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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Bacterial Activation of Type I Interferons (Hardcover, 2014 ed.)
Loot Price: R2,846
Discovery Miles 28 460
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Bacterial Activation of Type I Interferons (Hardcover, 2014 ed.)
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The type I interferon (IFN) signaling pathway is well recognized as
a pathway activated by viral infections. It is activated by a
variety of microbial pattern recognition receptors including the
Toll-like receptors, NOD-like receptors and several cytosolic
receptors. Activation of the type I IFN pathway leads to the
production of both antiviral factors and products that influence
immune cell function. More recently it has been shown that bacteria
are also capable of activating this pathway. Bacterial Activation
of Type I Interferons reviews both the current understanding of how
different bacterial species are able to activate this pathway as
well as the influence type I IFNs have on the outcome to infection.
Several different bacterial species are covered, spanning Gram
positive and Gram negative, intracellular, extracellular, and
different host infection sites. An introduction to the pathogenesis
of each organism is provided, and the signaling molecules involved
in the activation of the type I IFN pathway and the role it plays
in animal infection models are also covered.
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