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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Molecular Determinants of Head and Neck Cancer (Hardcover, 2nd ed. 2018)
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Molecular Determinants of Head and Neck Cancer (Hardcover, 2nd ed. 2018)
Series: Current Cancer Research
Expected to ship within 9 - 17 working days
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Squamous cell cancers of the head and neck (SCCHN), also known as
head and neck cancers (HNC) encompass malignancies of the oral
cavity, larynx, nasopharynx and pharynx, and are diagnosed in over
500,000 patients worldwide each year, accounting for 5% of all
malignancies. It is estimated that approximately 50,000 patients
develop head and neck cancer annually in the United States, of whom
approximately 50% succumb to this cancer. For most cases of SCCHN,
treatment is multimodal, often combining surgery or irradiation
with chemotherapy; even successfully treated patients frequently
experience durable and severe side effects. Improving cure rates
and reducing chronic morbidity are urgent clinical needs for head
and neck cancer. However, in contrast to cancer types such as
breast or prostate that have been much studied and have
well-defined biology, until recently, relatively few researchers
investigated the molecular basis of HNC, making it difficult to
design targeted treatments with better efficacy and less
debilitating side effects. This volume will provide an overview of
the factors contributing to disease pathogenesis, including the
recognition of discrete molecular subtypes with distinct etiology,
prognosis, and treatment response. This volume will familiarize the
reader with the critical signaling pathways and oncogenic drivers
for HNC. It will outline the differences between HPV-positive and
HPV-negative disease, and how these differences affect treatment
choice and outcome. The book will emphasize developments in the
past five years, including the growing understanding of the genomic
and epigenomic features of the disease based on analysis of next
generation sequencing (NGS) data, and timely topics such as the
analysis of HNC stem cell populations, non-coding mRNAs, and
inflammatory response. It will address exciting new therapeutic
approaches such as the use of immunotherapies to treat HNC
patients. Overall, the book will provide the reader with current
understanding of the biology and treatment of the disease, and
describe timely questions that will guide future research aimed at
controlling and curing this disease.
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