A comprehensive description of the current treatment modalities, and while special attention is paid to the role of radiotherapy, established alternative radical surgical procedures and the newer chemotherapeutic regimens are also considered in detail. Devoted entirely to female genital cancers, the book is written by internationally recognised experts from Europe, the United States, and Japan, who all have extensive experience of the special entities involved. Close to 200 tables present the impressive amount of data contributed by the authors in a clear manner and no attempt is made to avoid controversies concerning adequate treatment.

This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I Conference in 2006. Written by experts in the field, it addresses a critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that these findings will help readers to prevent and treat the long-term side-effects of irradiation.

Spine-related pain is the world's leading disabling condition, affecting every population and a frequent reason for seeking medical consultation and obtaining imaging studies. Numerous spinal phenotypes (observations/traits) and their respective measurements performed on various spine imaging have been shown to directly correlate and predict clinical outcomes. Atlas of Spinal Imaging: Phenotypes, Measurements and Classification Systems is a comprehensive visual resource that highlights various spinal phenotypes on imaging, describes their clinical and pathophysiological relevance, and discusses and illustrates their respective measurement techniques and classifications. Complies the knowledge and expertise of Dr. Dino Samartzis, the preeminent global authority on spinal phenotypes who has discovered and proposed new phenotypes and classification schemes; Dr. Howard S. An, a leading expert in patient management and at the forefront of 3D imaging of various spinal phenotypes; and Dr. Philip Louie, a young surgeon who is involved in one of the largest machine learning initiatives of spinal phenotyping. *Includes a Foreword by renowed spine surgeons Alexander Vaccaro and Max Aebi* Helps readers better understanding spinal phenotypes and their imaging, and how today's knowledge will facilitate new targeted drug discovery, novel diagnostics and biomarker discovery, and outcome predictions. Features step-by-step instructions on performing the radiographic measurements with examples of normal and pathologic images to demonstrate the various presentations. Presents clinical correlation of the phenotypes as well as the radiographic measurements with landmark references. Includes validated classification systems that complement the phenotypes and radiographic measurements. Complies the knowledge and expertise of Dr. Dino Samartzis, the preeminent global authority on spinal phenotypes who has discovered and proposed new phenotypes and classification schemes; Dr. Howard S. An, a leading expert in patient management and at the forefront of 3D imaging of various spinal phenotypes; and Dr. Philip Louie, a prolific surgeon who is involved in one of the largest machine learning initiatives of spinal phenotyping.

This issue of MRI Clinics of North America focuses on 7T MRI and is edited by Dr. Meng Law. Articles will include: 3T vs 7T MRI: Is It Really Worth It?; High Resolution Structural MRI & Quantitative Susceptibility Mapping; High Resolution Neurovascular Imaging at 7T: Arterial Spin Labeling Perfusion, 4-dimensional MR Angiography and Black blood MRI; 7T and Beyond Functional MRI; Sodium and Other UHF MRI; MR-EYE: Ultra High Field MRI of the Human Eye and Orbit at 7T; 7T MRI of Perivascular Spaces; 7T MRI in "Non Lesional" Epilepsy/ Perivascular Spaces; 7T Multiple Sclerosis; 7T Brain Tumors and Radiation Therapy; 7T Musculoskeletal MRI; Body Applications for 7T; MRI Safety at 7T/Implants; 7T Simultaneous MRI PET with PET Insert; GluCest 7T MRI; and more!

This issue of Neuroimaging Clinics of North America focuses on fMRI for the Diagnosis, Treatment and Management of Brain Tumors and is edited by Dr. Andrei I. Holodny. Articles will include: Introduction to fMRI; How to start your clinical fMRI program; Diffusion tractography; The problem of neurovascular uncoupling; Dynamic Resting State fMRI; Resting State fMRI of language function; Methods of fMRI analysis; Patient preparation and fMRI paradigm design; Functional brain anatomy; Neurosurgical Applications of fMRI; and more!

This new volume in the Radiotherapy in Practice series provides a comprehensive and evidence-based guide to radiotherapy in the management of children and young people with cancer. It explains the roles of the various modalities of treatment available, including image-guided and intensity modulated radiotherapy, brachytherapy, proton beam therapy, and molecular radiotherapy, and aids selection of the most appropriate technique in different situations. Each cancer type in children is explored, including diagnostic investigations, risk stratification, multi-modality approaches to treatment, and decision making with regard to radiotherapy. Specific guidance is given for the planning and prescription of radiotherapy for infants, children, and teenagers. The authors also identify the need for specialist paediatric radiotherapy service provision, and the wider requirements for radiotherapy in children, including consent, immobilisation, anaesthesia, multi-professional team working, and play specialist support. With over 75 colour illustrations, case histories to demonstrate the various approaches, and a carefully selected guide to further reading on each topic, this practical volume will be a valuable resource for physicians and trainees in radiotherapy and clinical oncology, and to nurses, radiographers and other allied health professionals who come into contact with young patients receiving radiotherapy. ABOUT THE SERIES Radiotherapy remains the major non-surgical treatment modality for the management of malignant disease. It is based on the application of the principles of applied physics, radiobiology, and tumour biology to clinical practice. Each volume in the series takes the reader through the basic principles of the use of ionizing radiation and then develops this by individual sites. This series of practical handbooks is aimed at physicians both training and practising in radiotherapy, as well as medical physics, dosimetrists, radiographers, and senior nurses.

This issue of Radiologic Clinics of North America focuses on Endocrine Imaging and is edited by Dr. Mark E. Lockhart. Articles will include: Molecular imaging in the head and neck: Diagnosis and therapy; Endocrine imaging: The referring clinician perspective; Thyroid disease in the age of incidental findings; Normal thyroid: US with technical pearls and pitfalls; Thyroid diffuse and nodular disease ultrasound; CT and MRI of thyroid disease; Multimodality imaging of neuroendocrine tumors; Neck, thyroid, and parathyroid imaging procedures; Parathyroid imaging; Neuroimaging of pituitary disease; Adrenal imaging; Neuroendocrine tumors: Imaging of treatment and follow-up; and more!

This issue of MRI Clinics of North America focuses on MR Safety and is edited by Dr. Robert E. Watson. Articles will include: Key elements of clinical MRI safety; Standardized approaches to MR safety assessment of patients with implanted devices; Performing MRI safely in patients with implanted electronic devices: cardiac electronic implanted devices and neurostimulators; Implanted devices: SAR considerations for common diagnostic examinations; Testing of commonly implanted devices for MR conditional labelling; MR safety in the 7T environment; Physics of MR safety; MRI safety considerations of gadolinium based contrast agents: gadolinium retention and nephrogenic systemic fibrosis; MRI safety: Siting and zoning considerations; Elements of effective patient screening to improve safety in MRI, including use of ferromagnetic detection systems; MRI safety in the interventional environment; MRI Safety: Pregnancy and Lactation; MR safety: Computer MRI simulations for testing of electronic devices; and more!

This issue of Neuroimaging Clinics of North America focuses on Artificial Intelligence and Machine Learning and is edited by Dr. Reza Forghani. Articles will include: A Brief History of Artificial Intelligence; Evolution of Approaches for Computerized Image Analysis; Overview of Machine Learning Part 1: Classic Approaches; Overview of Machine Learning Part 2: Artificial Neural Networks & Deep Learning; Overview of Natural Language Processing; Artificial Intelligence & Stroke Imaging: An East Coast Perspective; Artificial Intelligence & Stroke Imaging: A West Coast Perspective; Artificial Intelligence Applications for Brain Tumor Imaging; Diverse Applications of Artificial Intelligence in Neuroradiology; Artificial Intelligence Applications for Head and Neck Imaging; Artificial Intelligence Applications for Predictive Analytics and Workflow Optimization; Artificial Intelligence, Advanced Visualization, and 3D Printing; Ethical & Legal Considerations for Artificial Intelligence; Comprehensive (or 360) Artificial Intelligence: Beyond Image Interpretation Alone, and more!

This issue of PET Clinics focuses on Recent Advances in Imaging with PET, CT, and MR Techniques and is edited by Drs. Habib Zaidi, Abass Alavi and Drew A. Torigian. Articles will include: Total-body PET imaging: Developments in instrumentation; Prospects for total-body PET imaging using plastic scintillators; Total-body imaging: Potential clinical applications; New challenges for PET image reconstruction for total-body imaging; Advances in preclinical PET instrumentation; Applications of hybrid PET/MRI in CNS disorders; Applications of hybrid PET-MRI in MSK disorders; Assessment of total body atherosclerosis burden by PET-CT; Recent advances on CT and MR imaging in radiology; Potential impact of Total Body PET imaging in measuring global disease burden in systemic inflammatory disorders; Applications of PET-MRI in CV disorders; and more!

Advances in Clinical Radiology was established to review the year's most important questions in clinical radiology. A distinguished editorial board, headed by Dr. Frank Miller, identifies key areas of major progress and controversy, and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in radiology bring concepts to a clinical level and explore their everday impact on patient care.

This issue of MRI Clinics of North America focuses on Advanced MR Techniques for Imaging the Abdomen and Pelvis and is edited by Dr. Sudhakar Venkatesh. Articles will include: Advances in MR Elastography in Liver; Biliary Tract Imaging; Imaging of the Pancreas; PET/MRI Applications in Abdomen and Pelvis; Abbreviated MR Protocols for the Abdomen and Pelvis; Advances in MR Angiography of Abdomen and Pelvis; Advances in MRI of Prostate; Advances in MRI of the Female Pelvis; Advanced MR Techniques for Imaging the Abdomen and Pelvis; Texture Analysis and AI with MR in Abdomen and Pelvis; Advances in MRI of the Kidneys and Upper Urinary Tract, and more!

This issue of Neuroimaging Clinics of North America focuses on State of the Art Evaluation of the Head and Neck and is edited by Dr. Ashok Srinivasan. Articles will include: Diffusion MR in the head and neck: Principles and applications; Perfusion imaging in the head and neck: Go with the flow; MR spectroscopy of the head and neck: Principles, applications and challenges; Technological improvements in head and neck MR: At the cutting edge; Dual Energy CT in head and neck imaging: Pushing the envelope; Role of Ultrasound in head and neck evaluation; PET imaging in the head and neck: Current state and future directions; Patient centric head and neck cancer radiation therapy: Role of advanced imaging; AI in head and neck imaging: Glimpse into the future; NIRADS: Principles and implementation; Common data elements in head and neck reporting; and more!

This issue of Neuroimaging Clinics of North America focuses on Psychoradiology, and is edited by Dr. Qiyong Gong. Articles will include: Clinical Strategies and Technical Challenges in Psychoradiology; Resting State Functional MRI for Psychiatry; Magnetic Resonance Spectroscopy for Psychiatry; Psychoradiology of Major Depression; Psychoradiological Biomarkers for Psychopharmaceutical Effects; Implementing Imaging into Clinical Routine Screening for Psychosis; Imaging of Autism; Individual-specific Analysis for Psychoradiology; Interventional Psychoradiology: Imaging Guided Therapeutic Intervention of Neuropsychiatric Disorders; Imaging-based Subtyping for Psychiatric Syndromes; Imaging of Post-Traumatic Stress Disorder; Imaging of Schizophrenia; and more!

This issue of Radiologic Clinics of North America focuses on Imaging the Hospitalized Patient, and is edited by Drs. Travis S. Henry and Vincent M. Mellnick. Articles will include: Imaging of bowel wall thickening in the hospitalized patient; Imaging of acute hepatobiliary dysfunction; Imaging of GI tract perforation; Imaging of abdominal postoperative complications; Imaging of acute renal failure in the hospital setting; Imaging of diffuse lung disease in the ICU patient; Perioperative complications of cardiothoracic surgery; Approach to abnormal chest CT contrast enhancement in the hospitalized patient; Imaging of the misplaced venous catheter; Altered mental status in the hospitalized patient; Neuroimaging in the ICU patient: Pearls and pitfalls; Imaging of cardiovascular support; and more!

This issue of PET Clinics focuses on Evolving Role of PET in Assessing the Efficacy of Immunotherapy and Radiation Therapy in Malignant Disorders, and is edited by Drs. Charles B. Simone II, Nicolas Aide, and Abass Alavi (the Consulting Editor of PET Clinics). Articles will include: The Value of PET Imaging to Guide Target Delineation for Radiation Oncology; PET Imaging to Determine Radiation Dose, Adapt Radiation Plans, and Predict Patterns of Failure and Overall Survival for Non-small Cell Lung Cancer; The Utility of PET/CT for Radiation Oncology Planning, Surveillance, and Prognosis Prediction for Gastrointestinal Tumors; Evolving Role of PET Based Novel Quantitative Techniques to Detect Radiation-induced Complications; Current and Future PET Based Quantitative techniques to Assess Response to Radiation Therapy; Diagnosis, Staging, Radiation Treatment Response Assessment, and Prognostication; FDG PET/CT for Assessing Tumour Response to Immunotherapy and Detecting Immune-related Side Effects: A Checklist for the PET Reader; PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers; FDG PET/CT for Assessing Tumour Response to Immunotherapy in Lymphomas; FDG PET/CT for Assessing Tumour Response to Immunotherapy in Solid Tumours: Melanoma and Beyond; and more!

This issue of Neuroimaging Clinics of North America focuses on Spine Intervention and is edited by Dr. Majid Khan. Articles will include: The Spine: Embryology and anatomy; Osteoporosis and tumoral spine involvement: Overview and diagnosis; Hot and cold spine tumor ablations; Vertebral compression fractures treatment with cement augmentation procedures; Sacral fractures and sacroplasty; Conventional image guided procedures for painful spine; Advanced image guided procedures for painful spine; Image guided percutaneous treatment of lumbar stenosis and disc degeneration; Overview, diagnosis and treatment of spinal CSF leak; Overview, diagnosis and treatment of Spine vascular malformation; Rapid onsite evaluation (ROSE) for spine biopsies; and more!

This issue of Radiologic Clinics of North America focuses on Imaging of the Upper Limb and is edited by Drs. Giuseppe Guglielmi and Alberto Bazzocchi. Articles will include: Functional and surgical anatomy of the upper limb: what the radiologist needs to know; Overuse injuries of the shoulder; The acutely injured shoulder; Overuse injuries of the elbow; The acutely injured elbow; Overuse injuries of the wrist; The acutely injured wrist; Imaging of rheumatic diseases affecting the upper limb; Imaging of upper limb tumours and tumour-like pathology; Imaging the post-surgical upper limb, the radiologist perspective; MR imaging of the upper limb: pitfalls, tricks & tips; Ultrasound imaging dynamic evaluation of the upper limb; Upper limb intervention; Imaging of peripheral nerves; and more!

This issue of Neuroimaging Clinics of North America focuses on Brain Embryology and the Cause of Congenital Malformations and is edited by Drs. Thierry A.G.M. Huisman and Avner Meoded. Articles will include: Neuroimaging of normal brain development; Ultrasound and MRI of the normal fetal brain; Spinal dysraphia, Chiari 2 malformation, unified theory and advances in fetoscopic repair; Posterior fossa malformations; Synopsis of brain embryology; Cerebral dysplasia and overgrowth syndromes; Disorders of ventral induction/spectrum of holoprosencephaly; Classification and neurogenetics of intracranial vascular anomalies; DTI of brain malformations: Exploring the internal architecture; Connectomics in brain malformations: How is the malformed brain wired?; Commissural anomalies; and more!

This issue of PET Clinics focuses on PET in the Management of Hematologic Malignancies and is edited by Drs. Abass Alavi (the Consulting Editor of PET Clinics), Gary Ulaner, Jakub Svoboda, and Lale Kostakoglu. Articles will include: PET-CR as a surrogate to replace PFS in assessment of efficacy of DLBCL treatments; PET-Derived Quantitative Metrics for Response and Prognosis; Evolving Role of PET Based Novel Quantitative Techniques in the Management of Hematological Malignancies; Critical Role of FDG/NaF imaging in Assessment of Skeletal Involvement in Patients with Multiple Myeloma; Response adapted treatment strategies in Hodgkin lymphoma using PET scans; FDG PET/CT as a staging tool in multiple myeloma; FDG PET/CT as a predictor of prognosis in multiple myeloma; PET/CT as a response evaluation tool in multiple myeloma; PET imaging in CLL and Richter's transformation; Current Overview and Future Directions of PET for Hematologic Malignancies; and more!

This issue of Neuroimaging Clinics of North America focuses on Emergent Neuroimaging: A Patient Focused Approach, and is edited by Dr. Diego B. Nunez. Articles will include: The adult patient with acute neurologic deficit: an update on imaging trends; The patient with thunderclap headache; Imaging considerations in the patient with intracerebral hemorrhage; Emergent neuroimaging in the oncologic and immunosuppressed patient; Emergent neuroimaging during pregnancy and puerperium; Imaging the unconscious "found down" patient in the ED; Neurological emergencies in the pediatric patient including accidental and non-accidental trauma; Head and neck injuries: special considerations in the elderly patient; Current challenges in the use of CT and MRI in suspected cervical spine trauma; Radiation considerations in emergent neuroimaging; Blunt cranio-cervical trauma: Does the patient have a cerebral vascular injury?; New and emerging patient-centered CT imaging and image-guided treatment paradigms for maxillofacial trauma; Acute neurological syndromes beyond stroke: The role of emergent MRI; and more!

This issue of PET Clinics focuses on Gynecologic Oncology, and is edited by Drs. Drew Torigian and Domenico Rubello. Articles will include: The role of CT and MRI in gynecologic oncology; The utility of ultrasonography in gynecologic oncology; FDG-PET assessment of cervical cancer; FDG-PET assessment of ovarian cancer; FDG-PET assessment of other gynecologic cancers; The role of PET imaging in gynecologic radiation oncology; The utility of non-FDG PET in gynecologic oncology; Normal variants and pitfalls encountered in PET assessment of gynecologic malignancies; The role and future of quantitative imaging assessment in gynecologic oncology; Emerging molecular imaging techniques in gynecologic oncology; and more!

This issue of the Surgical Oncology Clinics of North America is devoted to Practical Radiation Oncology and is Guest Edited by Dr. Christopher Willett. Articles in this issue include: Radiotherapy After Mastectomy; Contemporary Radiotherapy in Head and Neck Cancer; Image Guided Brachytherapy: An Update for Gynecologic Surgeons; Radiation Therapy in the Current Management of Anal and Rectal Cancer; Novel Approaches to Treatment of Hepatocellular Carcinoma and Hepatic Metastases Using Thermal Ablation and Thermosensitive Liposomes; Contemporary Integration of Radiation Oncology with Surgery as Combined Modality Treatment; Chemoradiation Therapy: Localized Esophageal, Gastric, and Pancreatic Cancer; Stereotactic Body Radiotherapy for the Treatment of Primary and Metastatic Pulmonary Malignancies; Radiotherapy and Radiosurgery for Tumors of the Central Nervous System; Practical Radiation Oncology for Extremity Sarcomas; Radiation Therapy for Prostate Cancer; and Present and Future Innovations in Radiation Oncology.

Brachytherapy remains an important component of radical radiation therapy in the modern management of cancer. Widespread adoption of remote afterloading now enables brachytherapy to be delivered with minimum exposure to staff and other patients. Technical advances in imaging and computing power have improved the precision of implantation and complex dosimetry can now be achieved in routine practice. The advantages of direct placement of the radiation source into the area to be treated, overcoming the problems of patient and organ movement, together with the dosimetric advantages inherent in brachytherapy, will ensure that modern brachytheraoy continues to provide the optimal means of delivering accurate high does radiation therapy for many patients.
Fully updated for the second edition, this book provides practical guidance on the use of brachytherapy. Each chapter gives the reader a solid background in the physics and dosimetry of the technique, followed by practical information on its use in common disease sites. Whilst low, medium, and high dose rate techniques are covered, emphasis is placed on high dose rate afterloading techniques which are likely to replace most other forms of brachytherapy in the future.
ABOUT THE SERIES:
Radiotherapy remains the major non-surgical treatment modality for the management of malignant disease. It is based on the application of the principles of applied physics, radiobiology, and tumour biology to clinical practice. Each volume in this series takes the reader through the basic principles of the use of ionising radiation and then develops this by individual sites. This series of practical handbooks are aimed at physicians both training and practising in radiotherapy, as well as medical physicists, dosimetrists, radiographers and senior nurses.

Walter and Miller's Textbook of Radiotherapy is a key textbook for therapeutic radiography students as well as trainee clinical and medical oncologists, clinical physicists and technologists. The book is divided into 2 sections. The first section covers physics and provides a comprehensive review of radiotherapy physics. This section is designed to be non-physicist friendly, to simply and clearly explain the physical principles upon which radiotherapy and its technology are based. The second section is a systematic review by tumour site giving an up to date summary of radiotherapy practice. The title also covers the place of chemotherapy, surgery and non-radiotherapy treatments as well as the principles of cancer patient treatment including supportive care and palliative treatments. It is a comprehensive must-have resource for anyone studying therapeutic radiotherapy. Highly illustrated in full colour including 350 photographs. Clearly and simply explains the fundamental physics for clinicians Gives an up to date summary of radiotherapy practice organised by tumour site making it very easy to navigate. Describes the wide range of devices and clearly explains the principles behind their operation. Comprehensively explains the calculation models of dose predictions for treatment preparation. Heavy emphasis on how clinical trials have influenced current practice. Shows how radiobiological knowledge has influenced current practice such as the fractionation regimens for breast and prostate cancer Proton therapy; machines, dose measurement, covering the clinical advantages and pitfalls of this treatment modality. New radiotherapy modalities such as stereotactic radiotherapy, types of intensity modulated radiotherapy and imaged guided radiotherapy are comprehensively covered as are recent advances in chemotherapy and molecular targeted therapy. In depth coverage of dose measurement and new devices.