In the global war to control tuberculosis (TB), there are several critical battles which must be waged and won if we are to make significant progress. Broadly speaking, these battlefields may be regarded as diagnosis, treatment and prevention. Within the arena of treatment are various critical elements. Current drug regimens require 6 months to achieve predictable cures; it is essential that shorter regimens be developed to lessen non-adherence and to improve affordability. To facilitate directly-observed therapy, intermittent (less than daily) regimens have been employed. To ensure favourable outcomes, including patients with AIDS, thrice-weekly regimens are the current standard; reducing the frequency of dosing to twice- or once-weekly may offer significant advantages. Drug resistance to the current major medications, the rifamycins and isoniazid, threatens to make tuberculosis untreatable for rising numbers of patients in many regions of the world. Finding new, effective agents is essential to ensure cures for these cases and to halt transmission of multidrug-resistant tuberculosis to others. Additional issues include reducing the side effects and toxicity of anti-tuberculosis regimens and developing regimens that can be given simultaneously with anti-retroviral therapy without deleterious drug-drug interactions or unacceptable toxicity. Finally, attention must be directed to the potential utility of treating latent infection to prevent the evolution of active disease. The current vaccine Bacille Calmette-Guerin (BCG), while protecting infants and children against potentially lethal forms of TB, has done little to control the incidence of communicable adult pulmonary disease. Research is underway to develop improved vaccines, but due to the prolonged period to determine the efficacy of a TB vaccine (a minimum of 10 to 20 years) -- alternative strategies must be pursued. Furthermore, the utility of a traditional vaccine would be sorely limited by the fact that roughly two billion persons today harbour latent tuberculosis infection. This huge reservoir of future disease would not be eligible for a traditional pre-infection vaccine. "Preventive therapy" with isoniazid has been shown to reduce the subsequent risk of tuberculosis by about 70% in large, randomised placebo-controlled clinical trials. However, this strategy is limited by the requirement for extended duration of treatment (6 to 9 months), the risks of drug-induced hepatitis and rising rates of resistance to isoniazid in many regions of the world where the TB epidemic is most intense. Alternative means for the treatment of latent tuberculosis infection should be given high priority. The authors have assembled an outstanding panel of contributors to address these issues. The topics herein have great relevance both in the industrialised nations where contemporary medications and strategies appear to have exacted their maximum benefits and for the developing nations where this ancient scourge remains rampant. This book will provide an impetus for authorities and organisations devoted to the development of new drugs to address the aforementioned growing problems of TB world-wide.

Asthma is a disease that affects the lungs. It causes repeated episodes of wheezing, breathlessness, chest tightness, and night-time or early morning coughing. Tens of millions of people throughout the world suffer from asthma. Airways are the paths that carry air to the lungs. As the air moves through the lungs, the airways become smaller, like branches of a tree. During an attack, the sides of the airways in the lungs become inflamed and swollen. Muscles around the airways tighten, and less air passes in and out of the lungs. Excess mucus forms in the airways, clogging them even more. The attack, also called an episode, can include coughing, chest tightness, wheezing, and trouble breathing. Environmental exposures, such as house dust mites and environmental tobacco smoke, are important triggers of an attack. This new book presents important new research on the causes on asthma as well as its diagnosis and treatment.

Lung cancer is the most common form of cancer in the world and a major cause of death. This new book brings together stellar research from around the world. The two main types of primary lung cancer, small cell and non-small cell are examined. The book's scope encompasses the three main types of non-small cell lung cancer: squamous cell carcinoma which is the commonest type of lung cancer and develops in the cells which line the airways; adenocarcinoma develops from the cells which produce mucus in the lining of the airways; and large cell carcinoma gets its name from the large, rounded cells that are seen when they are examined under the microscope. About 1 in 5 lung cancers are small cell, the rest non-small cell. Causes of lung cancer are primarily smoking, but include as well exposure to radon, asbestos, uranium, arsenic, and certain petroleum products. Research and new drugs are appearing with increasing frequency in this field.

Das vorliegende Buch prasentiert das gesamte klinische und wissenschaftliche Spektrum der neurologischen Beatmungsmedizin. Es wendet sich an alle AErzte, die beatmete neurologische Patienten betreuen, wie Neurologen, Anasthesisten, Internisten, Pneumologen, Intensivmediziner, Schlafmediziner und Palliativmediziner. Das Werk vermittelt sowohl die fur die neurointensivmedizinische und neurorehabilitative Behandlung als auch die fur die optimale Versorgung ausserklinisch beatmeter Patienten erforderlichen Kenntnisse. Zahlreiche Handlungsempfehlungen fur das Vorgehen bei den oft schwierigen Beatmungs- und Atemwegssituationen machen das Werk besonders praxistauglich.

Analyzing asthma care in the twenty-first century Asthma is not a new problem, but today the disease is being reshaped by changing ecologies, healthcare systems, medical sciences, and built environments. A global epidemic, asthma (and our efforts to control it) demands an analysis attentive to its complexity, its contextual nature, and the care practices that emerge from both. At once clearly written and theoretically insightful, Breathtaking provides a sweeping ethnographic account of asthma's many dimensions through the lived experiences of people who suffer from disordered breathing, as well as by considering their support networks, from secondary school teachers and coaches, to breathing educators and new smartphone applications designed for asthma control. Against the backdrop of unbreathable environments, Alison Kenner describes five modes of care that illustrate how asthma is addressed across different sociocultural scales. These modes of care often work in combination, building from or preceding one another. Tensions also exist between them, a point reflected by Kenner's description of the structural conditions and material rhythms that shape everyday breathing, chronic disease, and our surrounding environments. She argues that new modes of distributed, collective care practices are needed to address asthma as a critical public health issue in the time of climate change.

This book meets the need for a resource that covers the core knowledge required to pass the SCE exam, which includes the broad field of respiratory medicine. This book is also highly applicable to core medical trainees sitting their MRCP examinations. The format is ideal for effective exam revision with individual chapters covering the key points of each condition in sufficient (but not excessive) detail. Examples of imaging (CXR, CT, PET-CT) are utilised to illustrate cases and descriptions of modern respiratory intervention such as the EBUS/EUS-guided sampling and medical thoracoscopy is included in this essential exam resource.

This book covers the complete field of pulmonary pathology - neoplastic and non-neoplastic - from Acinic cell tumor in the lung to Wegener`s Granulomatosis. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Der Band aus der Reihe „Module Innere Medizin“ ermöglicht Lernenden den Blick aufs Ganze. Systematisch stellen die Autoren das gesamte Organsystem Lunge und Atemwege dar: von der Anatomie über die Physiologie bis zur Diagnostik und Therapie von Erkrankungen. Wegen seiner Praxisnähe eignet sich der Band nicht nur für Studierende, sondern auch für Ärzte in der pneumologischen Aus- und Weiterbildung.

Lung Cancer is the most common cause of cancer death and cancer symptoms. The "ABC of Lung Cancer" is a much needed reference for those treating and caring for patients with lung cancer such as primary care doctors, specialist cancer nurses, junior doctors, nurses, physiotherapists, radiographers and other health care professionals.

This new title in the "ABC" series covers the epidemiology and diagnosis of lung cancer, focusing particularly on primary care issues such as what symptoms require urgent investigation, and when to refer to a specialist. This is a practical guide for all those involved in the care of the lung cancer patient, as well as patients and their families and carers.

You can breathe a little easier knowing there's a proven way to master respiratory pharmacology! For over 30 years, Rau's Respiratory Care Pharmacology has been considered the preeminent text on the subject. With easy to grasp terminology, relatable explanations, and reader-friendly writing, the 10th edition simplifies the process of learning pharmacology material like never before. As in previous editions, Rau's is organized into three logical sections, covering the basics of respiratory care, frequently used drugs, and critical care medications. New to this edition is a Clinical Connections feature that helps you to connect lessons from the book with the clinical setting. Rau's truly is the best source for preparing you for success on your exams and in professional practice! Learning objectives parallel the levels tested by the NBRC exams to help you to identify important information that goes beyond memorization and recall. Key terms with definitions provide easy access to the pharmacologic vocabulary you should embrace. Key points boxes in each chapter highlight important concepts in the lesson. Full-color design makes the text more reader-friendly and helps you to identify relevant details within an illustration. Self-assessment questions give you the opportunity to test yourself on content learned with thought-provoking questions that require short answers. Clinical scenarios with follow-up SOAP assessment help you to assess your comprehension of the material. Glossary of all key terms in the text aids you in understanding the terminology associated with respiratory care pharmacology. Appendices on common units, systems of measurement, and acceptable mixtures provides references to need-to-know information such as abbreviations, conversion charts for temperatures, liquid metric and solids, and a simple drug compatibility chart for drug mixtures. Alphabetical drug index offers a direct index to look up information based on drug name. NEW! Recently-approved FDA medications help familiarize you with current information. UPDATED All asthma (GINA & NAEPP) and COPD (Gold guidelines) protocols to the latest editions. UPDATED Enhanced readability helps you to more easily understand difficult material. NEW! Clinical Connection boxes helps you to connect what you've learned with the clinical setting.

How often have you been confronted with an image on a thoracic CT exam where you knew it didn't look 'normal', but you weren't sure whether it was 'abnormal' either? And if it is abnormal, is there a specific diagnosis you should be able to make directly off the images? Pearls and Pitfalls in Thoracic Imaging is your one-stop resource to answer questions such as: Is this a normal variant or a disease-related abnormality? Are these findings specific for an uncommon disease and if so what is the diagnosis? Is this set of findings strongly suggestive of a diagnosis? Which additional imaging test will allow me to be confident in that diagnosis? Could the 'abnormality' be due to an artifact mimicking disease? Written by leading thoracic radiologists and with concise, image-rich descriptions, Pearls and Pitfalls in Thoracic Imaging is an invaluable diagnostic tool for every radiologist.

This handy, accessible single volume presents useful clinical information to expose the pathophysiology underlying major pulmonary diseases, and traces the steps of treatment, from establishing diagnosis to managing therapy.
Contains more than 400 summary tables, radiographs, pathology specimens, and other illustrations that encapsulate information and highlight key points
A suggested reading list accompanies each chapter to facilitate further study
Written by over 55 internationally recognized experts who provide personal experiences, observations, and review statements, and recommend action based on their expertise dealing with patients, Medical Management of Pulmonary Diseases
assesses new, efficient, cost-effective technologies for asthma and for the delivery of oxygen therapy
evaluates new directions in the diagnosis and treatment of cystic fibrosis, lung cancer, occupational lung diseases, and diffuse interstitial lung disease
describes the anatomy and physiology of the respiratory tract and includes examples of abnormalities drawn from common respiratory diseases
discusses standard therapies for most pulmonary disease patients as well as targeted management for specific cases
addresses common diagnostic and treatment dilemmas and suggests helpful algorithms for care
spotlights asthma, chronic obstructive pulmonary disease, sleep-disordered breathing, tuberculosis, and other conditions that warrant careful management
follows the progression of lung cancer from initial diagnosis through staging, and explores individualized therapy options
considers special environments that may contribute to respiratory symptoms
details the effect pregnancy and surgery have on pulmonary disease
and more
Medical Management of Pulmonary Diseases serves as an excellent user-friendly guide ideal for primary care, internal medicine, and family practice physicians; pulmonologists and pulmonary disease specialists; clinical allergists; immunologists; respiratory therapists; thoracic surgeons; physiologists; and medical school students in these disciplines.

The flu is so common that people don't often see it as a deadly and debilitating disease. Despite the advances made by science, each year 5 million people worldwide get the flu, and thousands die from complications. This fascinating book sheds light on what the flu is, and the role of medical technology in diagnosing it and developing treatments such as drugs and vaccines.

This book, part of the European Society of Intensive Care Medicine textbook series, provides detailed up-to-date information on the physical, cognitive, and psychological impairments that are frequently present following a stay in an intensive care unit and examines in depth the available preventive and therapeutic strategies, including adapted rehabilitation programs. Beyond acquainting readers with the multiple facets of post-intensive care syndrome (PICS), the book aims to promote the effective follow-up of patients, thereby enhancing their ability to work and their functional autonomy, and to identify risk factors for the development of PICS as a stimulus to beneficial organizational changes in intensive care departments. The background to the book is the realization by healthcare providers that the quality of life of patients who have required a stay in an intensive care unit can be severely impaired or even become unacceptable. All too often, the diverse sequelae are overlooked by specialists of other disciplines. Moreover, families and caregivers are also at high risk of post-traumatic stress disorder and depression. The European Society of Intensive Care Medicine has developed the Lessons from the ICU series with the vision of providing focused and state-of-the-art overviews of central topics in Intensive Care and optimal resources for clinicians working in Intensive Care. This book, written by renowned experts in the field, will facilitate the transmission of key knowledge with significant clinical and financial benefits.

Extra-corporeal membrane oxygenation (ECMO) is an innovative therapy that is used to support the physiologic needs of a patient during illnesses associated with acute severe respiratory and/or cardiac failure. ECMO is used in those life-threatening situations in which the oxygenation, ventilation, and circulatory support needs of the patient cannot be adequately maintained with a maximal conventional ventilator or pharmaceutical support. Essentially, ECMO is a simple pump circuit that can be used to support the role of failing lungs or hearts while therapies are aimed at organ recovery. While simple in concept and theory, this text illustrates the complexities associated with clinical use. The use of ECMO has evolved substantially overall the years-in part due to broader and growing applications, a better understanding of the technologies and how they can be used (especially in the context of long-term human-ECMO circuit interactions), objective tools for patient selection, management protocols, and, most importantly, a growing body of evidence-based science and literature that demonstrates the effectiveness of this highly invasive, resource-intensive, and complex tool. The goal of this text is to draw from established thought leaders and experts around the world and present a comprehensive review of the rapidly-evolving and expanding literature regarding the spectrum of applications for ECMO. While by no means is this implied to be the final and exhaustive text on this topic, it does aim to be as comprehensive and up-to-date as possible which is, in itself, a challenge given how quickly this field is evolving. This text is aimed at students and providers, at all levels, who might have interest or be involved in the care of these critically ill patients. Chapters focus on how programs can be structured, the specific details of patient selection, management, and expanding roles of ECMO. Both basic and sophisticated concepts are presented with the goal that all may learn. We also present an objective assessment of some of the evolving challenges and limitations to ECMO in the context of the increased utilization and expansion of this therapy, combined with "sicker" patients, and the ongoing journey towards improved outcomes while offering a salvage therapy to patients who might otherwise die.

This book provides a case-based illustrative approach to the understanding and management of common and important sleep disorders, including snoring and sleep disordered breathing, insomnia and circadian-rhythm disorders, as well as primary neurological sleep disorders. Case histories are written by well-established experts from University College London Hospitals who have long-standing experience of providing a multi-disciplinary approach to the management of sleep disorders. Cases focus on the recognition of presenting features of sleep disorders and their clinical importance, using real life patients from sleep clinic. Each case report provides a detailed clinical description followed by a clear explanation of the salient points. The text is supported by photographs, diagrams and line drawing and concludes with a list of key learning points. Each case history reads as stand-alone, although a common theme of presenting features, clinical features, investigation and treatment is adhered to. Cases are written in an easy-flowing prose style in an attempt to simulate the experience of seeing and discussing a real life patient case in clinical practice. The book is of interest to all clinicians who are likely to come across patients with sleep disorders in their clinical practice and wish to improve their understanding and knowledge of sleep disorders.

A detailed guide to the latest endoscopic techniques in interventional pulmonology In Medical Thoracoscopy/Pleuroscopy: Manual and Atlas, international experts explain the current methodology and demonstrate different technical approaches to medical thoracoscopy/pleuroscopy (MT/P) in the diagnosis and treatment of pleuropulmonary diseases. A combination of instructive manual and atlas, this book presents clinical cases with indications, techniques, and outcomes for each procedure. In the 'Atlas', endoscopic photographs demonstrate the application of this minimally invasive technique in various pathologies, from pleural effusion to various manifestations of lung cancer. Features: Diagnostic and therapeutic indications reflect new technology such as the semi-rigid/semi-flexible pleuroscope, CT/MR imaging, and video-assisted thoracoscopic surgery (VATS) Over 150 full-color endoscopic photographs and 120 figures enhance the text An accompanying DVD contains video clips of 8 typical clinical cases, plus practical information on the use of talc poudrage, the induction of a pneumothorax, and more This comprehensive visual guide is an indispensable primer for residents and fellows in pulmonology or pneumology, and for respiratory physicians, internists, or thoracic surgeons. System Requirements for the DVD: Language: English; region code: 0; picture format: 4:3 NTSC; duration: 33 minutes (approximately); disk format: DVD-5.

This issue of World Clinics: Pulmonary & Critical Care Medicine focuses on respiratory critical care, presenting an up-to-date collection of articles on the latest developments in the field, authored by internationally renowned experts. The book begins with an introduction to respiratory critical care and assisted ventilation. The following chapters discuss different disorders including acute COPD and asthma, acute respiratory distress syndrome, pulmonary thromboembolism, and chronic respiratory failure. The final sections cover critical care in poisoning cases, nutritional management in the ICU, interpretation of arterial blood gases and acid-base abnormalities, and ICU infections and antibiotics. Each article concludes with comments by the editor highlighting their own experience and summarising the chapter. The book is enhanced by images, table and figures. Key Points Evidence-based review of respiratory critical care topics providing an overview of the latest advances in the field Part of the World Clinics: Pulmonary & Critical Care Medicine series Each article concludes with comments by the editor Comprehensive text enhanced by images, tables and figures

This book is a practical guide to the diagnosis of respiratory disorders, helping clinicians recognise signs and symptoms, decide on the most appropriate diagnostic tests, and to interpret the results. Divided into four sections, the book covers respiratory system assessment, evaluation of respiratory function, diagnostic imaging, and invasive diagnostic techniques. The imaging section includes radiograph, computed tomography, angiography, and ultrasonography. The invasive diagnostic procedures section covers bronchoscopy, lung biopsy, transbronchial needle aspiration and more. Video-assisted thoracic surgery as a diagnostic tool is also discussed. Authored by recognised expert Professor Claudio Sorino from University of Palermo, this useful manual is enhanced by clinical images and figures. Key Points Practical guide to diagnosis of respiratory disorders Helps clinicians recognise signs and symptoms, choose appropriate diagnostic tests and interpret results Includes chapter on video-assisted thoracic surgery as a diagnostic tool Authored by recognised expert from University of Palermo

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. 800 Q&A deliver a rigorous review for pulmonary board certification Part of the acclaimed McGraw-Hill Specialty Board Review series, this well-illustrated review is essential for pulmonary medicine physicians preparing for board certification or recertification. The coverage mirrors the board exam outline of the American Board of Internal Medicine (ABIM), focusing specifically on the most commonly tested topics in obstructive lung disease, critical care, diffuse parenchymal lung disease, sleep medicine, infections, and neoplasms. Offering more illustrations than similar reviews, Pulmonary Disease Examination and Board Review delivers authoritative coverage of the key concepts tested on the certification exam, including: making a diagnosis, test ordering and interpretation, treatment recommendations, understanding epidemiologic studies, understanding pathophysiology, and applying basic science knowledge to clinical situations. Case-based presentation mirrors the exam format Includes numerous high-quality images, including: x-rays, CT scans, and electrocardiograms Excellent as clinical refresher in pulmonary medicine

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. If you're looking for a fun, fast review that boils emergency airway and respiratory management to its mostessential, must-know points, your search ends here! EMS Respiratory Emergency Management Demystified is a complete yet concise overview of the basics of performing this critical procedure. This guide gives you the knowledge to help your patients as a student and as an EMT or paramedic once you start your career. You will learn how to perform an assessment of a patient's airway, managehis or her ventilation, utilize RSI, use best practices forspecial patient populations, and more. Studying is easy and effective with key objectives,important terms, brief overviews, tables and diagrams, and Q&As throughout the book. This fast and easy guide offers: Learning objectives at the beginning of each chapter Coverage of essential airway management techniques Chapter review questions with answer explanations A time-saving approach to performing better on an exam or at work Simple enough for a student, but comprehensive enough for a professional, EMS Respiratory Emergency Management DeMYSTiFieD is your shortcut to masteringthis essential, often life-saving topic.

In this book, the authors present current research in the study of non-small cell lung cancer. Topics discussed include the preclinical and clinical advances of epigenetics in lung cancer; therapeutic antibodies and non-coding RNAs (ncRNAs) in non-small cell lung cancer; molecular profiling in lung cancer specimens leads to targeted therapeutic options in patients with non-small cell lung carcinoma; the role of radiation dose escalation in the treatment of stage III locally advanced inoperable non-small cell lung cancer; and mechanisms of resistance to EGFR inhibitors.