Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Obesity, Inflammation and Cancer (Paperback, 2013 ed.)
Loot Price: R4,583
Discovery Miles 45 830
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Obesity, Inflammation and Cancer (Paperback, 2013 ed.)
Series: Energy Balance and Cancer, 7
Expected to ship within 10 - 15 working days
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Total price: R4,603
Discovery Miles: 46 030
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In addition to its metabolic and endocrinologic effects, obesity
and adipose tissue have now been shown to be associated with low
grade inflammation resulting in cellular and humoral inflammatory
factors of which the latter may act by endocrine, paracrine and
autocrine mechanisms. These inflammatory mediators have
increasingly been suggested as contributing to the obesity link to
carcinogenesis and cancer promotion. This volume of Energy Balance
and Cancer will focus on recent developments and cutting edge
research pointing to inflammation and inflammatory factors as key
mediators of this linkage. The volume first provides information on
inflammation as an important link between obesity and insulin
resistance, which is in itself linked to promotion of cancer
through hyperinsulinemia. The volume then covers some of the most
important mechanisms by which obesity leads to inflammation,
including the novel inflammasome concept, alterations in chromatin
structure, circulating inflammatory factors, unique cellular
interactions between adipocytes and macrophages and the direct link
of dietary fat to inflammation and cancer. Overall, this volume
will provide important insight to help understand how inflammation
may help modulate the linkage between obesity and cancer and serve
as a platform for developing future research in this area.
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