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Books > Medicine > Clinical & internal medicine > Endocrinology > Diabetes
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Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development - A Focus on Early Phase Clinical Studies (Paperback, Softcover reprint of the original 1st ed. 2015)
Loot Price: R4,107
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Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development - A Focus on Early Phase Clinical Studies (Paperback, Softcover reprint of the original 1st ed. 2015)
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The world is beset by a pandemic of obesity and type 2 diabetes and
the need for new drugs is startlingly clear; recent years have seen
a huge increase in research activity to fill this gap. The
development of new drugs for diabetes and obesity must be founded
upon a sound appreciation of the pathophysiology of these common
disorders. The dual defects of insulin resistance and impaired
insulin secretion are fundamental to the pathogenesis and
progression of obesity-associated type 2 diabetes. There is a need
to explain how new drugs can counter insulin resistance and insulin
deficiency to a broad range of professionals, from clinical
scientists active in early (and later) phase drug development to
specialist physicians and increasingly primary care doctors who
must tailor drug regimens to the individual patient. Clinical
research methods for measuring insulin action and insulin secretion
have become well-established in proof-of-mechanism studies;
however, selection of the best techniques is by no means
straightforward. The purpose of the book is to aid the selection of
the most appropriate techniques for assessing insulin action,
insulin secretion and body composition in humans (with particular
reference to new drugs) in phase 1 and 2 studies and aid the
understanding of drug effects and non-drug treatment strategies on
key biochemical-hormonal defects of obesity and type 2 diabetes.
The book will assume a working knowledge of human physiology
relating to glucose metabolism and will be of interest to
biomedical scientists, pharmacologists, academics involved in
metabolic research and clinicians practicing in these specialties.
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