As the definition of palliative-intent radiation therapy (RT) continues to evolve, the application of advanced radiotherapeutic technologies, such as intensity-modulated RT, and techniques, such as image-guidance, are no longer the provision solely of the curative realm. Treatment options previously considered strictly palliative are expanding, with conventional RT being delivered in conjunction with other modalities such as highly conformal radiation, surgery or systemic therapy, or being bypassed entirely. Additionally, as the median survival rate for many primary cancer histologies improve, more and more patients are outliving the palliative benefit of their first course of RT, making re-irradiation a commonly encountered scenario. Many factors should be taken into account when making RT treatment decisions, including those incorporating advanced technologies, such as individualised considerations of symptom burden, extent of disease, life expectancy, performance status, comorbidities, toxicity, prior treatment, and patient wishes. However, while palliative RT should be appropriately customised for each patient, it should also have a convincing evidence base. To date, research investigating the optimal use of palliative RT has been strikingly underrepresented, especially considering it comprises up to 50% of a department's workload. This book reviews state of the art in palliative radiation therapy across all disease sites, discussing available evidence supporting the use of advanced technologies and related clinical and dosimetric outcomes. Areas in which practice diverges from available evidence, as well as those in which no supporting evidence exists, are described. Many chapters include a historical overview highlighting lessons learned from past experience and techniques. Additionally, where specific palliative literature does not exist, generalisable excerpts from the curative setting are examined as well. Also, key practice points pertinent to management approaches and decisions, treatment planning and other clinical pearls are summarised by over 60 international experts from three continents, often incorporating a multinational and/or multi-institutional perspective. A foundational chapter reviewing these technologies is complimented by sections on their use in each primary cancer site, along with chapters focusing on emerging techniques such as stereotactic radiation, clinical settings such as oligometastases, and patient-reported outcomes including quality of life and toxicity. Clinical trial methodology applicable to palliative RT, prognostication, health services research, and the interface of radiation oncology with palliative care in the 21st century are highlighted. Finally, a concluding chapter provides an overview of clinical contexts in which conventional radiation therapy or best supportive care may be favoured.

Written and edited by internationally recognised leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Lung cancer, which was rare at the beginning of the 20th century, is now a major cause of cancer-related deaths in men and women. It is the most frequently diagnosed cancer in the world. With conventional radiation therapy, small doses of radiation are delivered on a daily Monday-to-Friday schedule over a period of approximately a month and a half. After receiving this therapy, some reversible side effects, such as local skin irritation, are common. Robotic stereotactic radiotherapy is based on the principle of delivering high doses of radiation to the tumor while sparing or avoiding the surrounding tissues, which has been one of the greatest limiting factors of conventional radiation therapy historically. Given the advancements in technology, the reproducibility of patient positioning and the capability to deliver radiation from hundreds of different directions while synchronizing respiration-induced target motion, this technology is now proposed as a new local treatment, completed in less than one week, with promising results.

In this issue of MRI Clinics, guest editors Drs. Erica B. Stein and Kim L. Shampain bring their considerable expertise to MR Imaging of the Adnexa. Top experts in the field cover key topics such as MR imaging of ovaries: from puberty to menopause; MR imaging of Mullerian anomalies; MR imaging of epithelial ovarian neoplasms; MR imaging of germ cell and sex-cord stromal neoplasms; and more. Contains 12 relevant, practice-oriented topics including MR imaging of endometriosis; MR imaging of mimics of adnexal pathology; MR imaging of the adnexa: technique and image acquisition; MR of fallopian tubes; MR imaging of acute adnexal pathology; and more. Provides in-depth clinical reviews on MR imaging of the adnexa, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Interventional Oncology is a fast-growing new field, as well as an emerging specialty. Many minimally-invasive, imaging-guided procedures seem set to replace more traditional open surgical techniques of treating solid tumors in a variety of organs. The aim of this book is to describe new interventional radiological methods in a succinct and practical form. Diagnostic radiological considerations relevant to the selection and follow-up of patients are also covered. The book begins with an overview of the basic principles of current interventional techniques, including thermal ablation, high intensity focused ultrasound, and embolization. Later chapters focus on tumors of the liver, kidney, lung, and bone, placing new interventional techniques in context by referring to the surgical and oncologic methods of treating the same conditions. With an emphasis on best practices, Interventional Oncology: A Practical Guide for the Interventional Radiologist will serve as a definitive guide to practicing physicians involved in this rapidly evolving field.

Radiofrequency Ablation of Cancer: Current Indications, Techniques and Outcomes discusses the principles and techniques of safe usage of radiofrequency current for the treatment of malignancies. Throughout the text, indications and outcomes data are stressed. Edited and authored by pioneers in the field, the book features extensive discussion of RFA for hepatic tumors, including treatment of liver metastases from colorectal cancer, combined modality therapy for liver metastases, treatment of hepatocellular carcinoma with RFA, laparoscopic RFA, percutaneous RFA, and hepatic metastases from neuroendocrine tumors. In addition, chapters consider the emerging role of RFA in the management of primary breast cancer, primary bone tumors as well as metastatic bone tumors, renal tumors, and lung tumors. The principles and instrumentation as well as the imaging aspects of RFA are presented with comprehensive chapters on ultrasound, MRI, PET and CT by leaders in the field. Complemented by 90 illustrations, this text is the gold standard reference on the use of RFA in treating a wide variety of malignant processes. It will serve as a valuable reference for all physicians engaged in the care of cancer patients.

Fallon Bentley's life outside the fence seemed perfect and was often envied. Yet her journey was like walking through a garden of china roses, fearing every step. Her family, her friends, her soul, the future lay in the balance. How would she survive? Fallon had a choice - conquer her cancer or the government. Her decision: BOTH! Those who said, she would never win these battles, had never walked a step in her shoes. Her determination - Endless. Her mind echoed a story, a continuous maze of moments set in time, building a stairway to a destiny...a future...unknown. Her new found voice of wisdom and an angelic spiritual connection removed the word "No" from her vocabulary forever. Yet with her new found wisdom and spiritual connection, would the growing mystery in her life be revealed?

TO THE ENGLISH EDITION Ionizing radiation has played an important role in the treatment of skin diseases for many decades. With strict adherence to modern standards of radiation protection, radiotherapy is a safe and effective method that benefits many patients who cannot be treated adequately by other means. Although indications for dermatologic radiotherapy have decreased significantly due to advances in other therapeutic modalities, many dermatologists feel strongly that ionizing radiation is an integral part of dermatologic therapy that should not be relinquished to other specialties because of the highly specialized anatomic, pathologic, and technologic knowledge required. A recent survey of the National Program for Dermatology showed that 44% of 2,444 responding dermatologists use radiotherapy regularly for various skin conditions, particularly in the treatment of cutaneous carcinomas. Significantly, the American Board of Dermatology has decided to continue its requirement of special knowledge in dermatologic radiation therapy for board certification. Because I have taught this dermatologic subspecialty at various levels, both in Europe and in the United States, I readily agreed to accept Pro fessor Braun-Falco's invitation to cooperate with him and Dr. Lukacs in the preparation of the English edition of this new guide. The text deals mostly with modern concepts of dermatologic radiotherapy and empha sizes practical aspects of treatment. Although it is written as an introduc tion for young dermatologists, it may also be useful to experienced clinicians who want to keep up with recent developments in this field."

Das Buch informiert uber die operative und konservative Therapie samtlicher Stadien des Harnblasenkrebses. Entsprechend der grossen Bedeutung der histologischen Einschatzung der Tumorausbreitung und Boesartigkeit wird die pathologische Anatomie des Harnblasenkarzinoms ausfuhrlich dargestellt. Bei den operativen Verfahren steht die transurethrale Tumorresektion im Vordergrund. Eine Verbesserung der operativen Behandlung, insbesondere der fortgeschrittenen Stadien des Harnblasenkrebses, bieten die Methoden der integrierten Therapie. Hierzu gehoeren Chemo- und Strahlentherapie, aber auch die neuesten Verfahren wie die lokale Hyperthermie. Insbesondere die komplizierte integrierte Therapie nimmt in dem Buch breiten Raum ein. Bei den Einzeldarstellungen der verschiedenen tragenden Saulen der integrierten Therapie (Operation, Chemotherapie, Strahlenbehandlung und Hyperthermie) wird ubergreifend versucht, das Ineinanderspiel der verschiedenen Therapieformen deutlich zu machen. Die Laserbehandlung, die photodynamische Therapie sowie der Stand der Immuntherapie werden ihrer Bedeutung entsprechend abgehandelt. Die praxisnahe, ubersichtliche Darstellung des Themas macht das Buch fur Urologen und andere, mit dem Problem befassten AErzte in Klinik und Praxis zu einem aktuellen Nachschlagewerk und Ratgeber.

Radiation Oncology Concepts is a book intended for medical students, general practitioners, and other allied health professionals interesting in learning more about the biology, physics and techniques used in radiation oncology. With a variety of patients receiving radiation as a curative or pallative treatment means, it is important to understand the foundation of this subspecialty. Many new techniques are being introduced to make radiation oncology one of the most cutting edge fields of medical practice.

Ein Team renommierter Experten stellt in diesem umfassenden Praxis-Leitfaden die moderne Therapie des Prostatakarzinoms aus urologischer und strahlentherapeutischer Sicht dar.
- Radikale Prostatektomie
- Palliativtherapie
- PSA-gesteuerte Therapie
- Grundlagen und klinischer Einsatz kombinierter urologisch-strahlentherapeutischer Strategien
Mit seinem topaktuellen, interdisziplinaren Ansatz bietet das Praxis-Buch eine unentbehrliche Orientierungshilfe, um sich schnell und kompetent uber die neuesten Entwicklungen in der Therapie des Prostatakarzinoms zu informieren."

From the Foreword: The second edition of this pocket-sized resource for radiology nurses continues to demystify complex procedures by providing concise yet comprehensive information on the basics of radiology. As the complexity of healthcare grows, so too does imaging ability. Different modalities, technologies, and skills levels must all work in harmony to provide precision images. Radiology nurses must be proactive, patient-focused, and able to work with a diverse team of individuals to care for the widest range of patients. Describing essential procedures and protocols in quick access style, Fast Facts for the Radiology Nurse, Second Edition covers over 50 different Interventional Radiology procedures. Woven throughout is an emphasis on interprofessional care and effective communication along with guidance on forming and maintaining a high-performing team. Abundant Clinical Pearls disseminate the hard-earned wisdom of expert radiology nurses. Extensively updated with the most current guidelines and protocols, the second edition presents four completely new chapters on Legal Issues Affecting Radiology, Strategies for Working with Difficult People, Safety and Quality in the Radiology Setting, and Emergency Management and Catastrophe Response. New to the Second Edition: Updated with the most current guidelines and protocols New chapter: Legal Issues Affecting Radiology New chapter: Strategies for Working with Difficult People New chapter: Safety and Quality in the Radiology Setting New chapter: Emergency Management and Catastrophe Response Updated information on sedation and analgesia in easy-to-read tables Key Features: Serves as an accessible, easy-to-use reference for practicing radiology nurses and orientees Highlights essential protocols and procedures with bullets and short paragraphs Provides abundant "Fast Facts" boxes displaying key information Discusses strategies for providing safe care Includes clinical pearls from radiology experts Addresses patient care in all radiology domains and with specific patient populations Covers vascular access issues and emergency situations

This book focuses on the conventional and emerging applications of radiations, which include radio waves and ultraviolet and gamma radiations. It discusses new techniques in radiation therapy and the effects of ionizing radiations on biological systems. The applications of radiations in the synthesis and use of nanoparticles along with the effects of hypergravity indicate a new trend. The book offers a concise account of the latest studies carried out so far and shows the new initiatives to be undertaken in the field of medicine and biology. It covers the medical use of radiations, such as ferrous sulfate-benzoic acid-xylenol orange dosimetry, Co-60 tomotherapy, radio-electro-chemotherapy, and fractional radiotherapy, and radiobiological effects, such as the effects of cell phone radiations on human health parameters and the combined effects of radiations and hypergravity on plants.

Der Erfolg einer onkologischen Therapie hangt wesentlich von der Kenntnis der moglichen Nebenwirkungen ab. Dieses Wissen steht Ihnen jetzt schnell griffbereit in dieser einzigartigen Zusammenstellung zur Verfugung.
In ubersichtlicher Tabellenform, mit zweisprachiger Systematik Deutsch/Englisch und praktischen Formblattern hilft Ihnen dieses handliche Taschenbuch
o die Qualitat verschiedener Therapieverfahren gezielt zu beurteilen,
o Nebenwirkungen prazise zu erfassen und exakt zu dokumentieren,
o mit diesen Daten Ihre Therapie-Entscheidungen schnell, flexibel und patientengerecht zu treffen.
"Aus dem Geleitwort" ..".Daher wunschen wir diesem Werk eine weite Verbreitung im deutschsprachigen Raum. Es sollte im Interesse unserer Patienten von allen onkologisch Tatigen regelmassig in Praxis, Klinik und Forschung genutzt werden. Jeder an dieser Thematik verantwortlich Beteiligte wird es bei seiner taglichen Arbeit als wertvoll und immer unverzichtbarer ansehen." (M. Bamberg, Tubingen; R.-P. Muller, Koln; K. Hoffken, Jena; Th. Junginger, Mainz; P. Hermanek, Erlangen)
"

As the definition of palliative-intent radiation therapy (RT) continues to evolve, the application of advanced radiotherapeutic technologies, such as intensity-modulated RT, and techniques, such as image-guidance, are no longer the provision solely of the curative realm. Treatment options previously considered strictly palliative are expanding, with conventional RT being delivered in conjunction with other modalities such as highly conformal radiation, surgery or systemic therapy, or being bypassed entirely. Additionally, as the median survival rate for many primary cancer histologies improve, more and more patients are outliving the palliative benefit of their first course of RT, making re-irradiation a commonly encountered scenario. Many factors should be taken into account when making RT treatment decisions, including those incorporating advanced technologies, such as individualised considerations of symptom burden, extent of disease, life expectancy, performance status, comorbidities, toxicity, prior treatment, and patient wishes. However, while palliative RT should be appropriately customised for each patient, it should also have a convincing evidence base. To date, research investigating the optimal use of palliative RT has been strikingly underrepresented, especially considering it comprises up to 50% of a department's workload. This book reviews state of the art in palliative radiation therapy across all disease sites, discussing available evidence supporting the use of advanced technologies and related clinical and dosimetric outcomes. Areas in which practice diverges from available evidence, as well as those in which no supporting evidence exists, are described. Many chapters include a historical overview highlighting lessons learned from past experience and techniques. Additionally, where specific palliative literature does not exist, generalisable excerpts from the curative setting are examined as well. Also, key practice points pertinent to management approaches and decisions, treatment planning and other clinical pearls are summarised by over 60 international experts from three continents, often incorporating a multinational and/or multi-institutional perspective. A foundational chapter reviewing these technologies is complimented by sections on their use in each primary cancer site, along with chapters focusing on emerging techniques such as stereotactic radiation, clinical settings such as oligometastases, and patient-reported outcomes including quality of life and toxicity. Clinical trial methodology applicable to palliative RT, prognostication, health services research, and the interface of radiation oncology with palliative care in the 21st century are highlighted. Finally, a concluding chapter provides an overview of clinical contexts in which conventional radiation therapy or best supportive care may be favoured.

This is a comprehensive learning tool for medical students, residents, and junior attending physicians in radiation oncology. Organised in chapters and sections by site, the book covers in detail all the sites and cancer types currently treated with radiotherapy. Emphasis is on treatment recommendations and the evidence behind them. Moreover, this book provides easily accessible information for residents and practitioners in radiation oncology. It presents the most essential information that is immediately required in the clinical setting. Important data of epidemiology, anatomy, pathology, and clinical presentation are highlighted. Key facets of the work-up are listed, followed by staging and/or risk classification systems. Treatment recommendations are discussed based on stage, histology, and/or risk classification. Brief summaries of key trials and studies provide rationale for the recommendations.

This is a comprehensive learning tool for medical students, residents, and junior attending physicians in radiation oncology. Organised in chapters and sections by site, the book covers in detail all the sites and cancer types currently treated with radiotherapy. Emphasis is on treatment recommendations and the evidence behind them. Moreover, this book provides easily accessible information for residents and practitioners in radiation oncology. It presents the most essential information that is immediately required in the clinical setting. Important data of epidemiology, anatomy, pathology, and clinical presentation are highlighted. Key facets of the work-up are listed, followed by staging and/or risk classification systems. Treatment recommendations are discussed based on stage, histology, and/or risk classification. Brief summaries of key trials and studies provide rationale for the recommendations.

Meningiomas are the most frequently reported neuro-oncologic condition, accounting for 12% to 30% of all primary intracranial tumors. The first case of intracranial meningioma treated with stereotactic radiosurgery was reported by Backlund E-O in 1971. Since then, more than 200,000 meningiomas have been treated with stereotactic radiosurgery worldwide to date. The large number of patients treated using this method is due to the fact that meningiomas are frequently located in critical areas and microsurgery is often associated with severe and permanent neurological complications. This book discusses the advantages, risks and limits of stereotactic radiosurgery relating to all regions of interest for a neuroradiosurgical approach for the treatment of central nervous system meningiomas. Firstly, it presents an introduction focusing on the "state of the art". It then discusses the physics, imaging, neurological and neuro-oncological issues in multidisciplinary management. Lastly, it features a summary of results, including the most recent published papers regarding all the locations involved in the stereotactic radiosurgery treatment as well as new approaches to meningiomas, with particular reference to the hypofrationated treatments. Intended for anyone involved in the neuroradiosurgical treatment of brain diseases, the book provides an up-to-date overview of the latest stereotactic radiosurgery treatment of central nervous system meningiomas.

This second edition of the Oxford Handbook of Cancer Nursing is an essential aid to the practising cancer nurse. It provides a quick reference to the key issues in cancer nursing, and a concise and systematic account of all of the main areas of cancer nursing practice. Filled with key tips and reflection points, each chapter supports professional development for the reader. The patient, their family, and the experience of cancer are at the heart of this handbook. For the new edition there is a greater focus on survivorship, drawing on recent developments in the area. The Oxford Handbook of Cancer Nursing promotes a multidisciplinary approach to cancer care, with references to current best evidence and the latest developments in treatment. Detailed guidance on complex aspects of care are outlined, integrating both psychosocial and physical care to better treat the whole patient. Written by experienced nurses, the book is laid out to enable quick access to precise, targeted information on the vast majority of potential clinical scenarios.

In this issue of MRI Clinics, guest editor Dr. Ahmed Abdel Khalek Abdel Razek brings his considerable expertise to the topic of MR Imaging of Head and Neck Cancer. Top experts in the field cover key topics such as artificial intelligence and deep learning of head and neck cancer, MR imaging of salivary gland tumors, MR imaging of vascular malformations and tumors of the head and neck, and more. Contains 14 relevant, practice-oriented topics including the role of MR imaging in head and neck squamous cell carcinoma; MR imaging of nasopharyngeal carcinoma; MR imaging of oropharyngeal cancer and oral cavity tumors; MR imaging of laryngeal and hypopharyngeal cancer; MR imaging of nasal and paranasal sinuses tumors; and more. Provides in-depth clinical reviews on MR imaging of head and neck cancer, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Because the liver is a common site of metastatic spread, effective MR imaging of this organ is critically important for patients with cancer as well as those with chronic liver disease. In this issue of MRI Clinics, editors Khaled Elsayes (MD Anderson Cancer Center) and Claude Sirlin (UC San Diego Health's Liver Imaging Group) bring their considerable expertise to the topic of MR Imaging of Chronic Liver Diseases and Liver Cancer. Top experts in the field cover key topics such as artificial intelligence, diffuse liver disease, LI-RADS, and hepatocarcinogenesis. Provides concise and comprehensive coverage of the issues physicians face every day. Presents the latest information on a timely, focused topic under the leadership of experienced editors in the field. Contains 14 relevant, practice-oriented topics including Chronic liver disease; What the hepatologists, oncologists and surgeons want to know from radiologists; CT techniques, protocols, advancements and the future; Errors and misinterpretations in imaging of chronic liver diseases; and more.

This issue of MRI Clinics of North America focuses on MR Safety and is edited by Dr. Robert E. Watson. Articles will include: Key elements of clinical MRI safety; Standardized approaches to MR safety assessment of patients with implanted devices; Performing MRI safely in patients with implanted electronic devices: cardiac electronic implanted devices and neurostimulators; Implanted devices: SAR considerations for common diagnostic examinations; Testing of commonly implanted devices for MR conditional labelling; MR safety in the 7T environment; Physics of MR safety; MRI safety considerations of gadolinium based contrast agents: gadolinium retention and nephrogenic systemic fibrosis; MRI safety: Siting and zoning considerations; Elements of effective patient screening to improve safety in MRI, including use of ferromagnetic detection systems; MRI safety in the interventional environment; MRI Safety: Pregnancy and Lactation; MR safety: Computer MRI simulations for testing of electronic devices; and more!

Now in its second edition, this popular text remains a comprehensive study and review aid for the radiation oncology trainee and practicing radiation oncologist. The updated Radiation Oncology Study Guide, 2e maintains its robust Q&A format, and has been comprehensively updated to include the latest staging information and treatment methods. Answer rationales have been modified to a more readable, high yield bulleted format. Each chapter covers a major disease site and is divided into two main parts: Questions & Answers and Rationale. Questions review the scope of clinical practice, spanning from initial presentation to complications of treatment. General content and work-up questions emphasize "pearls" of epidemiology, anatomy, pathology, clinical presentation, and staging. Treatment content questions not only review evidence-based data guiding treatment recommendations, but also practical aspects of radiation treatment planning, pertinent radiobiology and physics, and complications of treatment. This book is an ideal resource for physicians-in-training to prepare for initial written and oral exams and physicians in practice to maintain their skills and prepare for maintenance of certification longitudinal and written exams.

This issue of MRI Clinics of North America focuses on Advanced MR Techniques for Imaging the Abdomen and Pelvis and is edited by Dr. Sudhakar Venkatesh. Articles will include: Advances in MR Elastography in Liver; Biliary Tract Imaging; Imaging of the Pancreas; PET/MRI Applications in Abdomen and Pelvis; Abbreviated MR Protocols for the Abdomen and Pelvis; Advances in MR Angiography of Abdomen and Pelvis; Advances in MRI of Prostate; Advances in MRI of the Female Pelvis; Advanced MR Techniques for Imaging the Abdomen and Pelvis; Texture Analysis and AI with MR in Abdomen and Pelvis; Advances in MRI of the Kidneys and Upper Urinary Tract, and more!