Protein Expression in Down Syndrome Brain (Hardcover, 2001 ed.)

When we worked on Down Syndrome brain in the past we have been focus ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced proteomics to identify and quantify brain protein expression. We considered evaluation of brain protein expression in Down Syndrome brain by and by more important than gene hunting at the nucleic acid level realiz ing the long unpredictable way from RNA to protein. The availability of fetal samples along with the proteomic appproach stimulated and reinforced studies on Down Syndrome brain. And indeed, it was found out that some observations on aberrant protein expression in adult Down Syndrome brain could not be verified in the fetal samples indi cating that neurodegeneration in adult Down Syndrome brain may have been responsible rather than trisomy 21. Using brains from the early second trimester of gestation led to the generation of a series of clues for the under standing of aberrant wiring of the brain in Down Syndrome and enabled the determination of altered key functions in early life; e. g. undetectably low drebrin was observed in Down Syndrome cortex, an integral constituent and marker for dendritic spines, main effectors of cross-talk between neurons. In addition, evaluation of the nature of the neuronal deficits in terms of neuro transmission markers could be established as well as neuronal density in fetal Down Syndrome cortex."

General

Imprint:	Springer-Verlag
Country of origin:	Austria
Release date:	May 2002
First published:	2001
Editors:	G. Lubec
Dimensions:	279 x 210 x 22mm (L x W x T)
Format:	Hardcover
Pages:	374
Edition:	2001 ed.
ISBN-13:	978-3-211-83732-0
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > Other branches of medicine > Psychiatry Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Medicine > Clinical & internal medicine > Paediatric medicine > General Books > Medicine > Other branches of medicine > Pathology > Gross pathology Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
LSN:	3-211-83732-9
Barcode:	9783211837320

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