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Patho-Epigenetics of Infectious Disease (Hardcover, 1st ed. 2016)
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Patho-Epigenetics of Infectious Disease (Hardcover, 1st ed. 2016)
Series: Advances in Experimental Medicine and Biology, 879
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Epigenetic modification of cellular genomes is a fascinating means
of regulating tissue- and cell type-specific gene expression in all
developmental stages of the life of an organism. Carefully
orchestrated processes, such as DNA methylation and a plenitude of
specific histone modifications secure the faithful transmission of
gene expression patterns to progeny cells. Upon chronic infection,
the epigenetic cellular balance can become disrupted and, in the
long run, through the epigenetic reprogramming of host cell
genomes, contribute to the malignant conversion of formerly healthy
cells, in many cases preceded by the establishment of an epigenetic
field of cancerization. The present volume undertakes to highlight
the interactions of infectious pathogens and their effector
molecules with the epigenetic regulatory machinery of the cell.
Clearly, the recent take-off of epigenetics research did not leave
Research on Infectious Diseases and Infection-Associated Cancer
untouched. This resulted in a great many of clinically relevant
data on understanding the molecular mechanisms of chronic
infectious disease. Infectious pathogen- and disease-specific
epigenetic alterations are already being used for the early
detection of malignant disease and for the prediction of
chemotherapy resistance or response to treatment.
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