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Books > Medicine > Clinical & internal medicine > Haematology
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Dendritic Cells in Fundamental and Clinical Immunology - Volume 2 (Paperback, Softcover reprint of the original 1st ed. 1995)
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Dendritic Cells in Fundamental and Clinical Immunology - Volume 2 (Paperback, Softcover reprint of the original 1st ed. 1995)
Series: Advances in Experimental Medicine and Biology, 378
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These Proceedings contain the contributions of the partIcIpants of
the Third International Symposium on Dendritic Cells that was held
in Annecy, France, from June 19 to June 24, 1994. This symposium
represented a follow-up of the first and second international
symposia that were held in Japan in 1990 and in the Netherlands in
1992. Dendritic cells are antigen-presenting cells, and are found
in all tissues and organs of the body. They can be classified into:
(1) interstitial dendritic cells of the heart, kidney, gut, and
lung;(2) Langerhans cells in the skin and mucous membranes; (3)
interdigitating dendritic cells in the thymic medulla and secondary
lymphoid tissue; and (4) blood dendritic cells and lymph dendritic
cells (veiled cells). Although dendritic cells in each of these
compartments are all CD45+ leukocytes that arise from the bone
marrow, they may exhibit differences that relate to maturation
state and microenvironment. Dendritic cells are specialized
antigen-presenting cells for T lymphocytes: they process and
present antigens efficiently in situ, and stimulate responses from
naive and memory T cells in the paracortical area of secondary
lymphoid organs. Recent evidence also demonstrates their role in
induction of tolerance. By contrast, the primary and secondary
B-cell follicles contain follicular dendritic cells that trap and
retain intact antigen as immune complexes for long periods of time.
The origin of follicular dendritic cells is not clear, but most
investigators believe that these cells are not leukocytes.
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