An authoritative panel of basic and clinical researchers critically
reviews the latest findings on the role of folate in human
development, health, and disease. Specific areas addressed include
folate metabolism in zinc or copper deficiencies, choline and
folate in development, animal models of folate-related birth
defects, developmental toxicants potentially acting via folate
perturbation, and folate's role in vascular disease in women. There
are also cutting-edge discussions of genes and neural tube
development, folate receptor polymorphism and the risk for neural
defects, abnormal DNA synthesis and methylation with folate/methyl
insufficiency, and folic acid and homocysteine as risk factors for
neural tube defects.
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