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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Treatment of Dementias - A New Generation of Progress (Paperback, Softcover reprint of the original 1st ed. 1992)
Loot Price: R1,513
Discovery Miles 15 130
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Treatment of Dementias - A New Generation of Progress (Paperback, Softcover reprint of the original 1st ed. 1992)
Series: Advances in Behavioral Biology, 40
Expected to ship within 10 - 15 working days
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Alzheimer's disease is one the foremost health problems facing
every society fortunate enough to attain a level of medical care
that ensures an average lifespan of over 70 years of age. The cause
of the disease remains unknown, and no single therapeutic approach
has yet been found highly efficacious. Indeed, as the complexity of
its effects on brain neuronal systems becomes elucidated, the
concept emerges that Alzheimer's disease may be an umbrella term
for multiple Alzheimer's-type syndromes that can be differentiated
based on etiology (hereditary versus sporadic), neurochemical
deficits, and extent of pathology. Whether one or more disease
processes is involved, it seems increasingly unlikely that any
single drug will provide efficacious relief across the broad
spectrum of symptoms reflected in large subject populations.
Rational therapeutic approaches may yield long term amelioration of
many symptoms in selected groups of patients; and individual
symptoms may be ameliorated in larger populations. Multiple
approaches may be combined to optimize therapeutic effects. For
example, a variety of approaches remain focused on restoration of
cholinergic neurodegeneration and enhancing cholinergic
neurotransmission, whereas other approaches attempt to retard the
of the brain that occurs during Alzheimer's disease. Chapters cover
continuous degeneration topics from growth factor secretion of
proteases, which could modify amyloid processing, to neuronal gene
delivery using viral vectors. The breadth and thoroughness of the
chapters truly embrace a broad spectrurn of models, pathological
mechanisms and therapeutic approaches.
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