This third edition overviews the essential contemporary topics of neuroengineering, from basic principles to the state-of-the-art, and is written by leading scholars in the field. The book covers neural bioelectrical measurements and sensors, EEG signal processing, brain-computer interfaces, implantable and transcranial neuromodulation, peripheral neural interfacing, neuroimaging, neural modelling, neural circuits and system identification, retinal bioengineering and prosthetics, and neural tissue engineering. Each chapter is followed by homework questions intended for classroom use. This is an ideal textbook for students at the graduate and advanced undergraduate level as well as academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals seeking to learn the latest developments in this emerging field.Advance Praise for Neural Engineering, 3rd Edition: "A comprehensive and timely contribution to the ever growing field of neural engineering. Bin He's edited volume provides chapters that cover both the fundamentals and state-of-the-art developments by the world's leading neural engineers." Dr. Paul Sajda, Department of Biomedical Engineering, Electrical Engineering and Radiology, Columbia University "Neural Engineering, edited by Prof. He, is an outstanding book for students entering into this fast evolving field as well as experienced researchers. Its didactic and comprehensive style, with each chapter authored by leading scientific authorities, provides the ultimate reference for the field." Dr. Dario Farina, Department of Bioengineering, Imperial College London, London, UK "Neural Engineering has come of age. Major advances have made possible prosthesis for the blind, mind control for quadraplegics and direct intervention to control seizures in epilepsy patients. Neural Engineering brings together reviews by leading researchers in this flourishing field. Dr. Terrence Sejnowski, Salk Institute for Biolgical Studies and UC San Diego

This book gathers the proceedings of the 17th International Conference on Electrical Bioimpedance (ICEBI 2019), held on June 9-14, in Joinville, Santa Catarina, Brazil. The chapters cover the latest knowledge and developments concerning: sensors and instrumentation to measure bioimpendance, bioimpedance imaging techniques, theory and modeling and bioimpendance, as well as cutting-edge clinical applications of bioimpendance. All in all, this book provides graduate students and researchers with an extensive and timely snapshot of current research and challenges in the field of electrical bioimpendance, and a source of inspiration for future research and cross-disciplinary collaborations.

This book focuses on the processing, materials design, characterisation, and properties of polymer composites and nanocomposites for use as electromagnetic radiation shielding materials and to enhance radiation shielding capacity in order to meet the safety requirements for use in medical X-ray imaging facilities. It presents an in-depth analysis of materials synthesis methods such as melt-mixing, ion-implantation, solution casting and electrospinning. In addition, it measures the X-ray attenuation behaviour of fabricated composites and nanocomposites in four major types of X-ray equipment, namely general radiography, mammography, X-ray absorption spectroscopy and X-ray fluorescence spectroscopy units. Given its scope, the book will benefit researchers, engineers, scientists and practitioners in the fields of medical imaging, diagnostic radiology and radiation therapy.

Imaging plays an integral role in the diagnosis and intervention of debilitating, often fatal vascular diseases of the brain, such as ischemic and hemorrhagic stroke, aneurysms, and arteriovenous malformations (AVMs). Written by a world renowned neuro-radiologist and pioneer in the early adoption of magnetic resonance (MR) technology, Imaging of Cerebrovascular Disease is a concise yet remarkably thorough textbook that advances the reader's expertise on this subject. The text draws on the author's vast personal experience, case studies, and traditional educational sources, offering didactic dialogue with accompanying images. A practical clinical resource organized into six chapters, this book offers unparalleled breadth in delineating the diagnostic and treatment usages of modern imaging techniques. Chapter one sets a foundation with extensive coverage of modalities and their applications, including MR, computed tomography (CT) and digital subtraction angiography (DSA). Subsequent chapters cover utilization of imaging techniques specific to underlying pathologies. Key Features: In-depth discussion of medical and neuroradiologic/neurosurgical interventions, focusing on the use of imaging prior to, during, and following treatment Comprehensive text enhanced with more than 700 high-quality images Detailed evaluation of normal brain anatomy, as well as gyral anatomy in brain ischemia, an important subtopic Advantages, disadvantages, mortality, and morbidity of surgery (clipping) versus endovascular techniques (coiling and flow diversion) for aneurysms Presented in a style that facilitates cover-to-cover reading, this is an essential tool for residents and fellows, and provides a robust study guide prior to sitting for relevant certification exams. It is also a quick, invaluable reference for radiologists, neurosurgeons, and neurologists in the midst of a busy clinical day.

This book presents non-linear image enhancement approaches to mammograms as a robust computer-aided analysis solution for the early detection of breast cancer, and provides a compendium of non-linear mammogram enhancement approaches: from the fundamentals to research challenges, practical implementations, validation, and advances in applications. The book includes a comprehensive discussion on breast cancer, mammography, breast anomalies, and computer-aided analysis of mammograms. It also addresses fundamental concepts of mammogram enhancement and associated challenges, and features a detailed review of various state-of-the-art approaches to the enhancement of mammographic images and emerging research gaps. Given its scope, the book offers a valuable asset for radiologists and medical experts (oncologists), as mammogram visualization can enhance the precision of their diagnostic analyses; and for researchers and engineers, as the analysis of non-linear filters is one of the most challenging research domains in image processing.

The teaching of radiological interpretation is a crucial element of general surgical training and forms an important part of postgraduate examinations. In this book there is a strong emphasis toward the radiological assessment of the acute abdomen and also the investigation of the gastrointestinal tract. There is particular reference to the abdominal radiography which provides an important initial diagnostic tool in the acutely ill surgical patient. The book also contains sub-sections within each chapter devoted to the other facets of surgical radiology including trauma and orthopaedics, unoradiology, head and neck imaging, interventional and breast radiology.

Alongside key surgical points the text discusses further relevant imaging in each case. Numerous examples of barium contrast studies, ultrasound, CT and MRI scans are included to further illustrate the surgical cases chosen.

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

This exceptional book covers all aspects of diagnostic and interventional radiology within one volume, at a level appropriate for the specialist. From the basics through diagnosis to intervention: the reader will find a complete overview of all areas of radiology. The clear, uniform structure, with chapters organized according to organ system, facilitates the rapid retrieval of information. Features include: * Presentation of the normal radiological anatomy* Classification of the different imaging procedures according to their diagnostic relevance* Imaging diagnosis with many reference images* Precise description of the interventional options The inclusion of many instructive aids will be of particular value to novices in decision making: * Important take home messages and summaries of key radiological findings smooth the path through the jungle of facts* Numerous tables on differential diagnosis and typical findings in the most common diseases offer a rapid overview and orientation* Diagnostic flow charts outline the sequence of diagnostic evaluation All standard procedures within the field of interventional radiology are presented in a clinically relevant and readily understandable way, with an abundance of illustrations. This is a textbook, atlas, and reference in one: with more than 2500 images for comparison with the reader's own findings. This comprehensive and totally up-to-date book provides a superb overview of everything that the radiology specialist of today needs to know.

Die Herausgeber, anerkannte Spezialisten und aktiv in der Interdisziplinaren Arbeitsgruppe Weichteilsarkome (IAWS) der Deutschen Krebsgesellschaft, stehen fur fundiertes Fachwissen. Das Werk zeichnet sich durch eine praxisorientierte und ubersichtliche Darstellung aller bei Weichteilsarkomen klinisch relevanten Themen aus. Ausfuhrlich wird auf Diagnostik, Klassifikation, Stadieneinteilung wie auch molekulare und genetische Aspekte als Grundlage therapeutischer Entscheidungen eingegangen. Ein weiteres zentrales Thema ist die interdisziplinare Behandlung (Chirurgie, Strahlentherapie, medikamentoese Therapie) und deren Sequenz fur die zahlreichen, unterschiedlichen Entitaten von Weichteilsarkomen. Auch spezielle Therapieverfahren, wie Extremitatenperfusion und Hyperthermie werden besprochen. AErzte in Klinik und Praxis erhalten mit diesem Buch kompetente Unterstutzung fur die optimale Betreuung von Patienten mit Weichteilsarkomen.

This book offers the first comprehensive overview of artificial intelligence (AI) technologies in decision support systems for diagnosis based on medical images, presenting cutting-edge insights from thirteen leading research groups around the world. Medical imaging offers essential information on patients' medical condition, and clues to causes of their symptoms and diseases. Modern imaging modalities, however, also produce a large number of images that physicians have to accurately interpret. This can lead to an "information overload" for physicians, and can complicate their decision-making. As such, intelligent decision support systems have become a vital element in medical-image-based diagnosis and treatment. Presenting extensive information on this growing field of AI, the book offers a valuable reference guide for professors, students, researchers and professionals who want to learn about the most recent developments and advances in the field.

This issue of Radiologic Clinics of North America focuses on The Spine, and is edited by Dr. Lubdha M. Shah. Articles will include: Pearls and Pitfalls in Spine Imaging; Traumatic Spinal Cord; Vascular Disorders of the Spine; Approach to (acute, subacute, chronic) Myelopathy; Acute Low Back Pain; Spinal Manifestations of Systemic Disease; Intraspinal Tumors; Spinal Osseous Tumors and Oncology; Spinal Marrow Imaging: Clues to Disease; Postoperative Spine: What the Surgeons Wants to Know; Beyond the Spinal Canal; CSF Leak in Spontaneous Intracranial Hypotension: Diagnosis and Intervention; and more!

This book reviews and discusses the development of self-assembled nanomaterials applied in biomedical fields. Based on self-assembled nanomaterial constructions, it highlights the mechanisms of the stimuli-response-induced assembly/disassembly and transformation. Moreover, it examines healthcare-related diseases, the applications of nanomaterials and therapy/detection strategies, providing readers with both a deeper understanding of the subject and inspirations for future research. The book is primarily intended for researchers and graduate students in the fields of material sciences and chemistry who wish to learn about the principles, methods, mechanisms and biomedical applications of self-assembled nanomaterials.

In parallel with the continuous rise of cancer incidence, efficient treatment becomes an increasingly important public health concern. Radiotherapy has remained one of the most important anticancer approaches for clinical management of a variety of human tumours, as at least half of all oncological patients receive this therapy at some stages of their disease. With the hope to attain greater anticancer response, the interest in using natural plant-derived products as complementary treatments to conventional radiotherapy has substantially increased in the recent years. However, the interactions between phytochemicals and ionizing radiation are not always known and can be often unpredictable. Therefore, in this book, the current findings about the combined treatments of malignant cells with radiation and flavonoids, the largest group of human dietary plant polyphenols, are described. These data show that under carefully chosen dosage-schedule regimens, certain flavonoids or their natural mixtures can behave as potent radiosensitizers, augmenting radiotherapeutic efficacy in different preclinical cancer models. Such radio-sensitising action of flavonoids can be achieved through modulation of the redox status and suppression of several cellular survival pathways activated by radiotherapy, ultimately leading to the death of malignant cells. As flavonoids can concurrently protect normal healthy cells from irradiation-induced injury and thereby minimize toxic adverse reactions, use of these plant-derived agents as complementary approach to radiotherapy might open new avenues for enhancement of clinical outcome. Therefore, combining conventional anticancer modalities with conscious intake of flavonoid supplements as adjuvant agents might be an important future strategy to boost the therapeutic success in the treatment of various human malignancies.

This introduction to medical imaging introduces all of the major medical imaging techniques in wide use in both medical practice and medical research, including Computed Tomography, Ultrasound, Positron Emission Tomography, Single Photon Emission Tomography and Magnetic Resonance Imaging. Principles of Medical Imaging for Engineers introduces fundamental concepts related to why we image and what we are seeking to achieve to get good images, such as the meaning of 'contrast' in the context of medical imaging. This introductory text separates the principles by which 'signals' are generated and the subsequent 'reconstruction' processes, to help illustrate that these are separate concepts and also highlight areas in which apparently different medical imaging methods share common theoretical principles. Exercises are provided in every chapter, so the student reader can test their knowledge and check against worked solutions and examples. The text considers firstly the underlying physical principles by which information about tissues within the body can be extracted in the form of signals, considering the major principles used: transmission, reflection, emission and resonance. Then, it goes on to explain how these signals can be converted into images, i.e., full 3D volumes, where appropriate showing how common methods of 'reconstruction' are shared by some imaging methods despite relying on different physics to generate the 'signals'. Finally, it examines how medical imaging can be used to generate more than just pictures, but genuine quantitative measurements, and increasingly measurements of physiological processes, at every point within the 3D volume by methods such as the use of tracers and advanced dynamic acquisitions. Principles of Medical Imaging for Engineers will be of use to engineering and physical science students and graduate students with an interest in biomedical engineering, and to their lecturers.

This book is based on the best contributions to the advancement of bioimpedance knowledge and use from the Latin American Congress series, CLABIO. Basic bioimpedance facts as well as promising and original contributions to bioimpedance theory and applications are presented, giving the reader stimulating material for reflection, decision making, and further experiments. Contributions come from a diverse international pool of experts and address topics on electrode and skin impedance modelling, tomography, spectroscopy, instrumentation, and clinical applications.

This book chiefly addresses the analysis and design of geosynchronous synthetic aperture radar (GEO SAR) systems, focusing on the algorithms, analysis, methods used to compensate for ionospheric influences, and validation experiments for Global Navigation Satellite Systems (GNSS). Further, it investigates special problems in the GEO SAR context, such as curved trajectories, the Earth's rotation, the 'non-stop-and-go' model, high-order Doppler parameters, temporal-variant ionospheric errors etc. These studies can also be extended to SAR with very high resolution and long integration time. Given the breadth and depth of its coverage, scientists and engineers in SAR and advanced graduate students in related areas will greatly benefit from this book.

This book highlights the latest advances in functional micro/nano imaging probes and their applications for biomedical imaging and therapy. Given the rapid emergence of transdisciplinary research and applications in materials, chemical probes and translational medicine in recent years, scientists in these areas are expected to keep up to date on the latest technologies and advances to promote comprehensive innovations. Addressing this need, the book presents recently introduced features, emerging techniques, and new strategies, complemented by detailed illustrations. Covering the status quo and offering an outlook on the future, it benefits all readers with an interest in functional materials, especially micro/nano imaging materials for biomedical imaging applications, providing them with both vital updates and inspiration for their own research.

Prepare for success on the ARRT exam and in the practice of radiography! Essentials of Radiographic Physics and Imaging, 3rd Edition follows the ASRT recommended curriculum and focuses on what the radiographer needs to understand to safely and competently perform radiographic examinations. This comprehensive text gives you a foundational understanding of basic physics principles such as atom structure, electricity and magnetism, and electromagnetic radiation. It then covers imaging principles, radiation production and characteristics, digital image quality, imaging equipment, digital image acquisition and display, image analysis, and more- linking physics to the daily practice of radiographers. New for the third edition is updated information on radiation classifications, a shift in focus to SI units, and a thoroughly updated chapter on Fluoroscopic Imaging. UPDATED! Content reflects the newest standards outlined by the ARRT and ASRT, providing you with the information you needed to pass the boards. Chapter Review Questions at the end of every chapter allow you to evaluate how well you have mastered the material in each chapter. Critical Thinking Questions at the end of every chapter offer opportunity for review and greater challenge. Critical Concept boxes further explain and emphasize key points in the chapters. Radiation Protection callout boxes help you understand the ethical obligations to minimize radiation dosages, shielding, time and distance, how to limit the field of exposure and what that does to minimize dose, and technical factors and how they affect the primary beam and image quality. More than 400 photos and line drawings encourage you to visualize important concepts. Strong pedagogy, including chapter objectives, key terms, outlines, bulleted chapter summaries, and specialty boxes, help you to organize information and focus on what is most important in each chapter. An emphasis on the practical information highlights just what you need to know to ace the ARRT exam and become a competent practitioner. Numerous critique exercises teach you how to evaluate the quality of radiographic images and determine which factors produce poor images. NEW! A shift in focus to SI units aligns with international system of measurement. UPDATED Information regarding radiation classifications helps you to understand radiation levels. NEW! Inclusion of advances in digital imaging helps familiarize you with state-of-the-art images. NEW and UPDATED! Expanded Digital Fluoroscopy chapter, familiarizes you with the equipment you will encounter.

This book provides detailed practical guidelines on how to develop an efficient pathological brain detection system, reflecting the latest advances in the computer-aided diagnosis of structural magnetic resonance brain images. Matlab codes are provided for most of the functions described. In addition, the book equips readers to easily develop the pathological brain detection system further on their own and apply the technologies to other research fields, such as Alzheimer's detection, multiple sclerosis detection, etc.

This issue of PET Clinics focuses on Breast Cancer: Uses and Opportunities for Molecular Imaging, and is edited by Drs. Elizabeth McDonald and Gary A. Ulaner. Articles will include: Overview of Breast Cancer Screening and Diagnosis; Nuclear Imaging for Osseous Staging; Therapeutic Role of FDG in Breast Cancer: Treatment Response; Clinical Potential of HER2 Receptor Imaging; Novel Targets for Imaging Breast Cancer: Amino Acid Imaging with Fluciclovine; Overview of Breast Cancer Therapy; Molecular Classification of Breast Cancer; Clinical Potential of Estrogen and Progesterone Receptor Imaging; Diagnostic Role of FDG in Breast Cancer: Discovery to Current; Imaging Breast Cancer Proliferation; Dedicated Breast Gamma Camera Imaging and Breast Positron Emission Tomography: Current Status and Future Directions; and more!

This issue of Neuroimaging Clinics of North America focuses on Ischemic Stroke, and is edited by Dr. Lotfi Hacein-Bey. Articles will include: Clinical distinction of cerebral ischemia and triaging of patients in the ED: mimics, wake-ups, late strokes and chameleons; Telestroke; CT, CTA and CT perfusion of acute stroke; MRI based imaging of acute stroke; Advanced neuroimaging of acute stroke: collaterals, permeability imaging, Arterial Spin Labeling; Penumbra, oligemia, infarction: understanding hypoperfusion with neuroimaging?; Pathophysiology of thrombus and clinical implications; Neuro-interventional management of stroke; Non interventional treatment options for stroke; What to look for on post-stroke neuroimaging; Reperfusion changes after stroke and practical approaches for neuroprotection; Economics of stroke treatment (value-based payment models and other); Health care organization of neuroradiological management of stroke at regional and national levels: the French experience; and more!

This issue of MRI Clinics of North America focuses on Advanced Musculoskeletal MR Imaging, and is edited by Drs. Roberto Domingues and Flavia Martins Costa. Articles will include: Quantitative Whole Body MRI; Multiparametric Bone Marrow Imaging; MET-RADS-P in Practice; Whole Body MRI Beyond Oncology; Whole Body Imaging in Multiple Myeloma; MRI Neurography in Musculoskeletal Disorders; MR Imaging in Rheumatology; Multiparametric MRI of Soft Tissue Tumors and Pseudotumors; Multiparametric MRI of Benign and Malignant Bone Tumors; MR Imaging of Fetal Musculoskeletal Disorders; MRI at Rio 2016 Olympic and Paralympic Games: Our Experience using State-of-the-art 3.0 T and 1.5 T Wide-bore MRI Scanners in High Performance Athletes; Ultrasound and Advanced MRI Fusion for Musculoskeletal Tumors Biopsy; and more!