Rhinosinusitis is increasing in prevalence and incidence, and has been estimated to affect approximately 31 million patients in the United States each year. This comprehensive reference offers recommendations for the optimal treatment of chronic rhinosinusitis and indicates pathways for new research in the field. Offering an interdisciplinary approach to the topic, edited by an allergist and an otolaryngologist, this source discusses advances in the understanding of the pathophysiology of the diseases, as well as important diagnostic tools for the assessment of chronic rhinosinusitis. It also summarizes published studies of chronic rhinosinusitis management for evidence-based medical care.

Interpreting chest X-rays can seem baffling and intimidating for senior medical students and newly qualified doctors. This highly illustrated guide provides the ideal introduction to chest radiology. It uses 100 clinical cases to illuminate a wide range of common medical conditions, each illustrated with a chest X-ray and a clear description of the significant diagnostic features and their clinical relevance. Where appropriate CT scans and bronchoscopic imaging are also included as part of the investigation. Pulmonary medicine is largely based on a strong foundation on the plain chest radiograph. Indeed chest radiography is the single most common investigation done in hospital practice. This illustrated collection of case studies will help make the learning process easier and more enjoyable and less painful. As well as illuminating pearls of core knowledge in chest X-ray interpretation, it highlights some of the pitfalls that might wrong-foot the inexperienced practitioner.

Severe acute respiratory syndrome (SARS) is a devastating disease and although the virus would appear to have been contained, it is clear that the impact it has had around the world, and could have again in the future, is immense. Hong Kong has been significantly impacted in the recent SARS outbreak, and clinicians and researchers alike have gained a lot of experience in dealing with the disease at short notice. This new book aims to be a state-of-the art update on SARS, with particular reference to imaging, which plays a crucial role in the diagnosis, management and follow-up of patients with the disease (it is widely accepted that SARS patients cannot be managed without imaging and it is included in the WHO's own list of diagnostic criteria for the disease). The book will also provide a perspective on the treatment and experience of the disease outside Hong Kong.

This text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and allergic diseases, and offers unparalleled research from nearly 60 international contributors

Exploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders. Compiles previously unpublished data from the first extensive scientific investigations of Xolair! IgE and Anti-IgE Therapy in Asthma and Allergic Disease -reviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe -offers novel methods for the design and formulation of monoclonal antibodies -discusses the use of allergen bronchoprovocation to identify the characteristics and efficacy of new antiasthma and antiallergy medications -examines the role of IgE in food and parasitic allergies and covers -the pathogenesis of atopic dermatitis and urticaria -novel strategies to target mast cells and basophils -murine models of allergic pulmonary inflammation -the pathophysiology of allergic rhinitis Supplemented with nearly 2000 contemporary references to facilitate further study, IgE and Anti-IgE Therapy in Asthma and Allergic Disease is an in-depth and timely source for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medicalschool students in these disciplines.

Contents:
1. Reading of Chest Radiographs, Some Basic Anatomy and Physiology including, Pleural Fissures, Mediastinal Lines, The Bronchi and Para-Tracheal Lines, Hilar Anatomy, The Pulmonary Lobules, Acini and Lung Cortex, Distribution of Lung Disease in Relation to Anatomy and Physiology, Basic CT and Pathological Anatomy, Some Notes re Terminology 2. Lung Consolidation, Ground Glass Shadowing, Obstructive Emphysema, Collateral Air-drift, Mucoceles, Patterns of Collapse, Ling Torsion and Herniation 3. Tracheal and Bronchial Developmental Abnormalities, and Inflammatory Diseases including Bronchiectasis, Cystic Fibrosis and Bronchiolitis 4. Lung and Tracheo-Bronchial Tumours - main types (a) Historical Review and Some general Points, (b) Peripheral Tumours, Infection Complicating Tumours, (c) Central Bronchial Tumours, (d) Tracheal Tumours, Papillomas and Endobronchial Deposits 5. Less Common Lung and Bronchial Tumours; Bronchiolo-Alveolar Ca., Carcinoids, Hamartomas, reticuloses, Protein Disorders, Lung Deposits and Leukaemia 6. Cavitation, Thin-walled Cysts and Bullae, Their Association wih Tumours. Emphysema. Fat and Calcification. Spurious Tumours. Intravascular, Pulmonary Interstitial & Mediastinal gas, and Pneumoperitoneum 7. The Pulmonary and Bronchial Vessels, Pulmonary Vascular Abnormalities including Embolism, Pulmonary and Bronchial Angiography, and A/V Malformations 8. Pulmonary Oedema, Lymphangitis Carcinomatosa and ARDS 9. Systemic Veins of the Thorax 10. The Aorta and Related Disorders (except trauma) 11. Chest Trauma, Iatrogenic Trauma Including Drainage Tubes and Some Post-surgical Conditions and Complications of Radiotherapy 12. The Neck, Thoracic Inlet and Outlet, the Axillae and Chest Wall, the Ribs, Sternum and Clavicles 13. The Thoracic Lymphatic System and Lymph Nodes, and the Spread of Tumours within the Lungs, the Tracheobronchial Tree and the Mediastinum 14. The Extra-Pleural Spaces, including Plombages, Pleural Tumours and the Effects of Asbestos 15. The Phrenic Nerves, Diaphragm and Pericardium 16. The Oesophogus 17. The Spread of Chest Tumours to the Abdomen, and Some Abdominal Tumours to the Chest - also a consideration of some relevant abdominal conditions in different diagnosis, particularly of the Liver, Spleen and Pancreas 18. The Mediastinum (including pre-and para-spinal lines, neural tumours, andpneumomediastinum) 19. Inflammatory, Hypersensitivity and Immune Lung Diseases, Including Parasitic Diseases 20. Techniques for Chest radiography, Fluoroscopy, Tomography (including CT and MR) and Ultrasound 21. Biopsy etc. Procedures and Bronchography 22. Skletal, Muscle, Brain, etc. Deposits and Some Isotope Procedures 23. Hormonal and Para-Neoplastic Syndromes - also Skin Lesions 24. Lung Cancer (a) Diagnosis and causes, Smoking Habits, etc. (b) Types of Lung Cancer, Clinical and Radiological Features of the Different Types. Cell Types in the Lungs (c) The Radiologists' Role in the Investigation of Lung Cancer, TNM Staging, and the Value of Radiobiological Surveys of Screening for the Detection of Lung Cancer. (d) Patient Management - Possible Treatment Regimes and their Effects, Possible Surgery

Conducting studies of natural and man-made air contaminants is a specialized research activity that draws upon skills from a variety of disciplines including toxicology, pharmacology, industrial hygiene, and environmental health. Methods in Inhalation Toxicology describes how knowledge from these disciplines is integrated into the design and conduct of inhalation studies. Each of the vital aspects of conducting these studies is discussed in detail, including the use of animal subjects and the related quality control and ethical considerations, air purification methodology, exposure atmosphere generation and characterization, inhalation exposure systems, and real-time and post-exposure biological assessments. These methods will enable you to conduct inhalation studies, easily adding any specific measures of particular interest to your research.
The book covers techniques needed to:
provide suitable clean air for experiments
correctly generate the particles and gases being studied
select the proper exposure system
monitor the exposure
prepare tissues for study
ensure that animals do not have confounding lung disease
The helpful descriptions and detailed lists of suppliers of preferred equipment and materials will help you to perform valid, reproducible inhalation toxicology studies. Methods in Inhalation Toxicology is a perfect textbook for students in toxicology programs, as well as for scientists who conduct inhalation studies in both academic and industrial environments.

Audience
Postgraduates and researchers in the study of allergies, clinical immunology, chest diseases, pharmacology, physiology, and biochemistry.

This book represents a comprehensive update on pulmonary surfactant by merging classical knowledge with new information. Topics include surfactant secretion and alveolar processing and recycling; physical bases and different theoretical models of the physiological mechanism for pulmonary surfactant action; recent findings on surfactant-like material in other organs; developmental processes and multifactorial regulation; etiology and physiopathology of neonatal respiratory distress; and modern methods for functional explorations of the lung in neonates and experimental models in animals. The book also contains a discussion on the management of hyaline membrane disease, from both the experimental and clinical points of view.

This authoritative text on occupational lung disorders builds upon the fundamentals, including clinical, epidemiological, and predictive approaches. It discusses interstitial and malignant diseases, airways diseases, and other respiratory issues, such as diving, working at high altitudes, and abnormal sleep conditions. It also covers related long-term conditions, such as asthma and COPD. This edition has been completely revised and brought up to date for all physicians dealing with pulmonary disorders caused by the environment or the workplace. Print Versions of this book also include access to the ebook version.

This book provides an in-depth view on engineered nanomaterials (ENM) pulmonary effects and familiarizes readers with unique aspects of nanomaterial application and research, such as the effects of physicochemical properties on cellular uptake and toxicity. It focuses on the diagnostic and therapeutic utilities of nanomaterials in different lung diseases. The book discusses the novel applications of nanotechnology for the treatment of airway diseases such as asthma, allergy, chronic obstructive pulmonary diseases, cystic fibrosis, and lung cancer. It also discusses the strategies to overcome the pathophysiological and technical barriers as an attempt to synchronize the efforts of pulmonary biologists, chemists and clinicians to develop novel nano-based diagnostics, imaging, and therapeutics tools for airway diseases.

An ideal textbook for trainee and practising rhinologists and otolaryngologists, Practical Rhinology provides expert direction on all aspects of rhinology. Completely up-to-date, the text addresses the most pertinent aspects of contemporary rhinology and provides a distillation of the current advances in this superspecialty from several of the world's leaders in this field. This is a book to help the clinician during their day-to-day practice. There is an emphasis on clinical management and whilst it is written by a team of experienced international experts, it gives guidance on the management of common disorders and symptoms. General chapters on anatomy, pre- and post-operative management and overseeing complications are accompanied by skilled guidance on how to deal with specific surgical problems, such as anterior skull base surgery, the frontal sinus and nasal tumours. Further chapters provide invaluable information on topics including technical advances, paediatric conditions, CSF leaks, and orbital and lacrimal surgery. Chapters on how to interpret symptoms and the patient's perspective are also included to complement the key knowledge.

Using a multidisciplinary approach, Human Respiratory Viral Infections is set at the level between the definitive reference work and an essential clinical manual. Exploring recent advances in human respiratory viral research, the text builds on the basic sciences of epidemiology, virology, molecular biology, and immunology to cover clinical diagnosis, mechanism of pathogenesis, manifestations of disease, impact, treatment, and management strategies. Provides a comprehensive review of all the major human respiratory viral infections Supplies a detailed description of the anatomy of the respiratory system Discusses the salient features of specific viruses Examines the latest diagnostic tools Covers risk factors associated with incidence of respiratory viral infections in children and adults in different occupational and environmental settings Presenting the latest knowledge in human respiratory viral infections, this text will be immensely valuable for pulmonologists, biomedical scientists, research scholars, virologists, vaccinologists, immunologists, clinicians, pharmacologists, and public health specialists.

Packed with images depicting a range of laryngeal pathologies, this text explores the interesting features of many of the more common and clinically important vocal fold abnormalities seen in the clinic.

Most historians of tuberculosis have focused on the sanatorium era of the early twentieth century, losing interest in the disease with the discovery of curative antibiotics in the 1940s. In Contagion and Confinement, Barron H. Lerner offers the first in-depth look at the history of tuberculosis control in the antibiotic era, providing a vital account of this neglected chapter in the history of the disease. He argues that the new antibiotic drugs, rather than being a simple panacea, actually highlighted the complex social problems that continued to predispose people to tuberculosis and interfere with its treatment.

The most controversial strategy used by American health officers to control tuberculosis was forcible detention. Since 1903, Lerner notes, health departments have locked up tuberculosis patients whose behavior presented a public health threat. Using Seattle's Firland Sanatorium as a case study, he focuses on the surprisingly recent use of detention between 1950 and 1970. Although Firland planned to use confinement only as a last resort, Lerner explains, the facility detained nearly 2,000 patients, most of them alcoholics from Seattle's famous "Skid Road." In retrospect, it is clear that Firland staff members overused detention. But Lerner also finds that they worked hard to improve the lives of the alcoholic patients society had forgotten.

Given the resurgence of tuberculosis and the renewed use of detention in the 1990s, Contagion and Confinement raises issues that are both timely and controversial. Although modern public health officials are duly concerned with civil liberties, they still have great authority to detain tuberculosis patients who do not take theirantibiotics. Recent studies show that such persons are most likely to be homeless, HIV-positive, or drug users. Society is still struggling, Lerner concludes, to balance public health concerns with respect for patients.

This book brings together the expertise of respiratory physicians, critical care specialists, and surgeons to provide concise practical guidance on the perioperative management of patients with pre-existing respiratory disease. The authors begin with a review of key aspects of respiratory physiology, pre-operative assessment and preparation, then continue to discuss practical issues concerning airway management and respiratory monitoring. Also described are strategies for managing post-operative complications, and respiratory emergencies such as status asthmaticus, pulmonary hypertension, pneumothorax and respiratory failure. The text is supported throughout with diagnostic and therapeutic algorithms, checklists, and summary panels.

Why does tuberculosis, a disease which is both curable and preventable, continue to produce over 50,000 new cases a year in South Africa, primarily among blacks? In answering this question Randall Packard traces the history of one of the most devastating diseases in twentieth-century Africa, against the background of the changing political and economic forces that have shaped South African society from the end of the nineteenth century to the present. These forces have generated a growing backlog of disease among black workers and their families and at the same time have prevented the development of effective public health measures for controlling it. Packard's rich and nuanced analysis is a significant contribution to the growing body of literature on South Africa's social history as well as to the history of medicine and the political economy of health.

Cet ouvrage de la collection "Recherche Clinique et DA(c)cision ThA(c)rapeutique" est consacrA(c) aux mA(c)dicaments de la tuberculose chez l'enfant, thA]me retenu pour la NeuviA]me JournA(c)e de Pharmacologie Clinique PA(c)diatrique de l'HApital Saint-Vincent de Paul en Novembre 1998, organisA(c)e par GA(c)rard Pons, Dominique Gendrel et Jacques Grosset. Il fait le point sur la situation A(c)pidA(c)miologique actuelle de la tuberculose, l'importance de l'analyse rigoureuse des critA]res diagnostiques, la nA(c)cessitA(c) de la polychimiothA(c)rapie et la possibilitA(c) de traitements de plus courte durA(c)e, l'A(c)mergence de l'analyse des relations pharmacocinA(c)tiques-pharmacodyna- miques des mA(c)dicaments et de leur A(c)ventuel impact sur leur maniement pour obtenir l'efficacitA(c) sur l'oberservance du traitement. Il s'adresse aux pA(c)diatres, aux pharmacologues, aux bactA(c)riologistes, aux responsables de l'evaluation des mA(c)dicaments dans les A(c)tablissements de soins et dans l'industrie pharmaceutique.

Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide delivers a concise review of our current understanding of disease pathogenesis and provides current evidence in the medical literature regarding its diagnosis and management. Each chapter includes key points and a summary aiming to update clinicians about various issues concerning the diagnosis and management of IPF. In addition to outlining the current state of knowledge, each chapter also provides a summary of ongoing research and identifies the needs for future research in the field. Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide is an important new text that provides its readers with a better understanding of the pathobiology and natural history of IPF as it continues to evolve.

Chronic Obstructive Pulmonary Disease (COPD) is a disabling condition in which the patient 's airways become obstructed causing persistent and progressive breathlessness, which can greatly impair the ability to lead a normal life.

COPD is the sixth leading cause of chronic morbidity and mortality and is a major socio-economic burden in industrialized nations.

Although COPD cannot be cured, there are effective treatments that can greatly increase quality of life for patients, slow disease progression and prevent premature death from COPD or its complications.