This handbook provides clinical guidance to the practicing physician on the diagnosis and treatment of Interstitial Lung Diseases (ILD). A contributed work with invited chapters which draw on the knowledge and experience of recognised global leaders in respiratory medicine, it is authoritative, concise and portable and is intended for use in a fast-paced clinical setting. The book: offers practical tips and clear guidance for clinicians provides detailed explanations of the main therapeutic options for each individual ILD contains high-quality visuals, including radiology and histopathology of the most common as well as some of the rarer ILDs discusses individual ILDs and has topics common to all including critical care, lung transplantation and palliative care navigates clinicians through cases with decision making guidelines and algorithms includes appendices with international practice guidelines, sample patient information sheets and other helpful resources. Emphasizing how to perform a thorough assessment of an ILD patient for accurate diagnosis and their subsequent effective management, this is both a gold standard text as well as a daily companion for physicians caring for ILD patients. A first-of-its-kind, it will become the go-to guide for all clinicians who manage patients with ILD.

An in-depth knowledge of the wide spectrum of normal gallbladder appearances is vital to appropriate clinical workup and the correct diagnosis of patients with upper abdominal symptoms. This book covers the range of appearances of the normal gallbladder and its variants, including discussions of anatomy, embryology, and imaging techniques to promote a better understanding of the subject. Anomalies of number, location, and form are each addressed in separate chapters, and discussions of imaging artifacts of the gallbladder and pseudolesions, which can mimic gallbladder disease, are also included. A short chapter on the appearance of the fetal gallbladder is included to round out this comprehensive volume.

Written by a multidisciplinary group of contributors, including radiologists, emergency physicians, critical care specialists, anesthesiologists, and surgeons, Fundamentals of Emergency Ultrasound is a first-of-its-kind reference that clearly explains the many technical nuances and diagnostic skills necessary for optimal use of ultrasound in emergency settings. This concise, easy-to-read resource covers both non-invasive and invasive ultrasound-guided procedures for a wide range of adult and pediatric trauma and non-trauma conditions. A practical emphasis on differential diagnosis helps facilitate rapid diagnosis, triage, and disposition decisions in emergency situations where ultrasound can be used. Provides a depth of understanding and interpretation from a multidisciplinary group of chapter authors, with step-by-step details on anatomy, equipment considerations, positioning, technique, normal and abnormal findings, and common pitfalls. Covers invasive procedures and ultrasound-guided injections such as thoracentesis, paracentesis, nerve blocks, and central and peripheral venous access. Includes correlative CT, MR, and Doppler images to enhance ultrasound visualization, in addition to more than 500+ high-quality ultrasound images and 75+ line drawings. Offers up-to-date coverage on the e-FAST, trans-thoracic and trans-esophageal echocardiography, pulmonary, and cranial sonography, among other emergency modalities. Features more than 150 ultrasound video clips that show the many nuances of ultrasound use. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This comprehensive and topical volume presents a number of significant advances on many fronts in this area of research, particularly emphasizing current and future biomedical applications of electromagnetic fields.

This innovative textbook is modelled on problem-based learning. It bridges the gap between academic neuroanatomy and clinical neurology and effectively takes the reader from the classroom to the clinic, so that learning can be applied in practice. This second edition has been updated and expanded to include many more clinical cases within both the book and the accompanying Wweb site. This book and the associated Web site will be of practical value to all the professionals who deal with people who have neurological conditions, as well as being invaluable to medical students and residents. This includes physiatrists (rehabilitation medicine specialists), physiotherapists, occupational therapists and speech therapists, and nurses who specialize in the care of neurological patients. We think that this text will also be of value for family physicians and specialists in internal medicine and pediatrics, all of whom must differentiate between organic pathology of the nervous system and other conditions.

This textbook covers the full spectrum of tuberculosis-related topics in a comprehensive yet easy-to-follow, readily accessible format. Filling a significant gap in tuberculosis literature, it addresses tuberculosis sensu latu, mirroring the content of the London Queen Mary University tuberculosis Diploma. Covering all aspects related to this condition, from prevention, diagnosis and treatment to public and global health, the book provides a broad overview of tuberculosis management. Further, it includes a wealth of case studies and exercises, making it an essential guide for all staff involved in tuberculosis management. Written by an international and interdisciplinary panel of experts, the book appeals to a broad readership including students, postdoctoral fellows, clinicians, researchers, and nurses, as well as public health officers working in tuberculosis control programs.

Radiation dosimetry has made great progress in the last decade, mainly because radiation therapy is much more widely used. Since the first edition, many new developments have been made in the basic methods for dosimetry, i.e. ionization chambers, TLD, chemical dosimeters, and photographic films. Radiation Dosimetry: Instrumentation and Methods, Second Edition brings to the reader these latest developments. Written at a high level for medical physicists, engineers, and advanced dosimetrists, it concentrates only on evolvement during the last decade, relying on the first edition to provide the basics.

Tumors and cancers are insidious diseases characterized by uncontrolled growth of abnormal cells that extend beyond their usual boundaries and disrupt the normal functions of affected organs. Forming the second of the four volumes devoted to tumors and cancers, this volume focuses on the head/neck, cardiovascular, respiratory and digestive systems. Each chapter presents a state of the art summary of tumor/cancer of a particular organ/type in relation to its definition, biology, epidemiology, disease mechanism/pathogenesis, clinical signs, diagnosis, treatment and prognosis.

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Oncology, second edition, is an invaluable resource for radiologists and surgical and medical oncologists-anyone who requires an easily accessible, highly visual reference covering cancer imaging and staging. A team of renowned experts in radiology, oncology, and body imaging provide carefully updated information and an abundance of high-quality images throughout, making this edition a useful learning tool as well as a handy reference for daily practice. Features nearly 3,000 annotated images, including lavish, full-color graphics for each cancer stage and many new illustrations throughout Brings you up to speed with updated TNM and grading tables from the new American Joint Committee on Cancer (AJCC) Cancer Staging Manual and updated WHO classifications Includes new chapters covering radiological staging of tumors recently introduced in the AJCC 8th edition and new chapter divisions that reflect the current AJCC staging system Provides practical, easy-to-find details on routes of spread, imaging techniques, suggestions for treatment based on tumor stages identified in a patient's imaging studies, and extensive imaging examples of a variety of cancers in many different stages Begins each chapter with updated TNM staging tables from the AJCC followed by full-color graphic depictions of TNM criteria Uses bulleted, succinct text for quick comprehension of essential information, as well as a consistent chapter format offering an Overview, Relevant Pathology, Imaging Findings, Clinical Issues, Reporting Checklist, and Selected References Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

All radiologists need a thorough understanding of the principles of physics underlying the equipment the use. Radiodiagnosis embraces a range of equipment using ever more sophisticated physical properties. Increasing emphasis is being placed on physics in all postgraduate examinations in radiology. This book provides in a concise and comprehensive format the principles of physics necessary for an understanding of modern radiodiagnosis. It is an examination oriented book intended for all studying for postgraduate examinations in radiodiagnosis.

The proposed book aims to explain the basic principles, concepts and regulations behind radiation protection and their application in the field of radiation oncology practice. This book will be useful to all those students, teachers and practicing professionals involved in the field of radiation oncology.

This book introduces advanced and hybrid compression techniques specifically used for medical images. The book discusses conventional compression and compressive sensing (CS) theory based approaches that are designed and implemented using various image transforms, such as: Discrete Fourier Transform (DFT), Discrete Cosine Transform (DCT), Discrete Wavelet Transform (DWT), and Singular Value Decomposition (SVD) and greedy based recovery algorithm. The authors show how these techniques provide simulation results of various compression techniques for different types of medical images, such as MRI, CT, US, and x-ray images. Future research directions are provided for medical imaging science. The book will be a welcomed reference for engineers, clinicians, and research students working with medical image compression in the biomedical imaging field. Covers various algorithms for data compression and medical image compression; Provides simulation results of compression algorithms for different types of medical images; Provides study of compressive sensing theory for compression of medical images.

This book provides radiology trainees a valuable insight into the new Final Fellowship of the Royal College of Radiologists (FRCR) Part A examination format. It is a comprehensive collection of practice questions to aid thorough preparation for the examination.

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Breast, third edition, is an invaluable resource not only for radiologists, but for all health care professionals involved in the management of breast disease. From screening and diagnostic mammography and tomosynthesis, ultrasound, and MR to contrast-enhanced mammography and molecular imaging, Drs. Wendie Berg and Jessica Leung, along with their expert author team, provide carefully updated information in a concise, bulleted format. Thousands of high-quality illustrations highlight not only image acquisition and interpretation, but also screening guidelines, breast anatomy, genetic testing, image-guided procedures, determining the extent of disease and much more. This book provides essential, clinically-focused details for everyday breast imaging. Features more than 4,000 annotated, updated images throughout, including imaging findings complemented by histopathologic and clinical correlates of the spectrum of breast disease Provides timely coverage of less common but important topics such as gender reassignment, disease-causing mutations and risk assessment, malignancy in pregnancy, nodal disease in breast cancer care, and male breast disease Discusses new technologies, including abbreviated MR, contrast-enhanced mammography, and automated breast ultrasound Includes updated information on evolving medical, oncologic, surgical, and radiation, and oncoplastic treatment of the breast cancer patient, along with discussion of ongoing trials and future directions Offers expanded and updated information on dense breast reporting, screening recommendations, patients at elevated risk, and imaging paradigms in patients with dense breasts, as well as analysis of various updated breast cancer screening guidelines Uses bulleted, succinct text for fast and easy comprehension of essential information Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Most postgraduate examinations now include radiographic interpretation. This may be presented as a slide show of as a film-viewing session. Radiographs and other imaging modalities are also used ubiquitously in the viva' section of most such examinations including those of the American Boards and professional societies and universities worldwide. This series of Clinical Film Viewing will assist candidates to prepare for this process. Each book examines a particular system or technique followed by profusely illustrated cases typical of those presented in postgraduate examinations. The Cardiovascular System is aimed at candidates for postgraduate examinations in all specialties and especially those doctors with some training in cardiovascular disease who need to assess their knowledge of the subject. This book is particularly applicable to candidates for postgraduate examinations in radiology.

Functional MRI: Basic Principles and Emerging Clinical Applications provides an overview of the basic principles of fMRI for clinicians with minimal knowledge of the imaging technique and its research potential and clinical applications. The text is divided into two parts, with Section I covering the primary signal measured in fMRI (BOLD), the correlation between neuronal activity and the BOLD signal, and how the data is analyzed and interpreted in fMRI. Section II explores applications of fMRI in cognitive neuroscience and common psychiatric disorders, surgical planning in neurosurgery, anesthesia and the intensive care unit, and more. Timely and highly accessible, this book is a valuable resource for researchers and clinicians interested in understanding what fMRI is, how it works, and its applications.

This book is the product of a unique collaboration by experts from leading international, regional and national agencies and professional organizations discussing on the current 'hot' issue on the judicious use and safety of radiation in radiology. There have been several cases involving radiation overexposure that have received international attention. Strategies and solutions to guide readers how to maximize the benefits and minimize the risks when using radiation in medicine are covered.

The application of radiation to medical problems plays an ever-increasing role in diagnosis and treatment of disease. It is essential that medical physicists have the knowledge, understanding and practical skills to implement radiation protection as new techniques are developed. Practical Radiation Protection in Healthcare provides a practical guide for medical physicists and others involved with radiation protection in the healthcare environment. The guidance is based on principles set out in current recommendations of the International Commission for Radiological Protection and methods developed by a variety of professional bodies. Written by practitioners experienced in the field this practical reference manual covers both established techniques and new areas of application. This new edition has be fully revised and updated to cover new requirements linked to the increased knowledge of radiation effects, and the development of new technology. Each specialist area is covered in a separate chapter to allow easy reference with individual chapters being assigned to different types of non-ionising radiations. Tabulated data is included to allow the reader to carry out calculations for situations encountered frequently without reference to further texts.

Fascinated by X-rays and medical imaging technology? Drawn to work that helps others? PRINCIPLES OF RADIOGRAPHIC IMAGING: AN ART AND A SCIENCE, 6th Edition reveals the inner workings of radiography careers, including radiologist assistants, radiologic technologists, ultrasound techs, CT and MRI techs, and other imaging roles in health care. Some books dump too much on you too fast, but this one moves at your pace, delivering the math and physics behind radiology before advancing to complex subjects. And it's designed around actual job skills like creating the beam, running scans and tests, and analyzing images--so you can pass accreditation exams and work in emergency rooms and hospitals. Reader-friendly yet packed with information, this text offers all you need to know about digital radiography systems, digital exposure factors, instrumentation and so much more!

This simple, jargon-free text fits in your pocket, providing an 'on-the-spot' guide to clinician-performed ultrasound in the emergency department, intensive care unit or in the field. Written by an international team of experts and comprehensively updated in its third edition, Emergency Ultrasound Made Easy brings together in one volume the latest indications for focused ultrasound, including those related to the COVID-19 pandemic. The text is highly accessible and easy to use in an emergency. It is aimed at the rapidly expanding cohort of non-radiologist clinical sonographers who use focused ultrasound. However, its broad scope (for example using ultrasound in the rapid diagnosis of DVT) makes it an invaluable addition to the library of any doctor with an interest in the technique, whether in primary care or the hospital setting. Simple to read and follow Free of jargon Fast step-by-step guide to ultrasound procedures Clear diagrams Tips and pitfalls to avoid Multiple accompanying videos featuring examples of ultrasound in clinical practice New chapter on the use of ultrasound in small anatomical structures such as the eyes and testes New chapter on paediatric ultrasound Respiratory chapter updated to include COVID-19 Multiple accompanying videos featuring examples of ultrasound in clinical practice New chapter on the use of ultrasound in small anatomical structures such as the eyes and testes New chapter on paediatric ultrasound Respiratory chapter updated to include COVID-19

Acquire a better understanding of disease evolution and treatment response with Neuroradiology Spectrum and Evolution of Disease. The unique format includes carefully chosen clinical images that depict the pathologic evolution of disease from initial presentation across the continuum of progression. Colorful graphics plot characteristic changes, helping you visualize how normal and abnormal variations alter over time. Extensive illustrations and concise descriptions distill complex concepts, making this first-of-its-kind resource an excellent tool for imaging interpretation and clinical problem solving. Presents neurologic disease from a novel imaging perspective, emphasizing evolutionary development and pointing out patterns to recognize. Provides a state-of-the-art understanding of image interpretation based on early, middle, and late imaging characteristics; typical and atypical variants; and pre-treatment, post-treatment, progression, and regression characteristics. Guides you through the progression of disease with chronological indicators, additional clinical images and descriptions, and annotations that highlight atypical findings - for an easy-to-digest, visually memorable presentation. Helps you correctly interpret specific imaging characteristics you have never seen, even when the disease process is one you are familiar with. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Recently, the implication of biocompatible nanotechnologies has set the stage for an evolutionary leap in diagnostic imaging and therapy. In this scope, the book presents a comprehensive overview of the possible causes, diagnostic criteria, and treatment assessments of amyotrophic lateral sclerosis, and presents the recent findings using innovative, highly sensitive, and novel diagnostic molecular imaging approaches. In addition, the book offers new perspectives of an innovative and recently developed approach in neuroimaging using surface-enhanced nanoimaging microscopy, which can be a promising technique for early diagnosis and treatment assessments.

This book contains extended versions of papers presented at the international Conference VIPIMAGE 2009 - ECCOMAS Thematic Conference on Computational Vision and Medical Image, that was held at Faculdade de Engenharia da Universidade do Porto, Portugal, from 14th to 16th of October 2009. This conference was the second ECCOMAS thematic conference on computational vision and medical image processing. It covered topics related to image processing and analysis, medical imaging and computational modelling and simulation, considering their multidisciplinary nature. The book collects the state-of-the-art research, methods and new trends on the subject of computational vision and medical image processing contributing to the development of these knowledge areas.

The applications of image-based measurement are many and various: image-guided surgery, mobile-robot navigation, component alignment, part inspection and photogrammetry, among others. In all these applications, landmarks are detected and located in images, and measurements made from those locations.Precision Landmark Location for Machine Vision and Photogrammetry addresses the ubiquitous problem of measurement error associated with determining the location of landmarks in images. With a detailed model of the image formation process and landmark location estimation, the Cramer-Rao Lower Bound (CRLB) theory of statistics is applied to determine the least possible measurement uncertainty in a given situation.This monograph provides the reader with: the most complete treatment to date of precision landmark location and the engineering aspects of image capture and processing; detailed theoretical treatment of the CRLB; a software tool for analyzing the potential performance-specific camera/lens/algorithm configurations; two novel algorithms which achieve precision very close to the CRLB; an experimental method for determining the accuracy of landmark location; and, downloadable MATLAB registered] package to assist the reader with applying theoretically-derived results to practical engineering configurations. All of this adds up to a treatment that is at once theoretically sound and eminently practical.Precision Landmark Location for Machine Vision and Photogrammetry will be of great interest to computer scientists and engineers working with and/or studying image processing and measurement. It includes cutting-edge theoretical developments and practical tools so it will appeal to research investigators and system designers.

Advances and Technical Standards in Neurosurgery was conceived in 1972byitsfoundingfathersJeanBrihaye,BernardPertuiset,FritzLoew andHugoKrayenbuuhlatacombinedmeetingoftheItalianandGerman NeurosurgicalSocietiesinTaormina. Itwasdesignedtocomplementthe Europeanpost-graduatetrainingsystemforyoungneurosurgeonsandwas ?rst published in 1974 initially through sponsorship by the European AssociationofNeurosurgicalSocieties. Allcontributionshavebeenp- lishedinEnglishtofacilitateinternationalunderstanding. Theambitionofallsuccessiveeditorialboardshasbeentoprovidean opportunityformaturescholarshipandre?ection,notconstrainedbyar- ?ciallimitsonspace. Theseriesprovidesaremarkableaccountofprogress overthepast35years,bothwithregardtoadvances,detaileddescriptions of standard operative procedures and in- depth reviews of established knowledge. Thepresentvolumeisnoexceptionandshouldappealtoboth experiencedneurosurgeonsandyoungneurosurgeonsintrainingalike. TheEditors Contents Listofcontributors...XIII Advances Present and potential future adjuvant issues in high-grade astrocytic glioma 1,2 1 1 2 1 treatment. F. LEFRANC ,M. RYNKOWSKI,O. DEWITTE,andR. KISS, Department ofNeurosurgery,ErasmeUniversityHospital,FreeUniversityofBrussels(U. L. B. ), 2 Brussels,Belgium, LaboratoryofToxicology,InstituteofPharmacy,FreeUniversity ofBrussels(U. L. B. ),Brussels,Belgium Abstract...4 Introduction...5 Naturalresistanceofmigratingmalignantgliomacellstoapoptosis (radiotherapyandchemotherapy)...6 Patternsofcelldeath...8 Autophagy:apotentialTrojanhorseformalignantgliomas...11 Therapeuticbene?tsoftemozolomide...13 Localtherapiesforglioblastomas...15 Ongoingclinicaltrialsforglioblastomas...16 Growthfactorreceptorinhibitors ...17 PI3K=Akt,mTORandNF- Binhibitors...17 Matrixmetalloproteinase(MMP)inhibitors(MMPI)...18 Angiogenesistargeting ...19 Cellularandvaccinationtherapies...20 Genetherapy...20 Reducingmalignantgliomacellmotilityinordertorestore pro-apoptoticdrugsensitivity...20 Thesodiumpumpconstitutesapotentialtargettocombat malignantgliomas...21 Thesodiumpump...22 Cardiotonicsteroids:ligandsofthesodiumpump...24 VIII Contents Thesodiumpumpisinvolvedincancercellproliferation, migrationanddeath...24 Braintumorstemcellsapotentialtargettocombatmalignantgliomas...26 Conclusions...27 References...2 8 Deepbrainstimulationforpsychiatricdisorders-stateoftheart. T. E. SCHLA APFER and B. H. BEWERNICK, Brain Stimulation Group, Department of Psychiatry and Psychotherapy,UniversityHospitalBonn,GermanyandDepartmentsofPsychiatry andMentalHealth,TheJohnsHopkinsUniversity,MD,USA Abstract...37 Introduction...38 Historyofdeepbrainstimulation...39 PrinciplesofDBS...40 NeurobiologyofdepressionandOCD...41 Neurobiologyofdepression...41 NeurobiologyofOCD...42 StudiesofDBSandpsychiatricdisorders...43 Problemsintargetselection...43 Targetsindepression...43 TargetsinOCD ...46 SafetyandadvantagesofDBS...47 EthicalaspectsandstandardsinDBS...51 Ethicalconsiderations...51 ThepathtowardsmandatorystandardsforDBSinpsychiatricdisorders...52 Conclusions...53 ThefutureofDBS...54 References...54 Standards High?owextracranialtointracranialvascularbypassprocedureforgiantan- rysms:indications,surgicaltechnique,complicationsandoutcome. H. C. PATEL and P. J. KIRKPATRICK, Department of Academic Neurosurgery, Addenbrooke's Hospital,UniversityofCambridge,Cambridge,UK Abstract...61 Introduction...62 Surgicaltechnique...67 Cranialexposure...69 Cervicalexposure...70 Saphenousveinexposure...71 Preauriculartunnel...7 2 Contents IX Anastamoses...73 Distalanastamosis...73 Externalcarotidanastamosis...74 Closureandpostoperativecare...77 Discussion...77 Comparisonofoutcomes...77 Choosingthetypeofgraft...78 Longtermpatencyofgrafts...79 Ischaemiccomplications...79 Anticoagulationrelatedmorbidity...81 Conclusion...