Cancer will remain a global major health problem unless new
diagnostic, prognostic, and management approaches are discovered to
address both loss of life and quality of life. Here we summarize
the general physiology, pathology, heterogeneity, and evolution of
cancer, current status, limitations and challenges associated with
prevention, incidence, treatment, survival, and mortality, as well
as future directions with regards to solid tumors. Perspectives are
provided on how to improve pre-clinical understandings, outcomes,
and patient care. Further, this comprehensive, timely overview of
the literature has educational value as part of an academic course,
seminar, or as a supplementary text. Features : This book
summarizes the current status, successes, difficulties,
advancements, limitations, and challenges in medical interventions
that impact patients' quality of life. Includes concise
descriptions of all relevant cell and molecular biology concepts
including evolutionary paradigms, hallmarks of cancer, and
heterogeneity to help understand the pathophysiology of cancer,
cancer-associated disease conditions, and effective cancer therapy.
Contains an array of colorful figures and schematics summarizing
complex informative pathological, physiological, and biochemical
concepts. Covers a multitude of sub-topics pertaining to cancer
biology including diagnosis; chemotherapy, radiotherapy and
targeted therapy; metastasis; disseminated and circulating tumor
cells, and cancer stem cells; drug resistance and cellular
reprogramming; complex epigenetics; tumor-derived exosomes;
oncogenic viruses; metabolic syndrome and cancer metabolism;
convoluted neovascularization; efficient biomarkers; immunotherapy;
role of nutraceuticals and natural products. Provides perspectives
on how to improve pre-clinical understandings, and outcomes,
linking toxicological, and pharmacological aspects in patient care.
This timely, relevant comprehensive assortment of scientific
literature has educational value to a wider audience including as
part of an academic course, seminar, or as a supplementary text.
General
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