The advances of live cell video imaging and high-throughput
technologies for functional and chemical genomics provide
unprecedented opportunities to understand how biological processes
work in subcellularand multicellular systems. The interdisciplinary
research field of Video Bioinformatics is defined by BirBhanu as
the automated processing, analysis, understanding, data mining,
visualization, query-basedretrieval/storage of biological
spatiotemporal events/data and knowledge extracted from dynamic
imagesand microscopic videos. Video bioinformatics attempts to
provide a deeper understanding of continuousand dynamic life
processes.Genome sequences alone lack spatial and temporal
information, and video imaging of specific moleculesand their
spatiotemporal interactions, using a range of imaging methods, are
essential to understandhow genomes create cells, how cells
constitute organisms, and how errant cells cause disease. The
bookexamines interdisciplinary research issues and challenges with
examples that deal with organismal dynamics,intercellular and
tissue dynamics, intracellular dynamics, protein movement, cell
signaling and softwareand databases for video bioinformatics.Topics
and Features* Covers a set of biological problems, their
significance, live-imaging experiments, theory andcomputational
methods, quantifiable experimental results and discussion of
results.* Provides automated methods for analyzing mild traumatic
brain injury over time, identifying injurydynamics after neonatal
hypoxia-ischemia and visualizing cortical tissue changes during
seizureactivity as examples of organismal dynamics* Describes
techniques for quantifying the dynamics of human embryonic stem
cells with examplesof cell detection/segmentation, spreading and
other dynamic behaviors which are important forcharacterizing stem
cell health* Examines and quantifies dynamic processes in plant and
fungal systems such as cell trafficking,growth of pollen tubes in
model systems such as Neurospora Crassa and Arabidopsis* Discusses
the dynamics of intracellular molecules for DNA repair and the
regulation of cofilintransport using video analysis* Discusses
software, system and database aspects of video bioinformatics by
providing examples of5D cell tracking by FARSIGHT open source
toolkit, a survey on available databases and software,biological
processes for non-verbal communications and identification and
retrieval of moth imagesThis unique text will be of great interest
to researchers and graduate students of Electrical
Engineering,Computer Science, Bioengineering, Cell Biology,
Toxicology, Genetics, Genomics, Bioinformatics, ComputerVision and
Pattern Recognition, Medical Image Analysis, and Cell Molecular and
Developmental Biology.The large number of example applications will
also appeal to application scientists and engineers.Dr. Bir Bhanu
is Distinguished Professor of Electrical & C omputer
Engineering, Interim Chair of theDepartment of Bioengineering,
Cooperative Professor of Computer Science & Engineering, and
MechanicalEngineering and the Director of the Center for Research
in Intelligent Systems, at the University of California,Riverside,
California, USA.Dr. Prue Talbot is Professor of Cell Biology &
Neuroscience and Director of the Stem Cell Center and Core atthe
University of California Riverside, California, USA.
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