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Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocolitica (Hardcover, 1st ed. 2019)
Loot Price: R2,957
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Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocolitica (Hardcover, 1st ed. 2019)
Series: Springer Theses
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This book discusses the decoding of the lytic mechanism of an
-helical pore-forming toxin, YaxAB, composed of two different
subunits. Pore-forming toxins (PFTs) are among the most common
bacterial toxins. They are produced by a variety of pathogens,
which infect a wide range of organisms including plants, insects
and humans. Yet the maturation of these particles and the
structural changes required for pore formation are still poorly
understood for many PFT families. Using a diverse panel of
biochemical and structural techniques, including X-ray
crystallography and cryo-electron microscopy, Dr. Brauning and
colleagues have succeeded in identifying the mechanistic
contributions of the two toxin components and elucidating the lytic
state of the pore complex. The results of this thesis on the YaxAB
system are applicable to orthologues from agriculturally relevant
insect pathogens, and offer valuable structural and mechanistic
insights to inform future bioengineering efforts.
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