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Histamine and Histamine Antagonists (Paperback, Softcover reprint of the original 1st ed. 1991)
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Histamine and Histamine Antagonists (Paperback, Softcover reprint of the original 1st ed. 1991)
Series: Handbook of Experimental Pharmacology, 97
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Together with the two previous volumes of the Handbook of
Experimental Pharmacology on histamine and antihistamines the
present publication yields a picture of a still rapidly developing
field of research. New techniques and new experimental approaches
have brought us new knowledge and deeper insight into the
biomedical significance of histamine, even if many questions remain
to be answered about the functional and medical implications of
this old biogenic amine. The present volume covers the progress in
histamine research during the past two decades. A significant
chapter concerns techniques for histamine determination. As the
result of a consensus meeting in Munich in December 1988, a panel
of eminent specialists arrived at common recommendations as to the
usefulness of the available histamine assays for the most common
experimental biomedical conditions. The heterogeneity of mast
cells, with great differences in their reactivity to various
stimuli, has become apparent, not only among species but also among
the tissues of a species. New informa tion is presented about the
mechanism of exocytosis. The old questions about the role of
histamine in the mechanism of gastric secretion and in cardio
vascular and respiratory functions have been studied with new
techniques, and the role of HI and H2 receptors discussed. New
observations have been made on the occurrence and possible
functions of histaminergic neurons and histamine receptors in CNS
where a new type of receptor, the H, seems to 3 be widely
represented."
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