|
Books > Science & Mathematics > Biology, life sciences > Cellular biology
|
Buy Now
Genome Stability and Human Diseases (Paperback, 2010 ed.)
Loot Price: R5,445
Discovery Miles 54 450
|
|
|
Genome Stability and Human Diseases (Paperback, 2010 ed.)
Series: Subcellular Biochemistry, 50
Expected to ship within 10 - 15 working days
|
Since the establishment of the DNA structure researchers have been
highly interested in the molecular basis of the inheritance of
genes and of genetic disorders. Scientific investigations of the
last two decades have shown that, in addition to oncogenic viruses
and signalling pathways alterations, genomic instability is
important in the development of cancer. This view is supported by
the findings that aneuploidy, which results from chromosome
instability, is one of the hallmarks of cancer cells. Chromosomal
instability also underpins our fundamental principles of
understanding tumourigenesis: It thought that cancer arises from
the sequential acquisition of genetic alterations in specific
genes. In this hypothesis, these rare genetic events represent
rate-limiting 'bottlenecks' in the clonal evolution of a cancer,
and pre-cancerous cells can evolve into neoplastic cells through
the acquisition of somatic mutations. This book is written by
international leading scientists in the field of genome stability.
Chapters are devoted to genome stability and anti-cancer drug
targets, histone modifications, chromatin factors, DNA repair,
apoptosis and many other key areas of research. The chapters give
insights into the newest development of the genome stability and
human diseases and bring the current understanding of the
mechanisms leading to chromosome instability and their potential
for clinical impact to the reader.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
You might also like..
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
