Multifaceted Roles of Crystallography in Modern Drug Discovery (Hardcover)

The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design.

General

Imprint:	Springer
Country of origin:	Netherlands
Series:	NATO Science for Peace and Security Series A: Chemistry and Biology
Release date:	March 2015
Editors:	Giovanna Scapin • Disha Patel • Eddy Arnold
Dimensions:	235 x 155 x 16mm (L x W x T)
Format:	Hardcover - Cloth over boards
Pages:	240
ISBN-13:	978-9401797184
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Science & Mathematics > Physics > States of matter > Condensed matter physics (liquids & solids) Books > Science & Mathematics > Chemistry > Physical chemistry > Quantum & theoretical chemistry Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	9401797188
Barcode:	9789401797184

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