A novel strain of influenza A (H1N1) virus emerged and an outbreak of influenza A (H1N1) occurred worldwide in 2009 and 2010, posing a severe threat to the health of human beings. The two Editors work together in Beijing You An Hospital, to combat this type of influenza. This book, Radiology of Influenza A (H1N1), is intended to provide first-hand clinical data and its scientific analysis, thus supporting sound clinical practice for influenza A (H1N1) prevention and treatment as well as related scientific research. The authors have collected over 100 critical influenza A (H1N1) virus-infected cases. For cases of influenza A (H1N1) that resulted in death, autopsies were performed for 8 cases after receiving their families' informed consent. Over 200 reports on pathological and histological analysis as well as immunohistochemical and electroscopic analysis were brought together. This book was then compiled by comparing the published data with the present first-hand data. This book includes a wealth of content, including DR, CT and MRI images, pathological and histological figures, and immunohistochemical and electroscopic figures. Related research, clinical and educational needs can be readily satisfied by its detailed data, texts and figures, as well as typical case reports. Li Hongjun, is professor and director of the diagnostic radiology department in Beijing You An Hospital, affiliated with Capital Medical University, Beijing, China. Li Ning, is professor and president of Beijing You An Hospital, affiliated with Capital Medical University, Beijing, China.

The sixteen chapters included in this book were written by invited experts of international recognition and address important issues in Medical Image Processing and Computational Vision, including: Object Recognition, Object Detection, Object Tracking, Pose Estimation, Facial Expression Recognition, Image Retrieval, Data Mining, Automatic Video Understanding and Management, Edges Detection, Image Segmentation, Modelling and Simulation, Medical thermography, Database Systems, Synthetic Aperture Radar and Satellite Imagery. Different applications are addressed and described throughout the book, comprising: Object Recognition and Tracking, Facial Expression Recognition, Image Database, Plant Disease Classification, Video Understanding and Management, Image Processing, Image Segmentation, Bio-structure Modelling and Simulation, Medical Imaging, Image Classification, Medical Diagnosis, Urban Areas Classification, Land Map Generation. The book brings together the current state-of-the-art in the various multi-disciplinary solutions for Medical Image Processing and Computational Vision, including research, techniques, applications and new trends contributing to the development of the related areas.

This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.

Functional imaging has the capability to reveal changes in the pathophysiology of tissues and organ systems, mapping the progression and severity of disease, uptake of drugs, and the recovery of tissues following trauma, disease episodes or surgery. In this authoritative new work, leading specialists in neurology and neuroimaging present an update on the MRI and PET investigation of diseases of the central nervous system. An insightful reference for anyone working in the field, this work discusses how these new technologies can be used to investigate the most important disorders encountered in clinical neurology and psychiatry, ranging from chronic progressive diseases such as Alzheimer's, episodic disruptions of function as seen in epilepsy, and the subtle changes caused by drug dependency and abuse.

This book is a volume in the Penn Press Anniversary Collection. To mark its 125th anniversary in 2015, the University of Pennsylvania Press rereleased more than 1,100 titles from Penn Press's distinguished backlist from 1899-1999 that had fallen out of print. Spanning an entire century, the Anniversary Collection offers peer-reviewed scholarship in a wide range of subject areas.

Within the field of neuroscience, the past few decades have witnessed an exponential growth of research into the brain mechanisms underlying both normal and pathological states of consciousness in humans. The development of sophisticated imaging techniques to visualize and map brain activity in vivo has opened new avenues in our understanding of the pathological processes involved in common neuropsychiatric disorders affecting consciousness, such as epilepsy, coma, vegetative states, dissociative disorders, and dementia. This book presents the state of the art in neuroimaging exploration of the brain correlates of the alterations in consciousness across these conditions, with a particular focus on the potential applications for diagnosis and management. Although the book has a practical approach and is primarily targeted at neurologists, neuroradiologists, and psychiatrists, it will also serve as an essential reference for a wide range of researchers and health care professionals.

This book describes current examination techniques and advanced clinical applications of state-of-the-art multidetector computed tomography (MDCT) scanners. There are contributions from several distinguished radiologists and clinicians. Each chapter is written from a practical perspective, so that radiologists, residents, medical physicists, and radiology technologists can obtain relevant information about MDCT applications.

Multiauthored book dealing comprehensively with the various aspects of imaging of pediatric musculoskeletal trauma. The work is subdivided in three main sections: Overview of lesions; Imaging of traumatic injuries according to body region; typical traumatic injuries of early infancy. The third section includes also legal aspects of child abuse (battered child) and will indicate current international medical-legal guidelines. The didactical approach and the wide-ranging account of the subject makes the book particularly valuable to practitioners from various disciplines, involved in diagnosis and management of trauma of pediatric bone and joint

New Techniques for Thoracic Outlet Syndromes presents in a comprehensive format an up-to-date, state of the art reference that physicians can use in consultation to properly treat patients using the resources that modern medicine offers. This book offers the newer surgical approaches that have been developed during the past 30 years. Some of these techniques are modification of operations that were proposed previously but were not fully affective and left many patients suffering with permanent disability. This textbook is a compendium of the proper management of these patients that cannot be found in isolated reports of literature. The neurogenic-arterial thoracic outlet syndrome section covers how to diagnosis the illness using the proper tests, therefore eliminating the use of expensive, uncomfortable and inconvenient tests. The text is organized in three basic sections that cover all the aspects of the thoracic outlet syndromes. The first section addresses the neurogenic-arterial type, with the pertinent subsections: symptoms, diagnosis. A list of the useful tests is provided to make a correct diagnosis of this syndrome. This is followed by the sections on treatment, using the surgical approaches with historical aspects and evolution of the operations proposed. The second section involves the venous thoracic outlet syndrome divided into the corresponding subsections comprising: symptoms and physical findings, etiology, diagnosis. This section also includes a list of the usual tests to make the proper diagnosis. The last section of this text is dedicated to the presence of cervical ribs and their classification of the different types that occur, and also the proper surgical treatment when fusion of the upper ribs is present. New Techniques for Thoracic Outlet Syndromes offers the current, acceptable and most effective methods to handle thoracic outlet syndromes. It will be of great value to thoracic surgeons, vascular surgeons, interventional radiologists as well as fellows and residents in training for cardiothoracic and vascular surgery.

For the last half of the 20th century cobalt-60 units were the mainstay of radiation treatments for cancer. This book describes the development of the first cobalt -60 unit in the United States and the man behind it, Leonard Grimmett. Conceptually conceived before World War II it only became possible because of the development of nuclear reactors during the war. The initial idea was to replace the radium in the contemporary units of the time with cobalt-60, but with the realization that the reactors could produce much more cobalt-60 than originally thought the design of the cobalt-60 unit was drastically changed to take advantage that the application of the inverse square law to cancer radiation treatments would make. Although Grimmett conceived of and published his ideas first, the Canadians built the first units because of the capability of their reactor to produce more suitable cobalt-60 sources. The story tells how Grimmett and the other people involved came together at the time that the U S Atomic Energy Agency was pushing the use of radioactivity in medicine. But Grimmett died suddenly before his unit could be built and very little information about him was known until recently when various documents have come to light, allowing the full story to be told.

Urological Oncology, Second Edition offers an updated multi-disciplinary and multi professional approach to the assessment, diagnosis, treatment and follow-up care of patients being investigated and treated for urological malignancies. As a professional resource for all nurses involved in the care of uro-oncology patients, particularly those in advanced practice roles, there is an emphasis on developing advanced practice with in-depth discussions to support evidence based, patient focused care. Mainly aimed at trainee nurses, nurse practitioners in urology / urological oncology, Urological Oncology, Second Edition, is also useful for general nurse practitioners. With this in mind the level is higher than that of a general nursing book.

CAR is a symposium and exhibition covering the impact of computer and communication systems applied to radiology and other medical disciplines, which use digital imaging for diagnosis and therapy planning. CAR '93 also provides tutorials, but more emphasis is given to a broad variety of specific problems related to medical/technical issues in digital imaging. This is achieved through in-depth presentations of results of current medical imaging projects on a worldwide basis.

Sincethepublicationofthisbook in2005, thegrowthofpositron emission tomography(PET)andPET/CTmodalityhasbeenphenomenalwiththed- coveryofef?cientdetectorsandtheadditionofsophisticatedscannersand powerfulsoftware. Becauseofthevastadvancementandchangesintechn- ogy, andalso withgreatappreciationofthesuccess ofthe?rst edition, we thoughtasecondeditionofthebookwouldbeappropriate. Thebookisrevisedtoagainful?lltheneedsofnuclearmedicineprof- sionalssuchasphysicians, technologists, andresidents, alongwithstudents fortheirboardexaminationandtraining. Thecontentsofthebookhavebeen keptatthebasiclevelaswasinthe?rstedition. The organization of the book essentially has remained the same. Some chaptershavebeenrevisedvery extensively, while others haveonly minor changes. NochangehasbeenmadeinChap. 1asitisbasedonbasicphysics. Extensive revision has been made in Chaps. 2 and 3 to include up-to-date information on detectors, scanners, and data collection. Chapter 4 in the original edition has been divided into Chaps. 4 and 5 to allow for a se- ratechapteron"Storage,Display,andPACS. "Chapter6hasbeenupdated withnewinformationonNEMAstandardsonacceptancetestsofPETsc- ners. NewPETradionuclidesandthelistofcurrentavailablecyclotronshave beenaddedtoChap. 7. Chapter8includesasectiononCompoundingofPET Radiopharmaceuticals,inadditiontoseveralnewPETradiopharmaceuticals. NewregulationsconcerningtheuseofPETradiopharmaceuticals,thelice- ingofphysiciansandtechnologists,andtheaccreditationofPETfacilitiesto beeligibleforreimbursementforPETproceduresareallincludedinChap. 9. Chapter10hasbeenrevised,focusingontheissuesofcurrentreimbursement issuesforPETstudies. OnlyminorchangeshavebeenmadeinChaps. 11and 12toincludeup-to-dateinformation. Questionshavebeenaddedattheend ofeachchapter,asappropriate,tore?ectthechangesincontents. IthankmycolleaguesattheClevelandClinicFoundationfortheirsupport in manywaysand Mrs. DianeGrif?s for kindly typingand completingthe manuscriptontime. vii viii Preface IsincerelythankAndrewMoyer,editorofradiologyandnuclearmedicine, atSpringerforsupportandencouragement,andS. GeethalakshmiSrinivasan, ProjectManager,atSPiTechnologiesIndiaPvtLtdforexcellentproduction ofthebook. Cleveland,OH GopalB. Saha Contents 1. RadioactiveDecayandInteractionofRadiationwithMatter ...1 AtomicStructure ...1 RadioactiveDecay ...2 ?Decay ...2 ? ? Decay ...3 + Positron(?) Decay ...3 ElectronCapture ...3 IsomericTransition ...4 RadioactiveDecayEquations ...5 GeneralDecayEquations ...5 SuccessiveDecayEquations ...7 UnitsofRadioactivity ...9 UnitsofRadioactivityinSystemInternationale ...9 Calculations ...9 InteractionofRadiationwithMatter ...10 InteractionofChargedParticleswithMatter ...10 Interactionof?RadiationwithMatter ...12 Questions ...15 ReferencesandSuggestedReading ...17 2. PET ScanningSystems ...19 Background ...19 SolidScintillationDetectorsinPET ...20 PhotomultiplierTube ...24 PulseHeightAnalyzer ...25 ArrangementofDetectors ...25 PETScanners ...28 CoincidenceScintillationCameras ...29 PET/CTScanners ...30 SmallAnimalPETScanner ...33 MobilePETorPET/CT ...36 ix x Contents Questions ...38 ReferencesandSuggestedReading ...39 3. DataAcquisition and Corrections ...41 PETDataAcquisition ...41 TimeofFlightMethod ...46 Two-Dimensionalvs. Three-Dimensional DataAcquisition ...47 FactorsAffectingAcquiredPETData ...49 Normalization ...49 PhotonAttenuation ...50 AttenuationCorrectionMethods ...52 RandomCoincidences ...53 ScatterCoincidences ...55 CorrectionforScatterCoincidences ...56 DeadTime ...58 RadialElongation ...59 PET/CTDataAcquisition ...6 0 FactorsAffectingPET/CTData ...62 Questions ...67 ReferencesandSuggestedReading ...68 4. ImageReconstruction ...71 SimpleBackprojection ...71 FilteredBackprojection ...72 TheFourierMethod ...73 TypesofFilters ...75 IterativeReconstruction ...

This book covers the complete spectrum of deformable models, its evolution as an imagery field and its use in many biomedical engineering and clinical application disciplines. The book focuses on the core image processing techniques, theory and biomaterials useful to research and industry. Contributors are all pioneers in the field.

The impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. Many innovative molecular imaging probes have already entered clinical practice, and there is no doubt that the future emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.

MRI has become the main paraclinical test in the diagnosis and management of multiple sclerosis. More than 400 pictures of different typical and atypical MS lesions are demonstrated in this atlas. Each image has a teaching point. New diagnostic criteria and differential diagnosis are discussed.

Health Effects of Cell Phone Radiation will offer a concentrated and up-to-date overview on the effects of radio frequencies on human tissue. While significant advances are being made on many fronts, ranging in frequency from quasi-static to the optical regime, a special emphasis of this volume is on current understanding of biological interactions of cellular mobile communication radiation. The use of cell-phones has experienced phenomenal growth - some estimate that there will be more than 3.5 billion users of these wireless devices by the end of 2010, worldwide. The widespread impact of these new wireless technologies has raised concerns about the safety of human exposure to radio-frequency (RF) energy emitted by these telecommunication devices. A better understanding of the biological effects of RF electromagnetic field is needed to safeguard against possible harm to the general population. Fortunately in recent years there has been a resurgence of research interest in achieving a quantitative understanding of the relationships between the biological effects of RF radiation and the physical variables that may cause them. A significant number of results have and are beginning to appear in the literature. This volume reviews and assesses the biological effects of exposure to electromagnetic fields from wireless communication technology.

Unraveling the functional properties of structural elements in the brain is one of the fundamental goals of neuroscientific research. In the cerebral cortex this is no mean feat, since cortical areas are defined microstructurally in post-mortem brains but functionally in living brains with electrophysiological or neuroimaging techniques - and cortical areas vary in their topographical properties across individual brains. Being able to map both microstructure and function in the same brains noninvasively in vivo would represent a huge leap forward. In recent years, high-field magnetic resonance imaging (MRI) technologies with spatial resolution below 0.5 mm have set the stage for this by detecting structural differences within the human cerebral cortex, beyond the Stria of Gennari. This provides the basis for an in vivo microanatomical brain map, with the enormous potential to make direct correlations between microstructure and function in living human brains. This book starts with Brodmann's post-mortem map published in the early 20th century, moves on to the almost forgotten microstructural maps of von Economo and Koskinas and the Vogt-Vogt school, sheds some light on more recent approaches that aim at mapping cortical areas noninvasively in living human brains, and culminates with the concept of "in vivo Brodmann mapping" using high-field MRI, which was introduced in the early 21st century.

We dedicate this text to Drs. Ernest E. Aegerter, a pathologist, and John A. Kirkpatrick Jr., a radiologist. They were among the principal founders of the ?eld of skeletal pathology and radiology. During their time, their residents and colleagues knew them as great educators with a dedication and a passion for their work. Their textbook, Orthopedic Diseases, published initially in 1958 was among the ?rst interdisciplinary works devoted to this ?eld. Dr. Aegerter and Dr. Kirkpatrick illuminated many aspects of the ?eld of radiology. Today, with the advent of new technologies, this ?eld has grown to include not only diseases that affect the skeleton but also those that affect muscles, ligaments, tendons, and also the cartilaginous structures within joints. With this text we intend to carry on Dr. Aegerter and Dr. Kirkpatrick's tradition. We have recruited only well-known musculoskeletal radiologists and pathologists to participate in the writing of this book. Each author has been carefully selected for his expertise on the topic about which he's been asked to contribute. Each author is known as an experienced and seasoned teacher. Each author has made a mark on the ?eld.

This book summarizes 20 years of work on the kinetics of blood-brain transfer and metabolism mechanisms in mammalian brain. The substances affiliated with these mechanisms include glucose, amino acids, monocarboxylic acids, and oxygen. These substances are important to energy metabolism and neurotransmission in the mammalian brain at rest and during activation. To understand the processes addressed by these mechanisms, the book examines the kinetics of compartmentation and compartmental analysis, particularly as they relate to transporter, enzyme, and receptor function. Compartments are subsets of substances separated by transporters and receptors in membranes, and enzymes in cells. This book is divided in six major chapters covering compartmental analysis, kinetic analysis of transport and metabolism, blood-brain transfer and metabolism of glucose, amino acids, and oxygen, and amino acid metabolism and interaction of amino acid metabolites with receptors.

This book describes the design of the first functioning single-sided tomograph, the related measurement methods, and a number of applications in medicine, materials science, and chemical engineering. It will be the first comprehensive account of this new device and its applications. Among the key advances of this method is that images can be obtained in much shorter times than originally anticipated, and that even vector maps of flow fields can be measured although the magnetic fields are highly inhomogeneous. Furthermore, the equipment is small, mobile and affordable to small and medium enterprises and can be located in doctors' offices.

The 29th International Symposium on Acoustical Imaging was held in Shonan Village, Kanagawa, Japan, April 15-18, 2007. This interdisciplinary Symposium has been taking place every two years since 1968 and forms a unique forum for advanced research, covering new technologies, developments, methods and theories in all areas of acoustics. In the course of the years the volumes in the Acoustical Imaging Series have developed and become well-known and appreciated reference works. Offering both a broad perspective on the state-of-the-art in the field as well as an in-depth look at its leading edge research, this Volume 29 in the Series contains again an excellent collection of seventy papers presented in nine major categories: (1) Strain Imaging, (2) Biological and Medical Applications, (3) Acoustic Microscopy, (4) Non-Destructive Evaluation and Industrial Applications, (5) Components and Systems, (6) Geophysics and Underwater Imaging, (7) Physics and Mathematics, (8) Medical Image Analysis, (9) FDTD method and Other Numerical Simulations.

In 194 cases featuring over 450, high-quality images, Nuclear Medicine and PET/CT Cases provides a succinct review of clinically relevant cases covering the full range of nuclear medicine. Cases are grouped into sections including: Nuclear CNS Imaging, Nuclear Inflammation/Infection Imaging, Ventilation/Perfusion Lung Scintigraphy, Pediatric Nuclear Medicine, Cardiac Imaging, Bone Scintigraphy, PET/CT in Oncology, General Oncologic Imaging, Thyroid and Parathyroid, Radionuclide Therapy and Pre-Therapy Evaluation, Liver, Spleen and Biliary Tract, Gastrointestinal Tract, Renal Scintigraphy. Part of the Cases in Radiology series, this book follows the easy-to-use format of question and answer in which the patient history is provided on the first page of the case, and radiologic findings, differential diagnosis, teaching points, next steps in management, and suggestions for furthering reading are revealed on the following page. This casebook is an essential resource for radiology residents and practicing radiologists alike.

Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease. The cause remains elusive, preventing breakthroughs in its prevention. The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches. However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources. Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier. Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients.

This volume presents the proceedings of CLABIO 2015 - II Latin American Conference on Bioimpedance, held in Montevideo, Uruguay - September 30 - October 02, 2015. The works cover a broad range in Biomedical Engineering and Computing, Medical Physics and Medical Sciences, Environment, Biology and Chemistry. The topics are: ·Bioimpedance Applications ·Bioimpedance Instrumentation ·Body and Tissue Composition ·Cell Culture and Cell Suspension ·Electrical Impedance Tomography ·Electrode Modelling ·Magnetic Induction - Electrical Impedance Tomography ·Magnetic Resonance - Electrical Impedance Tomography ·Nonlinear Phenomena ·Organ and Tissue Impedance ·Plant Tissue Impedance ·Skin Impedance Modelling ·Technological Advances in Bioimpedance ·Theory and Modelling