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Books > Science & Mathematics > Chemistry > Physical chemistry > Quantum & theoretical chemistry
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Multifaceted Roles of Crystallography in Modern Drug Discovery (Paperback)
Loot Price: R3,249
Discovery Miles 32 490
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Multifaceted Roles of Crystallography in Modern Drug Discovery (Paperback)
Series: NATO Science for Peace and Security Series A: Chemistry and Biology
Expected to ship within 18 - 22 working days
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The present work offers a snapshot of the state-of-the-art of
crystallographic, analytical, and computational methods used in
modern drug design and development. Topics discussed include: drug
design against complex systems (membrane proteins, cell surface
receptors, epigenetic targets, and ribosomes); modulation of
protein-protein interactions; the impact of small molecule
structures in drug discovery and the application of concepts such
as molecular geometry, conformation, and flexibility to drug
design; methodologies for understanding and characterizing protein
states and protein-ligand interactions during the drug design
process; and monoclonal antibody therapies. These methods are
illustrated through their application to problems of medical and
biological significance, such as viral and bacterial infections,
diabetes, autoimmune disease, and CNS diseases. As approaches to
drug discovery have changed over time, so have the methodologies
used to solve the varied, new, and difficult problems encountered
in drug discovery. In recent years we have seen great progress in
the fields of genetics, biology, chemistry, and medicine, but there
are still many unmet medical needs, from bacterial infections to
cancer to chronic maladies, that require novel, different, or
better therapies. This work will be of interest to researchers and
policy makers interested in the latest developments in drug design.
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