Key features: * Provides a clear explanation for many of the pain generators in low back pain and illuminate this perplexing and ubiquitous problem. * Addresses a gap in the existing literature, as "non-specific" or mechanical lumbosacral spine pain accounts for by far most chronic spinal pain sufferers' complaints for clinicians dealing with spinal pain syndromes like general medical practitioners, and spinal specialists in various fields such as sports medicine. * Illustrates anatomical structures that can be injured and thus become responsible for causing mechanical lumbosacral spine pain, frequently, such injuries cannot be detected on sophisticated imaging such as MRI.

In the last few years, increasing effort has been devoted to better define the characteristics of tissue damage occurring outside MRI-visible lesions in patients with multiple sclerosis (MS) and, as a consequence, to improve our understanding of the disease pathobiology and of the mechanisms leading to the accumulation of irreversible disability. This book provides an updated review of the results obtained by leading research groups in this field. The potential clinical applications of what has been shown so far, as well as the areas for future research in the study of normal-appearing white and gray matter damage in MS are extensively discussed, making this book a valuable tool for clinical neurologists who are involved in the daily-life care of MS patients and for neuroscientists involved in MS research.

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Oncology, second edition, is an invaluable resource for radiologists and surgical and medical oncologists-anyone who requires an easily accessible, highly visual reference covering cancer imaging and staging. A team of renowned experts in radiology, oncology, and body imaging provide carefully updated information and an abundance of high-quality images throughout, making this edition a useful learning tool as well as a handy reference for daily practice. Features nearly 3,000 annotated images, including lavish, full-color graphics for each cancer stage and many new illustrations throughout Brings you up to speed with updated TNM and grading tables from the new American Joint Committee on Cancer (AJCC) Cancer Staging Manual and updated WHO classifications Includes new chapters covering radiological staging of tumors recently introduced in the AJCC 8th edition and new chapter divisions that reflect the current AJCC staging system Provides practical, easy-to-find details on routes of spread, imaging techniques, suggestions for treatment based on tumor stages identified in a patient's imaging studies, and extensive imaging examples of a variety of cancers in many different stages Begins each chapter with updated TNM staging tables from the AJCC followed by full-color graphic depictions of TNM criteria Uses bulleted, succinct text for quick comprehension of essential information, as well as a consistent chapter format offering an Overview, Relevant Pathology, Imaging Findings, Clinical Issues, Reporting Checklist, and Selected References Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Thoracic Imaging: Case Review, by Phillip M. Boiselle, MD, Theresa C. McLoud, MD and Gerald F. Abbott, MD, tests your ability to interpret a wide range of images seen in practice. The completely revised edition of this title in the popular Case Review series features all-new cases and superb-quality accompanying images that explore the newest imaging modalities, including new treatment guidelines for lung cancer, HIV/AIDS, and pneumonia. This complete study of thoracic imaging has been organized for quick reference and easy board and recertification review. Easily find and study the most challenging topics from among approximately 200 cases-organized by difficulty - and 400 images - with questions and answers, diagnoses, commentary, references, and cross-references to Thoracic Radiology: The Requisites. Presents more than 145 high-yield case studies organized by level of difficulty, helping you build your knowledge and confidence in stages. All cases have been refreshed and rewritten to capture the latest clinical implications and diagnostic pearls on thoracic conditions that you will be tested on. Includes multiple-choice questions, answers, and rationales that mimic the format of certification exams. Uses short, easily digestible chapters covering the full range of thoracic imaging for efficient, effective learning and exam preparation. Features hundreds of high-quality, full-color images (many new to this edition) representing a wide range of clinical situations encountered in thoracic imaging. Images include chest radiographs, CT, PET-CT, and MRI to help you expand your visual identification and diagnostic skills. Clearly see and interpret 400 high-quality, state-of-the-art images representing a wide range of clinical situations encountered in thoracic imaging. Get fresh perspectives from 200 updated or new cases reflecting the most recent changes in thoracic imaging, including PET-CT, emerging pulmonary infections, smoking-related lung diseases, Fleischner guidelines for management of incidentally detected lung nodules, and ground glass and part-solid lung nodules. Spend less time searching and more time learning with easy-to-navigate chapters focused on visual identification and diagnosis, and reorganized by degree of case difficulty. A top-selling volume of the popular Case Review series with new and improved images throughout is the perfect tool to prepare for the toughest cases in Thoracic radiology.

This book provides a comprehensive overview of how to use MRI for the imaging of lung disease. Special emphasis is placed on routine applications and the clinical impact of MRI in each setting. In addition, current technological developments are reviewed and information presented on dedicated applications of MRI in preclinical and translational research, clinical trials, and specialized institutions. During the past two decades, significant advances in the technology have enabled MRI to enter and mature in the clinical arena of chest imaging. Standard protocols are now readily available on MR scanners, and MRI is recommended as the first- or second-line imaging modality for a variety of lung diseases, not limited to cystic fibrosis, pulmonary hypertension, and lung cancer. The benefits and added value of MRI originate from its ability to both visualize lung structure and provide information on different aspects of lung function, such as perfusion, respiratory motion, ventilation, and gas exchange. On this basis, novel quantitative surrogates for lung function and therapy control (imaging biomarkers) are generated. The second edition of MRI of the Lung has been fully updated to take account of recent advances. It is written by an internationally balanced team of renowned authors representing all major groups in the field.

Modern physics, radiation, atomic and nuclear physics have revolutionized medical diagnosis and the treatment of cancer. The work of the scientists whose discoveries fuelled this revolution is an important part of our scientific and cultural heritage. Using basic physics and simple mathematics this book shows how the discoveries of fundamental physics lead to an understanding of the important design principles of diagnosis and radiation therapy. With its carefully chosen and realistic exercises and worked examples, it provides a brief introduction and broad foundation for students and practitioners in the life sciences. This book could be used as a text for an introductory course in medical physics or biophysics. For those who are starting their careers in medical sciences or are already practitioners, it offers some interesting and useful background and an aide-memoire of the basics. For members of the public it could provide a deeper understanding of the science that informs the medical procedures that too many will be subject to, at a deeper level than the often excellent but, of necessity very basic and purely practical information available from hospitals and Web sites. The former audience may be interested in the mathematical demonstrations; the latter certainly will not be. However, for both audiences, the details of the calculations are less important than the knowledge that they can be done.

Here is the second, completely revised and updated edition of the successful practical guide to image-guided spine intervention. It contains revised text and images as well as new sections and chapters. The updated text thoroughly discusses both well-established and new interventions that are applied to the spine for the purpose of pain relief.

Key Features * Shows how to select the best thermal imager for your clinical practice, care for it, and use it correctly. * Explains how to take medical quality thermal images and scale them for maximum visual effect using the guidelines detailed in this book. * Details the myriad ways that thermography can aid in medical diagnosis and improve surgical outcomes.

Cold atmospheric plasma is an auspicious new candidate in cancer treatment. Cold atmospheric plasma (CAP) is a partially ionized gas in which the ion temperature is close to room temperature. It contains electrons, charged particles, radicals, various excited molecules and UV photons. These various compositional elements have the potential to inhibit cancer cell activity whilst doing no harm to healthy cells. Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults; treatment including surgery, radio- and chemotherapy remains palliative for most patients as a cure remains elusive. The successful combination of the standard chemotherapeutic temozolomide (TMZ) and CAP treatment features synergistic effects even in resistant glioma cells. In particular in glioma therapy, CAP could offer an innovative approach allowing specific cancer cell / tumor tissue inhibition without damaging healthy cells. Thus CAP is a promising candidate for combination therapy especially for patients suffering from GBMs showing TMZ resistance.

Imaging modalities in radiology produce ever-increasing amounts of data which need to be displayed, optimized, analyzed and archived: a "big data" as well as an "image processing" problem. Computer programming skills are rarely emphasized during the education and training of medical physicists, meaning that many individuals enter the workplace without the ability to efficiently solve many real-world clinical problems. This book provides a foundation for the teaching and learning of programming for medical physicists and other professions in the field of Radiology and offers valuable content for novices and more experienced readers alike. It focuses on providing readers with practical skills on how to implement MATLAB (R) as an everyday tool, rather than on solving academic and abstract physics problems. Further, it recognizes that MATLAB is only one tool in a medical physicist's toolkit and shows how it can be used as the "glue" to integrate other software and processes together. Yet, with great power comes great responsibility. The pitfalls to deploying your own software in a clinical environment are also clearly explained. This book is an ideal companion for all medical physicists and medical professionals looking to learn how to utilize MATLAB in their work. Features Encompasses a wide range of medical physics applications in diagnostic and interventional radiology Advances the skill of the reader by taking them through real-world practical examples and solutions with access to an online resource of example code The diverse examples of varying difficulty make the book suitable for readers from a variety of backgrounds and with different levels of programming experience.

This invaluable little pocketbook takes the reader through the basics of chest X-ray examination and interpretation. It covers the range of conditions clinicians are likely to encounter on the wards, and guides the reader through the diagnostic process based on the appearance of the abnormality shown. Suitable for medical students, junior doctors and other health professionals who interpret chest X-rays, including radiographers, nurses and physiotherapists, this text is the ideal solution to increasing your skills and boosting your confidence in using chest X-rays for diagnosis and management. Chest X-Ray Made Easy has garnered international praise as the ideal quick and simple guide to understanding chest X-rays. Concise and succinct - makes interpretation of chest X-rays as simple as possible Comprehensive but easy to understand Specifically designed for junior doctors and students New chapter on what and when to request, and how to do that New images throughout, including obvious and subtle examples of abnormalities Includes CT images and how they correlate with chest X-rays Sections on radiation doses and indications for chest X-rays Sections on chest X-ray appearances in COVID-19 Updated section on imaging in pregnancy Features interpretation of placement of lines, tubes, and of complications Quiz section to test knowledge Established title that is trusted internationally

Comprehensive, yet concise, 3D Printing for the Radiologist presents an overview of three-dimensional printing at the point of care. Focusing on opportunities and challenges in radiology practice, this up-to-date reference covers computer-aided design principles, quality assurance, training, and guidance for integrating 3D printing across radiology subspecialties. Practicing and trainee radiologists, surgeons, researchers, and imaging specialists will find this an indispensable resource for furthering their understanding of the current state and future outlooks for 3D printing in clinical medicine. Covers a wide range of topics, including basic principles of 3D printing, quality assurance, regulatory perspectives, and practical implementation in medical training and practice. Addresses the challenges associated with 3D printing integration in clinical settings, such as reimbursement, regulatory issues, and training. Features concise chapters from a team of multidisciplinary chapter authors, including practicing radiologists, researchers, and engineers. Consolidates today's available information on this timely topic into a single, convenient, resource.

This state-of-the-art set of handbooks provides medical physicists with a comprehensive overview of the field of nuclear medicine. In addition to describing the underlying, fundamental theories of the field, it includes the latest research and explores the practical procedures, equipment, and regulations that are shaping the field and it's future. This set is split into three volumes, respectively titled: Instrumentation and Imaging Procedures; Modelling, Dosimetry and Radiation Protection; and Radiopharmaceuticals and Clinical Applications. Volume one, Instrumentation and Imaging Procedures, focuses primarily on providing a comprehensive review into the detection of radiation, beginning with an introduction to the history of nuclear medicine to the latest imaging technology. Volume two, Modelling, Dosimetry and Radiation Protection, explores the applications of mathematical modelling, dosimetry, and radiation protection in nuclear medicine. The third and final volume, Radiopharmaceuticals and Clinical Applications, highlights the production and application of radiopharmaceuticals and their role in clinical nuclear medicine practice. These books will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine. The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history

Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging provides a comprehensive overview of cell therapy imaging, ranging from the basic biology of cell therapeutic choices to the preclinical and clinical applications of cell therapy. It emphasizes the use of medical imaging for therapeutic delivery/targeting, cell tracking, and determining therapeutic efficacy. The book first presents background information and insight on the major classes of stem and progenitor cells. It then describes the main imaging modalities and state-of-the-art techniques that are currently employed for stem cell tracking. In the final chapters, leading scholars offer clinical perspectives on existing and potential uses of stem cells as well as the impact of image-guided delivery and tracking in major organ systems. Through clear descriptions and color images, this volume illustrates how noninvasive imaging is used to track stem cells as they repair damaged tissue in the body. With contributions from some of the most prominent preclinical and clinical researchers in the field, the book helps readers to understand the evolving concepts of stem cell labeling and tracking as the field continues to move forward.

Propelling quantitative MRI techniques from bench to bedside, Quantitative MRI in Cancer presents a range of quantitative MRI methods for assessing tumor biology. It includes biophysical and theoretical explanations of the most relevant MRI techniques as well as examples of these techniques in cancer applications.

The introductory part of the book covers basic cancer biology, theoretical aspects of NMR/MRI physics, and the hardware required to form MR images. Forming the core of the book, the next three parts illustrate how to characterize tissue properties with endogenous and exogenous contrast mechanisms and discuss common image processing techniques relevant for cancer. The final part explores emerging areas of MR cancer characterization, including radiation therapy planning, cellular and molecular imaging, pH imaging, and hyperpolarized MR. Each of the post-introductory chapters describes the salient qualitative and quantitative aspects of the techniques before proceeding to preclinical and clinical applications. Each chapter also contains references for further study.

Leading the way toward more personalized medicine, this text brings together existing and emerging quantitative MRI techniques for assessing cancer. It provides a self-contained overview of the theoretical and experimental essentials and state of the art in cancer MRI.

This volume presents pedagogical content to understand theoretical and practical aspects of diagnostic imaging techniques. It provides insights to current practices, and also discusses specific practical features like radiation exposure, radiation sensitivity, signal penetration, tissue interaction, and signal confinement with reference to individual imaging techniques. It also covers relatively less common imaging methods in addition to the established ones. It serves as a reference for researchers and students working in the field of medical, biomedical science, physics, and instrumentation. Key Features * Focusses on the clinical applications while ensuring a steady understanding of the underlying science * Follows a bottom-up approach to cover the theory, calculations, and modalities to aid students and researchers in biomedical imaging, radiology and instrumentation * Covers unique concepts of nanoparticle applications along with ethical issues in medical imaging

For the last half of the 20th century cobalt-60 units were the mainstay of radiation treatments for cancer. This book describes the development of the first cobalt -60 unit in the United States and the man behind it, Leonard Grimmett. Conceptually conceived before World War II it only became possible because of the development of nuclear reactors during the war. The initial idea was to replace the radium in the contemporary units of the time with cobalt-60, but with the realization that the reactors could produce much more cobalt-60 than originally thought the design of the cobalt-60 unit was drastically changed to take advantage that the application of the inverse square law to cancer radiation treatments would make.
Although Grimmett conceived of and published his ideas first, the Canadians built the first units because of the capability of their reactor to produce more suitable cobalt-60 sources.
The story tells how Grimmett and the other people involved came together at the time that the U S Atomic Energy Agency was pushing the use of radioactivity in medicine. But Grimmett died suddenly before his unit could be built and very little information about him was known until recently when various documents have come to light, allowing the full story to be told.

1.Provides clinical certainty about difficult and controversial areas of vascular malformation 2. Explains how to incorporate genetic studies to aid diagnosis 3. Illustrates and explains unique findings from world experts 4. Includes evidence-based material to reflect research from the last 2 decades 5.Multiple colour illustrations and clear explanations make the text easy to absorb.

This book covers the entire spectrum of cerebellopontine angle lesions, from the most common to the rarest. All aspects are considered, including biological and radiological characteristics, neurological presentation, diagnosis, treatment options and follow-up care. The main focus, however, is on surgical management, which is presented in detail with the aid of numerous figures and images documenting technical particularities. Emphasis is placed on an individualized approach tailored to the particular tumor type and extension pattern. Both novice and experienced surgeons will find the book to be an invaluable source of information and guidance. It will enable neurosurgeons in the initial years of training to understand and become familiar with the main steps in surgical management while simultaneously providing their senior colleagues with details and technical tips that will help to improve treatment results.

This edition of Neuroimaging Clinics focuses on these minimally invasive, image-guided therapies. It includes guidelines for patient assessment and selection, choices of pharmaceuticals and materials commonly used, as well as, advice from noted experts about complication avoidance. Common procedures such as biopsy, epidural steroid injection and vertebroplasty (or balloon assisted vertebroplasty) are discussed. Newer procedures, such as sacroplasty, synovial cyst rupture, spinal cord stimulators, neurolysis, percutaneous discectomy, and minimally invasive treatment of spinal stenosis, are introduced.

Each year, almost twenty million people worldwide receive the grim diagnosis of cancer, yet few are prepared for the difficult emotional journey ahead. Shortly after Dr. Charles Hayter graduated as a cancer specialist, his father was diagnosed with terminal cancer. As with many doctors, he found that his medical training did not prepare him for the anguish and turmoil he witnessed in himself, his patients, and their loved ones - anguish often worsened by the stigma and shame surrounding cancer and radiation. In Cancer Confidential, Dr. Hayter shares behind-the-scenes stories of people dealing with cancer and death - often through avoidance, denial, and conflict, but also as shining examples of quiet courage, resilience, and humour. The backdrop for the stories is the specialty of radiation oncology. One in three cancer patients will receive radiation therapy, yet it remains a mysterious and often maligned area of medicine. Told in a vivid, dramatic style, Cancer Confidential sheds light on this poorly understood field and reveals intimate stories of individuals and their families in difficult circumstances. It will lend insight, compassion, and support to anyone facing the diagnosis of cancer.

Optimize diagnostic accuracy with Problem Solving in Chest Imaging, a new volume in the Problem Solving in Radiology series. This concise title offers quick, authoritative guidance from experienced radiologists who focus on the problematic conditions you're likely to see-and how to reach an accurate diagnosis in an efficient manner. Addresses the practical aspects of chest imaging-perfect for practitioners, fellows, and senior level residents who may or may not specialize in chest radiology, but need to use and understand it. Helps you make optimal use of the latest imaging techniques and achieve confident diagnoses. Presents content by organ system and commonly encountered problems, with problem solving techniques integrated throughout. Features more than 1,500 high-quality images that provide a clear picture of what to look for when interpreting studies. Focuses on the core knowledge needed for successful results, covering anatomy, imaging techniques, imaging approach, entities by pathologic disease and anatomic region, and special situations. Key topics include Diffuse Lung Disease, Neoplasms of the Lung and Airways, Interstitial Lung Disease, Smoking-Related Lung Diseases, and Cardiovascular Disease. Shows how to avoid common problems that can lead to an incorrect diagnosis. Tables and boxes with tips, pitfalls, and other teaching points show you what to look for, while problem-solving advice helps you make sound clinical decisions. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Diffusion weighted imaging (DWI) is a key emerging imaging modality for the management of patients with possible breast lesions, and Diffusion MRI of the Breast is the first book to focus on all aspects of DWI in today's practice. It covers the knowledge necessary to undertake clinical breast DWI, with a thorough review of how DWI is currently used as a breast imaging modality and how breast lesions appear on DWI. Expert clinicians and physicists from around the world share their knowledge and expertise on everything from technical requirements and image analysis to clinical applications of DWI (diagnosis, prognosis, treatment monitoring) with case examples, and upcoming developments in the field (radiomics, AI). Offers an in-depth discussion of DWI's clinical applications in breast imaging, including the position of DWI with respect to other modalities, the use of DWI in the diagnosis of suspicious lesions with a multiparametric protocol, the use of DWI as an imaging biomarker of prognosis and response prediction, the potential role of DWI for unenhanced breast MR screening, and more. Provides a basic introduction to DWI before discussing a practical approach to clinical interpretation and quality assurance issues. Covers specific challenges and advanced techniques (IVIM, non-Gaussian diffusion, DTI, and other novel techniques), radiomics and artificial intelligence, and different vendor approaches in breast DWI packages. Features more than 500 high-quality images throughout. Explains how DWI could be specifically used to provide information on prognosis and prediction factors. Evaluates the current status of DWI, its potential for the management of breast cancer patients, and possible future developments in the field. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

First published in 1991, this book covers three major areas essential to in vivo biochemical studies with PET and SPECT: synthesis of radiopharmaceuticals, biological modeling, and clinical applications. The book emphasizes advances in the synthesis of radiopharmaceuticals used in PET and SPECT studies of brain flow and oxidatative metabolism, in addition to biological modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose models are discussed, as well as models used in the quantitation of brain receptors. Other topics include a possible model for converting 6-[18F] fluorodopa images into the quantitative rate of dopamine synthesis, evaluations of technetium- and iodine-labeled blood flow tracers, and possibilities for using SPECT to measure other pathophysiological variables. This book will be a valuable reference source to students and specialists interested in these in vivo measurements.