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Transformative Concepts for Drug Design: Target Wrapping (Paperback, 2010 ed.)
Loot Price: R4,540
Discovery Miles 45 400
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Transformative Concepts for Drug Design: Target Wrapping (Paperback, 2010 ed.)
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In spite of the enticing promises of the post-genomic era, the
pharmaceutical world is in a state of disarray. Drug discovery
seems now riskier and more uncertain than ever. Thus, projects get
routinely terminated in mid-stage clinical trials, new targets are
getting harder to find, and successful therapeutic agents are often
recalled as unanticipated side effects are discovered. Exploiting
the huge output of genomic studies to make safer drugs has proven
to be much more difficult than anticipated. More than ever, the
lead in the pharmaceutical industry depends on the ability to
harness innovative research, and this type of innovation can only
come from one source: fundamental knowledge. This book squarely
addresses this crucial problem since it introduces fundamental
discoveries in basic biomolecular research that hold potential to
broaden the technological base of the pharmaceutical industry. The
book takes a fresh and fundamental look at the problem of how to
design an effective drug with controlled specificity. Since the
novel transformative concepts are unfamiliar to most practitioners,
the first part of this book explains matters very carefully
starting from a fairly elementary physico-chemical level. The
second part of the book is devoted to practical applications,
aiming at nothing less than a paradigm shift in drug design. This
book is addressed to scientists working at the cutting edge of
research in the pharmaceutical industry, but the material is at the
same time accessible to senior undergraduates or graduate students
interested in drug discovery and molecular design.
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