Death Receptors and Cognate Ligands in Cancer (Paperback, 2009 ed.)

Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells. This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Results and Problems in Cell Differentiation, 49
Release date:	March 2012
First published:	2009
Editors:	Holger Kalthoff
Dimensions:	235 x 155 x 16mm (L x W x T)
Format:	Paperback
Pages:	280
Edition:	2009 ed.
ISBN-13:	978-3-642-26076-6
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Cellular physiology Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-642-26076-4
Barcode:	9783642260766

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