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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Rational Basis for Clinical Translation in Stroke Therapy (Hardcover)
Loot Price: R5,972
Discovery Miles 59 720
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Rational Basis for Clinical Translation in Stroke Therapy (Hardcover)
Series: Frontiers in Neurotherapeutics Series
Expected to ship within 12 - 17 working days
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Stroke remains one of the major causes of death and long-term
disability worldwide. Currently, the only approved therapy for the
acute treatment of this disease is thrombolysis, a strategy that
can only be applied to a small percentage of patients due to its
narrow therapeutic window. Unfortunately, during the last years
numerous promising drugs that showed neuroprotection in the
experimental setting failed to translate into the clinic because of
their toxicity or lack of efficacy. Researchers in the field now
face the crucial need to develop effective stroke therapies and
successfully translate novel strategies into the clinical setting.
Rational Basis for Clinical Translation in Stroke Therapy presents
the most recent promising preclinical approaches and the most
updated clinical evidence for treating stroke patients. By bringing
together the experience of accomplished stroke researchers and
clinicians, the book is a useful tool for improving the treatment
and management of stroke patients. The book describes current
approaches for the management of stroke patients including
thrombolysis and mechanical recanalization procedures as well as
other clinically relevant topics such as diagnosis, imaging, risk
factors, and prevention. Also described are emerging interventions
based on the use of stem cells, botulinum toxin, and
antidepressants which complement emergency stroke treatment and
conventional rehabilitation procedures. Clinical approaches are
integrated with the most promising therapeutic opportunities based
on targeting the immune system, hypothermia, and postconditioning.
The book also covers issues related to the improvement of R&D
strategies in stroke therapeutics, aimed at the implementation of
preclinical approaches with stroke model guidelines and at the
optimization of clinical trial design. This volume is a reference
for all those interested in the rational development of novel
stroke therapeutics.
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