Various aspects, including diagnosis, therapy, and prognosis, of two brain tumors (meningioma and schwannoma) , of brain tumors are discussed in this volume. Insights on the understanding of molecular pathways involved in brain tumor biology are explained. For example, the role of E-cadherin gene instability, carbonic anhydrase 11, urokinase plasminogen activator, and Wnt signaling is discussed in detail. Such information will lead to the development of effective aniicancer drugs. The role of molecular genetics and epigenetic mechanisms in schwannomas is explained. Also, is explained the role of cyclin D1 in vestibular schwannoma. The determination of subtypes of meningiomas using perfusion magnetic resonance imaging is explained. Diagnosis of incidentally discovered meningioma and cystic papillary meningioma is also included. Diagnosis of facial nerve schwannoma, vestibular schwannoma, and intermediate nerve schwannoma is explained. Treatments for atypical meningioma, oncocytic meneingioma, intracranial meningioma, and cavernous are presented. Therapeutic methods such as neurosurgery, Gamma knife radiosurgery, and adjuvant radiation for this cancer are included. Large number of other treatments, including radiosurgery, retrosigmoidal craniotomy, and immunotherapy, for vestibular schwannoma patients are detailed.

Imaging of the spine is given a thorough update in this issue, beginning with an article on spine segmentation, enumeration and normal variants.? Imaging of degenerative disease of the spine is then reviewed, giving consideration to appropriate utilization of imaging, specificity and sensitivity shortcomings in evaluation of degenerative disease, risks and benefits of imaging of degenerative disease, and the prevalence of radicular? and? xial pain and underlying? pain generators.? Next, the validity and socioeconomic? impact of spine imaging in evaluating "degenerative? pain syndromes is reviewed.? Pathophysiology and biomechanics of disc and posterior element of degenerative disease is reviewed, along with imaging of radiculopathy / radiculitis, ? imaging of central canal stenosis, and imaging of discogenic pain (using MRI and discography). Imaging of joint related axial pain, spine neoplasm, spine infection, and non-acute trauma is also covered

This issue reviews and updates a variety of topics in pancreatic imaging.? Pearls on the Multiphasic CT of the pancreas are offered, along with the key MRI techniques for pancreatic imaging. Emerging CT, MR and US techniques for pancreatic evaluation (such as dual energy, DCMRI, spectroscopy, and US contrast) are elucidated.? Ultrasound for pancreatic imaging is given a thorough review.? An update on staging and resectability of pancreatic adenocarcinoma is discussed.? Acute and chronic pancreatitis are reviewed, as well as cystic pancreatic lesions, congenital pancreatic anomalies, uncommon solid pancreatic neoplasms, and other pancreatic pathology. Post-operative imaging of the pancreas is discussed, and finally, an update on endoscopic techniques for the pancreas is provided.

The application of ultrasound technology to obstetric and gynacologic issues figures as one of the staples of this imaging modality. This issue of Ultrasound Clinics features the following articles: Demystifying Ovarian Cysts; Fetal Measurements and Anatomy; Fetal Echocardiography; Management of Threatened Miscarriage; Gestational Trophoblastic Diseases; Sonographic Depiction of Ovarian And Uterine Vasculature; Postmenopausal Endometrial Bleeding; and Pediatric Gynecologic Ultrasound. Acute Right Lower Quadrant Pain, and Early Anatomy Ultrasound.

Accurate interpretation of indications for treatment is the cornerstone of success in medicine. This book carefully examines the relation between clinical features, diagnosis, and choice of minimally invasive technique for a range of spine pathologies. It explains how selection of technique is intimately related to clinical and diagnostic aspects and how recognition of this relation forms the foundation for an optimal outcome. In addition to examining the various minimally invasive options, including the latest techniques, careful attention is paid to the role of medical treatment in avoiding recurrence after initial therapy. Nerve blocks, epidural injections, and intradiscal procedures are among the many options available in the armamentarium of the interventionalist, and advice is given on their use in different contexts. This volume will be of great value for neuroradiologists and others responsible for treating patients with spine disorders.

This issue of Radiologic Clinics updates the reader with the latest clinical information on the imaging of bone and soft-tissue tumors.? An article on how to approach patients with bone lesions leads off the issue followed by reviews of analysis of solitary lesions of bone, imaging of benign bone tumors, imaging of primary malignant bone tumors, and imaging of hematopoietic tumors and metastases involving bone.? Soft tissue tumors are also reviewed in articles from the clinician's perspective and with the use of MRI.? The use of MRI in the imaging of children with soft tissue masses is also covered.? Articles on mimics of bone and soft tissue tumors, biopsy and intervention, post-therapy imaging, and advanced MRI techniques round out the issue.

PET/CT holds great promise for the management of many types of infection and inflammation.? This issue discusses many of these uses, starting with arthroplasty-associated infection.? FDG PET/CT also has utility in inflammatory bowel disease.? This issue also discusses the utilization of FDG PET and PET/CT in the evaluation of diabetic foot, and in monitoring therapeutic effect in patients without malignancy. PET/CT is reviewed regarding its use in patients with sarcoidosis or IgG4 disease.? Also covered is the application of FDG PET/CT in detecting the source of fever of unknown origin. Artherosclerosis and vasculitis can be assessed by PET/CT and FDG PET/CT can also be used in the management of severe infection in patients with malignancies.? Finally, the issue discusses the use of PET and PET/CT in the evaluation of osteomyelitis.

Because of the number and variety of illnesses that can affect the pediatric respiratory system, being able to interpret thoracic images of children is important for the general radiologist.? This issue of Radiologic Clinics starts off with an overview of lung and pleural infections.? Reviews of small and large airway diseases are followed by separate articles on the uses of ultrasound, MR, and nuclear medicine to image pediatric patients.? Also included are articles on lung and vascular anomalies, thoracic trauma, and cardiac disease.? The issue is completed with articles on fetal lung imaging and radiation safety.

This issue covers a wide range of topics related to genitourinary imaging, across a variety of imaging modalities.? An update is given on dual-energy CT in urologic imaging.? Imaging of the retroperitoneum is also discussed. Imaging of infectious and inflammatory diseases of kidneys is reviewed, as is imaging of the features of common and uncommon neoplasms of the bladder.? Multimodality imaging of the ureter, unusual renal masses, and adrenal imaging are all addressed in detail.? Finally, advances in pediatric urologic imaging are reviewed.

This issue provides a complete update on PET imaging of lymphoma, starting with a clinical assessment of lymphoma and the role of medical imaging. The role of structural imaging in lymphoma is then discussed.? From a Nuclear Medicine perspective, FDG-PET in lymphoma is reviewed, as is the role of FDG-PET in pediatric lymphoma.? Next, the role of non-FDG tracers in lymphoma is reviewed.? Other articles cover the role of fMRI and optical imaging in lymphoma, the role of diffusion-weighted MRI in lymphoma, FDG-PET in personalization of therapy in patients with lymphoma, and PET and radiation oncology in lymphoma.

Diseases once believed to be confined to the tropics, such as parasitic, mycobacterial, fungal, bacterial, and viral infections are still a major cause of mortality and moribidity in the tropics, yet can affect the developed world in an era of increased global travel and migration. Neuroimaging technique developments over the last several decades have helped clinicians better understand and diagnose these conditions. Experts from tropical countries share their experiences regarding tropical disorders, some of which are rare in the western world, but possible to appear in patients and not readily recognized by specialists not familiar with these diseases.

Topics in this issue include: Relevance of neuroimaging in the diagnosis and management of tropical neurologic disorders; Pathology of Tropical Diseases; Viral Infections of the Central Nervous System; Central Nervous System Tuberculosis; Parasitic diseases of nervous system; Neuroimaging in Post-infectious Demyelination and Nutritional Disorders of the Central Nervous System; CNS Fungal Infections in the Tropics; Neuroimaging Epilepsy in the Tropics; Neuroimaging in Cranio-Vertebral Anomalies as seen in Tropics; Vascular Brain Pathologies; Neurobrucellosis; Hirayama Disease; Transverse Myelitis; and Pyomyositis.

PET imaging has become an essential part of radiation therapy for cancer patients. Leading off the issue are articles on clinical applications and technical aspects. Following those are reviews of the use of PET in the treatment for lung cancer, gynecologic malignancies, GI and pancreatic tumors, and brain tumors, lymphoma, and head and neck malignancies. The final article addresses advances in hybrid imaging in planning of radiation therapy.

This issue provides an overview of the latest advances in imaging the fetus and pregnant patient using ultrasound. Reviewed in this issue are the use of US for screening of musculoskeletal, facial, and cardiac abnormalities. Planning for complicated deliveries, imaging of twins, and detecting growth abnormalities are just some of the other topics covered by this issue.

Topics covered in this issue are: Basic principles of Diffusion Imaging; Diffusion MR Imaging: An Important Tool in the Assessment of Brain Tumors; Diffusion MR imaging of Acute Ischemic Stroke; Diffusion Imaging in Demyelinating Diseases; Diffusion Imaging in Brain Infection; Diffusion Imaging in Brain Trauma; Diffusion Imaging in the Neonate Brain; Diffusion MR Imaging for Monitoring Treatment Response; Assessment of Brain Development; Future Horizons in Diffusion Imaging of the Brain.

Topics include: Imaging of Ischemic Stroke; Hemorrhagic Stroke and Non-traumatic Intracranial Hemorrhage; Acute Neuro-Interventional Therapies; Orbital and Intracranial Complications of Sinusitis; Traumatic Brain Injury; Central Nervous System Infections; Facial Trauma: What the Surgeon Wants to Know; Intracranial Hypo- and Hypertension; Seizures; Pediatric Central Nervous System Emergencies; Spine Emergencies; Infections and Inflammatory Processes of the Neck.

Endocrine imaging is covered extensively in this issue of Radiologic Clinics. Articles will include: Thyroid Ultrasound, Part 1: Technique and Diffuse Disease; Thyroid Ultrasonography, Part 2: Nodules; Thyroid: Nuclear Medicine Update; Thyroid Cytology: Challenges in the Pursuit of Low-Grade Malignancies; Diagnosis and Treatment of Differentiated Thyroid Carcinoma; Thyroid Carcinoma: The Surgeon's Perspective; Imaging Surveillance of Differentiated Thyroid Cancer; Parathyroid Imaging; Adrenal Imaging: From Addison to Algorithms; Imaging of Neuroendocrine Tumors; Imaging of the Pituitary, and more!

Ultrasound is a modality with broad applications in the imaging of the genitourinary tract.? Reviewed are the uses of US imaging the kidneys, prostate, scrotum, and bladder.? Also included are reviews of fetal genitourinary abnormalities, urinary tract infection, and tuberculosis.? The issue is rounded out with articles on contrast agents and on US-guided interventions.

This issue presents the use of PET imaging in the diagnosis, staging, and follow up of melanoma. Differentiation of early versus advanced stages of melanomaare reviewed in separate articles. As with other forms of cancer, assessing response to treatment is essential as well monitoring for recurrence. The issue also provides a glimpse into the future through a review of newer radionuclide tracers currently in development.

Imaging of the breast can be one of the most challenging tasks in all of radiology.? This issue not only covers all of the modalities (plain film, multislice CT, MRI, US, and nuclear medicine and molecular imaging it also provides discussions on the controversy regarding when women should be screened, the costs involved in breast imaging, and the appropriate use of screening.

Incidentalomas, or tumors discovered unintentionally by radiologists, are a problem that all radiologists face in their practice. This issue provides not only an overview of neoplasms of the CNS, liver, chest, kidneys, pancreas, and adrenal glands commonly discovered during radiologic examinations but also provides a framework for understanding the legal implications and cost considerations involved for radiologists.

This issue includes every subject relevant to neuroradiology that one may expect to encounter in a general emergency radiology practice. The most important concepts in emergent brain, spine, head & neck imaging, as well as pediatric nonaccidental trauma are reviewed, and the issue provides an excellent starting point for learning the fundamentals of emergency neuroradiology and can serve as a reference for those wishing to reinforce their current knowledge base.

Computed Tomography (CT) has recently gained in importance in the imaging of the heart.? A basis for the use of CT is provided with articles on normal anatomy as well as anomalies, patient preparation and scanning techniques, and technology and radiation dose reduction strategies.? Evaluation of plaques and stenosis, bypass grafts and stents, and myocardial abnormities and ischemia are reviewed.? Acute chest pain and congenital heart disease are just two of the other topics included in this issue.

This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.

This atlas is a comprehensive compendium of congeni and two-dimensional echocardiographic examples. The tal cardiac morphology as depicted by tomographic two examples and experience span all ages and may be used dimensional echocardiography. Anatomic specimens by both pediatric and adult cardiologists. The intended cut in planes of section corresponding to the echocar emphasis is on tomographic morphology and not on diographic views help in the understanding of the echo specialty applications such as fetal, contrast, or Dop cardiographic sections. Composite photographs relate pler echocardiography. different planes of section or cardiac events. Still-frame The tomographic approach to congenital anomalies is photography cannot always adequately relate real-time the imaging modality of the 80s and is applicable to echocardiography, computerized tomography, and imaging events. However, the emphasis of this text is to demonstrate the tomographic morphology and no at magnetic resonance imaging. It is the building block tempt is made to discuss in detail functional or physio from which the expected three-dimensional imaging logic events. techniques of the 1990s will be developed. The wide spread clinical application of these imaging modalities Those performing two-dimensional echocardiography should have a working knowledge of cardiac anatomy has rekindled interest in cardiac anatomy and pathol and common congenital aberrations. This is an in-depth ogy, particularly in the evaluation of patients with con tomographic atlas not only of the common congenital genital heart disease."