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Novel Cytokine Inhibitors (Paperback, Softcover reprint of the original 1st ed. 2000)
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Novel Cytokine Inhibitors (Paperback, Softcover reprint of the original 1st ed. 2000)
Series: Progress in Inflammation Research
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Cytokines have become established as key mediators of the signs and
symptoms of inflammatory diseases such as arthritis, dermatitis,
asthma and multiple sclerosis. Furthermore, they are involved in
the cascade of events leading to cardiovascular shock and are major
regulators of the function of immune cells. This book reviews
recent advances in the development of new anti-inflammatory drugs.
It addresses different therapeutic intervention possibilities for
new drugs, such as the cellular source of cytokines, specific
receptors which induce cytokine synthesis, intracellular regulators
of cytokine gene induction and expression, secretion and activation
of cytokines, cytokine receptors and signalling pathways from these
receptors. Accordingly, experts were drawn from different
backgrounds including academic research institutes, the
pharmaceutical industry and clinical pharmacology. In each area,
the opportunities for drug development are highlighted and, where
possible, clinical data is reviewed.
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