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Genome Stability and Human Diseases (Hardcover, 2010 ed.)
Loot Price: R5,489
Discovery Miles 54 890
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Genome Stability and Human Diseases (Hardcover, 2010 ed.)
Series: Subcellular Biochemistry, 50
Expected to ship within 10 - 15 working days
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* Discusses cancer cell biology in relation to Genome stability and
Cell cycle regulation Unique assembly of experts in these fields
who wrote a comprehensive and deep up-to-date overview Discusses
models for the understanding of DNA damage-dependent signal
transduction and regulation in human cells Since the establishment
of the DNA structure researchers have been highly interested in the
molecular basis of the inheritance of genes and of genetic
disorders. Scientific investigations of the last two decades have
shown that, in addition to oncogenic viruses and signalling
pathways alterations, genomic instability is important in the
development of cancer. This view is supported by the findings that
aneuploidy, which results from chromosome instability, is one of
the hallmarks of cancer cells. Chromosomal instability also
underpins our fundamental principles of understanding
tumourigenesis: It thought that cancer arises from the sequential
acquisition of genetic alterations in specific genes. In this
hypothesis, these rare genetic events represent rate-limiting
bottlenecks' in the clonal evolution of a cancer, and pre-cancerous
cells can evolve into neoplastic cells through the acquisition of
somatic mutations. This book is written by international leading
scientists in the field of genome stability. Chapters are devoted
to genome stability and anti-cancer drug targets, histone
modifications, chromatin factors, DNA repair, apoptosis and many
other key areas of research. The chapters give insights into the
newest development of the genome stability and human diseases and
bring the current understanding of the mechanisms leading to
chromosome instability and their potential for clinical impact to
the reader.
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