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NMR Spectroscopy in Pharmaceutical Analysis (Hardcover, New)
Loot Price: R3,666
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NMR Spectroscopy in Pharmaceutical Analysis (Hardcover, New)
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For almost a decade, quantitative NMR spectroscopy (qNMR) has been
established as valuable tool in drug analysis. In all disciplines,
i. e. drug identification, impurity profiling and assay, qNMR can
be utilized.
Separation techniques such as high performance liquid
chromatography, gas chromatography, super fluid chromatography and
capillary electrophoresis techniques, govern the purity evaluation
of drugs. However, these techniques are not always able to solve
the analytical problems often resulting in insufficient methods.
Nevertheless such methods find their way into international
pharmacopoeias. Thus, the aim of the book is to describe the
possibilities of qNMR in pharmaceutical analysis.
Beside the introduction to the physical fundamentals and techniques
the principles of the application in drug analysis are described:
quality evaluation of drugs, polymer characterization, natural
products and corresponding reference compounds, metabolism, and
solid phase NMR spectroscopy for the characterization drug
substances, e.g. the water content, polymorphism, and drug
formulations, e.g. tablets, powders. This part is accompanied by
more special chapters dealing with representative examples. They
give more detailed information by means of concrete examples.
- combines theory, techniques, and concrete applications-all of
which closely resemble the laboratory experience
- considers international pharmacopoeias, addressing the concern
for licensing
- features the work of academics and researchers, appealing to a
broad readership
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