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Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
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Physical Methods to Characterize Pharmaceutical Proteins (Paperback, Softcover reprint of the original 1st ed. 1995)
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Physical Methods to Characterize Pharmaceutical Proteins (Paperback, Softcover reprint of the original 1st ed. 1995)
Series: Pharmaceutical Biotechnology, 7
Expected to ship within 18 - 22 working days
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Proteins are still gaining importance in the pharmaceutical world,
where they are used to improve our arsenal of therapeutic drugs and
vaccines and as diagnostic tools. Proteins are different from
"traditional" low-molecular-weight drugs. As a group, they exhibit
a number of biopharmaceutical and formulation problems. These
problems have drawn considerable interest from both industrial and
aca demic environments, forcing pharmaceutical scientists to
explore a domain previ ously examined only by peptide and protein
chemists. Biopharmaceutical aspects of proteins, e.g., low oral
bioavailability, have been extensively investigated. Although all
possible conventional routes of ad ministration have been examined
for proteins, no real, generally applicable alter native to
parenteral administration in order to achieve systemic effects has
yet been discovered. Several of these biopharmaceutical options
have been discussed in Volume 4 of this series, Biological Barriers
to Protein Delivery. Proteins are composed of many amino acids,
several of which are notorious for their chemical instability.
Rational design of formulations that optimize the native structure
and/or bioactivity of a protein is therefore of great importance
when long shelf life is required, as it is for pharmaceutical
products. This issue has also been examined in two prior volumes of
this series: Volume 2: Stability of Protein Pharmaceuticals (Part
A) and Volume 5: Stability and Characterization of Protein and
Peptide Drugs.
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