This volume addresses a fundamental puzzle in biology and medicine,
namely, how does tissue develop, repair and replace itself. The
answer appears to lie in growth factors and their regulation. To
thrive and survive we need growth factors and this book
concentrates on two factors that are related to growth hormone.
Growth hormone does not act directly on all tissues, but mediates
many of its actions through the release of insulin-like growth
factors from the liver. The growth factors were originally called
somatomedins by McConaghey and Sledge (1), who discovered that they
mediated growth-like effects of growth hormone. However, the
factors were purified on the basis of their insulinomimetic actions
on fat and muscle and it is their relationship to the insulin
family of pep tides that now gives them their name (2,3) of
insulin-like growth factors (IGFs). They mediate the actions of.
growth hormone on the proteoglycan synthesis of cartilage and
produce mitogenic effects in fibroblast cultures.
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