Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors (Paperback, Softcover reprint of the original 1st ed. 1991)

This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Advances in Experimental Medicine and Biology, 293
Release date:	March 2012
First published:	1991
Editors:	Derek Leroith • Mohan K. Raizada
Dimensions:	254 x 178 x 27mm (L x W x T)
Format:	Paperback
Pages:	498
Edition:	Softcover reprint of the original 1st ed. 1991
ISBN-13:	978-1-4684-5951-7
Categories:	Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Science & Mathematics > Biology, life sciences > Botany & plant sciences > General Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal physiology Promotions
LSN:	1-4684-5951-1
Barcode:	9781468459517

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