Short-Term Tests for Chemical Carcinogens (Paperback, Softcover reprint of the original 1st ed. 1981)

The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation. Moreover, it has been tacitly assumed that the mutagenic capacity alone of compounds would induce regulatory agencies to pass rules for their removal from the environment and would lead the public to avoid them. The actual response, however, is quite different. Governmental departments shy away from making any decisions on the basis of in vitro test systems. The public at large is becoming irritated by daily an nouncements that many of their cherished habits could adversely affect their health. Industry appears to feel threatened and may reduce its search for new beneficial chemicals. The reluctance to accept wholeheartedly the mutagenicity tests for the detection of carcinogens is partly due to uncertainty about the in volvement of mutations in neoplastic transformation, partly due to the present difficulty of extrapolating results from various endpoints obtained on numerous organisms to man, and partly due to a multitude of complex events that lead in vivo to the evolvement of benign or malignant tumors."

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Topics in Environmental Physiology and Medicine
Release date:	October 2011
First published:	1981
Editors:	H F Stich • R H C San
Dimensions:	254 x 178 x 28mm (L x W x T)
Format:	Paperback
Pages:	518
Edition:	Softcover reprint of the original 1st ed. 1981
ISBN-13:	978-1-4612-5849-0
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	1-4612-5849-9
Barcode:	9781461258490

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