Optimization for Renal Masses; Renal Infections and Inflammatory Disease; Image Interpretation: Practical Triage of Benign from Malignant Renal Masses; Renal Tumor Ablation, Case Selection, Techniques, and Complications; Comprehensive Renal Trauma Imaging; Reporting on Renal Masses, Terminology and Use of Templates; and more!

This book provides useful information on conventional radiology which will help the pediatricians in their day-to-day office practice as a ready to refer guide in pediatric radiological investigations. Discusses the discovery and evolution of X-rays. Provides an outline of radiation hazards, types of X-rays and radiographic positions in pediatrics. Advent of Digital Radiography and case scenarios of clinical importance added in all essential chapters. Contains information on emergency radiological investigation. This book will be of immense help for UG and PG students, practicing pediatricians and teaching faculties alike.

This book provides an essential overview of the broad range of functional brain imaging techniques, as well as neuroscientific methods suitable for various scientific tasks in fundamental and clinical neuroscience. It also shares information on novel methods in computational neuroscience, mathematical algorithms, image processing, and applications to neuroscience. The mammalian brain is a huge and complex network that consists of billions of neural and glial cells. Decoding how information is represented and processed by this neural network requires the ability to monitor the dynamics of large numbers of neurons at high temporal and spatial resolution over a large part of the brain. Functional brain optical imaging has seen more than thirty years of intensive development. Current light-using methods provide good sensitivity to functional changes through intrinsic contrast and are rapidly exploiting the growing availability of exogenous fluorescence probes. In addition, various types of functional brain optical imaging are now being used to reveal the brain's microanatomy and physiology.

This book addresses essential principles of research according to the scientific method for medical imaging technology research. The scope of this book covers the nature of scientific research; quantitative and qualitative approaches essentials; research planning; literature review fundamentals; research methods; data collection, analysis, and interpretation; and communicating research findings. The book meets the educational requirements on Research Principles and Concepts (for entry to practice) of the following professional radiologic technology associations: the American Society of Radiologic Technologists (ASRT), the Canadian Association of Medical Radiation Technologists (CAMRT), the College of Radiographers in the United Kingdom, and radiography societies and associations in Asia, Australia, Europe, and Africa. This is an ideal book for radiologic technologists, nuclear medicine technologists, and radiation therapists seeking to get started in research in their profession. Additionally, biomedical imaging engineering technologists, radiologists, and medical imaging physicists may use this as a "guiding principles" textbook.

This book describes and illustrates an approach to surgery for spinal cord tumors that is based on a refined concept of anatomic compartmentalization. The aim of this approach is to enable maximum preservation of spinal cord function through confinement of the surgical work to the involved compartment or compartments. Importantly, this involvement differs according to tumor type, and the classification favored by the author takes this fully into account. After introductory chapters on epidemiology and pathology, the anatomy of the spinal cord relevant to surgery for spinal cord tumors is discussed in detail and the proposed classification is clearly explained. The surgical approach to each of the identified anatomic compartments is then described, with attention to the roles of intraoperative mapping techniques, diffusion tensor imaging, and electrophysiologic studies in ensuring that spinal cord functions are spared. Examples of the author's experience when applying the proposed approach are presented. The book is meant for neurosurgeons at all levels of experience.

This book is a comprehensive review of a myriad of cases, a practical board review, a resource for maintenance of certification, and an interesting read with relevant images. The cases are real-life examples seen by radiologists around the United States. It is beneficial to the practicing radiologists, residents and fellows. A comprehensive ultrasound review book in a case-based format. Contains 125 cases to give a practical review. Each case includes a thorough discussion of ultrasound findings, many including cross-sectional correlation. Differential diagnoses are presented along with diagnostic pearls and management options.

This issue of Neuroimaging Clinics of North America focuses on Headache and Chiari Malformation, and is edited by Dr. Noriko Salamon. Articles will include: Adult headache and neuroimaging: Indication of neuroimaging in general and economical overview; Headache caused by intracranial hypotension CSF leak; Headache caused by sinus disease; Headache and Chiari malformation; Headache and aneurysm; Treatment of headaches; Headache and neuroimaging: Indication and modality of choice in headaches in pediatrics; Headache and brain tumor; Headache and advanced neuroimaging: Understanding pain circuit and functional assessment of head pain; and more!

This issue of MRI Clinics of North America focuses on Pediatric MR Imaging, and is edited by Dr. Edward Y. Lee. Articles will include: MRI Evaluation of Pediatric Neck Masses: Review and Update; MRI of Lungs and Airways in Children: Past and Present; Pediatric Mediastinal Masses: Role of MRI As a Problem-Solving Tool; Pediatric Cardiac MRI: Practical Preoperative Assessment; Hepatobiliary MRI in Children: Up-To-Date Imaging Techniques and Findings; Pediatric Renal Neoplasms: MRI-Based Practical Diagnostic Approach; MRI Evaluation of Inflammatory Bowel Disease in Children: Where Are We Now in 2018?; MRI Evaluation of Pediatric Genital Disorders: MR Technology Overview and Interpretation; Pediatric Sport-related Injuries: An Imaging Overview for Current and Future Daily Practice; MRI of Pediatric Musculoskeletal Tumors: Recent Advances and Clinical Applications; MRI Evaluation of Pediatric Lymphatics: Overview of Techniques and Imaging Findings; PET-MRI: Current Updates on Pediatric Applications; Tales from the Night: Emergency MRI in Pediatric Patients after Hours; and more!

This issue of Radiologic Clinics of North America focuses on Cardiac CT Imaging, and is edited by Drs. Suhny Abbara and Prabhakar Rajiah. Articles will include: Calcium scoring for cardiovascular CT: how, when and why?; Coronary CTA: acquisition, interpretation and state of the evidence; TAVR and TCMVR; Cardiac masses; Nonischemic cardiomyopathies; Acute and chronic myocardial infarcts, spectrum of manifestations; Pericardial disease; Relevant Adult Congenital Heart Disease; Congenital aortic disease; Cardiac Valves (excluding TAVR); Acute coronary and acute aortic syndromes; Acquired aortic disease (excluding acute aortic syndromes); Cardiac Trauma; Post Cardiovascular surgery findings; and more!

The present book on Molecular & Diagnostic Imaging and Treatment Strategies of ovarian cancer is one of two companion books with the second one being focused on Cell and Molecular Biology of Ovarian Cancer. Both books include new exciting aspects of ovarian cancer research with chapters written by experts in their respective fields who contributed their unique expertise in specific ovarian cancer research areas and include cell and molecular details that are important for the specific subtopics. Comprehensive and concise reviews are included of key topics in the field.

This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

This issue of PET Clinics is Part I of a two-part issue, and focuses on PET-CT-MRI Applications of Musculoskeletal Disorders. It is edited by Drs. Abass Alavi (the Consulting Editor of PET Clinics), Ali Salavati, Ali Gholamrezanezhad and Ali Guermazi. Articles will include: Basic principles, methodology, and imaging protocol for musculoskeletal applications; Sodium 18F-Fluoride PET-CT-MR of bone and joint disorders; In vivo molecular imaging of inflammation and infection; Radionuclide therapy for osseous metastases; Novel whole-body MR imaging techniques in MSK disorders; MRI of joint infection and inflammation with emphasis on DCE-MRI; Quantitative techniques for musculoskeletal MRI at 7 Tesla; Role of contrast enhanced (including iodine overlay image), spectral, and dual energy CT in MSK applications; Percutaneous thermal ablation in musculoskeletal system: Post-procedural PET-CT imaging; Soft tissue sarcomas of Musculoskeletal Origin; Application of PET/CT, PET/MR on primary bone malignancies; Future perspective of the application of PET-CT-MRI in musculoskeletal disorders, and more!

Written from the perspective of a diagnostic radiography educator, t his book introduces readers to ethnography as a methodology and examines how an ethnographic researcher sees the world in which they live.

Interventional Oncology is a fast-growing new field, as well as an emerging specialty. Many minimally-invasive, imaging-guided procedures seem set to replace more traditional open surgical techniques of treating solid tumors in a variety of organs. The aim of this book is to describe new interventional radiological methods in a succinct and practical form. Diagnostic radiological considerations relevant to the selection and follow-up of patients are also covered. The book begins with an overview of the basic principles of current interventional techniques, including thermal ablation, high intensity focused ultrasound, and embolization. Later chapters focus on tumors of the liver, kidney, lung, and bone, placing new interventional techniques in context by referring to the surgical and oncologic methods of treating the same conditions. With an emphasis on best practices, Interventional Oncology: A Practical Guide for the Interventional Radiologist will serve as a definitive guide to practicing physicians involved in this rapidly evolving field.

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

The field of interventional neuroradiology has expanded greatly in recent years, shifting emphasis onto neuroendovascular methods that, increasingly, have become the standard in modern treatment. This shift has placed a demand on hospitals to provide a standard of care for which many busy clinicians have not been trained. Dr. Pearse Morris has written a timely and comprehensive reference for those who are interested in expanding their knowledge of neuroendovascular procedures, but have not had a specialized neuroradiology fellowship. The emphasis throughout is on patient safety and the outcome of various treatments. Topics covered in this volume include: Platelets and coagulation basic techniques, devices, and arterioty closure aneurysms extracranial angioplasty and stenting endovascular treatment of vasospasm dural arteriovenous malformations carotid cavernous fistulas balloon test occlusion and post-occlusion patient care spine and vertebroplasty tumor embolization thrombolysis and treatment of acute stroke venous thrombotic disease arteriovenous malformations of the brain Neuroradiologists, neurosurgeons, and neurologists will find this reference a much needed and practical asset to both their education and updating their practices.

This issue of MRI Clinics of North America focuses on Breast Cancer, and is edited by Dr. Jessica Leung. Articles will include: Breast MRI: Atlas of anatomy, physiology, pathophysiology, and BI-RADS lexicon; Neoadjuvant therapy monitoring, including inflammatory breast cancer; Breast MRI biopsy considerations: Technique, histologic upgrading, and radiologic-pathologic concordance; Breast MRI techniques and developments: 1.5 vs 3T, diffusion, fast MRI, PET-MRI, and other developing techniques; ACR Accreditation, Performance Metrics, Reimbursement, and Economic Considerations in Breast MRI; Screening: high-risk and dense breasts, especially compared with tomosynthesis and ultrasound; Extent of breast disease, especially compared with tomosynthesis and ultrasound, with special focus on nodal assessment; Problem-solving tool for imaging finding and clinical symptoms of breast cancer; MRI compared with contrast-enhanced mammography; MRI compared with molecular breast imaging; MRI compared with positron emission mammography; How does MRI help care for my breast cancer patient? Perspective of a surgical oncologist; How does MRI help care for my breast cancer patient? Perspective of a medical oncologist; How does MRI help care for my breast cancer patient? Perspective of a radiation oncologist; and more!

Provides concise, handy and clear reference and in-depth knowledge of various ultrasound images in relation to various disease entities of different systems of the body so as to arrive at a correct diagnosis. Serves as an essential guide to practicing radiologists, sonologists, obstetricians and gynaecologists, physicians and surgeons and also to postgraduate students in their examination.

The second of two companion books which address the biology and clinical aspects of prostate cancer. This volume, Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, discusses both classic and the most recent imaging approaches for detection, early diagnosis and treatment of prostate cancer. The companion title, Cell & Molecular Biology of Prostate Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.